JP2009545526A5 - - Google Patents
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- Publication number
- JP2009545526A5 JP2009545526A5 JP2009520801A JP2009520801A JP2009545526A5 JP 2009545526 A5 JP2009545526 A5 JP 2009545526A5 JP 2009520801 A JP2009520801 A JP 2009520801A JP 2009520801 A JP2009520801 A JP 2009520801A JP 2009545526 A5 JP2009545526 A5 JP 2009545526A5
- Authority
- JP
- Japan
- Prior art keywords
- iodo
- rgia
- glu14
- peia
- tyr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102220243676 rs1555601019 Human genes 0.000 claims 16
- 102200063830 rs4880 Human genes 0.000 claims 16
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims 12
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000013543 active substance Substances 0.000 claims 10
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 8
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 8
- 229960002173 citrulline Drugs 0.000 claims 8
- 235000013477 citrulline Nutrition 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 238000004166 bioassay Methods 0.000 claims 5
- 108091058551 α-conotoxin Proteins 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 101710194445 Alpha-conotoxin PeIA Proteins 0.000 claims 4
- 101710144066 Alpha-conotoxin RgIA Proteins 0.000 claims 4
- 101100505161 Caenorhabditis elegans mel-32 gene Proteins 0.000 claims 4
- 101100109292 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) arg-13 gene Proteins 0.000 claims 4
- 102220495859 Putative protein ZBED10P_Y10F_mutation Human genes 0.000 claims 4
- KJQOYUHYAZGPIZ-PIJHVLQJSA-N conotoxin vc1.1 Chemical compound C([C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H]2NC(=O)[C@@H](NC(=O)CN)CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CC(O)=O)C(=O)N1)C(N)=O)=O)[C@@H](C)CC)C1=CN=CN1 KJQOYUHYAZGPIZ-PIJHVLQJSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 229940000406 drug candidate Drugs 0.000 claims 4
- 210000002865 immune cell Anatomy 0.000 claims 4
- 206010061218 Inflammation Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 230000000903 blocking effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000025747 Rheumatic disease Diseases 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83146806P | 2006-07-18 | 2006-07-18 | |
| US60/831,468 | 2006-07-18 | ||
| PCT/US2007/016163 WO2008011006A2 (en) | 2006-07-18 | 2007-07-17 | Methods for treating pain and screening analgesic compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014116680A Division JP5953338B2 (ja) | 2006-07-18 | 2014-06-05 | 痛みの処置方法および鎮痛化合物のスクリーニング方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009545526A JP2009545526A (ja) | 2009-12-24 |
| JP2009545526A5 true JP2009545526A5 (enExample) | 2010-09-02 |
| JP5558817B2 JP5558817B2 (ja) | 2014-07-23 |
Family
ID=38957314
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009520801A Expired - Fee Related JP5558817B2 (ja) | 2006-07-18 | 2007-07-17 | 痛みの処置方法および鎮痛化合物のスクリーニング方法 |
| JP2014116680A Expired - Fee Related JP5953338B2 (ja) | 2006-07-18 | 2014-06-05 | 痛みの処置方法および鎮痛化合物のスクリーニング方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014116680A Expired - Fee Related JP5953338B2 (ja) | 2006-07-18 | 2014-06-05 | 痛みの処置方法および鎮痛化合物のスクリーニング方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9717775B2 (enExample) |
| EP (1) | EP2051726B1 (enExample) |
| JP (2) | JP5558817B2 (enExample) |
| AU (1) | AU2007275764B2 (enExample) |
| CA (1) | CA2657532C (enExample) |
| WO (1) | WO2008011006A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008011006A2 (en) | 2006-07-18 | 2008-01-24 | University Of Utah Research Foundation | Methods for treating pain and screening analgesic compounds |
| US9284358B2 (en) * | 2006-07-18 | 2016-03-15 | University Of Utah Research Foundation | Conotoxin peptides |
| WO2014194284A1 (en) | 2013-05-31 | 2014-12-04 | Mcintosh J Michael | Conotoxin peptides, pharmaceutical compositions and uses thereof |
| KR102170077B1 (ko) * | 2018-05-21 | 2020-10-27 | 인하대학교 산학협력단 | Prss14/st14의 자가분해 고리부분을 특이적으로 인식하는 단일클론항체 및 이의 용도 |
| EP4393504A2 (en) * | 2018-12-26 | 2024-07-03 | Skinmed Co., Ltd. | Acetylcholine receptor inhibitory peptides and uses thereof |
| US11612661B2 (en) | 2019-01-04 | 2023-03-28 | Kineta Chronic Pain, Llc | Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions |
| AU2019418319B2 (en) * | 2019-01-04 | 2025-08-21 | Pacira Pharmaceuticals, Inc. | Conotoxin peptide analogs and uses for the treatment of pain and inflammatory conditions |
| WO2020234179A1 (en) * | 2019-05-17 | 2020-11-26 | Janssen Pharmaceutica Nv | Expression systems for the alpha 9/alpha 10 nicotinic acetylcholine receptor and methods of use thereof |
| CN113493502B (zh) * | 2020-04-01 | 2023-09-12 | 广西大学 | α-芋螺毒素肽TxIE、其药物组合物及用途 |
| WO2023008913A1 (ko) * | 2021-07-27 | 2023-02-02 | 주식회사 스킨메드 | 아세틸콜린 수용체 결합 최적화 단축 펩타이드 및 이의 용도 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4353888A (en) | 1980-12-23 | 1982-10-12 | Sefton Michael V | Encapsulation of live animal cells |
| US4883666A (en) | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| DE3829766A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Verfahren zur herstellung von membranen |
| DE3829752A1 (de) | 1988-09-01 | 1990-03-22 | Akzo Gmbh | Integrale asymmetrische polyaethersulfonmembran, verfahren zur herstellung und verwendung zur ultrafiltration und mikrofiltration |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US5084350A (en) | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| DK0585368T3 (da) | 1991-04-25 | 1998-03-16 | Univ Brown Res Found | Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter |
| US5854217A (en) | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| DE69423522T2 (de) | 1993-04-27 | 2000-09-21 | Cytotherapeutics, Inc. | Membran aus einem acrylnitrilpolymer |
| EP0708670A4 (en) | 1993-06-23 | 1998-07-01 | Cytotherapeutics Inc | METHOD AND APPARATUS FOR HERMETICALLY CLOSING IMPLANTABLE MEMBRANE ENCAPSULATING DEVICES |
| CA2169292C (en) | 1993-08-12 | 2010-11-23 | E. Edward Baetge | Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US5550050A (en) | 1994-04-15 | 1996-08-27 | Cytotherapeutics, Inc. | Method for implanting encapsulated cells in a host |
| US5776747A (en) | 1994-07-20 | 1998-07-07 | Cytotherapeutics, Inc. | Method for controlling the distribution of cells within a bioartificial organ using polycthylene oxide-poly (dimethylsiloxane) copolymer |
| US5834029A (en) | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| IN181898B (enExample) | 1995-06-07 | 1998-10-24 | Cytotherapeutics Inc | |
| AU7204996A (en) | 1995-10-02 | 1997-04-28 | Cytotherapeutics, Inc. | Method for treating amyotrophic lateral sclerosis |
| EP0893950A4 (en) * | 1996-03-26 | 2002-02-27 | Univ California | SELECTIVE TARGET CELL ACTIVATION BY EXPRESSION OF A RECEPTOR SPECIFICALLY ACTIVATED BY SYNTHETIC LIGANDS |
| US5844077A (en) | 1997-04-28 | 1998-12-01 | Cytotherapeutics, Inc. | Use of conantokins for producing analgesia or for neuroprotection |
| US6265541B1 (en) * | 1997-12-31 | 2001-07-24 | University Of Utah Research Foundation | Uses of α-conotoxin peptides |
| AU3473800A (en) | 1999-01-29 | 2000-08-18 | University Of Utah Research Foundation | Conotoxin peptides |
| WO2000044776A1 (en) | 1999-01-29 | 2000-08-03 | University Of Utah Research Foundation | Alpha-conotoxin peptides |
| JP2003509045A (ja) | 1999-09-15 | 2003-03-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ニコチン性アセチルコリン受容体：アルファ１０サブユニット |
| EP1090991A1 (en) | 1999-09-29 | 2001-04-11 | Sanofi-Synthelabo | Novel nicotinic acetylcholine receptor subunit, its isolation and use |
| US20030109670A1 (en) * | 2001-02-09 | 2003-06-12 | University Of Utah Research Foundation | Cone snail peptides |
| AUPR409401A0 (en) | 2001-03-29 | 2001-04-26 | University Of Melbourne, The | Analgesic compound |
| JP2009502976A (ja) * | 2005-08-02 | 2009-01-29 | メタボリック・ファーマシューティカルズ・リミテッド | 親水性ペプチド鎮痛薬の経口送達のためのペプチドコンジュゲート |
| AU2006236006B2 (en) | 2006-04-13 | 2012-09-06 | The University Of Queensland | Cyclised a-conotoxin peptides |
| US9284358B2 (en) | 2006-07-18 | 2016-03-15 | University Of Utah Research Foundation | Conotoxin peptides |
| WO2008011006A2 (en) | 2006-07-18 | 2008-01-24 | University Of Utah Research Foundation | Methods for treating pain and screening analgesic compounds |
-
2007
- 2007-07-17 WO PCT/US2007/016163 patent/WO2008011006A2/en not_active Ceased
- 2007-07-17 US US12/307,953 patent/US9717775B2/en active Active - Reinstated
- 2007-07-17 EP EP07796903.8A patent/EP2051726B1/en not_active Not-in-force
- 2007-07-17 CA CA2657532A patent/CA2657532C/en not_active Expired - Fee Related
- 2007-07-17 JP JP2009520801A patent/JP5558817B2/ja not_active Expired - Fee Related
- 2007-07-17 AU AU2007275764A patent/AU2007275764B2/en not_active Ceased
-
2014
- 2014-06-05 JP JP2014116680A patent/JP5953338B2/ja not_active Expired - Fee Related
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