JP5631595B2 - Ｎ型カルシウムチャネルを阻害せずに卒中および他の疾患を治療する方法 - Google Patents
Ｎ型カルシウムチャネルを阻害せずに卒中および他の疾患を治療する方法 Download PDFInfo
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- JP5631595B2 JP5631595B2 JP2009551748A JP2009551748A JP5631595B2 JP 5631595 B2 JP5631595 B2 JP 5631595B2 JP 2009551748 A JP2009551748 A JP 2009551748A JP 2009551748 A JP2009551748 A JP 2009551748A JP 5631595 B2 JP5631595 B2 JP 5631595B2
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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| PCT/US2008/002754 WO2008109010A1 (en) | 2007-03-02 | 2008-02-29 | Treating stroke and other diseases without inhibiting n-type calcium channels |
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| JP2010520209A JP2010520209A (ja) | 2010-06-10 |
| JP2010520209A5 JP2010520209A5 (enExample) | 2012-03-29 |
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| US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| CA2657665C (en) * | 2006-07-11 | 2015-06-02 | Arbor Vita Corporation | Method and compositions for treating stroke with fever |
| ES2446292T3 (es) | 2007-03-02 | 2014-03-07 | Nono Inc. | Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N |
| CN102088990A (zh) * | 2008-05-16 | 2011-06-08 | 阿尔伯维塔公司 | 癫痫的治疗 |
| JP5801197B2 (ja) | 2008-09-03 | 2015-10-28 | ノノ インコーポレイテッド | 痛みの治療に関する薬剤及び方法 |
| CA2765169C (en) | 2009-06-10 | 2019-06-18 | Nono Inc. | Model systems and treatment regimes for treatment of neurological disease |
| PT2440231T (pt) * | 2009-06-10 | 2020-01-08 | Nono Inc | Co-administração de um agente ligado a um peptido de internalização tat com um inibidor de desgranulação de mastócitos |
| US9629892B2 (en) * | 2010-08-12 | 2017-04-25 | Nono Inc. | Treatment of penetrative injury to the brain |
| WO2012050921A2 (en) * | 2010-09-28 | 2012-04-19 | Nono, Inc. | Nd2 peptides and methods of treating neurological disease |
| HRP20220519T1 (hr) | 2011-06-24 | 2022-05-27 | Nono Inc. | Kombinacijska terapija ishemije |
| EP2581384A1 (en) * | 2011-10-11 | 2013-04-17 | Institut Pasteur | Products useful for the treatment of malignant neoplasms of the human nervous system |
| AU2012354072B2 (en) * | 2011-12-13 | 2017-04-27 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
| US9241970B2 (en) | 2011-12-13 | 2016-01-26 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
| UA123820C2 (uk) | 2014-05-28 | 2021-06-09 | Ноно Інк. | Хлоридна сіль пептиду tat-nr2b9c |
| CN104497106B (zh) * | 2014-12-05 | 2017-05-10 | 华中科技大学 | 一种小分子多肽、其应用及产品 |
| CN110049994B (zh) * | 2016-12-08 | 2023-05-02 | 拜西欧斯（北京）生物技术有限公司 | 一种缀合物及其应用 |
| KR102403089B1 (ko) * | 2017-07-05 | 2022-06-02 | 바이오셀즈(베이징) 바이오테크 코., 엘티디. | 폴리펩타이드의 약학적으로 허용 가능한 염 및 이의 용도 |
| CN109232745B (zh) * | 2018-09-18 | 2020-02-28 | 深圳瑞健生物科技有限公司 | 一种可通过血脑屏障的多肽 |
| AU2021206472A1 (en) * | 2020-01-09 | 2022-08-18 | Nono Inc. | Plasmin-resistant peptides for treating stroke and related conditions |
| EP4274596A4 (en) | 2021-01-08 | 2024-12-25 | NoNO Inc. | Plasmin-resistant peptides for improved therapeutic index |
| CN113735939A (zh) * | 2021-07-30 | 2021-12-03 | 英纳氏(珠海)药业有限公司 | 一种组合多肽及其应用 |
| WO2026012336A1 (zh) * | 2024-07-08 | 2026-01-15 | 福建盛迪医药有限公司 | 一种psd-95多肽抑制剂的可药用盐及其制备方法 |
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| WO2000001720A2 (en) * | 1998-07-02 | 2000-01-13 | President And Fellows Of Harvard College | Compositions and methods for treating papillomavirus-infected cells |
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| AU3368301A (en) * | 2000-01-07 | 2001-07-16 | Artemis Pharmaceuticals Gmbh | Transduction of recombinases for inducible gene targeting |
| WO2003076561A2 (en) * | 2002-03-09 | 2003-09-18 | Artemis Pharmaceuticals Gmbh | Recombinase fusion protein with enhanced cellular uptake |
| JPWO2005035562A1 (ja) * | 2003-10-07 | 2007-11-22 | 伸弥 山中 | 新規な細胞増殖促進剤 |
| WO2006084179A2 (en) * | 2005-02-03 | 2006-08-10 | Novartis Vaccines And Diagnostics Inc. | Hiv tat-cd4 hybried molecules and methods of use thereof |
| ES2446292T3 (es) | 2007-03-02 | 2014-03-07 | Nono Inc. | Tratamiento del accidente cerebrovascular y otras enfermedades sin inhibir los canales de calcio de tipo N |
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Also Published As
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| CN101678068B (zh) | 2015-05-13 |
| WO2008109010A1 (en) | 2008-09-12 |
| EP2120987A4 (en) | 2010-08-18 |
| CA2679831A1 (en) | 2008-09-12 |
| US8288345B2 (en) | 2012-10-16 |
| CA2679831C (en) | 2018-10-02 |
| AU2008223469B2 (en) | 2013-09-05 |
| ES2446292T3 (es) | 2014-03-07 |
| EP2120987A1 (en) | 2009-11-25 |
| US20130172230A1 (en) | 2013-07-04 |
| AU2008223469A1 (en) | 2008-09-12 |
| CN101678068A (zh) | 2010-03-24 |
| JP2010520209A (ja) | 2010-06-10 |
| EP2120987B1 (en) | 2014-01-15 |
| US9061070B2 (en) | 2015-06-23 |
| DK2120987T3 (en) | 2014-02-24 |
| US20080274977A1 (en) | 2008-11-06 |
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