CN101678068B - 不抑制n型钙通道而治疗中风和其他疾病 - Google Patents
不抑制n型钙通道而治疗中风和其他疾病 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Abstract
Description
X-FGRKKRRQRRRKLSSIESDV(F-TatNR2B9c) | SEQ ID NOS:19,77,78,79 |
X-GKKKKKQKKKKLSSIESDV | SEQ ID NO:54,80,81,82 |
X-RKKRRQRRRKLSSIESDV | SEQ ID NO:55,83,84,85 |
X-GAKKRRQRRRKLSSIESDV | SEQ ID NO:56,86,87,88 |
X-AKKRRQRRRKLSSIESDV | SEQ ID NO:57,89,90,91 |
X-GRKARRQRRRKLSSIESDV | SEQ ID NO:58,92,93,94 |
X-RKARRQRRRKLSSIESDV | SEQ ID NO:59,95,96,97 |
X-GRKKARQRRRKLSSIESDV | SEQ ID NO:60,98,99,100 |
X-RKKARQRRRKLSSIESDV | SEQ ID NO:61,101,102,103 |
X-GRKKRRQARRKLSSIESDV | SEQ ID NO:62,104,105,106 |
X-RKKRRQARRKLSSIESDV | SEQ ID NO:63,107,108,109 |
X-GRKKRRQRARKLSSIESDV | SEQ ID NO:64,110,111,112 |
X-RKKRRQRARKLSSIESDV | SEQ ID NO:65,113,114,115 |
X-RRPRRPRRPRRKLSSIESDV | SEQ ID NO:66,116,117,118 |
X-RRARRARRARRKLSSIESDV | SEQ ID NO:67,119,120,121 |
X-RRRARRRARRKLSSIESDV | SEQ ID NO:68,122,123,124 |
X-RRRPRRRPRRKLSSIESDV | SEQ ID NO:69,125,126,127 |
X-RRPRRPRRKLSSIESDV | SEQ ID NO:70,128,129,130 |
X-RRARRARRKLSSIESDV | SEQ ID NO:71,131,132,133 |
活性剂 | 疾病 | 急性/慢性 | 施用途径 | 注解 | 参考文献 |
苯巴比妥(苯巴比妥钠) | 癫痫 | IV/口 | 依赖性,耐受问题,相互作用,副作用,出生缺陷 | Motamedi & Meador(2006)Curr NeurolNeurosci Rep,6(4):341-6.Drugs.com | |
扑米酮(Primidone)(myidone、麦苏林(mysoline)) | 癫痫 | 口 | 副作用,相互作用 | Koristkova等人(2006)Int J Clin PharmacolTher,44(9):438-42.Drugs.com | |
地西泮(Diazepam)(安定(valium)) | 焦虑 | IP/口 | 依赖性,副作用,相互作用 | Beard等人(2003)Health Technol Assess.7(40):iii,ix-x,1-111.Drugs.com | |
多巴胺 | 帕金森氏症 | 不能通过BBB,副作用 | Ahlskog(2001)NeurolClin,19(3):579-605.Drugs.com | ||
左旋多巴 | 帕金森氏症 | 在BBB之前降解,副作用,半衰期=1.5小时 | Nyholm(2006)ClinPharmacokinet,45(2):109-36.USPTO.gov(专利号7160913) | ||
阿扑吗啡(Apomorphine) | IP | 半衰期短 | Nyholm(2006)ClinPharmacokinet,45(2):109-36.Drugs.com | ||
替拉扎特甲磺酸酯(Tirilazadmesylate)(Freedox) | 中风 | IP | 低有效性,在第III相终止 | Hickenbottom &Grotta(1998)SeminNeurol 18(4):485-92.Strokecenter.org | |
环孢菌素A(Cyclosporine)(Gengraf) | 免疫抑制 | IP | 肽,5-18小时半衰期 | Kees等人(2006)TherDrug Monit,28(3):312-20.Drugs.com | |
Vacomycin | 抗生素 | IP | 肽,低吸收,4-6小时半衰期 | de Hoog等人(2004)Clin Pharmacokinet.43(7):417-40.Drugs.com | |
赖诺普利(Lisinopril)(Prinivil) | 高血压 | IP/口 | 肽,差BBB穿过性,12小时半衰期 | Tan等人(2005)Am JHypertens,18(2):158-64.Drugs.com | |
叠氮胸苷(AZT,齐多夫定(zidoridine),双汰芝(combivir)) | 抗病毒 | 口 | 差BBB穿过性,05-3小时半衰期,血液毒性 | Spitzenberger等人(2006)J Cereb BloodFlow Metab,10月25日,Epub ahead ofprint.Drugs.com | |
吡拉西坦(Piracetam) | 疼痛/癫痫 | 不能穿过BBB | Loscher & Potschka(2002)J PharmacolExp Ther,301(1):7-14.US7,157,421) | ||
Natrecor(BNP肽) | 心-肾代调失常综合征 | IV | 未知有效性 | Feldman & Sun(2004)Hcart Fail Rev,9(3):203-8. |
活性剂 | 疾病 | 急性/慢性 | 施用途径 | 注解 | 参考文献 |
Clinicaltrials.gov | |||||
AVR-118(肽) | 癌症姑息剂 | 皮下 | 未知有效性,未知剂量 | Clinicaltrials.gov | |
催产素(肽) | 心境障碍 | IV/IM | 相互作用,未知剂量 | Swaab等人(2005)Ageing Res Rev,4(2):141-94.Drugs.com | |
普伐他汀(普拉固) | MS | 口 | 未知有效性,低生物利用度 | Hatanaka(2000)ClinPharmacokinet,39(6):397-412.Clinicaltrials.gov | |
瑞芬太尼(Remifentanil) | 疼痛,烧伤 | IV | 3.5分钟半衰期,通过未知的酯酶代谢 | Scott & Perry(2005)Drugs,65(13):1793-1823.Clinicaltrials.gov | |
神经降压素(Neurotensin) | Schizphrenia,帕金森氏症,成瘾症 | 13AA肽,容易降解,不能穿过BBB | Boules等人,(2006)Peptides,27(10):2523-33. | ||
GDNF(神经胶质衍生的神经营养因子) | 帕金森氏症 | 慢性 | 实质细胞内 | 肽,不能穿过BBB | Grondin等人(2003)Prog Drug Res,61:101-23. |
蛋白酶抑制剂-洛匹那韦(lopinavir)-利托那韦(ritonavir)-沙奎那韦(saquinavir)-darunavir-atazanavir-安泼那韦(amprenavir) | HIV | 口 | 遭受HIV突变的急性能力的所有HIV蛋白酶抑制剂,产生药物抗性的HIV菌株 | -Oldfield & Plosker(2006)Drugs 66(9):1275-99.-Porter & Charman(2001)Adv Drug DelivRev,10月1日;50增刊1:S127-47.-Piacenti(2006)Pharmacotherapy26(8):1111-33. | |
氢化麦角胺 | 偏头痛 | IV,IM,sub-Q | 相互作用引起外周缺血,9小时半衰期 | Modi & Lowder(2006)Am Fam Physician73(1):72-8. | |
斯皮仁诺(Sporamax)(itaconazole) | 抗真菌剂 | 口 | 最终产生药物抗性,在一些人群中发生充血性心力衰竭 | Wang & Remold(2006)Cardiol Rev14(5):223-6. | |
蛋白激酶C抑制剂 | 急性心肌梗死、中风、缺血、再灌注损伤 | 美国专利公开20050267030,20060148702,20060293237,20050215483,20040204364,20040009922 | |||
AII-7 | 癌症,乳腺癌 | 慢性 | 封闭Erbb2胞内域并提高泰素灵敏度的拟肽 | Kunz等人,MolCancer Res2006;4(12):983-98 | |
CRAMP肽 | 沙门氏菌(Salmonella)感染 | 细胞内抗微生物肽,其降低沙门氏菌复制 | Rosenberger,CM.PNAS|2004年2月24日|第101卷|第8期 |
活性剂 | 疾病 | 急性/慢性 | 施用途径 | 注解 | 参考文献 |
|2422-2427 | |||||
钠通道肽 | 可能减轻肌痉挛(癫痫,腿不安静,帕金森氏症等等) | 对应于钠通道α亚基同源跨膜结构域III和IV之间短细胞内区段的肽,慢代谢型 | Vassilev,Science(1988)241:1658-6 | ||
适体KDI1 | 阻断EGF信号传导-可能抗癌 | Buerger.J.Biol.Chem.,第278卷,第39期,37610-37621,2003年9月23日 | |||
RNA/基因疗法 | 可使用转运肽引入RNA或siRNA/RNAi用于治疗 | Turner等人(2007)Blood Cells Mol Dis.38(1):1-7. |
Claims (15)
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US7595297B2 (en) * | 1999-06-02 | 2009-09-29 | Michael Tymianski | Method of reducing injury to mammalian cells |
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WO2012021854A2 (en) * | 2010-08-12 | 2012-02-16 | Nono, Inc. | Treatment of penetrative injury to the brain |
WO2012050921A2 (en) * | 2010-09-28 | 2012-04-19 | Nono, Inc. | Nd2 peptides and methods of treating neurological disease |
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AU2012354072B2 (en) * | 2011-12-13 | 2017-04-27 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
US9241970B2 (en) | 2011-12-13 | 2016-01-26 | Nono Inc. | Therapy for subarachnoid hemorrhage and ischemia |
CN106661126B (zh) | 2014-05-28 | 2021-12-10 | 诺诺公司 | TAT-NR2B9c的氯盐 |
CN104497106B (zh) * | 2014-12-05 | 2017-05-10 | 华中科技大学 | 一种小分子多肽、其应用及产品 |
CN110049994B (zh) * | 2016-12-08 | 2023-05-02 | 拜西欧斯(北京)生物技术有限公司 | 一种缀合物及其应用 |
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- 2008-02-29 DK DK08726313.3T patent/DK2120987T3/en active
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Also Published As
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EP2120987B1 (en) | 2014-01-15 |
US8288345B2 (en) | 2012-10-16 |
DK2120987T3 (en) | 2014-02-24 |
US20080274977A1 (en) | 2008-11-06 |
EP2120987A1 (en) | 2009-11-25 |
CA2679831A1 (en) | 2008-09-12 |
JP5631595B2 (ja) | 2014-11-26 |
CA2679831C (en) | 2018-10-02 |
US20130172230A1 (en) | 2013-07-04 |
EP2120987A4 (en) | 2010-08-18 |
AU2008223469A1 (en) | 2008-09-12 |
CN101678068A (zh) | 2010-03-24 |
JP2010520209A (ja) | 2010-06-10 |
US9061070B2 (en) | 2015-06-23 |
WO2008109010A1 (en) | 2008-09-12 |
ES2446292T3 (es) | 2014-03-07 |
AU2008223469B2 (en) | 2013-09-05 |
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