JP2004516823A5 - - Google Patents
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- JP2004516823A5 JP2004516823A5 JP2002530779A JP2002530779A JP2004516823A5 JP 2004516823 A5 JP2004516823 A5 JP 2004516823A5 JP 2002530779 A JP2002530779 A JP 2002530779A JP 2002530779 A JP2002530779 A JP 2002530779A JP 2004516823 A5 JP2004516823 A5 JP 2004516823A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- antibody
- phosphorylated
- specificity
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 235000018102 proteins Nutrition 0.000 claims 28
- 102000004169 proteins and genes Human genes 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 28
- 238000000034 method Methods 0.000 claims 8
- 230000026731 phosphorylation Effects 0.000 claims 6
- 238000006366 phosphorylation reaction Methods 0.000 claims 6
- 102000013498 tau Proteins Human genes 0.000 claims 4
- 108010026424 tau Proteins Proteins 0.000 claims 4
- 108091005981 phosphorylated proteins Proteins 0.000 claims 3
- 101001102158 Homo sapiens Phosphatidylserine synthase 1 Proteins 0.000 claims 2
- 102100039298 Phosphatidylserine synthase 1 Human genes 0.000 claims 2
- 239000007853 buffer solution Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101100495314 Caenorhabditis elegans cdk-5 gene Proteins 0.000 claims 1
- 102000052052 Casein Kinase II Human genes 0.000 claims 1
- 108010010919 Casein Kinase II Proteins 0.000 claims 1
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 1
- -1 PKA Proteins 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- SLPJGDQJLTYWCI-UHFFFAOYSA-N dimethyl-(4,5,6,7-tetrabromo-1h-benzoimidazol-2-yl)-amine Chemical compound BrC1=C(Br)C(Br)=C2NC(N(C)C)=NC2=C1Br SLPJGDQJLTYWCI-UHFFFAOYSA-N 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23562000P | 2000-09-27 | 2000-09-27 | |
| PCT/US2001/030186 WO2002027017A2 (en) | 2000-09-27 | 2001-09-27 | Method for quantifying phosphokinase activity on proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006079226A Division JP2006225396A (ja) | 2000-09-27 | 2006-03-22 | タンパク質に対するホスホキナーゼ活性の定量のための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004516823A JP2004516823A (ja) | 2004-06-10 |
| JP2004516823A5 true JP2004516823A5 (https=) | 2005-04-28 |
Family
ID=22886277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002530779A Withdrawn JP2004516823A (ja) | 2000-09-27 | 2001-09-27 | タンパク質に対するホスホキナーゼ活性の定量のための方法 |
| JP2006079226A Pending JP2006225396A (ja) | 2000-09-27 | 2006-03-22 | タンパク質に対するホスホキナーゼ活性の定量のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006079226A Pending JP2006225396A (ja) | 2000-09-27 | 2006-03-22 | タンパク質に対するホスホキナーゼ活性の定量のための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20030162230A1 (https=) |
| EP (3) | EP2298814A3 (https=) |
| JP (2) | JP2004516823A (https=) |
| AT (1) | ATE416385T1 (https=) |
| CA (1) | CA2423979C (https=) |
| DE (1) | DE60136840D1 (https=) |
| WO (1) | WO2002027017A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
| US20030162230A1 (en) * | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
| GB0208104D0 (en) * | 2002-04-09 | 2002-05-22 | Univ Dundee | Method |
| EP1506286B1 (en) | 2002-05-24 | 2014-03-19 | Merck Sharp & Dohme Corp. | Neutralizing human anti-igfr antibody |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7727752B2 (en) | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
| EP1668146B1 (en) | 2003-09-25 | 2014-11-12 | Life Technologies Corporation | Homogeneous populations of molecules |
| US7326567B2 (en) | 2003-11-12 | 2008-02-05 | Schering Corporation | Plasmid system for multigene expression |
| TW200526684A (en) | 2003-11-21 | 2005-08-16 | Schering Corp | Anti-IGFR1 antibody therapeutic combinations |
| PT1828249E (pt) | 2004-12-03 | 2011-02-25 | Schering Corp | Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r |
| US7807789B2 (en) * | 2004-12-21 | 2010-10-05 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in EGFR-signaling pathways |
| WO2007005605A2 (en) * | 2005-07-01 | 2007-01-11 | Washington University In St. Louis | Phosphospecific chemokine receptor antibodies |
| WO2007133688A2 (en) * | 2006-05-12 | 2007-11-22 | Cell Signaling Technology, Inc. | Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways |
| WO2008147687A1 (en) * | 2007-05-21 | 2008-12-04 | Mayo Foundation For Medical Education And Research | Treating pancreatitis |
| KR101612442B1 (ko) | 2008-05-13 | 2016-04-15 | 삼성전자주식회사 | 컨텐츠 시청 제한 정보의 제공 및 이용을 위한 방법 및장치 |
| AU2011235595B2 (en) * | 2010-03-29 | 2016-06-09 | Central Adelaide Local Health Network Inc. | A method of modulating protein 14-3-3 functionality by facilitating or inhibiting phosphorylation |
| EP2614372B1 (en) * | 2010-09-07 | 2018-07-25 | Stephen G. Marx | Kit for monitoring, detecting and staging gvhd |
| US20170016900A1 (en) | 2010-09-07 | 2017-01-19 | Stephen G. Marx | Kit for monitoring, detecting and staging gvhd |
| US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
| AU2014368696A1 (en) | 2013-12-20 | 2016-06-02 | F. Hoffmann-La Roche Ag | Humanized anti-Tau(pS422) antibodies and methods of use |
| EP4321165A3 (en) * | 2013-12-27 | 2024-08-21 | National University Corporation Tokyo Medical and Dental University | Method for diagnosis of alzheimer's disease and frontotemporal lobar degeneration, diagnostic agent, therapeutic agent, and screening method for said agents |
| AU2015240088B2 (en) * | 2014-03-31 | 2021-07-22 | Merck Patent Gmbh | Method for detecting protein modifications using specific antibodies |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| WO2016207245A1 (en) | 2015-06-24 | 2016-12-29 | F. Hoffmann-La Roche Ag | Humanized anti-tau(ps422) antibodies and methods of use |
| JO3711B1 (ar) * | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
| JP7040774B2 (ja) * | 2016-03-01 | 2022-03-23 | マックォーリー・ユニバーシティ | 神経学的症状の治療のためのリン酸化ｔａｕ及びｐ３８ガンマの使用 |
| PH12018502613B1 (en) | 2016-07-12 | 2023-02-01 | H Lundbeck As | Antibodies specific for hyperphosphorylated tau and methods of use thereof |
| ES2791962T3 (es) * | 2016-11-21 | 2020-11-06 | Univ Ruhr Bochum | Ensayo combinado para el diagnóstico diferencial de la enfermedad de Alzheimer |
| CN110267985B (zh) | 2017-01-04 | 2023-05-23 | H.隆德贝克有限公司 | 用于治疗眼科疾病的特异性针对过度磷酸化τ蛋白的抗体 |
| AU2018388549B2 (en) * | 2017-12-18 | 2023-06-01 | Yale University | Compounds and compositions for treating fibrosis |
| US10591492B2 (en) | 2018-03-05 | 2020-03-17 | Janssen Pharmaceutica Nv | Assays to detect neurodegeneration |
| CA3093200A1 (en) | 2018-03-05 | 2019-09-12 | Janssen Pharmaceutica Nv | Anti-phf-tau antibodies and uses thereof |
| US11085935B2 (en) * | 2018-05-03 | 2021-08-10 | Washington University | Methods of treating based on site-specific tau phosphorylation |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3150369A1 (en) | 2019-09-10 | 2021-03-18 | Randall Bateman | Blood-based assay for diagnosing and treating based on site-specific tau phosphorylation |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2354288C2 (de) | 1973-10-30 | 1976-01-02 | Hoechst Ag, 6000 Frankfurt | Verfahren zur Herstellung von Aminophenylalkyläthern |
| US4444879A (en) * | 1981-01-29 | 1984-04-24 | Science Research Center, Inc. | Immunoassay with article having support film and immunological counterpart of analyte |
| US5733734A (en) * | 1991-08-14 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments |
| JPH05126833A (ja) | 1991-10-31 | 1993-05-21 | Tosoh Corp | チロシンキナ−ゼ活性の免疫化学的測定法及びそのキツト |
| DK0618968T3 (da) * | 1991-12-06 | 2000-04-10 | Max Planck Gesellschaft | Midler til diagnostisering og behandling af Alzheimer's sygdom |
| EP0544942A1 (en) * | 1991-12-06 | 1993-06-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Novel tools for the diagnosis and treatment of Alzheimer disease |
| WO1993021230A1 (en) | 1992-04-10 | 1993-10-28 | Dana-Farber Cancer Institute, Inc. | Activation-state-specific phosphoprotein immunodetection |
| WO1994013795A1 (en) * | 1992-12-14 | 1994-06-23 | N.V. Innogenetics S.A. | Monoclonal antibodies directed against the microtubule-associated protein tau, hybridomas secreting these antibodies, antigen recognition by these monoclonal antibodies and their applications |
| US6924361B1 (en) | 1993-11-02 | 2005-08-02 | Phosphoproteomics Llc | Phosphopeptide-specific antibodies that are activity specific; methods of production and antibody uses |
| CA2175893C (en) * | 1993-11-23 | 2010-06-22 | Paul J. Godowski | Protein tyrosine kinases named rse |
| ES2270421T3 (es) | 1993-12-21 | 2007-04-01 | Innogenetics N.V. | Anticuerpos monoclonales especificos para phf-tau, hibridomas que secretan los mismos, reconocimiento de antigeno por estos anticuerpos y sus aplicaciones. |
| US6348310B1 (en) * | 1994-03-04 | 2002-02-19 | Promega Corporation | Quantitation of individual protein kinase activity |
| US5763198A (en) * | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
| WO1996004309A1 (en) * | 1994-07-29 | 1996-02-15 | Innogenetics N.V. | Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications |
| US6001580A (en) * | 1995-03-28 | 1999-12-14 | Takeda Chemical Industries, Inc. | Method for assaying ERK2 map kinase |
| ATE248189T1 (de) * | 1997-11-07 | 2003-09-15 | Vasopharm Biotech Gmbh | Antikörper gegen vasp (vasodilator-stimulated phosphoprotein), hybridomzellen für deren gewinnung, und deren verwendung |
| DK1036192T3 (da) * | 1997-12-05 | 2003-06-10 | Upjohn Co | Fluorescensbaserede screeningsanalyser med høj hastighedforproteinkinaser og phosphataser |
| GB9803399D0 (en) * | 1998-02-19 | 1998-04-15 | Imp Cancer Res Tech | Protein kinase c |
| JP2000034300A (ja) * | 1998-07-17 | 2000-02-02 | Mitsubishi Chemicals Corp | 抗リン酸化タウ蛋白質抗体及びそれを用いるアルツハイマー病の検出方法 |
| US6309863B1 (en) | 1999-01-25 | 2001-10-30 | Brookhaven Science Associates | Methods for generating phosphorylation site-specific immunological reagents |
| DE60045586D1 (de) * | 1999-06-09 | 2011-03-10 | Molecular Devices Inc | Testverfahren zur messung der phosphorylierung |
| JP4828752B2 (ja) | 1999-08-04 | 2011-11-30 | 株式会社医学生物学研究所 | サイクリン／ｃｄｋ複合体のリン酸化酵素活性測定方法 |
| ATE342509T1 (de) * | 2000-01-24 | 2006-11-15 | Innogenetics Nv | Diagnose von tauopathien durch bestimmung des verhältnisses von tau/phospho-tau |
| US20030166016A1 (en) | 2000-04-28 | 2003-09-04 | Foster Barbara A. | Assay methods for cyclin dependent kinases |
| US20030162230A1 (en) | 2000-09-27 | 2003-08-28 | Reagan Kevin J. | Method for quantifying phosphokinase activity on proteins |
-
2001
- 2001-09-07 US US09/948,972 patent/US20030162230A1/en not_active Abandoned
- 2001-09-27 DE DE60136840T patent/DE60136840D1/de not_active Expired - Lifetime
- 2001-09-27 EP EP10179876A patent/EP2298814A3/en not_active Withdrawn
- 2001-09-27 EP EP08169121A patent/EP2040078A1/en not_active Withdrawn
- 2001-09-27 AT AT01973567T patent/ATE416385T1/de not_active IP Right Cessation
- 2001-09-27 EP EP01973567A patent/EP1328812B1/en not_active Expired - Lifetime
- 2001-09-27 WO PCT/US2001/030186 patent/WO2002027017A2/en not_active Ceased
- 2001-09-27 CA CA2423979A patent/CA2423979C/en not_active Expired - Lifetime
- 2001-09-27 JP JP2002530779A patent/JP2004516823A/ja not_active Withdrawn
-
2006
- 2006-03-22 JP JP2006079226A patent/JP2006225396A/ja active Pending
-
2008
- 2008-07-24 US US12/179,526 patent/US7888050B2/en not_active Expired - Fee Related
-
2010
- 2010-12-16 US US12/970,250 patent/US8114617B2/en not_active Expired - Fee Related
-
2011
- 2011-09-26 US US13/245,045 patent/US20120135426A1/en not_active Abandoned
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