JP2010533726A5 - - Google Patents
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- Publication number
- JP2010533726A5 JP2010533726A5 JP2010517122A JP2010517122A JP2010533726A5 JP 2010533726 A5 JP2010533726 A5 JP 2010533726A5 JP 2010517122 A JP2010517122 A JP 2010517122A JP 2010517122 A JP2010517122 A JP 2010517122A JP 2010533726 A5 JP2010533726 A5 JP 2010533726A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- cycloalkyl
- alkyl
- heterocyclyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000753 cycloalkyl group Chemical group 0.000 claims 257
- 125000003118 aryl group Chemical group 0.000 claims 249
- 125000000217 alkyl group Chemical group 0.000 claims 224
- 125000000623 heterocyclic group Chemical group 0.000 claims 208
- 125000003342 alkenyl group Chemical group 0.000 claims 149
- 125000001072 heteroaryl group Chemical group 0.000 claims 141
- 125000000304 alkynyl group Chemical group 0.000 claims 140
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 134
- 125000003710 aryl alkyl group Chemical group 0.000 claims 105
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 98
- 125000004093 cyano group Chemical group *C#N 0.000 claims 91
- 125000001475 halogen functional group Chemical group 0.000 claims 91
- 229920000728 polyester Polymers 0.000 claims 90
- 125000001188 haloalkyl group Chemical group 0.000 claims 77
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 76
- 229910052739 hydrogen Inorganic materials 0.000 claims 71
- 239000001257 hydrogen Substances 0.000 claims 71
- 150000002431 hydrogen Chemical class 0.000 claims 66
- -1 -NH 2 Chemical group 0.000 claims 63
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000002950 monocyclic group Chemical group 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000004946 alkenylalkyl group Chemical group 0.000 claims 3
- 125000005038 alkynylalkyl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 101700062901 DPP Proteins 0.000 claims 2
- 102100012353 DPP4 Human genes 0.000 claims 2
- 206010061227 Lipid metabolism disease Diseases 0.000 claims 2
- 208000003067 Myocardial Ischemia Diseases 0.000 claims 2
- 206010038932 Retinopathy Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 230000037356 lipid metabolism Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 208000003432 Bone Disease Diseases 0.000 claims 1
- 206010007554 Cardiac failure Diseases 0.000 claims 1
- 206010057668 Cognitive disease Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 102000015787 HIV Protease Human genes 0.000 claims 1
- 108010010369 HIV Protease Proteins 0.000 claims 1
- 206010019280 Heart failure Diseases 0.000 claims 1
- 208000009576 Hypercholesterolemia Diseases 0.000 claims 1
- 206010060378 Hyperinsulinaemia Diseases 0.000 claims 1
- 206010062060 Hyperlipidaemia Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000006575 Hypertriglyceridemia Diseases 0.000 claims 1
- 206010022489 Insulin resistance Diseases 0.000 claims 1
- 206010024604 Lipoatrophy Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 1
- 206010029331 Neuropathy peripheral Diseases 0.000 claims 1
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 206010038428 Renal disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 230000000879 anti-atherosclerotic Effects 0.000 claims 1
- 230000000326 anti-hypercholesterolaemic Effects 0.000 claims 1
- 230000002058 anti-hyperglycaemic Effects 0.000 claims 1
- 230000001315 anti-hyperlipaemic Effects 0.000 claims 1
- 230000003276 anti-hypertensive Effects 0.000 claims 1
- 230000001346 anti-hypertriglyceridemic Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000003063 anti-neuropathic Effects 0.000 claims 1
- 230000003579 anti-obesity Effects 0.000 claims 1
- 230000002769 anti-restenotic Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 239000002830 appetite depressant Substances 0.000 claims 1
- 201000001320 atherosclerosis Diseases 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000003111 delayed Effects 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000004217 heart function Effects 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 239000000864 hyperglycemic agent Substances 0.000 claims 1
- 230000003451 hyperinsulinaemic Effects 0.000 claims 1
- 201000008980 hyperinsulinism Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 200000000008 restenosis Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95016207P | 2007-07-17 | 2007-07-17 | |
US60/950,162 | 2007-07-17 | ||
PCT/US2008/070101 WO2009012275A1 (en) | 2007-07-17 | 2008-07-16 | Pyridone gpr119 g protein-coupled receptor agonists |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013144778A Division JP2013237680A (ja) | 2007-07-17 | 2013-07-10 | ピリドンgpr119gタンパク質共役受容体アゴニスト |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010533726A JP2010533726A (ja) | 2010-10-28 |
JP2010533726A5 true JP2010533726A5 (US07928230-20110419-C00134.png) | 2011-02-24 |
JP5318867B2 JP5318867B2 (ja) | 2013-10-16 |
Family
ID=39864683
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010517122A Expired - Fee Related JP5318867B2 (ja) | 2007-07-17 | 2008-07-16 | ピリドンgpr119gタンパク質共役受容体アゴニスト |
JP2010517123A Expired - Fee Related JP5301539B2 (ja) | 2007-07-17 | 2008-07-16 | Gpr119gタンパク質共役受容体の調節方法および選択された化合物 |
JP2013144778A Withdrawn JP2013237680A (ja) | 2007-07-17 | 2013-07-10 | ピリドンgpr119gタンパク質共役受容体アゴニスト |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010517123A Expired - Fee Related JP5301539B2 (ja) | 2007-07-17 | 2008-07-16 | Gpr119gタンパク質共役受容体の調節方法および選択された化合物 |
JP2013144778A Withdrawn JP2013237680A (ja) | 2007-07-17 | 2013-07-10 | ピリドンgpr119gタンパク質共役受容体アゴニスト |
Country Status (27)
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2006059778A1 (ja) * | 2004-12-01 | 2006-06-08 | Banyu Pharmaceutical Co., Ltd. | 置換ピリドン誘導体 |
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CA2693439A1 (en) * | 2007-07-17 | 2009-01-22 | Bristol-Myers Squibb Company | Pyridone gpr119 g protein-coupled receptor agonists |
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-
2008
- 2008-07-16 CA CA2693439A patent/CA2693439A1/en not_active Abandoned
- 2008-07-16 PT PT08781868T patent/PT2173737E/pt unknown
- 2008-07-16 AT AT08781868T patent/ATE540945T1/de active
- 2008-07-16 ES ES08781867T patent/ES2371515T3/es active Active
- 2008-07-16 BR BRPI0814428-1A2A patent/BRPI0814428A2/pt not_active IP Right Cessation
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