JP2006502416A5 - - Google Patents
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- Publication number
- JP2006502416A5 JP2006502416A5 JP2004543745A JP2004543745A JP2006502416A5 JP 2006502416 A5 JP2006502416 A5 JP 2006502416A5 JP 2004543745 A JP2004543745 A JP 2004543745A JP 2004543745 A JP2004543745 A JP 2004543745A JP 2006502416 A5 JP2006502416 A5 JP 2006502416A5
- Authority
- JP
- Japan
- Prior art keywords
- mhc
- binding
- monomer
- binding peptide
- putative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims 25
- LZOIGVDSAMDBIO-LXWJMTKESA-N (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](N)CCSC)C1=CC=CC=C1 LZOIGVDSAMDBIO-LXWJMTKESA-N 0.000 claims 18
- 108010066345 MHC binding peptide Proteins 0.000 claims 18
- 230000027455 binding Effects 0.000 claims 15
- 102000043131 MHC class II family Human genes 0.000 claims 6
- 108091054438 MHC class II family Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- 102000043129 MHC class I family Human genes 0.000 claims 4
- 108091054437 MHC class I family Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/269,473 US20040072262A1 (en) | 2002-10-11 | 2002-10-11 | Methods and systems for detecting MHC class I binding peptides |
| PCT/US2003/032370 WO2004034033A2 (en) | 2002-10-11 | 2003-10-10 | Methods and systems for detecting mhc class i and class ii binding peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502416A JP2006502416A (ja) | 2006-01-19 |
| JP2006502416A5 true JP2006502416A5 (https=) | 2006-11-24 |
| JP4607590B2 JP4607590B2 (ja) | 2011-01-05 |
Family
ID=32068790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543745A Expired - Lifetime JP4607590B2 (ja) | 2002-10-11 | 2003-10-10 | Ｍｈｃクラスｉおよびクラスｉｉ結合ペプチドを検出するための方法およびシステム |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20040072262A1 (https=) |
| EP (1) | EP1549952B1 (https=) |
| JP (1) | JP4607590B2 (https=) |
| CN (1) | CN1703624B (https=) |
| AU (1) | AU2003284113B2 (https=) |
| CA (1) | CA2501864C (https=) |
| WO (1) | WO2004034033A2 (https=) |
Families Citing this family (39)
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| US8706421B2 (en) * | 2006-02-16 | 2014-04-22 | Microsoft Corporation | Shift-invariant predictions |
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| CN101529251B (zh) * | 2006-11-01 | 2014-04-02 | 贝克曼考尔特公司 | 用于亲合分析的结合性表面 |
| US8121797B2 (en) | 2007-01-12 | 2012-02-21 | Microsoft Corporation | T-cell epitope prediction |
| WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
| EP3620465B1 (en) | 2007-07-03 | 2025-02-19 | Dako Denmark A/S | Improved methods for generation, labeling and use of mhc multimers |
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| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
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| SMT202200205T1 (it) | 2011-10-28 | 2022-07-21 | Regeneron Pharma | Topi geneticamente modificati che esprimono molecole chimeriche del complesso maggiore di istocompatibilità (mhc) ii |
| EP3699190B9 (en) | 2013-02-22 | 2023-10-04 | Regeneron Pharmaceuticals, Inc. | Murine cell expressing humanized major histocompatibility complex |
| GB201313352D0 (en) | 2013-07-26 | 2013-09-11 | Isis Innovation | Identification of peptide ligands |
| JP2017529841A (ja) | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | キメラ抗原受容体 |
| EP4248744A3 (en) | 2015-04-06 | 2023-12-27 | Regeneron Pharmaceuticals, Inc. | Humanized t cell mediated immune responses in non-human animals |
| US20170205404A1 (en) * | 2016-01-19 | 2017-07-20 | General Electric Company | Multifunctional beads and methods of use for capturing rare cells |
| RU2653017C1 (ru) * | 2017-06-22 | 2018-05-04 | Общество с ограниченной ответственностью "Лидер Гласс" | Способ переработки специальных видов стекла |
| WO2019054409A1 (ja) * | 2017-09-12 | 2019-03-21 | 国立大学法人北海道大学 | Ｈｌａタンパク質に相互作用する物質のスクリーニング方法及びスクリーニング用キット |
| WO2019211864A1 (en) * | 2018-04-29 | 2019-11-07 | Chimera Translational Research Fraternity Private Limited | Molecular fluorescent multiplex assay to identify allo-antibodies against mhc antigens |
| WO2020127222A2 (en) | 2018-12-17 | 2020-06-25 | Immudex Aps | Panel comprising borrelia mhc multimers |
| CA3165862A1 (en) * | 2019-12-23 | 2021-07-01 | The Regents Of The University Of California | Stabilization of mhc complexes |
| CN118511853A (zh) | 2021-03-31 | 2024-08-20 | 瑞泽恩制药公司 | 包含具有改善的tcrb组库多样性的人源化细胞免疫系统组分的基因修饰的小鼠 |
| AU2024266326A1 (en) * | 2023-05-03 | 2025-11-13 | Immunoracle Inc. | Compositions and methods of analyzing a sample for antigen-specific immune cells |
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| JP2007536522A (ja) * | 2004-05-07 | 2007-12-13 | ベックマン コールター インコーポレーティッド | Ｃｔｌの媒介による抗原提示細胞の溶解を検出するためのｍｈｃ架橋系 |
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-
2002
- 2002-10-11 US US10/269,473 patent/US20040072262A1/en not_active Abandoned
-
2003
- 2003-10-10 WO PCT/US2003/032370 patent/WO2004034033A2/en not_active Ceased
- 2003-10-10 AU AU2003284113A patent/AU2003284113B2/en not_active Expired
- 2003-10-10 JP JP2004543745A patent/JP4607590B2/ja not_active Expired - Lifetime
- 2003-10-10 EP EP03776344A patent/EP1549952B1/en not_active Expired - Lifetime
- 2003-10-10 CN CN2003801010208A patent/CN1703624B/zh not_active Expired - Lifetime
- 2003-10-10 CA CA2501864A patent/CA2501864C/en not_active Expired - Lifetime
- 2003-10-10 US US10/684,268 patent/US20040137537A1/en not_active Abandoned
-
2011
- 2011-02-17 US US13/029,902 patent/US8815528B2/en not_active Expired - Lifetime
-
2014
- 2014-07-21 US US14/336,944 patent/US20150072886A1/en not_active Abandoned
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