JP2010521515A5 - - Google Patents
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- Publication number
- JP2010521515A5 JP2010521515A5 JP2009554009A JP2009554009A JP2010521515A5 JP 2010521515 A5 JP2010521515 A5 JP 2010521515A5 JP 2009554009 A JP2009554009 A JP 2009554009A JP 2009554009 A JP2009554009 A JP 2009554009A JP 2010521515 A5 JP2010521515 A5 JP 2010521515A5
- Authority
- JP
- Japan
- Prior art keywords
- carbonyl
- alkyl
- aminocarbonyl
- amino
- phenylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 hydroxy, amino Chemical group 0.000 claims 116
- 125000000623 heterocyclic group Chemical group 0.000 claims 14
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000006563 (C1-3) alkylaminocarbonyl group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 5
- 150000001721 carbon Chemical group 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 5
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims 4
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 4
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 4
- 125000006559 (C1-C3) alkylamino group Chemical group 0.000 claims 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 3
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- 125000005100 aryl amino carbonyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006594 (C1-C3) alkylsulfony group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- PUOQFQXJDVPBKJ-UHFFFAOYSA-N 2-[(1-acetyl-2,3-dihydroindol-5-yl)-(3,5-dichlorophenyl)sulfonylamino]acetic acid Chemical compound C=1C=C2N(C(=O)C)CCC2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 PUOQFQXJDVPBKJ-UHFFFAOYSA-N 0.000 claims 1
- SCMWFHHDOKKALH-UHFFFAOYSA-N 2-[(2,6-dichloropyridin-4-yl)sulfonyl-(9-ethylcarbazol-3-yl)amino]acetic acid Chemical compound C=1C=C2N(CC)C3=CC=CC=C3C2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(Cl)=NC(Cl)=C1 SCMWFHHDOKKALH-UHFFFAOYSA-N 0.000 claims 1
- GGSOZCUVFWAINP-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-(methylcarbamoyl)-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C=C2N(C(=O)NC)CCC2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 GGSOZCUVFWAINP-UHFFFAOYSA-N 0.000 claims 1
- ZYXYTKGFUFSYBH-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-(phenylcarbamoyl)-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1CC2)=CC=C1N2C(=O)NC1=CC=CC=C1 ZYXYTKGFUFSYBH-UHFFFAOYSA-N 0.000 claims 1
- JAYIVBVZGJWSSK-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-(phenylcarbamoyl)indol-5-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1C=C2)=CC=C1N2C(=O)NC1=CC=CC=C1 JAYIVBVZGJWSSK-UHFFFAOYSA-N 0.000 claims 1
- CIVWHOBJZOISLN-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-(pyridin-3-ylcarbamoyl)-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1CC2)=CC=C1N2C(=O)NC1=CC=CN=C1 CIVWHOBJZOISLN-UHFFFAOYSA-N 0.000 claims 1
- QTCMEGGMQTVZQB-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-(pyridin-4-ylcarbamoyl)-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1CC2)=CC=C1N2C(=O)NC1=CC=NC=C1 QTCMEGGMQTVZQB-UHFFFAOYSA-N 0.000 claims 1
- BAEAQZXUAAAWBD-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-[(2-nitrophenyl)carbamoyl]-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1CC2)=CC=C1N2C(=O)NC1=CC=CC=C1[N+]([O-])=O BAEAQZXUAAAWBD-UHFFFAOYSA-N 0.000 claims 1
- PGXLRRYGNCEZLL-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-[(3-nitrophenyl)carbamoyl]-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1CC2)=CC=C1N2C(=O)NC1=CC=CC([N+]([O-])=O)=C1 PGXLRRYGNCEZLL-UHFFFAOYSA-N 0.000 claims 1
- FUODTCUABYXNJF-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[1-methyl-3-(pyrrolidine-1-carbonyl)indol-6-yl]amino]acetic acid Chemical compound C12=CC=C(N(CC(O)=O)S(=O)(=O)C=3C=C(Cl)C=C(Cl)C=3)C=C2N(C)C=C1C(=O)N1CCCC1 FUODTCUABYXNJF-UHFFFAOYSA-N 0.000 claims 1
- MYFYKCZSTCOHMZ-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[3-(3-hydroxypyrrolidine-1-carbonyl)-1-methylindol-6-yl]amino]acetic acid Chemical compound C12=CC=C(N(CC(O)=O)S(=O)(=O)C=3C=C(Cl)C=C(Cl)C=3)C=C2N(C)C=C1C(=O)N1CCC(O)C1 MYFYKCZSTCOHMZ-UHFFFAOYSA-N 0.000 claims 1
- DORJFCIEWIBHMA-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[3-(dimethylcarbamoyl)-1-methylindol-6-yl]amino]acetic acid Chemical compound C=1C=C2C(C(=O)N(C)C)=CN(C)C2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 DORJFCIEWIBHMA-UHFFFAOYSA-N 0.000 claims 1
- WMRHPYBFEXHLKX-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[3-(hydroxymethyl)-1-(methylcarbamoyl)-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C=C2N(C(=O)NC)CC(CO)C2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 WMRHPYBFEXHLKX-UHFFFAOYSA-N 0.000 claims 1
- PURFAXVQWQAGNC-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[3-(methylcarbamoyl)-1-benzothiophen-6-yl]amino]acetic acid Chemical compound C=1C=C2C(C(=O)NC)=CSC2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(Cl)=CC(Cl)=C1 PURFAXVQWQAGNC-UHFFFAOYSA-N 0.000 claims 1
- QQNWLGOQSDGWIW-UHFFFAOYSA-N 2-[(3,5-dichlorophenyl)sulfonyl-[3-(morpholine-4-carbonyl)-1h-indol-6-yl]amino]acetic acid Chemical compound C=1C(Cl)=CC(Cl)=CC=1S(=O)(=O)N(CC(=O)O)C(C=C1NC=2)=CC=C1C=2C(=O)N1CCOCC1 QQNWLGOQSDGWIW-UHFFFAOYSA-N 0.000 claims 1
- LMABDGXECCIQFR-UHFFFAOYSA-N 2-[(3,5-dimethylphenyl)sulfonyl-[1-(methylcarbamoyl)-2,3-dihydroindol-5-yl]amino]acetic acid Chemical compound C=1C=C2N(C(=O)NC)CCC2=CC=1N(CC(O)=O)S(=O)(=O)C1=CC(C)=CC(C)=C1 LMABDGXECCIQFR-UHFFFAOYSA-N 0.000 claims 1
- HVMQVCZZNAATBE-UHFFFAOYSA-N 2-[(3,5-dimethylphenyl)sulfonyl-[1-methyl-3-(pyrrolidine-1-carbonyl)indol-6-yl]amino]acetic acid Chemical compound CC1=CC(C)=CC(S(=O)(=O)N(CC(O)=O)C=2C=C3N(C)C=C(C3=CC=2)C(=O)N2CCCC2)=C1 HVMQVCZZNAATBE-UHFFFAOYSA-N 0.000 claims 1
- BPMQMEWKTGVCSV-UHFFFAOYSA-N 2-[(3-chloro-5-methylphenyl)sulfonyl-[1-methyl-3-(pyrrolidine-1-carbonyl)indol-6-yl]amino]acetic acid Chemical compound CC1=CC(Cl)=CC(S(=O)(=O)N(CC(O)=O)C=2C=C3N(C)C=C(C3=CC=2)C(=O)N2CCCC2)=C1 BPMQMEWKTGVCSV-UHFFFAOYSA-N 0.000 claims 1
- NVZUMSKHQQZTPD-UHFFFAOYSA-N 2-[[3-(azetidine-1-carbonyl)-1-methylindol-6-yl]-(3,5-dichlorophenyl)sulfonylamino]acetic acid Chemical compound C12=CC=C(N(CC(O)=O)S(=O)(=O)C=3C=C(Cl)C=C(Cl)C=3)C=C2N(C)C=C1C(=O)N1CCC1 NVZUMSKHQQZTPD-UHFFFAOYSA-N 0.000 claims 1
- VCFLKMXHJFWMPA-UHFFFAOYSA-N 2-[[3-[cyclopropyl(methyl)carbamoyl]-1-methylindol-6-yl]-(3,5-dichlorophenyl)sulfonylamino]acetic acid Chemical compound C=1N(C)C2=CC(N(CC(O)=O)S(=O)(=O)C=3C=C(Cl)C=C(Cl)C=3)=CC=C2C=1C(=O)N(C)C1CC1 VCFLKMXHJFWMPA-UHFFFAOYSA-N 0.000 claims 1
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229920001774 Perfluoroether Polymers 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 125000000638 benzylaminocarbonyl group Chemical group C(C1=CC=CC=C1)NC(=O)* 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 0 C[n]1nc(*)c2c1C=*(*)CC=C2 Chemical compound C[n]1nc(*)c2c1C=*(*)CC=C2 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007012284A DE102007012284A1 (de) | 2007-03-16 | 2007-03-16 | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| PCT/EP2008/053087 WO2008113760A2 (en) | 2007-03-16 | 2008-03-14 | Arylsulphonyglycine derivatives as suppressors of the interaction of glycogen phosphorylase a with the gl subunit of glycogen-associated protein phosphatase 1 (ppl) for the treatment of metabolic disorders, particulary diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010521515A JP2010521515A (ja) | 2010-06-24 |
| JP2010521515A5 true JP2010521515A5 (https=) | 2011-05-12 |
Family
ID=39688104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554009A Pending JP2010521515A (ja) | 2007-03-16 | 2008-03-14 | 新規置換アリールスルホニルグリシン、その製法及びその医薬組成物としての使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8232312B2 (https=) |
| EP (1) | EP2125718B1 (https=) |
| JP (1) | JP2010521515A (https=) |
| AT (1) | ATE481382T1 (https=) |
| CA (1) | CA2681124A1 (https=) |
| DE (2) | DE102007012284A1 (https=) |
| ES (1) | ES2349331T3 (https=) |
| WO (1) | WO2008113760A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) * | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102008019838A1 (de) * | 2008-04-19 | 2009-12-10 | Boehringer Ingelheim International Gmbh | Neue Arylsulfonylglycin-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| JP5607025B2 (ja) | 2008-04-21 | 2014-10-15 | シグナム バイオサイエンシーズ， インコーポレイテッド | 化合物、組成物およびそれらを作製する方法 |
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| GB0909671D0 (en) | 2009-06-04 | 2009-07-22 | Xention Discovery Ltd | Compounds |
| GB0909672D0 (en) | 2009-06-04 | 2009-07-22 | Xention Discovery Ltd | Compounds |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2014139388A1 (en) * | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
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| DE3432320A1 (de) | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
| DK0604657T3 (da) | 1992-05-21 | 2000-04-17 | Otsuka Pharma Co Ltd | Phosphonsyrediesterderivat |
| TW260664B (https=) | 1993-02-15 | 1995-10-21 | Otsuka Pharma Factory Inc | |
| DE19753522A1 (de) | 1997-12-03 | 1999-06-10 | Boehringer Ingelheim Pharma | Substituierte Indole, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6114532A (en) * | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
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| BR0312593A (pt) | 2002-07-11 | 2005-04-12 | Aventis Pharma Gmbh | Aciluréias substituìdas por uréia e uretano, processo para a sua produção e sua aplicação |
| RS20050019A (sr) * | 2002-07-12 | 2007-09-21 | Sanofi - Aventis Pharma Deutschland Gmbh., | Heterociklično supstituisani benzoilkarbamidi,postupak za njihovu proizvodnju i njihova primena kao leka |
| EP1556040A1 (en) * | 2002-10-24 | 2005-07-27 | Sterix Limited | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2 |
| MXPA05012547A (es) | 2003-05-21 | 2006-05-25 | Prosidion Ltd | Inhibidores de amida de acido pirrolopiridina-2-carboxilico de fosforilasa de glucogeno. |
| ES2222829B1 (es) * | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| ES2222827B1 (es) | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| ES2222832B1 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| EP1513085A1 (en) | 2003-09-08 | 2005-03-09 | Abb Research Ltd. | Method of scheduling maintenance actions |
| JP2005206492A (ja) | 2004-01-21 | 2005-08-04 | Sankyo Co Ltd | スルホンアミド化合物 |
| AU2005286717A1 (en) * | 2004-09-21 | 2006-03-30 | Wyeth | Benzimidazole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof |
| AU2005304962B2 (en) | 2004-11-09 | 2009-11-19 | Smithkline Beecham Corporation | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
| CN101094677A (zh) * | 2004-11-15 | 2007-12-26 | 塞普泰尔公司 | 蛋白酪氨酸磷酸酶抑制剂及其使用方法 |
| EP2308839B1 (en) * | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| BRPI0617162B8 (pt) | 2005-10-07 | 2021-05-25 | Exelixis Inc | compostos inibidores de fosfatidilinositol 3-quinase composições farmacêuticas que os contem e métodos de uso dos mesmos |
| DE102007007751A1 (de) | 2007-02-16 | 2008-08-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| WO2008103354A2 (en) | 2007-02-20 | 2008-08-28 | Cropsolution, Inc. | Modulators of acetyl-coenzyme a carboxylase and methods of use thereof |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035334A1 (de) * | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
-
2007
- 2007-03-16 DE DE102007012284A patent/DE102007012284A1/de not_active Withdrawn
-
2008
- 2008-03-14 AT AT08735421T patent/ATE481382T1/de active
- 2008-03-14 ES ES08735421T patent/ES2349331T3/es active Active
- 2008-03-14 CA CA002681124A patent/CA2681124A1/en not_active Abandoned
- 2008-03-14 JP JP2009554009A patent/JP2010521515A/ja active Pending
- 2008-03-14 EP EP08735421A patent/EP2125718B1/en not_active Not-in-force
- 2008-03-14 US US12/530,507 patent/US8232312B2/en active Active
- 2008-03-14 WO PCT/EP2008/053087 patent/WO2008113760A2/en not_active Ceased
- 2008-03-14 DE DE602008002567T patent/DE602008002567D1/de active Active
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