JP2010532173A5 - - Google Patents
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- JP2010532173A5 JP2010532173A5 JP2010515226A JP2010515226A JP2010532173A5 JP 2010532173 A5 JP2010532173 A5 JP 2010532173A5 JP 2010515226 A JP2010515226 A JP 2010515226A JP 2010515226 A JP2010515226 A JP 2010515226A JP 2010532173 A5 JP2010532173 A5 JP 2010532173A5
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- Prior art keywords
- cells
- pluripotent
- cell
- population
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims description 122
- 238000000034 method Methods 0.000 claims description 60
- 239000007788 liquid Substances 0.000 claims description 26
- 102000035195 Peptidases Human genes 0.000 claims description 25
- 108091005804 Peptidases Proteins 0.000 claims description 25
- 239000002609 medium Substances 0.000 claims description 25
- 239000001963 growth medium Substances 0.000 claims description 22
- 239000003112 inhibitor Substances 0.000 claims description 20
- 238000000926 separation method Methods 0.000 claims description 19
- 108091000080 Phosphotransferase Proteins 0.000 claims description 14
- 102000020233 phosphotransferase Human genes 0.000 claims description 14
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 9
- 238000004113 cell culture Methods 0.000 claims description 9
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 8
- 238000013019 agitation Methods 0.000 claims description 7
- 230000012010 growth Effects 0.000 claims description 6
- 229940122618 Trypsin inhibitor Drugs 0.000 claims description 5
- 101710162629 Trypsin inhibitor Proteins 0.000 claims description 5
- VVBXXVAFSPEIJQ-CVIPOMFBSA-N [(2r)-3-[[(2r)-1-[[(2s,5r,8r,11r,12s,15s,18s,21s)-15-[3-(diaminomethylideneamino)propyl]-21-hydroxy-5-[(4-hydroxyphenyl)methyl]-4,11-dimethyl-2-(2-methylpropyl)-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]am Chemical compound C([C@@H]1C(=O)N[C@@H](C(=O)O[C@H](C)[C@@H](C(N[C@@H](CCCN=C(N)N)C(=O)N[C@H]2CC[C@H](O)N(C2=O)[C@@H](CC(C)C)C(=O)N1C)=O)NC(=O)[C@H](NC(=O)[C@H](O)COS(O)(=O)=O)CC(C)C)C(C)C)C1=CC=C(O)C=C1 VVBXXVAFSPEIJQ-CVIPOMFBSA-N 0.000 claims description 5
- 230000010261 cell growth Effects 0.000 claims description 5
- 239000002753 trypsin inhibitor Substances 0.000 claims description 5
- 102000004142 Trypsin Human genes 0.000 claims description 4
- 108090000631 Trypsin Proteins 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 4
- 238000012423 maintenance Methods 0.000 claims description 4
- 230000035755 proliferation Effects 0.000 claims description 4
- 239000012588 trypsin Substances 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 3
- 108090000790 Enzymes Proteins 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 3
- 244000068988 Glycine max Species 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 2
- 239000012530 fluid Substances 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000010899 nucleation Methods 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 235000019833 protease Nutrition 0.000 claims description 2
- 235000019419 proteases Nutrition 0.000 claims description 2
- 230000001810 trypsinlike Effects 0.000 claims description 2
- 102000000568 rho-Associated Kinases Human genes 0.000 claims 9
- 108010041788 rho-Associated Kinases Proteins 0.000 claims 9
- ADDJDJQFPKUMAF-SFHVURJKSA-N (4s)-5-amino-5-oxo-4-[[4-(4-phenylthiophen-2-yl)benzoyl]amino]pentanoic acid Chemical compound C1=CC(C(=O)N[C@@H](CCC(O)=O)C(=O)N)=CC=C1C1=CC(C=2C=CC=CC=2)=CS1 ADDJDJQFPKUMAF-SFHVURJKSA-N 0.000 claims 1
- 229940121649 protein inhibitor Drugs 0.000 claims 1
- 239000012268 protein inhibitor Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011435 rock Substances 0.000 description 9
- 239000011159 matrix material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94701307P | 2007-06-29 | 2007-06-29 | |
| US60/947,013 | 2007-06-29 | ||
| PCT/US2008/068814 WO2009006422A1 (en) | 2007-06-29 | 2008-06-30 | Automated method and apparatus for embryonic stem cell culture |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014063625A Division JP2014110817A (ja) | 2007-06-29 | 2014-03-26 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016125186A Division JP2016168056A (ja) | 2007-06-29 | 2016-06-24 | 胚性幹細胞培養のための自動化された方法および装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010532173A JP2010532173A (ja) | 2010-10-07 |
| JP2010532173A5 true JP2010532173A5 (https=) | 2012-07-26 |
| JP5991796B2 JP5991796B2 (ja) | 2016-09-14 |
Family
ID=39672032
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010515226A Active JP5991796B2 (ja) | 2007-06-29 | 2008-06-30 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2014063625A Pending JP2014110817A (ja) | 2007-06-29 | 2014-03-26 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016125186A Pending JP2016168056A (ja) | 2007-06-29 | 2016-06-24 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016217785A Pending JP2017023158A (ja) | 2007-06-29 | 2016-11-08 | 胚性幹細胞培養のための自動化された方法および装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014063625A Pending JP2014110817A (ja) | 2007-06-29 | 2014-03-26 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016125186A Pending JP2016168056A (ja) | 2007-06-29 | 2016-06-24 | 胚性幹細胞培養のための自動化された方法および装置 |
| JP2016217785A Pending JP2017023158A (ja) | 2007-06-29 | 2016-11-08 | 胚性幹細胞培養のための自動化された方法および装置 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8815585B2 (https=) |
| EP (2) | EP3293256B1 (https=) |
| JP (4) | JP5991796B2 (https=) |
| KR (2) | KR20160005142A (https=) |
| AU (1) | AU2008272949B2 (https=) |
| CA (1) | CA2691793A1 (https=) |
| DK (2) | DK2173863T3 (https=) |
| WO (1) | WO2009006422A1 (https=) |
Families Citing this family (81)
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|---|---|---|---|---|
| EP1962719A4 (en) | 2005-08-29 | 2011-05-04 | Technion Res And Dev Of Foundation Ltd | MEDIA FOR BREEDING STEM CELLS |
| DK3441459T3 (da) | 2006-08-02 | 2021-06-07 | Technion Res & Dev Foundation | Fremgangsmåder til ekspansion af embryonale stamceller i en suspensionskultur |
| US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
| DK2185693T3 (da) | 2007-07-31 | 2019-09-23 | Lifescan Inc | Differentiering af humane embryoniske stamceller |
| JP5733986B2 (ja) | 2008-02-21 | 2015-06-10 | ヤンセン バイオテツク，インコーポレーテツド | 細胞の付着、培養、及び剥離のための方法、表面改質されたプレート、並びに組成物 |
| US8691569B2 (en) | 2008-03-17 | 2014-04-08 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| JP2011514169A (ja) | 2008-03-17 | 2011-05-06 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 幹細胞培養のためのマイクロキャリア |
| US8828720B2 (en) | 2008-03-17 | 2014-09-09 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| MX2010010165A (es) | 2008-03-17 | 2010-11-25 | Scripps Research Inst | Procedimientos quimicos y geneticos combinados para generacion de celulas madre pluripotentes inducidas. |
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| DE102004043256B4 (de) | 2004-09-07 | 2013-09-19 | Rheinische Friedrich-Wilhelms-Universität Bonn | Skalierbarer Prozess zur Kultivierung undifferenzierter Stammzellen in Suspension |
| ATE549395T1 (de) * | 2004-09-08 | 2012-03-15 | Wisconsin Alumni Res Found | Medium und kultur von embryonalen stammzellen |
| US20060198827A1 (en) | 2005-02-04 | 2006-09-07 | Shulamit Levenberg | Engineering vascularized muscle tissue |
| US20060199265A1 (en) | 2005-03-02 | 2006-09-07 | Wolf Michael F | Seeding implantable medical devices with cells |
-
2008
- 2008-06-30 WO PCT/US2008/068814 patent/WO2009006422A1/en not_active Ceased
- 2008-06-30 DK DK08781187.3T patent/DK2173863T3/en active
- 2008-06-30 CA CA2691793A patent/CA2691793A1/en not_active Abandoned
- 2008-06-30 US US12/164,969 patent/US8815585B2/en active Active
- 2008-06-30 EP EP17192886.4A patent/EP3293256B1/en active Active
- 2008-06-30 KR KR1020157036767A patent/KR20160005142A/ko not_active Ceased
- 2008-06-30 EP EP08781187.3A patent/EP2173863B1/en active Active
- 2008-06-30 AU AU2008272949A patent/AU2008272949B2/en active Active
- 2008-06-30 KR KR1020107002003A patent/KR20100059789A/ko not_active Ceased
- 2008-06-30 JP JP2010515226A patent/JP5991796B2/ja active Active
- 2008-06-30 DK DK17192886.4T patent/DK3293256T3/da active
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2013
- 2013-03-19 US US13/847,349 patent/US20130316445A1/en not_active Abandoned
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2014
- 2014-03-26 JP JP2014063625A patent/JP2014110817A/ja active Pending
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2016
- 2016-06-24 JP JP2016125186A patent/JP2016168056A/ja active Pending
- 2016-11-08 JP JP2016217785A patent/JP2017023158A/ja active Pending
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