JP4842400B2 - Ｇタンパク質共役型受容体変異体及びその選択方法 - Google Patents

Ｇタンパク質共役型受容体変異体及びその選択方法 Download PDF

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JP4842400B2
JP4842400B2 JP2010500347A JP2010500347A JP4842400B2 JP 4842400 B2 JP4842400 B2 JP 4842400B2 JP 2010500347 A JP2010500347 A JP 2010500347A JP 2010500347 A JP2010500347 A JP 2010500347A JP 4842400 B2 JP4842400 B2 JP 4842400B2
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gpcr
receptor
ligand
amino acid
parent
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JP2010521983A (ja
JP2010521983A5 (https=
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リチャード・ヘンダーソン
クリストファー・ゴードン・テート
フランシスカ・マグナニ
マリア・ジョセファ・セラノ−ベガ
庸子 柴田
アンソニー・ヨハネス・ウォーン
マルコム・ピーター・ウェアー
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ヘプテアズ・セラピューティクス・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
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  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP2010500347A 2007-03-22 2008-03-20 Ｇタンパク質共役型受容体変異体及びその選択方法 Active JP4842400B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0705450A GB0705450D0 (en) 2007-03-22 2007-03-22 Mutant proteins and method for selecting them
GB0705450.5 2007-03-22
GB0724052A GB0724052D0 (en) 2007-12-08 2007-12-08 Mutant proteins and methods for selecting them
GB0724052.6 2007-12-08
PCT/GB2008/000986 WO2008114020A2 (en) 2007-03-22 2008-03-20 Mutant g-protein coupled receptors and methods for selecting them

Related Child Applications (1)

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JP2011171887A Division JP2011224018A (ja) 2007-03-22 2011-08-05 Ｇタンパク質共役型受容体変異体及びその選択方法

Publications (3)

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JP2010521983A JP2010521983A (ja) 2010-07-01
JP2010521983A5 JP2010521983A5 (https=) 2010-09-24
JP4842400B2 true JP4842400B2 (ja) 2011-12-21

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JP2010500347A Active JP4842400B2 (ja) 2007-03-22 2008-03-20 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2011171887A Pending JP2011224018A (ja) 2007-03-22 2011-08-05 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2014100213A Pending JP2014155502A (ja) 2007-03-22 2014-05-14 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2016129938A Active JP6426661B2 (ja) 2007-03-22 2016-06-30 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2018135756A Pending JP2018164456A (ja) 2007-03-22 2018-07-19 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2020193343A Active JP7419217B2 (ja) 2007-03-22 2020-11-20 Ｇタンパク質共役型受容体変異体及びその選択方法

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JP2011171887A Pending JP2011224018A (ja) 2007-03-22 2011-08-05 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2014100213A Pending JP2014155502A (ja) 2007-03-22 2014-05-14 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2016129938A Active JP6426661B2 (ja) 2007-03-22 2016-06-30 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2018135756A Pending JP2018164456A (ja) 2007-03-22 2018-07-19 Ｇタンパク質共役型受容体変異体及びその選択方法
JP2020193343A Active JP7419217B2 (ja) 2007-03-22 2020-11-20 Ｇタンパク質共役型受容体変異体及びその選択方法

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US (7) US8785135B2 (https=)
EP (4) EP2386635A3 (https=)
JP (6) JP4842400B2 (https=)
CN (2) CN101688203B (https=)
AT (1) ATE544854T1 (https=)
AU (1) AU2008228085B2 (https=)
CA (1) CA2681415C (https=)
DK (1) DK2121919T3 (https=)
ES (2) ES3008359T3 (https=)
GB (4) GB2456236B8 (https=)
HR (1) HRP20120336T1 (https=)
PL (1) PL2121919T3 (https=)
PT (1) PT2121919E (https=)
WO (1) WO2008114020A2 (https=)

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JP2016187348A (ja) * 2007-03-22 2016-11-04 ヘプテアズ・セラピューティクス・リミテッド Ｇタンパク質共役型受容体変異体及びその選択方法

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