JP2010521983A5 - - Google Patents
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- Publication number
- JP2010521983A5 JP2010521983A5 JP2010500347A JP2010500347A JP2010521983A5 JP 2010521983 A5 JP2010521983 A5 JP 2010521983A5 JP 2010500347 A JP2010500347 A JP 2010500347A JP 2010500347 A JP2010500347 A JP 2010500347A JP 2010521983 A5 JP2010521983 A5 JP 2010521983A5
- Authority
- JP
- Japan
- Prior art keywords
- gpcr
- ligand
- variant
- agonist
- parent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 29
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 28
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 28
- 239000003446 ligand Substances 0.000 claims description 27
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims description 2
- 239000000556 agonist Substances 0.000 claims 5
- 239000005557 antagonist Substances 0.000 claims 3
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000009346 Adenosine receptors Human genes 0.000 claims 1
- 108050000203 Adenosine receptors Proteins 0.000 claims 1
- 102000008102 Ankyrins Human genes 0.000 claims 1
- 108010049777 Ankyrins Proteins 0.000 claims 1
- 102000003916 Arrestin Human genes 0.000 claims 1
- 108090000328 Arrestin Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 102000008924 GPCR kinases Human genes 0.000 claims 1
- 108050000878 GPCR kinases Proteins 0.000 claims 1
- 101000596394 Homo sapiens Vesicle-fusing ATPase Proteins 0.000 claims 1
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims 1
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims 1
- 102000017922 Neurotensin receptor Human genes 0.000 claims 1
- 108060003370 Neurotensin receptor Proteins 0.000 claims 1
- -1 RAMP Proteins 0.000 claims 1
- 102000008944 RGS Proteins Human genes 0.000 claims 1
- 108010074020 RGS Proteins Proteins 0.000 claims 1
- 102100035054 Vesicle-fusing ATPase Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 1
- 230000003196 chaotropic effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940125425 inverse agonist Drugs 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0705450A GB0705450D0 (en) | 2007-03-22 | 2007-03-22 | Mutant proteins and method for selecting them |
| GB0705450.5 | 2007-03-22 | ||
| GB0724052.6 | 2007-12-08 | ||
| GB0724052A GB0724052D0 (en) | 2007-12-08 | 2007-12-08 | Mutant proteins and methods for selecting them |
| PCT/GB2008/000986 WO2008114020A2 (en) | 2007-03-22 | 2008-03-20 | Mutant g-protein coupled receptors and methods for selecting them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011171887A Division JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521983A JP2010521983A (ja) | 2010-07-01 |
| JP2010521983A5 true JP2010521983A5 (https=) | 2010-09-24 |
| JP4842400B2 JP4842400B2 (ja) | 2011-12-21 |
Family
ID=39386585
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500347A Active JP4842400B2 (ja) | 2007-03-22 | 2008-03-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2011171887A Pending JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011171887A Pending JP2011224018A (ja) | 2007-03-22 | 2011-08-05 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2014100213A Pending JP2014155502A (ja) | 2007-03-22 | 2014-05-14 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2016129938A Active JP6426661B2 (ja) | 2007-03-22 | 2016-06-30 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2018135756A Pending JP2018164456A (ja) | 2007-03-22 | 2018-07-19 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
| JP2020193343A Active JP7419217B2 (ja) | 2007-03-22 | 2020-11-20 | Ｇタンパク質共役型受容体変異体及びその選択方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US8785135B2 (https=) |
| EP (4) | EP2386635A3 (https=) |
| JP (6) | JP4842400B2 (https=) |
| CN (2) | CN101688203B (https=) |
| AT (1) | ATE544854T1 (https=) |
| AU (1) | AU2008228085B2 (https=) |
| CA (1) | CA2681415C (https=) |
| DK (1) | DK2121919T3 (https=) |
| ES (2) | ES3008359T3 (https=) |
| GB (4) | GB2456236B8 (https=) |
| HR (1) | HRP20120336T1 (https=) |
| PL (1) | PL2121919T3 (https=) |
| PT (1) | PT2121919E (https=) |
| WO (1) | WO2008114020A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2121919T3 (da) | 2007-03-22 | 2012-05-21 | Heptares Therapeutics Ltd | Mutante g-proteinkoblede receptorer og fremgangsmåder til udvælgelse heraf |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| GB0724860D0 (en) * | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
| GB0802474D0 (en) | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
| US20110112037A1 (en) * | 2008-03-05 | 2011-05-12 | Heptares Therapeutics Limited BioPark | Crystal structure |
| GB0910725D0 (en) | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
| GB201014715D0 (en) | 2010-09-06 | 2010-10-20 | Vib Vzw | Nanobodies stabilizing functional conformational states of GPCRS |
| WO2012022928A2 (en) | 2010-08-20 | 2012-02-23 | Heptares Therapeutic Ltd | Biological materials and uses thereof |
| WO2012098413A1 (en) | 2011-01-21 | 2012-07-26 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| SG10201701547VA (en) | 2011-02-23 | 2017-03-30 | Massachusetts Inst Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| WO2012120315A2 (en) | 2011-03-10 | 2012-09-13 | Heptares Therapeutics Limited | Mutant proteins and methods for producing them |
| DK2742066T3 (en) | 2011-08-10 | 2018-03-05 | Heptares Therapeutics Ltd | STABLE PROTEINS |
| ES2676827T3 (es) * | 2012-06-01 | 2018-07-25 | Heptares Therapeutics Limited | Ensayos |
| WO2014118297A1 (en) | 2013-01-30 | 2014-08-07 | Vib Vzw | Novel chimeric polypeptides for screening and drug discovery purposes |
| EP2970425B1 (en) | 2013-03-15 | 2019-10-30 | United Kingdom Research and Innovation | Mutant membrane proteins and methods for their production |
| WO2014176544A1 (en) * | 2013-04-25 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Water soluble g-protein coupled receptor |
| WO2014176524A2 (en) | 2013-04-25 | 2014-10-30 | The Trustees Of The University Of Pennsylvania | Opioid detection based on high quality graphene transistor arrays and a synthetic mu receptor |
| CA2914831C (en) * | 2013-06-11 | 2022-10-11 | Paul Scherrer Institut | Method for determining mutateable ligand-gpcr binding at single amino acid resolution and pairs of mutated ligand and gpcr |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
| CN104151401A (zh) * | 2014-06-05 | 2014-11-19 | 维亚生物科技(上海)有限公司 | 融合表达离子通道蛋白及运输蛋白的方法及其使用的蛋白片断 |
| GB2527286A (en) * | 2014-06-11 | 2015-12-23 | Rsr Ltd | Glycoprotein hormone receptor mutations |
| WO2016070022A1 (en) | 2014-10-31 | 2016-05-06 | Abilita Bio, Inc. | Modified membrane spanning proteins and methods for the preparation and use thereof |
| US11618777B2 (en) | 2015-07-31 | 2023-04-04 | Shigeyuki Yokoyama | Method of manufacturing membrane protein and utilization thereof |
| GB201601690D0 (en) | 2016-01-29 | 2016-03-16 | Heptares Therapeutics Ltd | G proteins |
| EP3205450A1 (de) * | 2016-02-09 | 2017-08-16 | Hermes Schleifkörper GmbH | Verfahren zur herstellung eines keramischen formkörpers |
| EP3452516A4 (en) | 2016-05-04 | 2019-11-27 | Abilita Bio, Inc. | Methods and platform for preparing multispanning membrane proteins |
| CN113501881B (zh) * | 2017-09-27 | 2023-07-28 | 北京大学 | 融合蛋白 |
| US12123814B1 (en) * | 2019-06-14 | 2024-10-22 | Pierce Biotechnology, Inc. | G- protein coupled receptor extraction formulations |
| TW202242114A (zh) | 2020-12-23 | 2022-11-01 | 美商再生元醫藥公司 | 用於獲得結合至跨膜蛋白之抗體以及抗體生成細胞的方法 |
| CN114038498B (zh) * | 2022-01-06 | 2022-03-18 | 北京晶泰科技有限公司 | Gpcr的热稳定性突变预测方法、结构筛选方法及其装置 |
| CN120948816B (zh) * | 2025-10-20 | 2026-03-03 | 国科大杭州高等研究院 | 一种g蛋白偶联受体的热稳定性突变位点筛选方法及其用途 |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| EP0397834B1 (en) | 1988-10-28 | 2000-02-02 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| US6780613B1 (en) * | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| JP3147916B2 (ja) * | 1991-03-08 | 2001-03-19 | 森永製菓株式会社 | 体外免疫方法 |
| DK0580737T3 (da) | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US20030036092A1 (en) * | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| JPH08500967A (ja) * | 1992-06-12 | 1996-02-06 | ガーヴァン インスティチュート オブ メディカル リサーチ | ヒトＡ１，Ａ２ａおよびＡ２ｂアデノシン受容体をエンコードするＤＮＡ配列 |
| US5585277A (en) * | 1993-06-21 | 1996-12-17 | Scriptgen Pharmaceuticals, Inc. | Screening method for identifying ligands for target proteins |
| WO1995032425A1 (en) | 1994-05-23 | 1995-11-30 | Smithkline Beecham Corporation | Encoded combinatorial libraries |
| US20020028443A1 (en) * | 1999-09-27 | 2002-03-07 | Jay M. Short | Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process |
| AU2020497A (en) | 1996-03-27 | 1997-10-17 | Susan R. George | Receptor and transporter antagonists |
| US5925549A (en) * | 1996-04-15 | 1999-07-20 | The Board Of Trustees Of The Leland Stanford Junior University | Soluble 7-transmembrane domain G-protein-coupled receptor compositions and methods |
| US6153410A (en) * | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| AU3463699A (en) * | 1998-04-03 | 1999-10-25 | Phylos, Inc. | Addressable protein arrays |
| US6475733B1 (en) | 1998-04-06 | 2002-11-05 | Lerner Pharmaceuticals, Inc. | Cell surface receptors for the detection and identification of compounds |
| US6692696B1 (en) | 1998-06-18 | 2004-02-17 | ARETé ASSOCIATES | Biosensor |
| US7094593B1 (en) * | 1998-09-01 | 2006-08-22 | Basf Aktiengesellschaft | Method for improving the function of heterologous G protein-coupled receptors |
| CA2343046A1 (en) * | 1998-09-01 | 2000-03-09 | Basf Aktiengesellschaft | Enhanced functional expression of g protein-coupled receptors |
| WO2000070343A2 (en) | 1999-05-14 | 2000-11-23 | Repliscent, Inc. | G-protein coupled receptor based biosensors and sense replication systems |
| CN1310945C (zh) | 1999-11-17 | 2007-04-18 | 阿瑞那制药公司 | 人g蛋白偶联受体的内源形式和非内源形式 |
| US20020048786A1 (en) | 2000-02-09 | 2002-04-25 | Rosen Craig A. | Human G-protein Chemokine Receptor HDGNR10 |
| US7678539B2 (en) | 2000-08-10 | 2010-03-16 | Corning Incorporated | Arrays of biological membranes and methods and use thereof |
| WO2002018590A2 (en) * | 2000-08-30 | 2002-03-07 | John Hopkins University School Of Medicine | Identification of activated receptors and ion channels |
| US6448377B1 (en) * | 2000-09-27 | 2002-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Modified G protein sunbunits |
| CA2425149A1 (en) | 2000-10-26 | 2002-08-01 | New England Medical Center Hospitals, Inc. | Constitutively active, hypersensitive, and nonfunctional receptors as novel therapeutic agents |
| US20030232331A1 (en) * | 2000-12-05 | 2003-12-18 | Casman Stacie J. | Novel proteins and nucleic acids encoding same |
| US20030171541A1 (en) * | 2001-02-14 | 2003-09-11 | Amgen Inc., A Corporation Of The State Of Delaware | G-protein coupled receptor molecules and uses thereof |
| CA2439383A1 (en) | 2001-02-26 | 2002-09-06 | Arena Pharmaceuticals, Inc. | Endogenous and non-endogenous versions of human g protein-coupled receptors |
| US7208279B2 (en) * | 2001-03-14 | 2007-04-24 | Caden Biosciences, Inc. | Method for identifying inhibitors of G protein coupled receptor signaling |
| US7294472B2 (en) | 2001-03-14 | 2007-11-13 | Caden Biosciences | Method for identifying modulators of G protein coupled receptor signaling |
| EP1376132A4 (en) | 2001-03-30 | 2005-02-23 | Suntory Ltd | STRUCTURAL MODEL FOR A G-PROTEIN-COUPLED RECEPTOR AND METHOD FOR DESIGNING LIGANDING BINDING TO THE G-PROTEIN-COUPLED RECEPTOR USING THE STRUCTURE MODEL |
| US20030129649A1 (en) * | 2001-04-24 | 2003-07-10 | Kobilka Brian K. | Conformational assays to detect binding to G protein-coupled receptors |
| US20050009204A1 (en) | 2003-07-11 | 2005-01-13 | Ye Fang | Multiplexed binding assays for receptor arrays |
| DE60214869T2 (de) | 2001-10-25 | 2007-04-12 | Astex Technology Ltd., Cambridge | Cytochrome p450 2c9 kristalle, strukturen und dessen verwendung |
| US7115377B2 (en) * | 2001-10-26 | 2006-10-03 | Atto Bioscience, Inc. | Cell-based assays for G-protein-coupled receptor-mediated activities |
| JP2004238384A (ja) * | 2002-03-28 | 2004-08-26 | Takeda Chem Ind Ltd | 新規スクリーニング方法 |
| EP1491207A4 (en) | 2002-03-28 | 2006-02-08 | Takeda Pharmaceutical | NEW SCREENING PROCESS |
| JP4344928B2 (ja) * | 2002-04-24 | 2009-10-14 | 萬有製薬株式会社 | ヒスタミン受容体ｈ３常活性変異体およびその利用 |
| EP1549318B1 (en) * | 2002-05-01 | 2010-02-17 | Vertex Pharmaceuticals Incorporated | Crystal structure of aurora-2 protein and binding pockets thereof |
| EP1581648A2 (en) * | 2002-09-09 | 2005-10-05 | Nura, Inc. | G protein coupled receptors and uses thereof |
| AU2002951995A0 (en) * | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
| US20040096914A1 (en) | 2002-11-20 | 2004-05-20 | Ye Fang | Substrates with stable surface chemistry for biological membrane arrays and methods for fabricating thereof |
| US7405053B2 (en) * | 2003-05-20 | 2008-07-29 | The University Court Of The University Of Glasgow | Materials and methods relating to G-protein coupled receptor oligomers |
| US7745161B2 (en) * | 2003-12-19 | 2010-06-29 | Palo Alto Research Center Incorporated | Amplification of enzymatic reactions for use with an enthalpy array |
| US20050287565A1 (en) * | 2004-05-12 | 2005-12-29 | Merchiers Pascal G | Methods, compositions and compound assays for inhibiting amyloid-beta protein production |
| WO2005121755A1 (en) | 2004-06-14 | 2005-12-22 | Commonwealth Scientific And Industrial Research Organisation | Cell free g-protein coupled receptor and ligand assay |
| WO2006023248A2 (en) | 2004-07-28 | 2006-03-02 | The Trustees Of Columbia University In The City Of New York | Processes for producing and crystallizing g-protein coupled receptors |
| JP2006340717A (ja) * | 2005-05-11 | 2006-12-21 | Sekisui Chem Co Ltd | Ｇタンパク質共役型受容体に対する結合性評価方法及び評価用組成物、融合タンパク質、並びに、遺伝子 |
| FR2890174B1 (fr) | 2005-08-30 | 2009-04-24 | Cis Bio Internat Sa | Procede pour la mise en evidence d'un processus biologique par mesure d'un fret |
| US20070154947A1 (en) * | 2005-08-31 | 2007-07-05 | The Trustees Of Princeton University | Chemical biodiscriminator |
| JP5492418B2 (ja) * | 2005-11-18 | 2014-05-14 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | ウイルス関連疾患を予防するためのウイルス遺伝子産物およびワクチン接種の方法 |
| US7495024B2 (en) * | 2006-08-07 | 2009-02-24 | Via Pharmaceuticals, Inc. | Phenylalkyl N-hydroxyureas for combating atherosclerotic plaque |
| DK2121919T3 (da) * | 2007-03-22 | 2012-05-21 | Heptares Therapeutics Ltd | Mutante g-proteinkoblede receptorer og fremgangsmåder til udvælgelse heraf |
| EP2220245B1 (en) | 2007-10-17 | 2015-04-22 | The Board of Trustees of The Leland Stanford Junior University | Method and composition for crystallizing g protein-coupled receptors |
| EP2203475B1 (en) | 2007-10-22 | 2014-04-16 | The Scripps Research Institute | Methods and compostions for obtaining high-resolution crystals of membrane proteins |
| GB0724051D0 (en) * | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
| GB0724860D0 (en) | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
| GB0802474D0 (en) * | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
| US20110112037A1 (en) * | 2008-03-05 | 2011-05-12 | Heptares Therapeutics Limited BioPark | Crystal structure |
| GB0910725D0 (en) * | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
| WO2012022928A2 (en) | 2010-08-20 | 2012-02-23 | Heptares Therapeutic Ltd | Biological materials and uses thereof |
| DK2611826T3 (en) | 2010-08-30 | 2017-01-09 | Confometrx Inc | A method and composition for the crystallization of a family-C-GPCR |
| WO2012098413A1 (en) * | 2011-01-21 | 2012-07-26 | Heptares Therapeutics Limited | Mutant g-protein coupled receptor proteins and methods for producing them |
| US20120288913A1 (en) | 2011-05-13 | 2012-11-15 | The Scripps Research Institute | Novel fusion partners for the purpose of crystallizing g-protein coupled receptors |
| DK2742066T3 (en) | 2011-08-10 | 2018-03-05 | Heptares Therapeutics Ltd | STABLE PROTEINS |
| EP2617732A1 (en) | 2012-01-19 | 2013-07-24 | Vib Vzw | Tools and methods for expression of membrane proteins |
| WO2013142278A1 (en) | 2012-03-22 | 2013-09-26 | New York University | Plasmodium vivax vaccine compositions |
| ES2676827T3 (es) | 2012-06-01 | 2018-07-25 | Heptares Therapeutics Limited | Ensayos |
| WO2014028644A1 (en) | 2012-08-15 | 2014-02-20 | Cyvax, Inc. | Methods and compositions for preventing a condition |
| US20150261911A1 (en) | 2014-03-13 | 2015-09-17 | Heptares Therapeutics Limited | Crystal structure |
-
2008
- 2008-03-20 DK DK08718823.1T patent/DK2121919T3/da active
- 2008-03-20 WO PCT/GB2008/000986 patent/WO2008114020A2/en not_active Ceased
- 2008-03-20 JP JP2010500347A patent/JP4842400B2/ja active Active
- 2008-03-20 EP EP11075136A patent/EP2386635A3/en not_active Ceased
- 2008-03-20 CA CA2681415A patent/CA2681415C/en active Active
- 2008-03-20 CN CN2008800093780A patent/CN101688203B/zh active Active
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