JP2010532381A - Ｒａｆキナーゼ阻害剤として有用な複素環式化合物 - Google Patents

Ｒａｆキナーゼ阻害剤として有用な複素環式化合物 Download PDF

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Publication number
JP2010532381A
JP2010532381A JP2010515223A JP2010515223A JP2010532381A JP 2010532381 A JP2010532381 A JP 2010532381A JP 2010515223 A JP2010515223 A JP 2010515223A JP 2010515223 A JP2010515223 A JP 2010515223A JP 2010532381 A JP2010532381 A JP 2010532381A
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JP
Japan
Prior art keywords
compound
optionally substituted
mmol
nitrogen
ring
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Pending
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JP2010515223A
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English (en)
Japanese (ja)
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JP2010532381A5 (OSRAM
Inventor
ジェニファー コスロー，
ビン グアン，
アレクセイ イシチェンコ，
ジョン ホワード ジョーンズ，
グナナサンバンダム クマールエーベル，
アレクセイ ルゴフスコイ，
ハイルー ペン，
ノエル ポーウェル，
ブライアン レイムンド，
裕子 田中
ジェフリー ベッセルズ，
トーマス ウィン，
チリ シン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen Inc
Biogen MA Inc
Original Assignee
Biogen Inc
Biogen Idec Inc
Biogen Idec MA Inc
Biogen MA Inc
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Application filed by Biogen Inc, Biogen Idec Inc, Biogen Idec MA Inc, Biogen MA Inc filed Critical Biogen Inc
Publication of JP2010532381A publication Critical patent/JP2010532381A/ja
Publication of JP2010532381A5 publication Critical patent/JP2010532381A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2010515223A 2007-06-29 2008-06-30 Ｒａｆキナーゼ阻害剤として有用な複素環式化合物 Pending JP2010532381A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94731907P 2007-06-29 2007-06-29
PCT/US2008/068789 WO2009006404A2 (en) 2007-06-29 2008-06-30 Heterocyclic compounds useful as raf kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2010532381A true JP2010532381A (ja) 2010-10-07
JP2010532381A5 JP2010532381A5 (OSRAM) 2012-07-26

Family

ID=40015666

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010515223A Pending JP2010532381A (ja) 2007-06-29 2008-06-30 Ｒａｆキナーゼ阻害剤として有用な複素環式化合物

Country Status (8)

Country Link
US (1) US7968536B2 (OSRAM)
EP (1) EP2167497A2 (OSRAM)
JP (1) JP2010532381A (OSRAM)
CN (1) CN101743242A (OSRAM)
AU (1) AU2008273017C1 (OSRAM)
CA (1) CA2694284A1 (OSRAM)
NZ (1) NZ582349A (OSRAM)
WO (1) WO2009006404A2 (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106898779A (zh) * 2015-12-21 2017-06-27 斯沃奇集团研究和开发有限公司 用于金属/空气电池的正极和制造该正极的方法
JP2021512861A (ja) * 2018-02-01 2021-05-20 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP2023517519A (ja) * 2020-03-02 2023-04-26 シロナックス・リミテッド フェロトーシス阻害剤ジアリールアミンパラアセトアミド類

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EP2379513A1 (en) * 2008-12-30 2011-10-26 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as raf kinase inhibitors
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CN102936251A (zh) * 2012-11-05 2013-02-20 上海毕得医药科技有限公司 一种吡咯并[2,3-d]嘧啶衍生物的制备方法
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US20160221964A1 (en) 2013-09-16 2016-08-04 Basf Se Fungicidal pyrimidine compounds
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CN104761502A (zh) * 2014-01-03 2015-07-08 中国药科大学 苯并咪唑衍生物、其制法及医药用途
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UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
WO2016113863A1 (ja) * 2015-01-14 2016-07-21 株式会社 東芝 非水電解質電池及び電池パック
JP2019196307A (ja) 2016-09-15 2019-11-14 武田薬品工業株式会社 複素環アミド化合物
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CN106928152A (zh) * 2017-03-03 2017-07-07 符爱清 一种尿嘧啶的制备方法
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US11858930B2 (en) * 2020-07-28 2024-01-02 Jazz Pharmaceuticals Ireland Limited Fused bicyclic RAF inhibitors and methods for use thereof
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Cited By (7)

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Publication number Priority date Publication date Assignee Title
CN106898779A (zh) * 2015-12-21 2017-06-27 斯沃奇集团研究和开发有限公司 用于金属/空气电池的正极和制造该正极的方法
CN106898779B (zh) * 2015-12-21 2020-05-12 斯沃奇集团研究和开发有限公司 用于金属/空气电池的正极和制造该正极的方法
JP2021512861A (ja) * 2018-02-01 2021-05-20 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP2022160635A (ja) * 2018-02-01 2022-10-19 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP7184383B2 (ja) 2018-02-01 2022-12-06 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP7590004B2 (ja) 2018-02-01 2024-11-26 ザ・ユニバーシティ・オブ・シドニー 抗癌性化合物
JP2023517519A (ja) * 2020-03-02 2023-04-26 シロナックス・リミテッド フェロトーシス阻害剤ジアリールアミンパラアセトアミド類

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Publication number Publication date
NZ582349A (en) 2012-06-29
US20090005359A1 (en) 2009-01-01
AU2008273017A1 (en) 2009-01-08
WO2009006404A3 (en) 2009-07-30
AU2008273017C1 (en) 2014-02-13
EP2167497A2 (en) 2010-03-31
CA2694284A1 (en) 2009-01-08
CN101743242A (zh) 2010-06-16
WO2009006404A2 (en) 2009-01-08
AU2008273017B2 (en) 2013-10-10
US7968536B2 (en) 2011-06-28

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