JP2019531716A5 - - Google Patents
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- JP2019531716A5 JP2019531716A5 JP2019513015A JP2019513015A JP2019531716A5 JP 2019531716 A5 JP2019531716 A5 JP 2019531716A5 JP 2019513015 A JP2019513015 A JP 2019513015A JP 2019513015 A JP2019513015 A JP 2019513015A JP 2019531716 A5 JP2019531716 A5 JP 2019531716A5
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- JP
- Japan
- Prior art keywords
- peptide
- amino acid
- seq
- peptides
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 93
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 24
- 206010028417 myasthenia gravis Diseases 0.000 claims description 24
- 108010009685 Cholinergic Receptors Proteins 0.000 claims description 18
- 102000034337 acetylcholine receptors Human genes 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 230000004048 modification Effects 0.000 claims description 14
- 238000012986 modification Methods 0.000 claims description 14
- 239000011324 bead Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
- 229920002101 Chitin Polymers 0.000 claims description 6
- 238000002965 ELISA Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000003472 neutralizing effect Effects 0.000 claims description 6
- 239000000523 sample Substances 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 230000002163 immunogen Effects 0.000 claims description 5
- 239000000020 Nitrocellulose Substances 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 238000002493 microarray Methods 0.000 claims description 4
- 229920001220 nitrocellulos Polymers 0.000 claims description 4
- 230000005847 immunogenicity Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 claims description 2
- 108010093488 His-His-His-His-His-His Proteins 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 239000012472 biological sample Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229940098197 human immunoglobulin g Drugs 0.000 claims description 2
- 238000010166 immunofluorescence Methods 0.000 claims description 2
- 238000001114 immunoprecipitation Methods 0.000 claims description 2
- 238000004020 luminiscence type Methods 0.000 claims description 2
- 210000001806 memory b lymphocyte Anatomy 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 claims description 2
- -1 porous strip Substances 0.000 claims description 2
- 238000003127 radioimmunoassay Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662384896P | 2016-09-08 | 2016-09-08 | |
| US62/384,896 | 2016-09-08 | ||
| PCT/US2017/050521 WO2018049053A2 (en) | 2016-09-08 | 2017-09-07 | Peptides and uses thereof for diagnosing and treating myasthenia gravis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019531716A JP2019531716A (ja) | 2019-11-07 |
| JP2019531716A5 true JP2019531716A5 (https=) | 2020-10-08 |
| JP7169267B2 JP7169267B2 (ja) | 2022-11-10 |
Family
ID=61562129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019513015A Active JP7169267B2 (ja) | 2016-09-08 | 2017-09-07 | 重症筋無力症を診断および治療するためのペプチドおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11422132B2 (https=) |
| EP (1) | EP3512873B1 (https=) |
| JP (1) | JP7169267B2 (https=) |
| KR (1) | KR102501179B1 (https=) |
| CN (1) | CN109996812A (https=) |
| AU (1) | AU2017322312B2 (https=) |
| CA (1) | CA3036130A1 (https=) |
| WO (1) | WO2018049053A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109996812A (zh) | 2016-09-08 | 2019-07-09 | 加利福尼亚大学董事会 | 用于诊断和治疗重症肌无力的肽及其用途 |
| US11986536B2 (en) | 2019-03-23 | 2024-05-21 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
| EP3715374A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
| US20220242931A1 (en) * | 2019-05-13 | 2022-08-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods of acetylcholine receptor chimeric autoantibody receptor cells |
| WO2021236724A2 (en) * | 2020-05-20 | 2021-11-25 | Remd Biotherapeutics, Inc. | Human endothelin receptor a (etar) antagonist antibodies |
| CN112029880B (zh) * | 2020-09-15 | 2023-04-28 | 石家庄市人民医院(石家庄市第一医院、石家庄市肿瘤医院、河北省重症肌无力医院、石家庄市心血管病医院) | 用于重症肌无力的检测的微生物及应用 |
| US20230381328A1 (en) | 2020-09-24 | 2023-11-30 | Ablevia Biotech Gmbh | Compound for the prevention or treatment of myasthenia gravis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3391831B2 (ja) * | 1993-01-13 | 2003-03-31 | 株式会社クラレ | 環状ペプチド |
| US20020081652A1 (en) * | 1997-05-07 | 2002-06-27 | Sara Fuchs | Recombinant fragments of the human acetylcholine receptor and their use for treatment of myasthenia gravis |
| KR20020059331A (ko) * | 1999-09-15 | 2002-07-12 | 디르크 반테 | 니코틴성 아세틸콜린 수용체 |
| CA2405484A1 (en) * | 2000-03-31 | 2001-10-11 | Corixa Corporation | Immunodominant acetylcholine receptor alpha subunit peptides, complexes thereof with mhc class ii components and their use |
| JP4283812B2 (ja) * | 2006-01-06 | 2009-06-24 | 財団法人工業技術研究院 | 重症筋無力症の診断方法およびそのキット |
| US8530245B2 (en) * | 2008-07-29 | 2013-09-10 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to acetylocholine receptor conjugates |
| JP4495776B1 (ja) * | 2009-07-30 | 2010-07-07 | 日本製薬株式会社 | 融合蛋白質 |
| CN109996812A (zh) | 2016-09-08 | 2019-07-09 | 加利福尼亚大学董事会 | 用于诊断和治疗重症肌无力的肽及其用途 |
-
2017
- 2017-09-07 CN CN201780064528.7A patent/CN109996812A/zh active Pending
- 2017-09-07 CA CA3036130A patent/CA3036130A1/en active Pending
- 2017-09-07 JP JP2019513015A patent/JP7169267B2/ja active Active
- 2017-09-07 AU AU2017322312A patent/AU2017322312B2/en not_active Ceased
- 2017-09-07 EP EP17849543.8A patent/EP3512873B1/en active Active
- 2017-09-07 WO PCT/US2017/050521 patent/WO2018049053A2/en not_active Ceased
- 2017-09-07 KR KR1020197009929A patent/KR102501179B1/ko active Active
-
2019
- 2019-03-06 US US16/294,820 patent/US11422132B2/en active Active
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