JP2010521470A5 - - Google Patents
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- JP2010521470A5 JP2010521470A5 JP2009553636A JP2009553636A JP2010521470A5 JP 2010521470 A5 JP2010521470 A5 JP 2010521470A5 JP 2009553636 A JP2009553636 A JP 2009553636A JP 2009553636 A JP2009553636 A JP 2009553636A JP 2010521470 A5 JP2010521470 A5 JP 2010521470A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- binding fragment
- factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
- 201000010099 disease Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 230000004913 activation Effects 0.000 claims 5
- 208000037883 airway inflammation Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- 230000024203 complement activation Effects 0.000 claims 4
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 208000026935 allergic disease Diseases 0.000 claims 3
- 230000009610 hypersensitivity Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 206010035664 Pneumonia Diseases 0.000 claims 2
- 208000010370 Adenoviridae Infections Diseases 0.000 claims 1
- 206010060931 Adenovirus infection Diseases 0.000 claims 1
- 206010052613 Allergic bronchitis Diseases 0.000 claims 1
- 206010003557 Asthma exercise induced Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 102000003712 Complement factor B Human genes 0.000 claims 1
- 108090000056 Complement factor B Proteins 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010073508 Drug reaction with eosinophilia and systemic symptoms Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000004657 Exercise-Induced Asthma Diseases 0.000 claims 1
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 208000016999 Parasitic Lung disease Diseases 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 208000011589 adenoviridae infectious disease Diseases 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 230000009285 allergic inflammation Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 206010006451 bronchitis Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000009580 eosinophilic pneumonia Diseases 0.000 claims 1
- 208000024695 exercise-induced bronchoconstriction Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 1
- 208000007892 occupational asthma Diseases 0.000 claims 1
- 206010039083 rhinitis Diseases 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90681607P | 2007-03-14 | 2007-03-14 | |
| US60/906,816 | 2007-03-14 | ||
| PCT/US2008/003381 WO2008140653A2 (en) | 2007-03-14 | 2008-03-14 | Humaneered anti-factor b antibody |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014080917A Division JP2014133753A (ja) | 2007-03-14 | 2014-04-10 | 人工ヒト抗b因子抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010521470A JP2010521470A (ja) | 2010-06-24 |
| JP2010521470A5 true JP2010521470A5 (enExample) | 2011-05-06 |
| JP5872757B2 JP5872757B2 (ja) | 2016-03-01 |
Family
ID=40002836
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009553636A Expired - Fee Related JP5872757B2 (ja) | 2007-03-14 | 2008-03-14 | ヒト化抗b因子抗体 |
| JP2014080917A Pending JP2014133753A (ja) | 2007-03-14 | 2014-04-10 | 人工ヒト抗b因子抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014080917A Pending JP2014133753A (ja) | 2007-03-14 | 2014-04-10 | 人工ヒト抗b因子抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7964705B2 (enExample) |
| EP (3) | EP2118142A2 (enExample) |
| JP (2) | JP5872757B2 (enExample) |
| CN (1) | CN101668773B (enExample) |
| AU (1) | AU2008251943B2 (enExample) |
| BR (1) | BRPI0808227A2 (enExample) |
| CA (1) | CA2680344A1 (enExample) |
| ES (1) | ES2507542T3 (enExample) |
| WO (1) | WO2008140653A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1713503T3 (da) | 2004-02-10 | 2013-11-04 | Univ Colorado Regents | Hæmning af faktor b, den alternative komplemenpathway og dertil relaterede fremgangsmåde |
| ES2548700T3 (es) | 2005-05-26 | 2015-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas |
| AU2007261315B2 (en) | 2006-06-21 | 2012-10-25 | Musc Foundation For Research Development | Targeting complement factor H for treatment of diseases |
| AU2008251943B2 (en) | 2007-03-14 | 2013-09-05 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| US20090324585A1 (en) * | 2008-06-12 | 2009-12-31 | The Trustees of the Leland Standford Junior University | Complement inhibitory agents as therapeutics in posttraumatic and degenerative arthritis |
| US20110160636A1 (en) * | 2008-09-10 | 2011-06-30 | Rekha Bansal | Device and method for inhibiting complement activation |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| CA3045436C (en) | 2009-01-29 | 2025-10-07 | Forsight Vision4 Inc | Posterior segment drug delivery |
| AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| EA201290286A1 (ru) | 2009-11-05 | 2013-01-30 | Алексион Кембридж Корпорейшн | Лечение пароксизмальной ночной гемоглобинурии, гемолитических анемий и патологических состояний с вовлечением внутрисосудистого и внесосудистого гемолиза |
| US10166142B2 (en) | 2010-01-29 | 2019-01-01 | Forsight Vision4, Inc. | Small molecule delivery with implantable therapeutic device |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| EP2585110A4 (en) | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| US20130324482A1 (en) * | 2010-07-09 | 2013-12-05 | Apellis Pharmaceuticals, Inc. | Compstatin analogs for treatment of rhinosinusitis and nasal polyposis |
| HUE057267T2 (hu) * | 2010-08-05 | 2022-05-28 | Forsight Vision4 Inc | Berendezés szem kezelésére |
| EP2640360A2 (en) | 2010-11-19 | 2013-09-25 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| CN102830228B (zh) * | 2011-06-15 | 2015-01-21 | 格诺思博生物科技(上海)有限公司 | 定量分析循环肿瘤细胞的试剂及试剂盒 |
| WO2013091903A1 (en) * | 2011-12-22 | 2013-06-27 | Novo Nordisk A/S | Anti-crac channel antibodies |
| EP2834271B1 (en) * | 2012-04-03 | 2019-01-16 | NovelMed Therapeutics, Inc. | Humanized and chimeric anti-factor bb antibodies and uses thereof |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| AU2014236455B2 (en) | 2013-03-14 | 2018-07-12 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| ES2972168T3 (es) | 2013-03-28 | 2024-06-11 | Forsight Vision4 Inc | Implante oftálmico para administración de sustancias terapéuticas |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| SG10202104175YA (en) | 2014-02-27 | 2021-06-29 | Allergan Inc | COMPLEMENT FACTOR Bb ANTIBODIES |
| CA2957548A1 (en) | 2014-08-08 | 2016-02-11 | Forsight Vision4, Inc. | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
| WO2020210512A1 (en) | 2019-04-09 | 2020-10-15 | Abcuro, Inc. | Killer cell lectin-like receptor subfamily g member 1 (klrg1) depleting antibodies |
| MX2022001309A (es) * | 2019-07-30 | 2022-05-10 | Immunome Inc | Anticuerpos específicos il-38. |
| KR102509648B1 (ko) * | 2019-08-06 | 2023-03-15 | 아프리노이아 테라퓨틱스 리미티드 | 병리학적 타우 종에 결합하는 항체 및 이의 용도 |
| JP6982129B2 (ja) * | 2020-04-27 | 2021-12-17 | 田中貴金属工業株式会社 | 抗水痘帯状疱疹ウイルス抗体、免疫学的測定方法及び免疫学的測定用装置 |
| US20230331853A1 (en) * | 2020-09-11 | 2023-10-19 | National Jewish Health | Methods and compositions for treating respiratory diseases or conditions related to innate lymphoid cells |
| KR20240004375A (ko) * | 2021-03-28 | 2024-01-11 | 이뮤놈 인코포레이티드 | Il-38-특이적 항체 |
| JP2024520497A (ja) | 2021-05-28 | 2024-05-24 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | Cm-tmaバイオマーカーを検出するための方法 |
| KR20250158063A (ko) | 2023-03-16 | 2025-11-05 | 젠자임 코포레이션 | 건식 연령-관련 황반 변성의 치료 |
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| US4845083A (en) | 1983-10-05 | 1989-07-04 | Merck Frosst Canada, Inc. | Method of inhibiting mammalian leukotriene biosynthesis |
| JPH0742235B2 (ja) * | 1985-11-08 | 1995-05-10 | 三共株式会社 | 自己免疫性疾病の予防・治療剤 |
| US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
| EP0512733A2 (en) * | 1991-05-03 | 1992-11-11 | Washington University | Modified complement system regulator |
| DE4222534A1 (de) * | 1992-07-09 | 1994-01-13 | Behringwerke Ag | Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura |
| US5976540A (en) * | 1993-05-17 | 1999-11-02 | T Cell Sciences, Inc. | Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions |
| US5679546A (en) * | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
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| GB9624731D0 (en) * | 1996-11-28 | 1997-01-15 | Univ Leicester | Complement inhibitor |
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| US8088386B2 (en) * | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
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| EP2026073B1 (en) * | 2000-04-29 | 2016-03-30 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
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| US20040014782A1 (en) | 2002-03-29 | 2004-01-22 | Krause James E. | Combination therapy for the treatment of diseases involving inflammatory components |
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| DK1713503T3 (da) * | 2004-02-10 | 2013-11-04 | Univ Colorado Regents | Hæmning af faktor b, den alternative komplemenpathway og dertil relaterede fremgangsmåde |
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| EP2357257B1 (en) * | 2005-02-14 | 2019-07-31 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| ES2548700T3 (es) | 2005-05-26 | 2015-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas |
| CN101262855A (zh) | 2005-09-08 | 2008-09-10 | 帝斯曼知识产权资产管理有限公司 | 治疗或预防年龄相关性黄斑变性的方法 |
| WO2007032876A2 (en) | 2005-09-09 | 2007-03-22 | University Of Iowa Research Foundation | Biomarkers associated with age-related macular degeneration |
| ES2551202T5 (es) | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uso de inhibidores de la vía del complemento para tratar enfermedades oculares |
| AU2007261315B2 (en) | 2006-06-21 | 2012-10-25 | Musc Foundation For Research Development | Targeting complement factor H for treatment of diseases |
| AU2008251943B2 (en) | 2007-03-14 | 2013-09-05 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| US20090175847A1 (en) * | 2007-05-30 | 2009-07-09 | Abbott Laboratories | Humanized antibodies to ab (20-42) globulomer and uses thereof |
| KR100951695B1 (ko) | 2007-12-24 | 2010-04-07 | (주)페타리 | 아이솔레이터 및 그 제조 방법 |
| US7964105B2 (en) | 2008-08-07 | 2011-06-21 | William Harris Moss | Method for improving belt press dewatering |
| AU2010266127B2 (en) | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| EA201290286A1 (ru) | 2009-11-05 | 2013-01-30 | Алексион Кембридж Корпорейшн | Лечение пароксизмальной ночной гемоглобинурии, гемолитических анемий и патологических состояний с вовлечением внутрисосудистого и внесосудистого гемолиза |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| EP2585110A4 (en) | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
-
2008
- 2008-03-14 AU AU2008251943A patent/AU2008251943B2/en not_active Ceased
- 2008-03-14 EP EP08794326A patent/EP2118142A2/en not_active Withdrawn
- 2008-03-14 EP EP12189893.6A patent/EP2565207A3/en not_active Withdrawn
- 2008-03-14 CA CA002680344A patent/CA2680344A1/en not_active Abandoned
- 2008-03-14 WO PCT/US2008/003381 patent/WO2008140653A2/en not_active Ceased
- 2008-03-14 JP JP2009553636A patent/JP5872757B2/ja not_active Expired - Fee Related
- 2008-03-14 BR BRPI0808227-8A patent/BRPI0808227A2/pt not_active IP Right Cessation
- 2008-03-14 US US12/049,233 patent/US7964705B2/en active Active
- 2008-03-14 EP EP10164673.5A patent/EP2236518B1/en not_active Not-in-force
- 2008-03-14 ES ES10164673.5T patent/ES2507542T3/es active Active
- 2008-03-14 CN CN200880008123.2A patent/CN101668773B/zh not_active Expired - Fee Related
-
2011
- 2011-05-25 US US13/115,810 patent/US20110318337A1/en not_active Abandoned
-
2012
- 2012-12-20 US US13/722,071 patent/US9096677B2/en active Active
-
2014
- 2014-04-10 JP JP2014080917A patent/JP2014133753A/ja active Pending
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