JP2010535346A - 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法 - Google Patents
衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法 Download PDFInfo
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Abstract
Description
本願は、米国仮出願第60/953,045号(2007年7月31日出願)の利益を主張する。該仮出願は、その全体において参照により本明細書に援用される。
本発明は、国立衛生研究所による契約番号U01AI070801に基づく支援を得ている。政府は、本発明における一定の権利を享有する。
本発明は、特殊化した形態および機能の医療用および獣医用サンプル採取デバイスと、医療用および獣医用分析デバイスと、サンプル採取および分析の両方のための統合マイクロ流体デバイスとに関する。本発明はさらに、生物学的有害物質サンプル採取のための方法に関する。
a)サンプルと、本体およびサンプル受容口を有する試料採取容器とを提供するステップであって、上記の本体は外面および内部中空容積を有し、上記の外面は1つまたは複数の使い捨てスキンを有し、上記のサンプル受容口は密閉可能な閉鎖具を有する、ステップと、
b)上記のサンプル受容口内に上記のサンプルを挿入するステップと、
c)上記のサンプル受容口を上記の密閉可能な閉鎖具で閉じ、それによって上記のサンプルを捕捉するステップと、
d)上記の外面から1つまたは複数の上記の使い捨てスキンを除去し、それによって上記の外面を清新するステップと、
を含む。
以下の定義は、本書の特許請求の範囲および明細書を解釈に資するために提供される。文献が引用または参照することによって組み込まれ、その中に含まれる任意の定義が本書に提供されるものと矛盾する場合、その中で使用される定義は、本書に提供される定義に優先または本書に提供される定義を制限するものではない。
Claims (27)
- スワブ上の生物学的有害物質サンプルの衛生的採取のためのスワブ採取デバイスであって、
a)外面(11)を有する本体(10、30、45、131、140)と、
該スワブを受容するための少なくとも1つの内部中空容積(33、36)と、
該スワブの採取後に該外面(11)を該内部中空容積(33、36、156)から分離するための密閉可能な閉鎖具(7、34、35、165)と
を備え、
b)該外面はさらに、少なくとも1つの使い捨て外部スキン層(2、3、50、60、71、72、81、132、133、142、144、155、159)を備えるものとして特徴付けられ、それによって、生物学的有害物質サンプルを有する該スワブ(20、32、152、158)が該内部中空容積内に封入および密閉された後、該デバイス本体の該外面上に蓄積したあらゆる生物学的有害物質の残留物は、該使い捨て外部スキン層の除去および廃棄によって除去される、
スワブ採取デバイス。 - 前記スワブを受容するための、前記内部中空容積の第1のコンパートメント(33)と、
マイクロ流体アッセイ回路(42)を有する、前記内部中空容積の第2のコンパートメントとを流体結合する、弁付き(37)マイクロ流体チャネル(39)と
をさらに備え、
該マイクロ流体アッセイ回路は、該スワブ上に採取された前記サンプルに流体操作を実行するためのものである、請求項1に記載のスワブ採取デバイス。 - 前記流体操作を実行するための少なくとも1つの搭載液体試薬(40、41)をさらに備える、請求項2に記載のスワブ採取デバイス。
- 前記流体操作は、サンプル分析またはサンプル調製から選択される、請求項3に記載のスワブ採取デバイス。
- 前記使い捨てスキン層は、プラスチックから成る、請求項1に記載のスワブ採取デバイス。
- 前記使い捨て外部スキン層(2、3)は、1つまたは複数の前記外面に接着されたポリエチレン層から成る、請求項1に記載のスワブ採取デバイス。
- 前記使い捨て外部スキン層(2、3、50、60、71、72、81、132、133、142、144、155、159)は、紙を備える、請求項1に記載のスワブ採取デバイス。
- 前記使い捨て外部スキン層(2、3、50、60、71、72、81、132、133、142、144、155、159)は、紙/プラスチック複合材料を備える、請求項1に記載のスワブ採取デバイス。
- 前記使い捨て外部スキン層(2、3)は、フィルムである、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(2、3、50、60、71、72、81、132、133、142、144、155、159)は、吸収性バットをさらに備える、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(71、72、132、133、142、144、155、159)は、成形品である、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(71、72、132、133、142、144、155、159)は、2つのStyrofoamブロックを備えるクラムシェルである、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(50、81)は、熱収縮性プラスチックから成る、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(2、3)は、剥離するためのタブ(4、5)と、除去可能な感圧接着剤の下層とをさらに備える、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(132、133、155、159)は、引き裂くための開封帯(168)をさらに備える、請求項1に記載のスワブ採取デバイス。
- 前記使い捨てスキン層(60)は、前記外面上の雌シール溝(62)と相互係止するための円周密閉リブ(61)をさらに備える、請求項1に記載のスワブ採取デバイス。
- スワブ受容チャンバ(33、156)を備え、前記密閉可能な閉鎖具(7、34、35、165)は、前記スワブ(20、32、152、158)を受容するためのスワブ受容口(134、141、153)に嵌められる、請求項1に記載のスワブ採取デバイス。
- 抽出試薬(41)を含む内部貯留部をさらに備える、請求項1に記載のスワブ採取デバイス。
- 前記抽出試薬は、壊れ易いブリスターパック内に含まれる、請求項18に記載のスワブ採取デバイス。
- 請求項1のスワブ採取デバイスが提供されたトレイまたはボックスを備える、キット。
- 前記使い捨て外部スキンは、標識情報を備える、請求項1に記載のスワブ採取デバイス。
- 生物学的有害物質サンプルを採取するための方法であって、
a)スワブと、本体およびスワブ受容口を有するマイクロ流体分析デバイスとを提供するステップであって、該スワブは、試料採取先端およびハンドルを有し、該先端およびハンドルは、切断点を有する壊れ易いシャフトによって接合され、該本体は、外面および内部中空容積を有し、該外面は、1つまたは複数の使い捨てスキンを有し、該スワブ受容口は、密閉可能な閉鎖具を有する、ステップと、
b)生物学的有害物質サンプルを採取するために該スワブを使用し、該ハンドル上の該切断点まで、該スワブ受容口内に該試料採取先端を挿入するステップと、
c)該切断点において該スワブハンドルを折り取り、該スワブ受容口の上で該密閉可能な閉鎖具を閉めることによって、該デバイスの該本体内に該スワブ試料採取先端を密閉するステップと、
d)該外面から1つまたは複数の該使い捨てスキンを除去するステップと
を含む、方法。 - 生物学的有害物質サンプルを採取するための方法であって、
a)スワブと、本体およびスワブ受容口を有するマイクロ流体分析デバイスとを提供するステップであって、該スワブは、試料採取先端およびハンドルを有し、該先端およびハンドルは、切断点を有する壊れ易いシャフトによって接合され、該本体は、外面および内部中空容積を有し、該外面は、1つまたは複数の使い捨てスキンを有し、該スワブ受容口は、密閉可能な閉鎖具を有する、ステップと、
b)生物学的有害物質サンプルを採取するために該スワブを使用し、該ハンドル上の該切断点まで、該スワブ受容口内に該試料採取先端を挿入するステップと、
c)該切断点においてスワブハンドルを折り取り、該スワブ受容口の上で該密閉可能な閉鎖具を閉めることによって、該デバイスの該本体内に該スワブ試料採取先端を密閉するステップと、
d)該外面から1つまたは複数の該使い捨てスキンを除去するステップと、
e)内蔵された統合分析手段によって該生物学的有害物質サンプルの分析を実行し、結果を表示するステップと
を含む、方法。 - 生物学的有害物質サンプルを採取するための方法であって、
a)スワブと、本体およびスワブ受容口を有するマイクロ流体分析デバイスとを提供するステップであって、該スワブは、試料採取先端およびハンドルを有し、該先端およびハンドルは、切断点を有する壊れ易いシャフトによって接合され、該本体は、外面および内部中空容積を有し、該外面は、1つまたは複数の使い捨てスキンを有し、該スワブ受容口は、密閉可能な閉鎖具を有する、ステップと、
b)生物学的有害物質サンプルを採取するために該スワブを使用し、該ハンドル上の該切断点まで、該スワブ受容口内に該試料採取先端を挿入するステップと、
c)該切断点においてスワブハンドルを折り取り、該スワブ受容口上で該密閉可能な閉鎖具を閉めることによって、該デバイスの該本体内に該スワブ試料採取先端を密閉するステップと、
d)該外面から1つまたは複数の該使い捨てスキンを除去するステップと、
e)該生物学的有害物質サンプルに少なくとも1つのサンプル処理ステップを実行するステップと
を含む、方法。 - 生物学的有害物質サンプルを採取するための方法であって、
a)スワブと、本体およびスワブ受容口を有する試料採取容器とを提供するステップであって、該スワブは、試料採取先端およびハンドルを有し、該先端およびハンドルは、切断点を有する壊れ易いシャフトによって接合され、該本体は、外面および内部中空容積を有し、該外面は、1つまたは複数の使い捨てスキンを有し、該スワブ受容口は、密閉可能な閉鎖具を有する、ステップと、
b)生物学的有害物質サンプルを採取するために該スワブを使用し、該ハンドル上の該切断点まで、該スワブ受容口内に該試料採取先端を挿入するステップと、
c)該切断点においてスワブハンドルを折り取り、該スワブ受容口上で該密閉可能な閉鎖具を閉めることによって、該デバイスの該本体内に該スワブ試料採取先端を密閉するステップと、
d)該外面から1つまたは複数の該使い捨てスキンを除去するステップと
を含む、方法。 - 生物学的有害物質サンプルを採取するための方法であって、
a)サンプルと、本体およびサンプル受容口を有する試料採取容器とを提供するステップであって、該本体は、外面および内部中空容積を有し、該外面は、1つまたは複数の使い捨てスキンを有し、該サンプル受容口は、密閉可能な閉鎖具を有する、ステップと、
b)該サンプル受容口内に該サンプルを挿入するステップと、
c)該サンプル受容口を該密閉可能な閉鎖具で閉じ、それによって該サンプルを捕捉するステップと、
d)該外面から1つまたは複数の該使い捨てスキンを除去し、それによって該外面を清新するステップと
を含む、方法。 - 個別に、または集合的に、本書で開示される、または本願の明細書で示されるステップ、特徴、整数、組成物、および/または化合物、ならびに該ステップまたは特徴のうちの2つ以上の任意の組み合わせ。
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Also Published As
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US20100274155A1 (en) | 2010-10-28 |
WO2009018473A1 (en) | 2009-02-05 |
EP2171420A1 (en) | 2010-04-07 |
US20120271127A1 (en) | 2012-10-25 |
US8216832B2 (en) | 2012-07-10 |
JP5852781B2 (ja) | 2016-02-03 |
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