ES2446292T3 - Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N - Google Patents
Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N Download PDFInfo
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- ES2446292T3 ES2446292T3 ES08726313.3T ES08726313T ES2446292T3 ES 2446292 T3 ES2446292 T3 ES 2446292T3 ES 08726313 T ES08726313 T ES 08726313T ES 2446292 T3 ES2446292 T3 ES 2446292T3
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
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- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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| US90450707P | 2007-03-02 | 2007-03-02 | |
| US904507P | 2007-03-02 | ||
| PCT/US2008/002754 WO2008109010A1 (en) | 2007-03-02 | 2008-02-29 | Treating stroke and other diseases without inhibiting n-type calcium channels |
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| ES2446292T3 true ES2446292T3 (es) | 2014-03-07 |
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| Country | Link |
|---|---|
| US (2) | US8288345B2 (enExample) |
| EP (1) | EP2120987B1 (enExample) |
| JP (1) | JP5631595B2 (enExample) |
| CN (1) | CN101678068B (enExample) |
| AU (1) | AU2008223469B2 (enExample) |
| CA (1) | CA2679831C (enExample) |
| DK (1) | DK2120987T3 (enExample) |
| ES (1) | ES2446292T3 (enExample) |
| WO (1) | WO2008109010A1 (enExample) |
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| US20060148711A1 (en) * | 1999-05-14 | 2006-07-06 | Arbor Vita Corporation | Molecular interactions in neurons |
| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| CA2657665C (en) * | 2006-07-11 | 2015-06-02 | Arbor Vita Corporation | Method and compositions for treating stroke with fever |
| ES2446292T3 (es) | 2007-03-02 | 2014-03-07 | Nono Inc. | Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N |
| CN102088990A (zh) * | 2008-05-16 | 2011-06-08 | 阿尔伯维塔公司 | 癫痫的治疗 |
| JP5801197B2 (ja) | 2008-09-03 | 2015-10-28 | ノノ インコーポレイテッド | 痛みの治療に関する薬剤及び方法 |
| CA2765169C (en) | 2009-06-10 | 2019-06-18 | Nono Inc. | Model systems and treatment regimes for treatment of neurological disease |
| PT2440231T (pt) * | 2009-06-10 | 2020-01-08 | Nono Inc | Co-administração de um agente ligado a um peptido de internalização tat com um inibidor de desgranulação de mastócitos |
| US9629892B2 (en) * | 2010-08-12 | 2017-04-25 | Nono Inc. | Treatment of penetrative injury to the brain |
| WO2012050921A2 (en) * | 2010-09-28 | 2012-04-19 | Nono, Inc. | Nd2 peptides and methods of treating neurological disease |
| HRP20220519T1 (hr) | 2011-06-24 | 2022-05-27 | Nono Inc. | Kombinacijska terapija ishemije |
| EP2581384A1 (en) * | 2011-10-11 | 2013-04-17 | Institut Pasteur | Products useful for the treatment of malignant neoplasms of the human nervous system |
| AU2012354072B2 (en) * | 2011-12-13 | 2017-04-27 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
| US9241970B2 (en) | 2011-12-13 | 2016-01-26 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
| UA123820C2 (uk) | 2014-05-28 | 2021-06-09 | Ноно Інк. | Хлоридна сіль пептиду tat-nr2b9c |
| CN104497106B (zh) * | 2014-12-05 | 2017-05-10 | 华中科技大学 | 一种小分子多肽、其应用及产品 |
| CN110049994B (zh) * | 2016-12-08 | 2023-05-02 | 拜西欧斯（北京）生物技术有限公司 | 一种缀合物及其应用 |
| KR102403089B1 (ko) * | 2017-07-05 | 2022-06-02 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도 |
| CN109232745B (zh) * | 2018-09-18 | 2020-02-28 | 深圳瑞健生物科技有限公司 | 一种可通过血脑屏障的多肽 |
| AU2021206472A1 (en) * | 2020-01-09 | 2022-08-18 | Nono Inc. | Plasmin-resistant peptides for treating stroke and related conditions |
| EP4274596A4 (en) | 2021-01-08 | 2024-12-25 | NoNO Inc. | Plasmin-resistant peptides for improved therapeutic index |
| CN113735939A (zh) * | 2021-07-30 | 2021-12-03 | 英纳氏(珠海)药业有限公司 | 一种组合多肽及其应用 |
| WO2026012336A1 (zh) * | 2024-07-08 | 2026-01-15 | 福建盛迪医药有限公司 | 一种psd-95多肽抑制剂的可药用盐及其制备方法 |
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| WO2000001720A2 (en) * | 1998-07-02 | 2000-01-13 | President And Fellows Of Harvard College | Compositions and methods for treating papillomavirus-infected cells |
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| AU3368301A (en) * | 2000-01-07 | 2001-07-16 | Artemis Pharmaceuticals Gmbh | Transduction of recombinases for inducible gene targeting |
| WO2003076561A2 (en) * | 2002-03-09 | 2003-09-18 | Artemis Pharmaceuticals Gmbh | Recombinase fusion protein with enhanced cellular uptake |
| JPWO2005035562A1 (ja) * | 2003-10-07 | 2007-11-22 | 伸弥 山中 | 新規な細胞増殖促進剤 |
| WO2006084179A2 (en) * | 2005-02-03 | 2006-08-10 | Novartis Vaccines And Diagnostics Inc. | Hiv tat-cd4 hybried molecules and methods of use thereof |
| ES2446292T3 (es) | 2007-03-02 | 2014-03-07 | Nono Inc. | Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N |
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2008
- 2008-02-29 ES ES08726313.3T patent/ES2446292T3/es active Active
- 2008-02-29 DK DK08726313.3T patent/DK2120987T3/en active
- 2008-02-29 AU AU2008223469A patent/AU2008223469B2/en not_active Ceased
- 2008-02-29 WO PCT/US2008/002754 patent/WO2008109010A1/en not_active Ceased
- 2008-02-29 CN CN200880014311.6A patent/CN101678068B/zh not_active Expired - Fee Related
- 2008-02-29 EP EP08726313.3A patent/EP2120987B1/en active Active
- 2008-02-29 US US12/040,851 patent/US8288345B2/en not_active Expired - Fee Related
- 2008-02-29 JP JP2009551748A patent/JP5631595B2/ja not_active Expired - Fee Related
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2012
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101678068B (zh) | 2015-05-13 |
| WO2008109010A1 (en) | 2008-09-12 |
| EP2120987A4 (en) | 2010-08-18 |
| CA2679831A1 (en) | 2008-09-12 |
| US8288345B2 (en) | 2012-10-16 |
| CA2679831C (en) | 2018-10-02 |
| AU2008223469B2 (en) | 2013-09-05 |
| EP2120987A1 (en) | 2009-11-25 |
| US20130172230A1 (en) | 2013-07-04 |
| AU2008223469A1 (en) | 2008-09-12 |
| CN101678068A (zh) | 2010-03-24 |
| JP2010520209A (ja) | 2010-06-10 |
| EP2120987B1 (en) | 2014-01-15 |
| US9061070B2 (en) | 2015-06-23 |
| JP5631595B2 (ja) | 2014-11-26 |
| DK2120987T3 (en) | 2014-02-24 |
| US20080274977A1 (en) | 2008-11-06 |
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