JP2017523130A5 - - Google Patents
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- Publication number
- JP2017523130A5 JP2017523130A5 JP2016568920A JP2016568920A JP2017523130A5 JP 2017523130 A5 JP2017523130 A5 JP 2017523130A5 JP 2016568920 A JP2016568920 A JP 2016568920A JP 2016568920 A JP2016568920 A JP 2016568920A JP 2017523130 A5 JP2017523130 A5 JP 2017523130A5
- Authority
- JP
- Japan
- Prior art keywords
- nmo
- peptide
- seq
- antibody
- optic neuromyelitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000012002 Aquaporin 4 Human genes 0.000 claims description 30
- 108010036280 Aquaporin 4 Proteins 0.000 claims description 30
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
- 102000010637 Aquaporins Human genes 0.000 claims description 14
- 108010075254 C-Peptide Proteins 0.000 claims description 11
- 239000012634 fragment Substances 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 39
- 238000000034 method Methods 0.000 description 38
- 238000002650 immunosuppressive therapy Methods 0.000 description 31
- 229960004641 rituximab Drugs 0.000 description 30
- 239000000203 mixture Substances 0.000 description 27
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 20
- 108010036949 Cyclosporine Proteins 0.000 description 20
- 108010008165 Etanercept Proteins 0.000 description 20
- 108010005716 Interferon beta-1a Proteins 0.000 description 20
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 20
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 20
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 20
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 20
- 230000003053 immunization Effects 0.000 description 19
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 description 18
- 125000000539 amino acid group Chemical group 0.000 description 12
- 108010006654 Bleomycin Proteins 0.000 description 10
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 10
- 108010092160 Dactinomycin Proteins 0.000 description 10
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 10
- 102000000521 Immunophilins Human genes 0.000 description 10
- 108010016648 Immunophilins Proteins 0.000 description 10
- 102100026720 Interferon beta Human genes 0.000 description 10
- 108090000467 Interferon-beta Proteins 0.000 description 10
- 102000014150 Interferons Human genes 0.000 description 10
- 108010050904 Interferons Proteins 0.000 description 10
- 102000010789 Interleukin-2 Receptors Human genes 0.000 description 10
- 108010038453 Interleukin-2 Receptors Proteins 0.000 description 10
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 10
- 229940123573 Protein synthesis inhibitor Drugs 0.000 description 10
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 10
- 229960002964 adalimumab Drugs 0.000 description 10
- 239000000556 agonist Substances 0.000 description 10
- 229940100198 alkylating agent Drugs 0.000 description 10
- 239000002168 alkylating agent Substances 0.000 description 10
- 150000001413 amino acids Chemical class 0.000 description 10
- 229940045799 anthracyclines and related substance Drugs 0.000 description 10
- 229940003504 avonex Drugs 0.000 description 10
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 10
- 229960002170 azathioprine Drugs 0.000 description 10
- 229960001561 bleomycin Drugs 0.000 description 10
- OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 10
- 229960001265 ciclosporin Drugs 0.000 description 10
- 229960004397 cyclophosphamide Drugs 0.000 description 10
- 229930182912 cyclosporin Natural products 0.000 description 10
- 239000000824 cytostatic agent Substances 0.000 description 10
- 229960000640 dactinomycin Drugs 0.000 description 10
- 229960002224 eculizumab Drugs 0.000 description 10
- 229940073621 enbrel Drugs 0.000 description 10
- 229960000403 etanercept Drugs 0.000 description 10
- 229960002949 fluorouracil Drugs 0.000 description 10
- 239000003862 glucocorticoid Substances 0.000 description 10
- 229940048921 humira Drugs 0.000 description 10
- 229960000598 infliximab Drugs 0.000 description 10
- 229960004461 interferon beta-1a Drugs 0.000 description 10
- 229960000681 leflunomide Drugs 0.000 description 10
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 description 10
- -1 malononitrile amide Chemical class 0.000 description 10
- 229960004961 mechlorethamine Drugs 0.000 description 10
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 10
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 10
- 229960001428 mercaptopurine Drugs 0.000 description 10
- 229960000485 methotrexate Drugs 0.000 description 10
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 description 10
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 10
- 229960004857 mitomycin Drugs 0.000 description 10
- 229960000951 mycophenolic acid Drugs 0.000 description 10
- 229960005027 natalizumab Drugs 0.000 description 10
- OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 10
- 150000003058 platinum compounds Chemical class 0.000 description 10
- 229960003171 plicamycin Drugs 0.000 description 10
- 229940072288 prograf Drugs 0.000 description 10
- 239000000007 protein synthesis inhibitor Substances 0.000 description 10
- 229940099538 rapamune Drugs 0.000 description 10
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 10
- 229940116176 remicade Drugs 0.000 description 10
- 230000004044 response Effects 0.000 description 10
- 229940063122 sandimmune Drugs 0.000 description 10
- 229960002930 sirolimus Drugs 0.000 description 10
- 229960001967 tacrolimus Drugs 0.000 description 10
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 10
- 229940079023 tysabri Drugs 0.000 description 10
- 102000014914 Carrier Proteins Human genes 0.000 description 9
- 108091008324 binding proteins Proteins 0.000 description 9
- 229940079322 interferon Drugs 0.000 description 9
- 230000000306 recurrent effect Effects 0.000 description 8
- 238000002649 immunization Methods 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 206010060860 Neurological symptom Diseases 0.000 description 3
- 210000001744 T-lymphocyte Anatomy 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000006044 T cell activation Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 229940126062 Compound A Drugs 0.000 description 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000003926 Myelitis Diseases 0.000 description 1
- 206010029240 Neuritis Diseases 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 108700039855 mouse a Proteins 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 210000001328 optic nerve Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000356P | 2014-05-19 | 2014-05-19 | |
| US62/000,356 | 2014-05-19 | ||
| PCT/US2015/031514 WO2015179360A1 (en) | 2014-05-19 | 2015-05-19 | Highly soluble aquaporin -4 extracelluar loop c peptide immunization for treatment of neuromyelitis optica |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523130A JP2017523130A (ja) | 2017-08-17 |
| JP2017523130A5 true JP2017523130A5 (enExample) | 2018-07-05 |
| JP6764790B2 JP6764790B2 (ja) | 2020-10-07 |
Family
ID=54554614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568920A Active JP6764790B2 (ja) | 2014-05-19 | 2015-05-19 | 視神経脊髄炎の治療に対する高可溶性アクアポリン−４細胞外ループペプチド免疫化 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20170080063A1 (enExample) |
| EP (1) | EP3145528A4 (enExample) |
| JP (1) | JP6764790B2 (enExample) |
| WO (1) | WO2015179360A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107643397A (zh) * | 2017-07-26 | 2018-01-30 | 中国人民解放军总医院 | 一种用于视神经脊髓炎致病自身抗体分型的膜条 |
| US11332527B2 (en) | 2017-10-12 | 2022-05-17 | Keio University | Anti AQP3 monoclonal antibody specifically binding to extracellular domain of aquaporin 3 (AQP3) and use thereof |
| CN108129563B (zh) * | 2018-01-12 | 2020-12-01 | 沈阳眼产业技术研究院有限公司 | 一种抗aqp4的小分子抗体及其应用 |
| WO2020213084A1 (en) | 2019-04-17 | 2020-10-22 | Keio University | Anti aqp3 monoclonal antibody specifically binding to extracellular domain of aquaporin 3 (aqp3) and use thereof |
| CN111272998A (zh) * | 2020-01-09 | 2020-06-12 | 天津天海新域生物科技有限公司 | 一种同时检测中枢脱髓鞘自身抗体aqp4、mog和mbp的方法 |
| US11858989B2 (en) | 2020-12-22 | 2024-01-02 | Lee Chao Lin | Anti-AQP4 antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741671A (en) * | 1991-12-12 | 1998-04-21 | The Johns Hopkins University | Isolation cloning and expression of transmembrane water channel aquaporin 1(AQP1) |
| GB0316878D0 (en) * | 2003-07-18 | 2003-08-20 | Letton Alan P | Cooler food/drink container |
| US7101679B2 (en) * | 2003-11-25 | 2006-09-05 | Mayo Foundation For Medical Education And Research | Marker for neuromyelitis optica |
| US9891219B2 (en) * | 2008-10-10 | 2018-02-13 | Mayo Foundation For Medical Education And Research | Methods for treating neuromyelitis optica (NMO) by administration of eculizumab to an individual that is aquaporin-4 (AQP4)-IgG autoantibody positive |
| GB0823366D0 (en) * | 2008-12-22 | 2009-01-28 | Uni I Oslo | Synthesis |
| US9234017B2 (en) * | 2012-12-11 | 2016-01-12 | The Regents Of The University Of California | Aquaporin-4 peptide compositions and methods of use thereof |
-
2015
- 2015-05-19 EP EP15796927.0A patent/EP3145528A4/en not_active Withdrawn
- 2015-05-19 JP JP2016568920A patent/JP6764790B2/ja active Active
- 2015-05-19 US US15/312,368 patent/US20170080063A1/en not_active Abandoned
- 2015-05-19 WO PCT/US2015/031514 patent/WO2015179360A1/en not_active Ceased
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