CA2687321C - Pyridyl piperidine orexin receptor antagonists - Google Patents

Pyridyl piperidine orexin receptor antagonists Download PDF

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Publication number
CA2687321C
CA2687321C CA2687321A CA2687321A CA2687321C CA 2687321 C CA2687321 C CA 2687321C CA 2687321 A CA2687321 A CA 2687321A CA 2687321 A CA2687321 A CA 2687321A CA 2687321 C CA2687321 C CA 2687321C
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Prior art keywords
methyl
methylpiperidin
fluoropyridin
carbonyl
oxy
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Expired - Fee Related
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CA2687321A
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English (en)
French (fr)
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CA2687321A1 (en
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Michael J. Breslin
Paul J. Coleman
Christopher D. Cox
John D. Schreier
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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CA2687321A 2007-05-23 2008-05-22 Pyridyl piperidine orexin receptor antagonists Expired - Fee Related CA2687321C (en)

Applications Claiming Priority (3)

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