JP2010526536A5 - - Google Patents
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- Publication number
- JP2010526536A5 JP2010526536A5 JP2010507693A JP2010507693A JP2010526536A5 JP 2010526536 A5 JP2010526536 A5 JP 2010526536A5 JP 2010507693 A JP2010507693 A JP 2010507693A JP 2010507693 A JP2010507693 A JP 2010507693A JP 2010526536 A5 JP2010526536 A5 JP 2010526536A5
- Authority
- JP
- Japan
- Prior art keywords
- natural
- genetically modified
- thermophilic
- mesophilic
- modified microorganism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000005700 microbiome Species 0.000 claims 58
- 108090000623 proteins and genes Proteins 0.000 claims 32
- 102000004190 Enzymes Human genes 0.000 claims 24
- 108090000790 Enzymes Proteins 0.000 claims 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 24
- 235000000346 sugar Nutrition 0.000 claims 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 9
- -1 hexose sugars Chemical class 0.000 claims 9
- 150000007524 organic acids Chemical class 0.000 claims 8
- 229920002678 cellulose Polymers 0.000 claims 6
- 239000001913 cellulose Substances 0.000 claims 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 230000002503 metabolic effect Effects 0.000 claims 6
- 241000186339 Thermoanaerobacter Species 0.000 claims 5
- 238000000855 fermentation Methods 0.000 claims 5
- 230000004151 fermentation Effects 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 230000001105 regulatory effect Effects 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229920001221 xylan Polymers 0.000 claims 5
- 150000004823 xylans Chemical class 0.000 claims 5
- 108010092060 Acetate kinase Proteins 0.000 claims 4
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 4
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 4
- 108700023175 Phosphate acetyltransferases Proteins 0.000 claims 4
- 241000193830 Bacillus <bacterium> Species 0.000 claims 3
- 241000193403 Clostridium Species 0.000 claims 3
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 239000004310 lactic acid Substances 0.000 claims 3
- 235000014655 lactic acid Nutrition 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 150000002972 pentoses Chemical class 0.000 claims 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 2
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 2
- 241000186063 Arthrobacter Species 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 2
- 108010011939 Pyruvate Decarboxylase Proteins 0.000 claims 2
- 241001137870 Thermoanaerobacterium Species 0.000 claims 2
- 241001147773 Thermoanaerobacterium xylanolyticum Species 0.000 claims 2
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 150000002402 hexoses Chemical class 0.000 claims 2
- 239000002029 lignocellulosic biomass Substances 0.000 claims 2
- 241001455623 Anaerocellum Species 0.000 claims 1
- 235000007119 Ananas comosus Nutrition 0.000 claims 1
- 244000099147 Ananas comosus Species 0.000 claims 1
- 241001626813 Anoxybacillus Species 0.000 claims 1
- 241001468259 Anoxybacillus flavithermus Species 0.000 claims 1
- 241001520170 Anoxybacillus gonensis Species 0.000 claims 1
- 241001487119 Anoxybacillus kamchatkensis Species 0.000 claims 1
- 241000321602 Caldanaerobius zeae Species 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 241000626621 Geobacillus Species 0.000 claims 1
- 241000193385 Geobacillus stearothermophilus Species 0.000 claims 1
- 108010018080 L-arabinose isomerase Proteins 0.000 claims 1
- 108090000416 L-ribulose-5-phosphate 4-epimerases Proteins 0.000 claims 1
- 241000933069 Lachnoclostridium phytofermentans Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241000179039 Paenibacillus Species 0.000 claims 1
- 241000933952 Paenibacillus campinasensis Species 0.000 claims 1
- 241001621940 Parageobacillus caldoxylosilyticus Species 0.000 claims 1
- 241000193448 Ruminiclostridium thermocellum Species 0.000 claims 1
- 241001147742 Saccharococcus Species 0.000 claims 1
- 241000235070 Saccharomyces Species 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 241001147775 Thermoanaerobacter brockii Species 0.000 claims 1
- 241000186337 Thermoanaerobacter ethanolicus Species 0.000 claims 1
- 241000193447 Thermoanaerobacter thermohydrosulfuricus Species 0.000 claims 1
- 241000216452 Thermoanaerobacterium aotearoense Species 0.000 claims 1
- 241001137871 Thermoanaerobacterium saccharolyticum Species 0.000 claims 1
- 241000193446 Thermoanaerobacterium thermosaccharolyticum Species 0.000 claims 1
- 241001468159 Thermoanaerobacterium thermosulfurigenes Species 0.000 claims 1
- 108700040099 Xylose isomerases Proteins 0.000 claims 1
- 102100029089 Xylulose kinase Human genes 0.000 claims 1
- 241000193453 [Clostridium] cellulolyticum Species 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Chemical class 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 108091022915 xylulokinase Proteins 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91697807P | 2007-05-09 | 2007-05-09 | |
| PCT/US2008/063237 WO2008141174A2 (en) | 2007-05-09 | 2008-05-09 | Gene knockout mesophilic and thermophilic organisms, and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010526536A JP2010526536A (ja) | 2010-08-05 |
| JP2010526536A5 true JP2010526536A5 (enExample) | 2011-06-23 |
Family
ID=40002867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507693A Pending JP2010526536A (ja) | 2007-05-09 | 2008-05-09 | 遺伝子ノックアウト中温性および好熱性生物、ならびにその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8435770B2 (enExample) |
| EP (5) | EP2511285A3 (enExample) |
| JP (1) | JP2010526536A (enExample) |
| KR (1) | KR20100037031A (enExample) |
| CN (1) | CN101848924A (enExample) |
| AU (1) | AU2008251465B2 (enExample) |
| BR (1) | BRPI0811556A2 (enExample) |
| CA (1) | CA2685879A1 (enExample) |
| IL (1) | IL201824A0 (enExample) |
| NZ (2) | NZ581493A (enExample) |
| RU (1) | RU2541785C2 (enExample) |
| WO (1) | WO2008141174A2 (enExample) |
| ZA (1) | ZA200908721B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8163516B2 (en) * | 2008-02-08 | 2012-04-24 | Algenol Biofuels Inc. | Selection of ADH in genetically modified cyanobacteria for the production of ethanol |
| WO2009109630A1 (en) * | 2008-03-07 | 2009-09-11 | Dsm Ip Assets B.V. | A pentose sugar fermenting cell |
| DE102008031350B4 (de) * | 2008-07-02 | 2011-02-10 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Prokaryotische Xylose-Isomerase zur Konstruktion Xylose-vergärender Hefen |
| WO2010014632A2 (en) | 2008-07-28 | 2010-02-04 | University Of Massachusetts | Methods and compositions for improving the production of products in microorganisms |
| US20120094343A1 (en) * | 2008-11-12 | 2012-04-19 | Mascoma Corporation | Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof |
| EP2194120A1 (en) * | 2008-12-02 | 2010-06-09 | Total S.A. | Bioprocessing ligno-cellulose into ethanol with recombinant clostridium |
| US20120107892A1 (en) * | 2008-12-22 | 2012-05-03 | Frank Agbogbo | Production of ethanol from lignocellulosic biomass |
| WO2011059314A1 (en) * | 2009-11-12 | 2011-05-19 | Stichting Voor De Technische Wetenschappen | Pentose transporters and uses thereof |
| WO2011092638A2 (en) | 2010-01-26 | 2011-08-04 | Scale Biofuel Aps | Methods for producing and harvesting ethanol and apparatus for producing and harvesting the same |
| GB2478791A (en) * | 2010-03-19 | 2011-09-21 | Qteros Inc | Ethanol production by genetically-modified bacteria |
| US8927254B2 (en) | 2010-09-29 | 2015-01-06 | University Of Georgia Research Foundation, Inc. | Pyrococcus furiosus strains and methods of using same |
| CA2822654A1 (en) * | 2010-12-22 | 2012-06-28 | Mascoma Corporation | Genetically modified clostridium thermocellum engineered to ferment xylose |
| CA2864086C (en) | 2011-02-28 | 2018-07-10 | Midori Renewables, Inc. | Polymeric acid catalysts and uses thereof |
| US8962333B2 (en) | 2011-04-04 | 2015-02-24 | University Of Georgia Research Foundation, Inc. | Restriction/modification polypeptides, polynucleotides, and methods |
| EP2710308A1 (en) | 2011-05-18 | 2014-03-26 | Scale Biofuel APS | Solar-assisted volatile fermentation products production processes |
| WO2013041668A1 (en) * | 2011-09-22 | 2013-03-28 | Direvo Industrial Biotechnology Gmbh | Single-step bioconversion of lignocellulosic biomass to biofuels using extreme thermophilic bacteria |
| US9803221B2 (en) | 2011-09-30 | 2017-10-31 | Enchi Corporation | Engineering microorganisms to increase ethanol production by metabolic redirection |
| CA2857498A1 (en) * | 2011-11-30 | 2013-09-26 | Mascoma Corporation | Engineering an increase in ethanol production by altering cofactor specificity |
| US9309542B2 (en) | 2012-08-17 | 2016-04-12 | University Of Georgia Research Foundation, Inc. | Recombinant Caldicellulosiruptor bescii and methods of use |
| US9238845B2 (en) | 2012-08-24 | 2016-01-19 | Midori Usa, Inc. | Methods of producing sugars from biomass feedstocks |
| US9587256B2 (en) | 2012-09-06 | 2017-03-07 | University Of Georgia Research Foundation, Inc. | Sequestration of carbon dioxide with hydrogen to useful products |
| US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
| US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
| GB2528177B (en) | 2014-06-11 | 2019-08-28 | Univ Duke | Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves |
| CN104263680B (zh) * | 2014-09-05 | 2017-02-01 | 华南理工大学 | 一种嗜热厌氧杆菌及利用其生产乙醇的方法 |
| CN105154465A (zh) * | 2015-07-23 | 2015-12-16 | 昆明理工大学 | 一种敲除乙酸激酶基因的重组质粒及其应用 |
| CN106893745A (zh) * | 2017-04-12 | 2017-06-27 | 浙江畯和生物科技有限公司 | 一种木质纤维素生物质的高效转化利用方法 |
| TWI664286B (zh) * | 2017-08-02 | 2019-07-01 | 國立清華大學 | 生產醋酸的基因轉殖藍綠菌及其應用 |
| WO2019246488A1 (en) | 2018-06-21 | 2019-12-26 | Duke University | Compositions and methods for the production of pyruvic acid and related products using dynamic metabolic control |
| KR20220025884A (ko) | 2019-07-02 | 2022-03-03 | 코덱시스, 인코포레이티드 | 조작된 아세테이트 키나제 변이체 효소 |
| CN110484466B (zh) * | 2019-08-15 | 2023-04-21 | 华南理工大学 | 一种提高嗜热厌氧杆菌发酵性能的方法 |
| CN111423256A (zh) * | 2020-04-23 | 2020-07-17 | 上海国璨环境科技有限公司 | 一种有机垃圾热解方法 |
| CN117343885A (zh) * | 2022-07-04 | 2024-01-05 | 宁波牛形山生物科技合伙企业(有限合伙) | 一种通过代谢工程改造提高嗜热厌氧乙醇杆菌生物合成乳酸的方法 |
| WO2025240457A1 (en) * | 2024-05-13 | 2025-11-20 | North Carolina State University | Conversion of biomass into industrial chemicals using engineered bacteria |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6027895A (en) | 1995-09-12 | 2000-02-22 | The Ohio State University Research Foundation | Methods for cleaving DNA with nucleotide integrases |
| US5698421A (en) | 1995-09-12 | 1997-12-16 | The Ohio State Research Foundation | Ribonucleoprotein particles for cleaving double-stranded DNA and inserting an RNA/DNA molecule into the cleavage site |
| ES2231835T3 (es) * | 1996-09-27 | 2005-05-16 | Dsm Ip Assets B.V. | Genes biosinteticos ii de biotina. |
| US5804418A (en) | 1996-11-19 | 1998-09-08 | The Ohio State University Research Foundation | Methods for preparing nucleotide integrases |
| AU2973799A (en) | 1998-02-26 | 1999-09-15 | Ohio State Research Foundation, The | Methods for cleaving single-stranded and double-stranded dna substrates with nucleotide integrase |
| GB0000185D0 (en) | 2000-01-06 | 2000-03-01 | Agrol Limited | Ethanol production |
| GB0011186D0 (en) | 2000-05-09 | 2000-06-28 | Agrol Limited | Modification of bacteria |
| CN1336432A (zh) * | 2000-07-31 | 2002-02-20 | 武汉迪普生物技术有限公司 | 重组枯激酶的生产方法及其生物活性 |
| BR0114477A (pt) | 2000-10-06 | 2004-01-13 | Elsworth Biotech Ltd | Produção de etanol |
| US20030165859A1 (en) * | 2001-10-23 | 2003-09-04 | Invitrogen Corporation | Primers and methods for the detection and discrimination of nucleic acids |
| US7026464B2 (en) * | 2002-10-21 | 2006-04-11 | E. I. Du Pont De Nemours And Company | Natural promoters for gene expression in C1 metabolizing bacteria |
| EP1769092A4 (en) | 2004-06-29 | 2008-08-06 | Europ Nickel Plc | IMPROVED LIXIVIATION OF BASE METALS |
| US20060105348A1 (en) | 2004-11-15 | 2006-05-18 | Lee Jun E | Compositions and methods for the detection and discrimination of nucleic acids |
| WO2006099615A2 (en) | 2005-03-16 | 2006-09-21 | The Johns Hopkins University | Adenoviral fiber exchange shuttle system |
| KR20080012934A (ko) | 2005-05-04 | 2008-02-12 | 티엠오 리뉴어블스 리미티드 | 에탄올 생산을 위해 락테이트 디하이드로게나제 유전자가비활성화된 호열성 미생물 |
| GB0511602D0 (en) | 2005-06-07 | 2005-07-13 | Tmo Biotec Ltd | Microorganisms |
| ATE498358T1 (de) | 2005-06-29 | 2011-03-15 | Compumedics Ltd | Sensoranordnung mit leitfähiger brücke |
| US20090070896A1 (en) | 2005-08-30 | 2009-03-12 | Phyllom Llc | Insect resistant transgenic turf grass |
| GB0520344D0 (en) | 2005-10-06 | 2005-11-16 | Tmo Biotec Ltd | Microoganisms |
| CA2627191A1 (en) * | 2005-10-31 | 2007-05-10 | The Trustees Of Dartmouth College | Thermophilic organisms for conversion of lignocellulosic biomass to ethanol |
| TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
| ATE485370T1 (de) | 2006-09-14 | 2010-11-15 | Tmo Renewables Ltd | Lipase |
| EA017548B1 (ru) | 2006-09-28 | 2013-01-30 | Тмо Реньюаблз Лимитед | Термофильный микроорганизм, модифицированный для повышенной выработки этанола, и способ получения этанола при его использовании |
-
2008
- 2008-05-09 EP EP12164671A patent/EP2511285A3/en not_active Withdrawn
- 2008-05-09 WO PCT/US2008/063237 patent/WO2008141174A2/en not_active Ceased
- 2008-05-09 RU RU2009145274/10A patent/RU2541785C2/ru not_active IP Right Cessation
- 2008-05-09 EP EP08769395A patent/EP2064225A4/en not_active Withdrawn
- 2008-05-09 CN CN200880024031A patent/CN101848924A/zh active Pending
- 2008-05-09 KR KR1020097025740A patent/KR20100037031A/ko not_active Ceased
- 2008-05-09 BR BRPI0811556A patent/BRPI0811556A2/pt not_active IP Right Cessation
- 2008-05-09 AU AU2008251465A patent/AU2008251465B2/en not_active Ceased
- 2008-05-09 JP JP2010507693A patent/JP2010526536A/ja active Pending
- 2008-05-09 NZ NZ581493A patent/NZ581493A/en not_active IP Right Cessation
- 2008-05-09 US US12/599,458 patent/US8435770B2/en not_active Expired - Fee Related
- 2008-05-09 EP EP12164670A patent/EP2511284A3/en not_active Withdrawn
- 2008-05-09 EP EP12164672A patent/EP2511286A3/en not_active Withdrawn
- 2008-05-09 EP EP12164673A patent/EP2511287A3/en not_active Withdrawn
- 2008-05-09 CA CA002685879A patent/CA2685879A1/en not_active Abandoned
-
2009
- 2009-10-29 IL IL201824A patent/IL201824A0/en unknown
- 2009-12-08 ZA ZA200908721A patent/ZA200908721B/xx unknown
-
2012
- 2012-04-20 NZ NZ599526A patent/NZ599526A/xx not_active IP Right Cessation
-
2013
- 2013-05-07 US US13/888,610 patent/US20150024450A1/en not_active Abandoned
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