DE60136840D1 - Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen - Google Patents

Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen

Info

Publication number
DE60136840D1
DE60136840D1 DE60136840T DE60136840T DE60136840D1 DE 60136840 D1 DE60136840 D1 DE 60136840D1 DE 60136840 T DE60136840 T DE 60136840T DE 60136840 T DE60136840 T DE 60136840T DE 60136840 D1 DE60136840 D1 DE 60136840D1
Authority
DE
Germany
Prior art keywords
phosphorylation
protein
proteins
quantitating
tau
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136840T
Other languages
German (de)
English (en)
Inventor
Kevin J Reagan
Erik Schaeffer
Jimin Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Invitrogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitrogen Corp filed Critical Invitrogen Corp
Application granted granted Critical
Publication of DE60136840D1 publication Critical patent/DE60136840D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE60136840T 2000-09-27 2001-09-27 Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen Expired - Lifetime DE60136840D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23562000P 2000-09-27 2000-09-27
PCT/US2001/030186 WO2002027017A2 (en) 2000-09-27 2001-09-27 Method for quantifying phosphokinase activity on proteins

Publications (1)

Publication Number Publication Date
DE60136840D1 true DE60136840D1 (de) 2009-01-15

Family

ID=22886277

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60136840T Expired - Lifetime DE60136840D1 (de) 2000-09-27 2001-09-27 Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen

Country Status (7)

Country Link
US (4) US20030162230A1 (https=)
EP (3) EP2298814A3 (https=)
JP (2) JP2004516823A (https=)
AT (1) ATE416385T1 (https=)
CA (1) CA2423979C (https=)
DE (1) DE60136840D1 (https=)
WO (1) WO2002027017A2 (https=)

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CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
EP1668146B1 (en) 2003-09-25 2014-11-12 Life Technologies Corporation Homogeneous populations of molecules
US7326567B2 (en) 2003-11-12 2008-02-05 Schering Corporation Plasmid system for multigene expression
TW200526684A (en) 2003-11-21 2005-08-16 Schering Corp Anti-IGFR1 antibody therapeutic combinations
PT1828249E (pt) 2004-12-03 2011-02-25 Schering Corp Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2007005605A2 (en) * 2005-07-01 2007-01-11 Washington University In St. Louis Phosphospecific chemokine receptor antibodies
WO2007133688A2 (en) * 2006-05-12 2007-11-22 Cell Signaling Technology, Inc. Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways
WO2008147687A1 (en) * 2007-05-21 2008-12-04 Mayo Foundation For Medical Education And Research Treating pancreatitis
KR101612442B1 (ko) 2008-05-13 2016-04-15 삼성전자주식회사 컨텐츠 시청 제한 정보의 제공 및 이용을 위한 방법 및장치
AU2011235595B2 (en) * 2010-03-29 2016-06-09 Central Adelaide Local Health Network Inc. A method of modulating protein 14-3-3 functionality by facilitating or inhibiting phosphorylation
EP2614372B1 (en) * 2010-09-07 2018-07-25 Stephen G. Marx Kit for monitoring, detecting and staging gvhd
US20170016900A1 (en) 2010-09-07 2017-01-19 Stephen G. Marx Kit for monitoring, detecting and staging gvhd
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
AU2014368696A1 (en) 2013-12-20 2016-06-02 F. Hoffmann-La Roche Ag Humanized anti-Tau(pS422) antibodies and methods of use
EP4321165A3 (en) * 2013-12-27 2024-08-21 National University Corporation Tokyo Medical and Dental University Method for diagnosis of alzheimer's disease and frontotemporal lobar degeneration, diagnostic agent, therapeutic agent, and screening method for said agents
AU2015240088B2 (en) * 2014-03-31 2021-07-22 Merck Patent Gmbh Method for detecting protein modifications using specific antibodies
AR100978A1 (es) 2014-06-26 2016-11-16 Hoffmann La Roche LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS
WO2016207245A1 (en) 2015-06-24 2016-12-29 F. Hoffmann-La Roche Ag Humanized anti-tau(ps422) antibodies and methods of use
JO3711B1 (ar) * 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
JP7040774B2 (ja) * 2016-03-01 2022-03-23 マックォーリー・ユニバーシティ 神経学的症状の治療のためのリン酸化ｔａｕ及びｐ３８ガンマの使用
PH12018502613B1 (en) 2016-07-12 2023-02-01 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
ES2791962T3 (es) * 2016-11-21 2020-11-06 Univ Ruhr Bochum Ensayo combinado para el diagnóstico diferencial de la enfermedad de Alzheimer
CN110267985B (zh) 2017-01-04 2023-05-23 H.隆德贝克有限公司 用于治疗眼科疾病的特异性针对过度磷酸化τ蛋白的抗体
AU2018388549B2 (en) * 2017-12-18 2023-06-01 Yale University Compounds and compositions for treating fibrosis
US10591492B2 (en) 2018-03-05 2020-03-17 Janssen Pharmaceutica Nv Assays to detect neurodegeneration
CA3093200A1 (en) 2018-03-05 2019-09-12 Janssen Pharmaceutica Nv Anti-phf-tau antibodies and uses thereof
US11085935B2 (en) * 2018-05-03 2021-08-10 Washington University Methods of treating based on site-specific tau phosphorylation
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CA3150369A1 (en) 2019-09-10 2021-03-18 Randall Bateman Blood-based assay for diagnosing and treating based on site-specific tau phosphorylation

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US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
US5733734A (en) * 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
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ATE248189T1 (de) * 1997-11-07 2003-09-15 Vasopharm Biotech Gmbh Antikörper gegen vasp (vasodilator-stimulated phosphoprotein), hybridomzellen für deren gewinnung, und deren verwendung
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JP2000034300A (ja) * 1998-07-17 2000-02-02 Mitsubishi Chemicals Corp 抗リン酸化タウ蛋白質抗体及びそれを用いるアルツハイマー病の検出方法
US6309863B1 (en) 1999-01-25 2001-10-30 Brookhaven Science Associates Methods for generating phosphorylation site-specific immunological reagents
DE60045586D1 (de) * 1999-06-09 2011-03-10 Molecular Devices Inc Testverfahren zur messung der phosphorylierung
JP4828752B2 (ja) 1999-08-04 2011-11-30 株式会社医学生物学研究所 サイクリン／ｃｄｋ複合体のリン酸化酵素活性測定方法
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US20030162230A1 (en) 2000-09-27 2003-08-28 Reagan Kevin J. Method for quantifying phosphokinase activity on proteins

Also Published As

Publication number Publication date
US20110165588A1 (en) 2011-07-07
US20120135426A1 (en) 2012-05-31
EP2298814A2 (en) 2011-03-23
CA2423979C (en) 2012-03-06
EP2298814A3 (en) 2012-05-30
EP1328812B1 (en) 2008-12-03
US7888050B2 (en) 2011-02-15
US20090104628A1 (en) 2009-04-23
US8114617B2 (en) 2012-02-14
ATE416385T1 (de) 2008-12-15
EP2040078A1 (en) 2009-03-25
US20030162230A1 (en) 2003-08-28
JP2006225396A (ja) 2006-08-31
CA2423979A1 (en) 2002-04-04
WO2002027017A3 (en) 2003-01-16
JP2004516823A (ja) 2004-06-10
WO2002027017A2 (en) 2002-04-04
EP1328812A2 (en) 2003-07-23

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