JP7044948B1 - 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 - Google Patents
疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 Download PDFInfo
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)
- G01N2333/92—Triglyceride splitting, e.g. by means of lipase
Abstract
Description
該当しない。
該当しない。
Claims (8)
- 臨床化学機器を使用するためのマイクロ流体デバイスであって:
標的疎水性分析物を含むことが疑われる試料を受け入れることが可能な少なくとも1つのコンパートメントを含み、ここで、該少なくとも1つのコンパートメントは:
リポタンパク質を消化する少なくとも1つの酵素を含む前処理試薬;および
該試料中に存在する標的疎水性分析物の濃度を決定するための、疎水性分析物を検出することが可能な少なくとも1つのアッセイ試薬
を含む、前記マイクロ流体デバイス。 - マイクロ流体デバイスが、少なくとも2つのコンパートメントを含むものとしてさらに定義され、ここで、前処理試薬は、試料を受け入れることが可能な第1のコンパートメントに配置され、少なくとも1つのアッセイ試薬は、第1のコンパートメントと流体連通していることが可能な第2のコンパートメントに配置され、ここで、該第1のコンパートメントまたは該第2のコンパートメントは、試料中に存在する標的疎水性分析物の濃度を決定するための検出アッセイが実行される読み取りチャンバーである、請求項1に記載のマイクロ流体デバイス。
- リポタンパク質を消化する少なくとも1つの酵素が、リパーゼおよび/または少なくとも1つの消化酵素を含む、請求項1に記載のマイクロ流体デバイス。
- 酵素が、約0.1mg/mL~約20mg/mLの範囲の濃度で前処理試薬中に存在する、請求項1に記載のマイクロ流体デバイス。
- 前処理試薬が、酵素の補助因子、界面活性剤、プロテアーゼ、およびその組合せからなる群から選択される少なくとも1つの追加物質をさらに含む、請求項1に記載のマイクロ流体デバイス。
- リポタンパク質を消化する少なくとも1つの酵素がリパーゼであり、前処理試薬が、リパーゼの補助因子として胆汁酸および/またはその塩を含む、請求項5に記載のマイクロ
流体デバイス。 - 標的疎水性分析物が、ビタミンD、タクロリムス、シロリムス、エベロリムス、エストロゲン、エストロン、エストラジオール、エストリオール、アルファトラジオール、シクロスポリン、エチニルエストラジオール、エステル化エストロゲン、モキセストロール、キネストロール、プロゲスチン、プロゲステロン、アンドロゲン、テストステロン、ジヒドロテストステロン(DHT)、デヒドロエピアンドロステロン(DHEA)、硫酸DHEA、アンドロステンジオン、アルドステロン、コルチゾール、カテコールアミン、25-ヒドロキシビタミンD2、25-ヒドロキシビタミンD3、1,25-ジヒドロキシビタミンD2、および1,25-ジヒドロキシビタミンD3からなる群から選択される、請求項1に記載のマイクロ流体デバイス。
- 少なくとも1つのアッセイ試薬が、さらに免疫アッセイ試薬と定義される、請求項1に記載のマイクロ流体デバイス。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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JP2022040883A JP7377901B2 (ja) | 2019-03-19 | 2022-03-16 | 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 |
JP2023182232A JP2024010075A (ja) | 2019-03-19 | 2023-10-24 | 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 |
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US201962820409P | 2019-03-19 | 2019-03-19 | |
US62/820,409 | 2019-03-19 | ||
PCT/US2020/013629 WO2020190358A1 (en) | 2019-03-19 | 2020-01-15 | Compositions, devices, and methods of mitigating lipoprotein interference in in vitro diagnostic assays for hydrophobic analytes |
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JP2022040883A Division JP7377901B2 (ja) | 2019-03-19 | 2022-03-16 | 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 |
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JP7044948B1 true JP7044948B1 (ja) | 2022-03-30 |
JP2022521814A JP2022521814A (ja) | 2022-04-12 |
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JP2022040883A Active JP7377901B2 (ja) | 2019-03-19 | 2022-03-16 | 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 |
JP2023182232A Pending JP2024010075A (ja) | 2019-03-19 | 2023-10-24 | 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 |
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JP2023182232A Pending JP2024010075A (ja) | 2019-03-19 | 2023-10-24 | 疎水性分析物のin vitro診断アッセイにおけるリポタンパク質妨害を軽減する組成物、デバイス、および方法 |
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US (2) | US11358143B2 (ja) |
EP (1) | EP3941627B1 (ja) |
JP (3) | JP7044948B1 (ja) |
CN (2) | CN113631272B (ja) |
WO (1) | WO2020190358A1 (ja) |
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WO2022259890A1 (ja) | 2021-06-10 | 2022-12-15 | 恵和株式会社 | 光拡散シート、光拡散シート積層体、バックライトユニット、及び液晶表示装置 |
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JP2010535346A (ja) | 2007-07-31 | 2010-11-18 | マイクロニクス, インコーポレイテッド | 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法 |
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- 2020-01-15 EP EP20773681.0A patent/EP3941627B1/en active Active
- 2020-01-15 CN CN202080022535.2A patent/CN113631272B/zh active Active
- 2020-01-15 JP JP2021556430A patent/JP7044948B1/ja active Active
- 2020-01-15 WO PCT/US2020/013629 patent/WO2020190358A1/en unknown
- 2020-01-15 US US17/310,469 patent/US11358143B2/en active Active
- 2020-01-15 CN CN202211234022.5A patent/CN115418389A/zh active Pending
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2022
- 2022-03-16 JP JP2022040883A patent/JP7377901B2/ja active Active
- 2022-05-12 US US17/663,020 patent/US20220387994A1/en active Pending
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JP2010535346A (ja) | 2007-07-31 | 2010-11-18 | マイクロニクス, インコーポレイテッド | 衛生的スワブ採取システム、マイクロ流体アッセイデバイスおよび診断アッセイのための方法 |
JP2018501485A (ja) | 2014-12-17 | 2018-01-18 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. | 疎水性ハプテン被検体の正確なアッセイ測定 |
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CN115418389A (zh) | 2022-12-02 |
EP3941627A4 (en) | 2022-08-03 |
EP3941627B1 (en) | 2024-04-24 |
EP3941627A1 (en) | 2022-01-26 |
JP2024010075A (ja) | 2024-01-23 |
JP2022078307A (ja) | 2022-05-24 |
US20220040693A1 (en) | 2022-02-10 |
CN113631272B (zh) | 2022-12-20 |
US11358143B2 (en) | 2022-06-14 |
WO2020190358A1 (en) | 2020-09-24 |
US20220387994A1 (en) | 2022-12-08 |
CN113631272A (zh) | 2021-11-09 |
JP7377901B2 (ja) | 2023-11-10 |
JP2022521814A (ja) | 2022-04-12 |
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