JP2017538671A5 - - Google Patents
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- JP2017538671A5 JP2017538671A5 JP2017521577A JP2017521577A JP2017538671A5 JP 2017538671 A5 JP2017538671 A5 JP 2017538671A5 JP 2017521577 A JP2017521577 A JP 2017521577A JP 2017521577 A JP2017521577 A JP 2017521577A JP 2017538671 A5 JP2017538671 A5 JP 2017538671A5
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- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 7
- 238000002965 ELISA Methods 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 6
- 238000003018 immunoassay Methods 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 102100030708 GTPase KRas Human genes 0.000 claims 4
- 238000011200 topical administration Methods 0.000 claims 4
- 239000012491 analyte Substances 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 238000007918 intramuscular administration Methods 0.000 claims 3
- 238000004811 liquid chromatography Methods 0.000 claims 3
- 238000004949 mass spectrometry Methods 0.000 claims 3
- 239000007922 nasal spray Substances 0.000 claims 3
- 229940097496 nasal spray Drugs 0.000 claims 3
- 239000007921 spray Substances 0.000 claims 3
- 238000007920 subcutaneous administration Methods 0.000 claims 3
- 238000013518 transcription Methods 0.000 claims 3
- 230000035897 transcription Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000003889 eye drop Substances 0.000 claims 2
- 229940012356 eye drops Drugs 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000007911 parenteral administration Methods 0.000 claims 2
- GOZMBJCYMQQACI-UHFFFAOYSA-N 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one;dihydrochloride Chemical compound Cl.Cl.C=1OC2=CC(C)=C(C)C=C2C(=O)C=1CN(C)CCN(C)CC(C1=CC=CC=C11)=CN1C1=CC=CC(C(F)(F)F)=C1 GOZMBJCYMQQACI-UHFFFAOYSA-N 0.000 claims 1
- 102000004495 STAT3 Transcription Factor Human genes 0.000 claims 1
- 108010017324 STAT3 Transcription Factor Proteins 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 102200006539 rs121913529 Human genes 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019149269A JP6928773B2 (ja) | 2014-10-23 | 2019-08-16 | 細胞内抗原に対して指向された単一ドメイン抗体 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462067908P | 2014-10-23 | 2014-10-23 | |
| US62/067,908 | 2014-10-23 | ||
| US201562148656P | 2015-04-16 | 2015-04-16 | |
| US62/148,656 | 2015-04-16 | ||
| US201562188353P | 2015-07-02 | 2015-07-02 | |
| US62/188,353 | 2015-07-02 | ||
| US201562210795P | 2015-08-27 | 2015-08-27 | |
| US62/210,795 | 2015-08-27 | ||
| PCT/US2015/057223 WO2016065323A2 (en) | 2014-10-23 | 2015-10-23 | Single domain antibodies directed against intracellular antigens |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019062231A Division JP6670963B2 (ja) | 2014-10-23 | 2019-03-28 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2019149269A Division JP6928773B2 (ja) | 2014-10-23 | 2019-08-16 | 細胞内抗原に対して指向された単一ドメイン抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538671A JP2017538671A (ja) | 2017-12-28 |
| JP2017538671A5 true JP2017538671A5 (enExample) | 2018-11-29 |
Family
ID=55761757
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017521577A Pending JP2017538671A (ja) | 2014-10-23 | 2015-10-23 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2019062231A Active JP6670963B2 (ja) | 2014-10-23 | 2019-03-28 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2019149269A Active JP6928773B2 (ja) | 2014-10-23 | 2019-08-16 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2021105631A Active JP6986180B2 (ja) | 2014-10-23 | 2021-06-25 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2021192139A Active JP7195400B2 (ja) | 2014-10-23 | 2021-11-26 | 細胞内抗原に対して指向された単一ドメイン抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019062231A Active JP6670963B2 (ja) | 2014-10-23 | 2019-03-28 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2019149269A Active JP6928773B2 (ja) | 2014-10-23 | 2019-08-16 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2021105631A Active JP6986180B2 (ja) | 2014-10-23 | 2021-06-25 | 細胞内抗原に対して指向された単一ドメイン抗体 |
| JP2021192139A Active JP7195400B2 (ja) | 2014-10-23 | 2021-11-26 | 細胞内抗原に対して指向された単一ドメイン抗体 |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US9663570B2 (enExample) |
| EP (3) | EP3209685B1 (enExample) |
| JP (5) | JP2017538671A (enExample) |
| KR (4) | KR101831123B1 (enExample) |
| CN (2) | CN106852148B (enExample) |
| AU (4) | AU2015335600B2 (enExample) |
| BR (4) | BR122020006907B8 (enExample) |
| CA (3) | CA3114318A1 (enExample) |
| CY (2) | CY1122035T1 (enExample) |
| DK (2) | DK3209685T3 (enExample) |
| ES (2) | ES2731876T3 (enExample) |
| HR (2) | HRP20191056T1 (enExample) |
| HU (2) | HUE047601T2 (enExample) |
| IL (2) | IL289769B2 (enExample) |
| LT (2) | LT3590962T (enExample) |
| MX (2) | MX379450B (enExample) |
| PL (2) | PL3209685T3 (enExample) |
| PT (2) | PT3590962T (enExample) |
| RS (2) | RS59063B1 (enExample) |
| RU (1) | RU2017116710A (enExample) |
| SI (2) | SI3209685T1 (enExample) |
| SM (2) | SMT202100695T1 (enExample) |
| TW (1) | TWI664289B (enExample) |
| WO (1) | WO2016065323A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2015335600B2 (en) | 2014-10-23 | 2019-04-04 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
| US20170267784A1 (en) | 2014-10-23 | 2017-09-21 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
| US20180072815A1 (en) | 2014-10-23 | 2018-03-15 | Singh Biotechnology, Llc | Single Domain Antibodies Directed Against Intracellular Antigens |
| ES2913200T3 (es) | 2015-03-31 | 2022-06-01 | Sorriso Pharmaceuticals Inc | Polipéptidos |
| CA2981098A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Peptide construct having a protease-cleavable linker |
| CA2981103A1 (en) | 2015-03-31 | 2016-10-06 | Vhsquared Limited | Polypeptides |
| KR20180080189A (ko) | 2015-09-01 | 2018-07-11 | 퍼스트 웨이브 바이오, 인코포레이티드 | 이상 염증 반응과 연관된 질환을 치료하기 위한 방법 및 조성물 |
| TWI746473B (zh) | 2015-11-02 | 2021-11-21 | 美商辛分子醫藥有限公司 | 針對細胞內抗原之單域抗體 |
| US20190119259A1 (en) * | 2015-12-10 | 2019-04-25 | City Of Hope | Cell penetrating cyanine-coupled antibodies |
| WO2018060453A1 (en) | 2016-09-30 | 2018-04-05 | Vhsquared Limited | Compositions |
| EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
| CN111010866A (zh) | 2017-05-24 | 2020-04-14 | 潘迪恩治疗公司 | 靶向免疫耐受性 |
| TW201922780A (zh) | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| EP3730150A4 (en) | 2017-12-22 | 2021-10-06 | Rophibio, Inc. | ANTI-STAT3 BISPECIFIC ANTIBODY WITH CELL-PENETRATING ABILITY AND THIS PHARMACEUTICAL COMPOSITION |
| KR20190076354A (ko) * | 2017-12-22 | 2019-07-02 | 주식회사 로피바이오 | 세포 내 침투능을 갖는 항 stat3 이중특이 항체를 포함하는, 염증성 질환 치료용 약학적 조성물 |
| JP2021523115A (ja) * | 2018-05-04 | 2021-09-02 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | 炎症性疾患または障害を治療するための方法および組成物 |
| KR102101561B1 (ko) * | 2018-07-25 | 2020-04-20 | 가톨릭대학교 산학협력단 | 신생혈관 표적용 조영제 조성물 및 이의 제조방법 |
| CN114679909A (zh) | 2019-05-20 | 2022-06-28 | 潘迪恩运营公司 | MAdCAM靶向的免疫耐受 |
| CN119684455A (zh) | 2019-06-21 | 2025-03-25 | 索瑞索制药公司 | 多肽 |
| AU2020294980A1 (en) | 2019-06-21 | 2022-02-17 | Sorriso Pharmaceuticals, Inc. | Polypeptides |
| CN110357965A (zh) * | 2019-06-24 | 2019-10-22 | 浙江大学 | 一种突变型kras特异性抗体及其制备方法 |
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| CA3171066A1 (en) | 2020-03-11 | 2021-09-16 | Saar GILL | Methods and composition for gene delivery using an engineered viral particle |
| US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
| CN115215939B (zh) * | 2021-04-14 | 2025-09-23 | 中山大学 | 一种融合蛋白及其制备方法与应用 |
| JP2024525990A (ja) * | 2021-07-07 | 2024-07-12 | シン バイオテクノロジー、エルエルシー | 単一ドメイン抗体によるブドウ膜炎の抑制 |
| JP2024534833A (ja) * | 2021-08-27 | 2024-09-26 | シン バイオテクノロジー、エルエルシー | 治療用単一ドメイン抗体 |
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-
2015
- 2015-10-23 AU AU2015335600A patent/AU2015335600B2/en active Active
- 2015-10-23 EP EP15853465.1A patent/EP3209685B1/en active Active
- 2015-10-23 PL PL15853465T patent/PL3209685T3/pl unknown
- 2015-10-23 KR KR1020177006630A patent/KR101831123B1/ko active Active
- 2015-10-23 ES ES15853465T patent/ES2731876T3/es active Active
- 2015-10-23 CA CA3114318A patent/CA3114318A1/en active Pending
- 2015-10-23 RS RS20190750A patent/RS59063B1/sr unknown
- 2015-10-23 US US14/922,098 patent/US9663570B2/en active Active
- 2015-10-23 DK DK15853465.1T patent/DK3209685T3/da active
- 2015-10-23 PL PL19165430T patent/PL3590962T3/pl unknown
- 2015-10-23 JP JP2017521577A patent/JP2017538671A/ja active Pending
- 2015-10-23 BR BR122020006907A patent/BR122020006907B8/pt active IP Right Grant
- 2015-10-23 LT LTEP19165430.0T patent/LT3590962T/lt unknown
- 2015-10-23 KR KR1020197026711A patent/KR102207382B1/ko active Active
- 2015-10-23 CN CN201580056968.9A patent/CN106852148B/zh active Active
- 2015-10-23 PT PT191654300T patent/PT3590962T/pt unknown
- 2015-10-23 BR BR112017008165A patent/BR112017008165B8/pt active IP Right Grant
- 2015-10-23 HU HUE15853465A patent/HUE047601T2/hu unknown
- 2015-10-23 SI SI201530789T patent/SI3209685T1/sl unknown
- 2015-10-23 SI SI201531763T patent/SI3590962T1/sl unknown
- 2015-10-23 KR KR1020197026708A patent/KR102207381B1/ko active Active
- 2015-10-23 EP EP21192390.9A patent/EP4006052A1/en active Pending
- 2015-10-23 KR KR1020187004337A patent/KR102023289B1/ko active Active
- 2015-10-23 RS RS20211519A patent/RS62694B1/sr unknown
- 2015-10-23 PT PT15853465T patent/PT3209685T/pt unknown
- 2015-10-23 CN CN202010738353.7A patent/CN111848793B/zh not_active Expired - Fee Related
- 2015-10-23 IL IL289769A patent/IL289769B2/en unknown
- 2015-10-23 BR BR122020006914A patent/BR122020006914B8/pt active IP Right Grant
- 2015-10-23 CA CA2962275A patent/CA2962275C/en active Active
- 2015-10-23 ES ES19165430T patent/ES2900253T3/es active Active
- 2015-10-23 RU RU2017116710A patent/RU2017116710A/ru not_active Application Discontinuation
- 2015-10-23 WO PCT/US2015/057223 patent/WO2016065323A2/en not_active Ceased
- 2015-10-23 CA CA3052777A patent/CA3052777C/en active Active
- 2015-10-23 HR HRP20191056TT patent/HRP20191056T1/hr unknown
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