JP2010520209A5 - - Google Patents

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Publication number
JP2010520209A5
JP2010520209A5 JP2009551748A JP2009551748A JP2010520209A5 JP 2010520209 A5 JP2010520209 A5 JP 2010520209A5 JP 2009551748 A JP2009551748 A JP 2009551748A JP 2009551748 A JP2009551748 A JP 2009551748A JP 2010520209 A5 JP2010520209 A5 JP 2010520209A5
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JP
Japan
Prior art keywords
peptide
amino acid
acid sequence
internalization
active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2009551748A
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English (en)
Japanese (ja)
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JP2010520209A (ja
JP5631595B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/002754 external-priority patent/WO2008109010A1/en
Publication of JP2010520209A publication Critical patent/JP2010520209A/ja
Publication of JP2010520209A5 publication Critical patent/JP2010520209A5/ja
Application granted granted Critical
Publication of JP5631595B2 publication Critical patent/JP5631595B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009551748A 2007-03-02 2008-02-29 Ｎ型カルシウムチャネルを阻害せずに卒中および他の疾患を治療する方法 Expired - Fee Related JP5631595B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90450707P 2007-03-02 2007-03-02
US60/904,507 2007-03-02
PCT/US2008/002754 WO2008109010A1 (en) 2007-03-02 2008-02-29 Treating stroke and other diseases without inhibiting n-type calcium channels

Publications (3)

Publication Number Publication Date
JP2010520209A JP2010520209A (ja) 2010-06-10
JP2010520209A5 true JP2010520209A5 (enExample) 2012-03-29
JP5631595B2 JP5631595B2 (ja) 2014-11-26

Family

ID=39738586

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009551748A Expired - Fee Related JP5631595B2 (ja) 2007-03-02 2008-02-29 Ｎ型カルシウムチャネルを阻害せずに卒中および他の疾患を治療する方法

Country Status (9)

Country Link
US (2) US8288345B2 (enExample)
EP (1) EP2120987B1 (enExample)
JP (1) JP5631595B2 (enExample)
CN (1) CN101678068B (enExample)
AU (1) AU2008223469B2 (enExample)
CA (1) CA2679831C (enExample)
DK (1) DK2120987T3 (enExample)
ES (1) ES2446292T3 (enExample)
WO (1) WO2008109010A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060148711A1 (en) * 1999-05-14 2006-07-06 Arbor Vita Corporation Molecular interactions in neurons
US7595297B2 (en) * 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
CA2657665C (en) * 2006-07-11 2015-06-02 Arbor Vita Corporation Method and compositions for treating stroke with fever
ES2446292T3 (es) 2007-03-02 2014-03-07 Nono Inc. Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N
CN102088990A (zh) * 2008-05-16 2011-06-08 阿尔伯维塔公司 癫痫的治疗
JP5801197B2 (ja) 2008-09-03 2015-10-28 ノノ インコーポレイテッド 痛みの治療に関する薬剤及び方法
CA2765169C (en) 2009-06-10 2019-06-18 Nono Inc. Model systems and treatment regimes for treatment of neurological disease
PT2440231T (pt) * 2009-06-10 2020-01-08 Nono Inc Co-administração de um agente ligado a um peptido de internalização tat com um inibidor de desgranulação de mastócitos
US9629892B2 (en) * 2010-08-12 2017-04-25 Nono Inc. Treatment of penetrative injury to the brain
WO2012050921A2 (en) * 2010-09-28 2012-04-19 Nono, Inc. Nd2 peptides and methods of treating neurological disease
HRP20220519T1 (hr) 2011-06-24 2022-05-27 Nono Inc. Kombinacijska terapija ishemije
EP2581384A1 (en) * 2011-10-11 2013-04-17 Institut Pasteur Products useful for the treatment of malignant neoplasms of the human nervous system
AU2012354072B2 (en) * 2011-12-13 2017-04-27 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
US9241970B2 (en) 2011-12-13 2016-01-26 Nono Inc. Therapy for subarachnoid hemorrhage and ischemia
UA123820C2 (uk) 2014-05-28 2021-06-09 Ноно Інк. Хлоридна сіль пептиду tat-nr2b9c
CN104497106B (zh) * 2014-12-05 2017-05-10 华中科技大学 一种小分子多肽、其应用及产品
CN110049994B (zh) * 2016-12-08 2023-05-02 拜西欧斯（北京）生物技术有限公司 一种缀合物及其应用
KR102403089B1 (ko) * 2017-07-05 2022-06-02 바이오셀즈(베이징) 바이오테크 코., 엘티디. 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도
CN109232745B (zh) * 2018-09-18 2020-02-28 深圳瑞健生物科技有限公司 一种可通过血脑屏障的多肽
AU2021206472A1 (en) * 2020-01-09 2022-08-18 Nono Inc. Plasmin-resistant peptides for treating stroke and related conditions
EP4274596A4 (en) 2021-01-08 2024-12-25 NoNO Inc. Plasmin-resistant peptides for improved therapeutic index
CN113735939A (zh) * 2021-07-30 2021-12-03 英纳氏(珠海)药业有限公司 一种组合多肽及其应用
WO2026012336A1 (zh) * 2024-07-08 2026-01-15 福建盛迪医药有限公司 一种psd-95多肽抑制剂的可药用盐及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6582698A (en) * 1997-03-19 1998-10-12 Johns Hopkins University, The Therapeutic uses of grip and grip-related molecules
WO2000001720A2 (en) * 1998-07-02 2000-01-13 President And Fellows Of Harvard College Compositions and methods for treating papillomavirus-infected cells
US7510824B2 (en) * 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
AU3368301A (en) * 2000-01-07 2001-07-16 Artemis Pharmaceuticals Gmbh Transduction of recombinases for inducible gene targeting
WO2003076561A2 (en) * 2002-03-09 2003-09-18 Artemis Pharmaceuticals Gmbh Recombinase fusion protein with enhanced cellular uptake
JPWO2005035562A1 (ja) * 2003-10-07 2007-11-22 伸弥 山中 新規な細胞増殖促進剤
WO2006084179A2 (en) * 2005-02-03 2006-08-10 Novartis Vaccines And Diagnostics Inc. Hiv tat-cd4 hybried molecules and methods of use thereof
ES2446292T3 (es) 2007-03-02 2014-03-07 Nono Inc. Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N

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