JP2011516422A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011516422A5 JP2011516422A5 JP2011502090A JP2011502090A JP2011516422A5 JP 2011516422 A5 JP2011516422 A5 JP 2011516422A5 JP 2011502090 A JP2011502090 A JP 2011502090A JP 2011502090 A JP2011502090 A JP 2011502090A JP 2011516422 A5 JP2011516422 A5 JP 2011516422A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- eosinophilic
- composition according
- human
- humanized anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010065563 Eosinophilic bronchitis Diseases 0.000 claims description 5
- 210000003979 eosinophil Anatomy 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 150000003431 steroids Chemical class 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 102000000743 Interleukin-5 Human genes 0.000 claims 7
- 108010002616 Interleukin-5 Proteins 0.000 claims 7
- 230000003472 neutralizing effect Effects 0.000 claims 7
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 6
- 229960004618 prednisone Drugs 0.000 claims 6
- 208000030852 Parasitic disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000002327 eosinophilic effect Effects 0.000 claims 2
- 201000001564 eosinophilic gastroenteritis Diseases 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000032671 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 208000028185 Angioedema Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000018428 Eosinophilic granulomatosis with polyangiitis Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000006968 Helminthiasis Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000016300 Idiopathic chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010028594 Myocardial fibrosis Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 241000243981 Onchocerca Species 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000009323 chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 206010057271 eosinophilic colitis Diseases 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 201000001561 eosinophilic gastritis Diseases 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 208000037916 non-allergic rhinitis Diseases 0.000 claims 1
- 208000001797 obstructive sleep apnea Diseases 0.000 claims 1
- 208000014837 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 208000015768 polyposis Diseases 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4036308P | 2008-03-28 | 2008-03-28 | |
| US61/040,363 | 2008-03-28 | ||
| PCT/US2009/038509 WO2009120927A2 (en) | 2008-03-28 | 2009-03-27 | Methods of treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014158170A Division JP6069267B2 (ja) | 2008-03-28 | 2014-08-01 | 処置方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011516422A JP2011516422A (ja) | 2011-05-26 |
| JP2011516422A5 true JP2011516422A5 (enExample) | 2016-02-04 |
| JP5917143B2 JP5917143B2 (ja) | 2016-05-11 |
Family
ID=41114741
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502090A Active JP5917143B2 (ja) | 2008-03-28 | 2009-03-27 | 処置方法 |
| JP2014158170A Active JP6069267B2 (ja) | 2008-03-28 | 2014-08-01 | 処置方法 |
| JP2016214438A Active JP6457463B2 (ja) | 2008-03-28 | 2016-11-01 | 処置方法 |
| JP2018238018A Pending JP2019065029A (ja) | 2008-03-28 | 2018-12-20 | 処置方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014158170A Active JP6069267B2 (ja) | 2008-03-28 | 2014-08-01 | 処置方法 |
| JP2016214438A Active JP6457463B2 (ja) | 2008-03-28 | 2016-11-01 | 処置方法 |
| JP2018238018A Pending JP2019065029A (ja) | 2008-03-28 | 2018-12-20 | 処置方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9834600B2 (enExample) |
| EP (1) | EP2274009B1 (enExample) |
| JP (4) | JP5917143B2 (enExample) |
| KR (1) | KR20100134702A (enExample) |
| CN (1) | CN102026660A (enExample) |
| AU (1) | AU2009228163B2 (enExample) |
| BR (1) | BRPI0910854A2 (enExample) |
| CA (1) | CA2719786A1 (enExample) |
| EA (1) | EA201071137A1 (enExample) |
| ES (1) | ES2441945T3 (enExample) |
| IL (1) | IL208354A0 (enExample) |
| MX (1) | MX2010010667A (enExample) |
| WO (1) | WO2009120927A2 (enExample) |
| ZA (1) | ZA201006648B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008113056A2 (en) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| AU2009228163B2 (en) * | 2008-03-28 | 2012-08-30 | Glaxosmithkline Llc | Methods of treatment |
| CN102186350A (zh) | 2008-08-19 | 2011-09-14 | 诺普神经科学股份有限公司 | 使用(r)-普拉克索的组合物与方法 |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| SMT202100119T1 (it) | 2013-07-12 | 2021-05-07 | Knopp Biosciences Llc | Trattamento dei livelli elevati di eosinofili e/o basofili |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| AU2014306597B2 (en) | 2013-08-13 | 2018-05-17 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
| EP3038467B1 (en) | 2013-08-13 | 2020-07-29 | Knopp Biosciences LLC | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| WO2016040007A1 (en) * | 2014-09-08 | 2016-03-17 | Cephalon, Inc. | Use of reslizumab to treat moderate to severe eosinophilic asthma |
| CN116474091A (zh) | 2015-08-24 | 2023-07-25 | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 生物医药组合物 |
| CN117018189A (zh) | 2017-05-26 | 2023-11-10 | 葛兰素史密斯克莱知识产权发展有限公司 | 生物制药组合物和相关方法 |
| KR20230067604A (ko) * | 2020-08-05 | 2023-05-16 | 아레테이아 테라퓨틱스, 인코포레이티드 | 중등도 내지 중증 천식의 치료를 위한 덱스프라미펙솔의 용도 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
| US5096704A (en) * | 1988-11-03 | 1992-03-17 | Schering Corporation | Method of treating eosinophilia |
| KR960002183B1 (ko) | 1988-11-03 | 1996-02-13 | 쉐링 코포레이션 | 호산구증다증 억제또는 경감을 위한 약제학적 조성물 |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0533006A1 (en) * | 1991-09-18 | 1993-03-24 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Chimaeric interleukin 5-receptor/immunoglobulin polypeptides |
| WO1993015210A1 (en) | 1992-01-23 | 1993-08-05 | Merck Patent Gmbh | Monomeric and dimeric antibody-fragment fusion proteins |
| AR248044A1 (es) | 1992-02-06 | 1995-05-31 | Schering Corp | Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped. |
| JPH06141885A (ja) | 1992-11-05 | 1994-05-24 | Chemo Sero Therapeut Res Inst | モノクローナル抗体 |
| AU1289795A (en) | 1993-11-19 | 1995-06-06 | Baylor College Of Medicine | Monoclonal antibodies specific for human interleukin-5 |
| GB9412230D0 (en) | 1994-06-17 | 1994-08-10 | Celltech Ltd | Interleukin-5 specific recombiant antibodies |
| US7399837B2 (en) * | 1995-12-22 | 2008-07-15 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| US5783184A (en) * | 1994-12-23 | 1998-07-21 | Smithkline Beecham Corporation | Method for treatment and diagnosis of IL-5 mediated disorders |
| US5683892A (en) * | 1994-12-23 | 1997-11-04 | Smithkline Beecham Corporation | DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
| EP0800536B1 (en) * | 1994-12-23 | 2006-11-29 | Smithkline Beecham Corporation | Recombinant il-5 antagonists useful in treatment of il-5 mediated disorders |
| US6248723B1 (en) * | 1997-06-10 | 2001-06-19 | National Jewish Medical And Research Center | Method for treatment of inflammatory disease |
| DK1024814T3 (da) * | 1997-10-22 | 2008-01-02 | Jens Ponikau | Anvendelse af antisvampemidler til topisk behandling af svampe-induceret mucositis |
| WO2001012646A1 (en) | 1999-08-19 | 2001-02-22 | Smithkline Beecham Corporation | Sialoadhesin factor-1 agonist and antagonist antibodies |
| US20030017169A1 (en) * | 2000-12-29 | 2003-01-23 | Sidney Pestka | Controlled release systems for polymers |
| MXPA04009418A (es) * | 2002-03-29 | 2005-06-08 | Schering Corp | Anticuerpos monoclonales humanos par interleucina-5, y metodos y composiciones que comprenden los mismos. |
| US7339507B1 (en) * | 2006-09-13 | 2008-03-04 | Jiun-In Guo | Device for video decoding |
| US9333272B2 (en) * | 2006-12-11 | 2016-05-10 | Bracco Imaging Spa | Fibrin binding peptide conjugates for diagnostic and therapeutic applications |
| PT2152290E (pt) | 2007-04-30 | 2014-09-03 | Glaxosmithkline Llc | Métodos para administrar anticorpos anti-il-5 |
| US20090035216A1 (en) * | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
| AU2009228163B2 (en) * | 2008-03-28 | 2012-08-30 | Glaxosmithkline Llc | Methods of treatment |
| US8926631B2 (en) | 2010-08-06 | 2015-01-06 | MoMelan Technologies, Inc. | Methods for preparing a skin graft without culturing or use of biologics |
| EP2672986B1 (en) | 2011-02-09 | 2020-03-18 | GlaxoSmithKline LLC | Lyophilized formulations |
-
2009
- 2009-03-27 AU AU2009228163A patent/AU2009228163B2/en not_active Ceased
- 2009-03-27 WO PCT/US2009/038509 patent/WO2009120927A2/en not_active Ceased
- 2009-03-27 CN CN2009801176573A patent/CN102026660A/zh active Pending
- 2009-03-27 EA EA201071137A patent/EA201071137A1/ru unknown
- 2009-03-27 US US12/935,038 patent/US9834600B2/en active Active
- 2009-03-27 EP EP09725345.4A patent/EP2274009B1/en not_active Revoked
- 2009-03-27 MX MX2010010667A patent/MX2010010667A/es not_active Application Discontinuation
- 2009-03-27 CA CA2719786A patent/CA2719786A1/en not_active Abandoned
- 2009-03-27 ES ES09725345.4T patent/ES2441945T3/es active Active
- 2009-03-27 KR KR1020107024046A patent/KR20100134702A/ko not_active Withdrawn
- 2009-03-27 BR BRPI0910854A patent/BRPI0910854A2/pt not_active IP Right Cessation
- 2009-03-27 JP JP2011502090A patent/JP5917143B2/ja active Active
-
2010
- 2010-09-16 ZA ZA2010/06648A patent/ZA201006648B/en unknown
- 2010-09-21 IL IL208354A patent/IL208354A0/en unknown
-
2014
- 2014-08-01 JP JP2014158170A patent/JP6069267B2/ja active Active
-
2016
- 2016-11-01 JP JP2016214438A patent/JP6457463B2/ja active Active
-
2017
- 2017-11-06 US US15/804,104 patent/US20180057582A1/en not_active Abandoned
-
2018
- 2018-12-20 JP JP2018238018A patent/JP2019065029A/ja active Pending
-
2019
- 2019-09-19 US US16/575,903 patent/US11325972B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011516422A5 (enExample) | ||
| JP2014240408A5 (enExample) | ||
| Dakhama et al. | Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice | |
| JP2012046518A5 (enExample) | ||
| EP2433650A3 (en) | Administration of anti-CD3 antibodies in the treatment of autoimmune diseases | |
| JP2013538553A5 (enExample) | ||
| JP2014502968A5 (enExample) | ||
| TW200630346A (en) | Pyrimidines as prostaglandin D2 receptor antagonists | |
| JP2011511072A5 (enExample) | ||
| WO2008050329A3 (en) | Novel sirnas and methods of use thereof | |
| JP2019523295A5 (enExample) | ||
| JP2011507891A5 (enExample) | ||
| JP2015529225A5 (enExample) | ||
| JP2020517696A5 (enExample) | ||
| JP2014530226A5 (enExample) | ||
| JP2013543501A5 (enExample) | ||
| JP2014533279A5 (enExample) | ||
| JP2015525798A5 (enExample) | ||
| RU2010132581A (ru) | Способы терапии заболеваний легких | |
| JP2018505882A5 (enExample) | ||
| JP2016512817A5 (enExample) | ||
| RU2010126598A (ru) | Применение человеческого антитела, способного нейтрализовать вирус гепатита в, для профилактики или лечения инфекции вирусом гепатита в | |
| Cho et al. | Clinical characteristics of angioedema with eosinophilia | |
| Eskian et al. | Monoclonal antibodies for treatment of eosinophilic esophagitis | |
| JP2011513310A5 (enExample) |