JP2010528011A5 - - Google Patents
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- Publication number
- JP2010528011A5 JP2010528011A5 JP2010509380A JP2010509380A JP2010528011A5 JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5 JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010509380 A JP2010509380 A JP 2010509380A JP 2010528011 A5 JP2010528011 A5 JP 2010528011A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound according
- fluoropyridin
- methylphenyl
- pyrimidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- NPFDWHQSDBWQLH-QZTJIDSGSA-N filorexant Chemical compound C([C@@H]1CC[C@H](N(C1)C(=O)C=1C(=CC=C(C)C=1)C=1N=CC=CN=1)C)OC1=CC=C(F)C=N1 NPFDWHQSDBWQLH-QZTJIDSGSA-N 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- -1 5-fluoropyridin-2-yl Chemical group 0.000 claims 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 206010022437 insomnia Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93145807P | 2007-05-23 | 2007-05-23 | |
| US60/931,458 | 2007-05-23 | ||
| PCT/US2008/006563 WO2008147518A1 (en) | 2007-05-23 | 2008-05-22 | Pyridyl piperidine orexin receptor antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Division JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010528011A JP2010528011A (ja) | 2010-08-19 |
| JP2010528011A5 true JP2010528011A5 (cg-RX-API-DMAC7.html) | 2011-12-08 |
| JP4881476B2 JP4881476B2 (ja) | 2012-02-22 |
Family
ID=39708485
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010509380A Expired - Fee Related JP4881476B2 (ja) | 2007-05-23 | 2008-05-22 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011229710A Expired - Fee Related JP5639564B2 (ja) | 2007-05-23 | 2011-10-19 | ピリジルピペリジン・オレキシン受容体アンタゴニスト |
Country Status (33)
Families Citing this family (78)
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| ES2350460T3 (es) * | 2006-09-29 | 2011-01-24 | Actelion Pharmaceuticals Ltd. | Derivados de 3-aza-biciclo[3.1.0]hexano. |
| CA2669060A1 (en) | 2006-12-01 | 2008-06-05 | Actelion Pharmaceuticals Ltd | Piperidine compounds |
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| CL2008000836A1 (es) * | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| PL2152690T3 (pl) | 2007-05-23 | 2012-06-29 | Merck Sharp & Dohme | Pirydylo piperydynowi antagoniści receptora oreksyny |
| KR20100046047A (ko) * | 2007-07-27 | 2010-05-04 | 액테리온 파마슈티칼 리미티드 | 2-아자-비시클로[3.3.0]옥탄 유도체 |
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| GB0806536D0 (en) * | 2008-04-10 | 2008-05-14 | Glaxo Group Ltd | Novel compounds |
| CN102015645B (zh) * | 2008-04-30 | 2012-11-14 | 埃科特莱茵药品有限公司 | 哌啶和吡咯烷化合物 |
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| WO2010048014A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| CA2739927A1 (en) | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | Disubstituted azepan orexin receptor antagonists |
| JP2012506374A (ja) | 2008-10-21 | 2012-03-15 | メルク・シャープ・エンド・ドーム・コーポレイション | ２，５−二置換ピペリジンオレキシン受容体アンタゴニスト |
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| EP2275421A1 (en) | 2009-07-15 | 2011-01-19 | Rottapharm S.p.A. | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction |
| WO2011023578A1 (en) * | 2009-08-24 | 2011-03-03 | Glaxo Group Limited | 5-methyl-piperidine derivatives as orexin receptor antagonists for the treatment of sleep disorder |
| US9012636B2 (en) | 2010-10-29 | 2015-04-21 | Merck Sharp & Dohme Corp. | Process for the preparation of an orexin receptor antagonist |
| EP2484674A1 (en) | 2011-02-02 | 2012-08-08 | Rottapharm S.P.A. | Spiro aminic compounds with NK1 antagonist activity |
| WO2012114252A1 (en) * | 2011-02-21 | 2012-08-30 | Actelion Pharmaceuticals Ltd | Novel indole and pyrrolopyridine amides |
| US20140228377A1 (en) * | 2011-07-05 | 2014-08-14 | Taisho Pharmaceutical Co., Ltd. | Methylpiperidine derivative |
| WO2013016668A2 (en) * | 2011-07-28 | 2013-01-31 | Kempharm Inc. | Methylphenidate-prodrugs, processes of making and using the same |
| AR088352A1 (es) | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| EP2768305A4 (en) * | 2011-10-21 | 2015-04-29 | Merck Sharp & Dohme | 2,5-DISUBSTITUTED THIOMORPHOLIN OREXINE RECEPTOR ANTAGONISTS |
| ITMI20112329A1 (it) | 2011-12-21 | 2013-06-22 | Rottapharm Spa | Nuovi derivati spiro amminici |
| WO2013119639A1 (en) * | 2012-02-07 | 2013-08-15 | Eolas Therapeutics, Inc. | Substituted prolines / piperidines as orexin receptor antagonists |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| EP2814798B1 (en) * | 2012-02-17 | 2019-04-03 | Eisai R&D Management Co., Ltd. | Methods and compounds useful in the synthesis of orexin-2 receptor antagonists |
| ITMI20120322A1 (it) | 2012-03-01 | 2013-09-02 | Rottapharm Spa | Composti di 4,4-difluoro piperidina |
| ITMI20120424A1 (it) | 2012-03-19 | 2013-09-20 | Rottapharm Spa | Composti chimici |
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| EP2934517A4 (en) * | 2012-12-20 | 2016-05-25 | Merck Sharp & Dohme | 2-PYRIDYLOXY-3-NITRIL-4-SUBSTITUTED OREXINE RECEPTOR ANTAGONISTS |
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| JP6423372B2 (ja) | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体 |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| EP2964226A4 (en) * | 2013-03-08 | 2016-08-10 | Merck Sharp & Dohme | 2-pyridyloxy-4-ESTER-orexin receptor antagonists |
| WO2014176142A1 (en) * | 2013-04-23 | 2014-10-30 | Merck Sharp & Dohme Corp. | Hydroxy-substituted orexin receptor antagonists |
| EP2988746A1 (en) * | 2013-04-23 | 2016-03-02 | Merck Sharp & Dohme Corp. | Halo and trifluoromethyl substituted orexin receptor antagonists |
| WO2015018029A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Oxazole orexin receptor antagonists |
| WO2015018027A1 (en) | 2013-08-08 | 2015-02-12 | Merck Sharp & Dohme Corp. | Thiazole orexin receptor antagonists |
| WO2015095441A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-amino-3-ester-pyridyl orexin receptor antagonists |
| PE20170184A1 (es) * | 2014-03-06 | 2017-04-07 | Shanghai Haiyan Pharmaceutical Tech Co Ltd | Derivados de piperidina como antagonista de receptores de orexina |
| JP6598844B2 (ja) | 2014-03-27 | 2019-10-30 | バード・ロック・バイオ・インコーポレイテッド | ヒトカンナビノイド１（ｃｂ１）受容体に結合する抗体 |
| US10221170B2 (en) | 2014-08-13 | 2019-03-05 | Eolas Therapeutics, Inc. | Difluoropyrrolidines as orexin receptor modulators |
| WO2016065587A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole orexin receptor antagonists |
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| WO2016065584A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine oxadiazole and thiadiazole orexin receptor antagonists |
| WO2016065586A1 (en) | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Pyrazole, triazole and tetrazole orexin receptor antagonists |
| WO2016065585A1 (en) * | 2014-10-30 | 2016-05-06 | Merck Sharp & Dohme Corp. | Piperidine isoxazole and isothiazole orexin receptor antagonists |
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| US10000499B2 (en) | 2014-11-26 | 2018-06-19 | Merck Sharp & Dohme Corp. | Methyl diazepane orexin receptor antagonists |
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| EP3454857A1 (en) | 2016-05-10 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
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| WO2020004537A1 (ja) * | 2018-06-29 | 2020-01-02 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
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-
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- 2008-05-22 PL PL08754659T patent/PL2152690T3/pl unknown
- 2008-05-22 SI SI200830593T patent/SI2152690T1/sl unknown
- 2008-05-22 DK DK08754659.4T patent/DK2152690T3/da active
- 2008-05-22 RS RS20120111A patent/RS52200B/sr unknown
- 2008-05-22 WO PCT/US2008/006563 patent/WO2008147518A1/en not_active Ceased
- 2008-05-22 CN CN2008800169258A patent/CN101679366B/zh not_active Expired - Fee Related
- 2008-05-22 PT PT08754659T patent/PT2152690E/pt unknown
- 2008-05-22 UA UAA200913366A patent/UA99620C2/ru unknown
- 2008-05-22 US US12/600,388 patent/US8242121B2/en active Active
- 2008-05-22 NZ NZ580887A patent/NZ580887A/en not_active IP Right Cessation
- 2008-05-22 CA CA2687321A patent/CA2687321C/en not_active Expired - Fee Related
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- 2008-05-22 EP EP08754659A patent/EP2152690B1/en active Active
- 2008-05-22 RU RU2009147733/04A patent/RU2470021C2/ru not_active IP Right Cessation
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