JP2010229138A5 - - Google Patents
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- Publication number
- JP2010229138A5 JP2010229138A5 JP2010110683A JP2010110683A JP2010229138A5 JP 2010229138 A5 JP2010229138 A5 JP 2010229138A5 JP 2010110683 A JP2010110683 A JP 2010110683A JP 2010110683 A JP2010110683 A JP 2010110683A JP 2010229138 A5 JP2010229138 A5 JP 2010229138A5
- Authority
- JP
- Japan
- Prior art keywords
- celiac disease
- agent
- epitope
- peptide
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 238000000034 method Methods 0.000 claims 20
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 208000015943 Coeliac disease Diseases 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 241000209219 Hordeum Species 0.000 claims 4
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 4
- 241000209140 Triticum Species 0.000 claims 4
- 235000021307 Triticum Nutrition 0.000 claims 4
- 108091026890 Coding region Proteins 0.000 claims 3
- 108091008874 T cell receptors Proteins 0.000 claims 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108060008539 Transglutaminase Proteins 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 208000032309 susceptibility to 1 celiac disease Diseases 0.000 claims 3
- 230000009261 transgenic effect Effects 0.000 claims 3
- 102000003601 transglutaminase Human genes 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108010047762 HLA-DQ8 antigen Proteins 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108010061711 Gliadin Proteins 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0212885.8 | 2002-06-05 | ||
| GBGB0212885.8A GB0212885D0 (en) | 2002-06-05 | 2002-06-05 | Therapeutic epitopes and uses thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Division JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021737A Division JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Division JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010229138A JP2010229138A (ja) | 2010-10-14 |
| JP2010229138A5 true JP2010229138A5 (enExample) | 2010-12-02 |
| JP5635302B2 JP5635302B2 (ja) | 2014-12-03 |
Family
ID=9937994
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Withdrawn JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
| JP2010110683A Expired - Lifetime JP5635302B2 (ja) | 2002-06-05 | 2010-05-12 | 治療用エピトープ及びそれらの使用 |
| JP2013021737A Expired - Lifetime JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Expired - Lifetime JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
| JP2014198382A Pending JP2015052599A (ja) | 2002-06-05 | 2014-09-29 | 治療用エピトープ及びそれらの使用 |
| JP2016037111A Expired - Lifetime JP6438423B2 (ja) | 2002-06-05 | 2016-02-29 | 治療用エピトープ及びそれらの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004511341A Withdrawn JP2006512893A (ja) | 2002-06-05 | 2003-06-05 | 治療用エピトープ及びそれらの使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013021737A Expired - Lifetime JP6055689B2 (ja) | 2002-06-05 | 2013-02-06 | 治療用エピトープ及びそれらの使用 |
| JP2014162664A Expired - Lifetime JP5977293B2 (ja) | 2002-06-05 | 2014-08-08 | 治療用エピトープ及びそれらの使用 |
| JP2014198382A Pending JP2015052599A (ja) | 2002-06-05 | 2014-09-29 | 治療用エピトープ及びそれらの使用 |
| JP2016037111A Expired - Lifetime JP6438423B2 (ja) | 2002-06-05 | 2016-02-29 | 治療用エピトープ及びそれらの使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10053497B2 (enExample) |
| EP (3) | EP1513873B1 (enExample) |
| JP (6) | JP2006512893A (enExample) |
| AU (1) | AU2003244771B2 (enExample) |
| CA (1) | CA2488218C (enExample) |
| CY (1) | CY1115730T1 (enExample) |
| DK (1) | DK1513873T3 (enExample) |
| ES (1) | ES2510440T3 (enExample) |
| GB (1) | GB0212885D0 (enExample) |
| MX (2) | MXPA04012117A (enExample) |
| NZ (1) | NZ537226A (enExample) |
| PT (1) | PT1513873E (enExample) |
| SI (1) | SI1513873T1 (enExample) |
| WO (1) | WO2003104273A2 (enExample) |
| ZA (1) | ZA200409740B (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923306D0 (en) | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| EP1572127B2 (en) * | 2002-02-14 | 2014-10-29 | The Board of Trustees of the Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7202216B2 (en) * | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| WO2003096984A2 (en) * | 2002-05-14 | 2003-11-27 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| GB0212885D0 (en) * | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| DK1563300T3 (da) * | 2002-11-20 | 2012-07-23 | Univ Leland Stanford Junior | Diagnostisk fremgangsmåde til cøliaki |
| US7579313B2 (en) * | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| ATE497782T1 (de) | 2004-04-16 | 2011-02-15 | Univ Alberta | Anti-gluten-eigelb-antikörper zur behanldung von zoeliakie |
| US7563864B2 (en) * | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| US7534426B2 (en) * | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7628985B2 (en) * | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| EP1755639B1 (en) * | 2004-04-28 | 2017-08-16 | BTG International Limited | Epitopes related to coeliac disease |
| US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
| MX2009009780A (es) | 2007-03-16 | 2010-05-20 | Univ Leland Stanford Junior | Terapia de enzima de combinacion para la digestion de gluten dietetico. |
| US8282928B2 (en) | 2007-05-30 | 2012-10-09 | The Governors Of The University Of Alberta | Anti-gluten egg yolk antibodies for the treatment of celiac disease |
| DE102007044673A1 (de) * | 2007-09-18 | 2009-03-19 | Zimmer, Klaus-Peter, Prof. Dr. med. | Impfstoff zur Behandlung von Zöliakie und Verfahren zur Herstellung des Impfstoffes, Verwendung einer mit einem bakteriellen Toxin konjugierten Peptidsequenz zur Aktivierung des Immunsystems gegen Prolamine sowie Designerpeptid |
| US8835603B2 (en) * | 2008-11-30 | 2014-09-16 | Immusant, Inc. | Agents for the treatment of celiac disease |
| AU2013204429B9 (en) * | 2008-11-30 | 2017-01-05 | Immusant, Inc. | Compositions and methods for treatment of celiac disease |
| AU2011289579B2 (en) | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| WO2012108827A1 (en) * | 2011-02-08 | 2012-08-16 | Phadia Ab | Wheat antigens and peptides for diagnosis of wheat induced hypersensitivity |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| JP6012767B2 (ja) | 2012-02-07 | 2016-10-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 基板、ペプチドアレイ、および方法 |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
| EP2956771B1 (en) | 2013-02-15 | 2020-04-08 | Vibrant Holdings, LLC | Methods and compositions for amplified electrochemiluminescence detection |
| AU2014318889B2 (en) | 2013-09-10 | 2020-02-20 | Immusant, Inc. | Dosage of a gluten peptide composition |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| EP3909603A1 (en) | 2014-02-21 | 2021-11-17 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Glycotargeting therapeutics |
| WO2015164747A1 (en) | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Methods for diagnosing celiac disease using circulating cytokines/chemokines |
| US10900964B2 (en) | 2014-09-10 | 2021-01-26 | Vibrant Holdings, Llc | Peptide microarrays and novel biomarkers for celiac disease |
| AU2015323979A1 (en) | 2014-09-29 | 2017-05-18 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| HK1244821A1 (zh) | 2014-11-21 | 2018-08-17 | Immusant Inc. | 用於治疗和诊断1型糖尿病中使用的肽 |
| EP3313868A1 (en) * | 2015-06-26 | 2018-05-02 | Institut National De La Recherche Agronomique (INRA) | Immunogenic composition |
| EP3109255A1 (en) | 2015-06-26 | 2016-12-28 | Institut National De La Recherche Agronomique | Immunogenic composition |
| JP6738888B2 (ja) * | 2016-02-23 | 2020-08-12 | 田中貴金属工業株式会社 | グリアジン検出用免疫クロマト分析装置、免疫クロマト分析キットおよび免疫クロマト分析方法 |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| JP6568193B2 (ja) * | 2017-12-19 | 2019-08-28 | ホーユー株式会社 | エピトープ |
| CA3099046A1 (en) | 2018-05-09 | 2019-11-14 | Vibrant Holdings, Llc | Methods of synthesizing a polynucleotide array using photoactivated agents________________________________________________________ |
| JP2021528371A (ja) | 2018-05-09 | 2021-10-21 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 免疫寛容に関する組成物および方法 |
| WO2021001784A1 (en) * | 2019-07-04 | 2021-01-07 | Ukko Inc. | De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity |
| EP4034144A1 (en) | 2019-09-27 | 2022-08-03 | Intrexon Actobiotics NV d/b/a Precigen Actobio | Treatment of celiac disease |
| GB202113858D0 (en) * | 2021-09-28 | 2021-11-10 | Nextera As | Peptides |
| CN115124606B (zh) * | 2022-06-27 | 2025-03-28 | 上海理工大学 | 含有氨基酸结构pqqp的寡肽及其制备方法和应用 |
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| EP1332760A1 (en) | 2002-02-04 | 2003-08-06 | Academisch Ziekenhuis Leiden | Novel epitopes for celiac disease and autoimmune diseases, methods for detecting those and novel non-antigenic food compounds |
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| GB0212885D0 (en) * | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
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-
2002
- 2002-06-05 GB GBGB0212885.8A patent/GB0212885D0/en not_active Ceased
-
2003
- 2003-06-05 WO PCT/GB2003/002450 patent/WO2003104273A2/en not_active Ceased
- 2003-06-05 PT PT37382561T patent/PT1513873E/pt unknown
- 2003-06-05 SI SI200332396T patent/SI1513873T1/sl unknown
- 2003-06-05 MX MXPA04012117A patent/MXPA04012117A/es active IP Right Grant
- 2003-06-05 AU AU2003244771A patent/AU2003244771B2/en not_active Expired
- 2003-06-05 EP EP03738256.1A patent/EP1513873B1/en not_active Expired - Lifetime
- 2003-06-05 DK DK03738256.1T patent/DK1513873T3/da active
- 2003-06-05 ES ES03738256.1T patent/ES2510440T3/es not_active Expired - Lifetime
- 2003-06-05 US US10/516,837 patent/US10053497B2/en active Active
- 2003-06-05 NZ NZ537226A patent/NZ537226A/en not_active IP Right Cessation
- 2003-06-05 EP EP14184972.9A patent/EP2826787B1/en not_active Expired - Lifetime
- 2003-06-05 JP JP2004511341A patent/JP2006512893A/ja not_active Withdrawn
- 2003-06-05 CA CA2488218A patent/CA2488218C/en not_active Expired - Lifetime
- 2003-06-05 EP EP10181717.9A patent/EP2292649B1/en not_active Expired - Lifetime
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2004
- 2004-12-01 ZA ZA200409740A patent/ZA200409740B/en unknown
- 2004-12-03 MX MX2012011506A patent/MX338122B/es unknown
-
2010
- 2010-05-12 JP JP2010110683A patent/JP5635302B2/ja not_active Expired - Lifetime
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2013
- 2013-02-06 JP JP2013021737A patent/JP6055689B2/ja not_active Expired - Lifetime
-
2014
- 2014-08-08 JP JP2014162664A patent/JP5977293B2/ja not_active Expired - Lifetime
- 2014-09-29 JP JP2014198382A patent/JP2015052599A/ja active Pending
- 2014-11-07 CY CY20141100928T patent/CY1115730T1/el unknown
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2016
- 2016-02-29 JP JP2016037111A patent/JP6438423B2/ja not_active Expired - Lifetime
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2018
- 2018-04-11 US US15/951,116 patent/US20180334484A1/en not_active Abandoned
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