JP2004516823A5 - - Google Patents

Info

Publication number

JP2004516823A5

JP2004516823A5 JP2002530779A JP2002530779A JP2004516823A5 JP 2004516823 A5 JP2004516823 A5 JP 2004516823A5 JP 2002530779 A JP2002530779 A JP 2002530779A JP 2002530779 A JP2002530779 A JP 2002530779A JP 2004516823 A5 JP2004516823 A5 JP 2004516823A5

Authority

JP

Japan

Prior art keywords

protein

antibody

phosphorylated

specificity

binds

Prior art date

2001-09-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 235000018102 proteins Nutrition 0.000 claims 28
• 102000004169 proteins and genes Human genes 0.000 claims 28
• 108090000623 proteins and genes Proteins 0.000 claims 28
• 238000000034 method Methods 0.000 claims 8
• 230000026731 phosphorylation Effects 0.000 claims 6
• 238000006366 phosphorylation reaction Methods 0.000 claims 6
• 102000013498 tau Proteins Human genes 0.000 claims 4
• 108010026424 tau Proteins Proteins 0.000 claims 4
• 108091005981 phosphorylated proteins Proteins 0.000 claims 3
• 101001102158 Homo sapiens Phosphatidylserine synthase 1 Proteins 0.000 claims 2
• 102100039298 Phosphatidylserine synthase 1 Human genes 0.000 claims 2
• 239000007853 buffer solution Substances 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101100495314 Caenorhabditis elegans cdk-5 gene Proteins 0.000 claims 1
• 102000052052 Casein Kinase II Human genes 0.000 claims 1
• 108010010919 Casein Kinase II Proteins 0.000 claims 1
• 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 1
• 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 1
• -1 PKA Proteins 0.000 claims 1
• 108091000080 Phosphotransferase Proteins 0.000 claims 1
• SLPJGDQJLTYWCI-UHFFFAOYSA-N dimethyl-(4,5,6,7-tetrabromo-1h-benzoimidazol-2-yl)-amine Chemical compound BrC1=C(Br)C(Br)=C2NC(N(C)C)=NC2=C1Br SLPJGDQJLTYWCI-UHFFFAOYSA-N 0.000 claims 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
• 102000020233 phosphotransferase Human genes 0.000 claims 1