JP2019504107A5 - - Google Patents
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- Publication number
- JP2019504107A5 JP2019504107A5 JP2018543026A JP2018543026A JP2019504107A5 JP 2019504107 A5 JP2019504107 A5 JP 2019504107A5 JP 2018543026 A JP2018543026 A JP 2018543026A JP 2018543026 A JP2018543026 A JP 2018543026A JP 2019504107 A5 JP2019504107 A5 JP 2019504107A5
- Authority
- JP
- Japan
- Prior art keywords
- administration
- sdab
- subject
- pharmaceutical composition
- hiv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims description 28
- 229920001184 polypeptide Polymers 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
- 102100034343 Integrase Human genes 0.000 claims description 11
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims description 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 10
- 238000002965 ELISA Methods 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 238000003018 immunoassay Methods 0.000 claims description 8
- 229940126619 mouse monoclonal antibody Drugs 0.000 claims description 7
- 239000012491 analyte Substances 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000003889 eye drop Substances 0.000 claims description 4
- 229940012356 eye drops Drugs 0.000 claims description 4
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 4
- 238000007918 intramuscular administration Methods 0.000 claims description 4
- 238000001990 intravenous administration Methods 0.000 claims description 4
- 238000004811 liquid chromatography Methods 0.000 claims description 4
- 238000004949 mass spectrometry Methods 0.000 claims description 4
- 239000007922 nasal spray Substances 0.000 claims description 4
- 229940097496 nasal spray Drugs 0.000 claims description 4
- 238000007920 subcutaneous administration Methods 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 4
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 241001529936 Murinae Species 0.000 claims 1
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 7
- 101150010086 VP24 gene Proteins 0.000 description 7
- 108010003723 Single-Domain Antibodies Proteins 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 2
- 102000011730 Arachidonate 12-Lipoxygenase Human genes 0.000 description 1
- 108010076676 Arachidonate 12-lipoxygenase Proteins 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021119218A JP7186266B2 (ja) | 2015-11-02 | 2021-07-20 | 細胞内抗原に対して向けられた単一ドメイン抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562249868P | 2015-11-02 | 2015-11-02 | |
| US62/249,868 | 2015-11-02 | ||
| PCT/US2016/060134 WO2017079314A2 (en) | 2015-11-02 | 2016-11-02 | Single domain antibodies directed against intracellular antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021119218A Division JP7186266B2 (ja) | 2015-11-02 | 2021-07-20 | 細胞内抗原に対して向けられた単一ドメイン抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019504107A JP2019504107A (ja) | 2019-02-14 |
| JP2019504107A5 true JP2019504107A5 (enExample) | 2019-10-03 |
| JP6918005B2 JP6918005B2 (ja) | 2021-08-11 |
Family
ID=58634379
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543026A Expired - Fee Related JP6918005B2 (ja) | 2015-11-02 | 2016-11-02 | 細胞内抗原に対して向けられた単一ドメイン抗体 |
| JP2021119218A Active JP7186266B2 (ja) | 2015-11-02 | 2021-07-20 | 細胞内抗原に対して向けられた単一ドメイン抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021119218A Active JP7186266B2 (ja) | 2015-11-02 | 2021-07-20 | 細胞内抗原に対して向けられた単一ドメイン抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10369223B2 (enExample) |
| EP (1) | EP3371215A4 (enExample) |
| JP (2) | JP6918005B2 (enExample) |
| KR (1) | KR20180069064A (enExample) |
| CN (2) | CN113512112A (enExample) |
| AR (1) | AR106556A1 (enExample) |
| AU (1) | AU2016349876B2 (enExample) |
| BR (1) | BR112018008840B1 (enExample) |
| CA (1) | CA3002239A1 (enExample) |
| IL (1) | IL258742B (enExample) |
| MX (1) | MX2018005154A (enExample) |
| RU (3) | RU2742248C2 (enExample) |
| TW (1) | TWI746473B (enExample) |
| WO (1) | WO2017079314A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170267784A1 (en) | 2014-10-23 | 2017-09-21 | Singh Molecular Medicine, Llc | Single domain antibodies directed against intracellular antigens |
| US12383634B2 (en) * | 2019-07-24 | 2025-08-12 | Korea Basic Science Institute | Single domain antibody targeting αVβ3 integrin |
| CN111234019B (zh) * | 2020-01-16 | 2022-06-24 | 佛山汉腾生物科技有限公司 | 抗ctla-4纳米抗体、药物组合物及其应用 |
| CN111184864B (zh) * | 2020-01-20 | 2022-01-14 | 武汉大学 | Alox12特异性抑制剂在制备治疗非酒精性脂肪肝病和/或ⅱ型糖尿病的药物中的应用 |
| CN113214392B (zh) * | 2020-12-30 | 2022-07-01 | 中国人民解放军海军军医大学 | 抗水母毒素纳米抗体ky031、制备方法及用途 |
| CN115414482A (zh) * | 2022-07-13 | 2022-12-02 | 同济大学 | Stat3信号通路抑制剂的应用 |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
| CA2066171A1 (en) * | 1989-10-05 | 1991-04-06 | Stephen H. Hughes | Monoclonal antibodies to segments of hiv-1 reverse transcriptase |
| EP0651805B1 (en) | 1992-07-17 | 2006-12-13 | Dana Farber Cancer Institute | Method of intracellular binding of target molecules |
| FR2706486B1 (fr) | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
| US5645836A (en) * | 1995-04-14 | 1997-07-08 | Research Development Foundation | Anti-AIDS immunotoxins |
| WO2001006989A2 (en) | 1999-07-27 | 2001-02-01 | Abgenix, Inc. | Methods and compositions for inhibiting polypeptide accumulation associated with neurological disorders |
| WO2001016183A1 (en) * | 1999-08-30 | 2001-03-08 | U.S. Army Medical Research Institute Of Infectious Diseases | Monoclonal antibodies and vaccines against epitopes on the ebola virus glycoprotein |
| CN1184484C (zh) | 1999-12-20 | 2005-01-12 | 恩益禧电子股份有限公司 | 用来精确测量阻抗的装置及方法 |
| DE10019157A1 (de) | 2000-04-18 | 2001-11-15 | Stefan Duebel | Verfahren zum Einbringen von Liganden in lebende Zellen |
| WO2002057445A1 (en) | 2000-05-26 | 2002-07-25 | National Research Council Of Canada | Single-domain brain-targeting antibody fragments derived from llama antibodies |
| US20020155127A1 (en) * | 2000-06-02 | 2002-10-24 | Danher Wang | Genetic vaccine against human immunodeficiency virus |
| US20040052762A1 (en) | 2001-09-10 | 2004-03-18 | Hua Yu | Stat3 agonists and antagonists and therapeutic uses thereof |
| JP2002253239A (ja) * | 2001-02-27 | 2002-09-10 | Jo Chiba | ヒト免疫不全ウイルスの逆転写酵素の活性を阻害するポリペプチドをコードする遺伝子およびその利用 |
| RU2186106C1 (ru) * | 2001-03-29 | 2002-07-27 | Вирусологический центр Научно-исследовательского института микробиологии | Штамм гибридных клеток э4/n-6g5 животных mus musculus l., продуцирующих моноклональные антитела к вирусу эбола |
| JP4213586B2 (ja) * | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| JP2005517674A (ja) * | 2002-01-03 | 2005-06-16 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー | 腫瘍の処置に有用な新規免疫コンジュゲート |
| AU2003219277A1 (en) | 2002-03-14 | 2003-09-29 | Medical Research Council | Intracellular antibodies |
| GB0226727D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intrabodies |
| WO2003086276A2 (en) * | 2002-04-05 | 2003-10-23 | Selective Genetics, Inc. | Compositions and methods for portal specific gene delivery and treatment of infection |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP3299393A1 (en) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| RU2455312C2 (ru) * | 2002-11-08 | 2012-07-10 | Аблинкс Н.В. | Однодоменные антитела, направленные против фактора некроза опухолей альфа, и их применение |
| US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| GB0226729D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intracellular antibodies |
| US7638122B2 (en) | 2003-03-07 | 2009-12-29 | University Of South Florida | Stat3 antagonists and their use as vaccines against cancer |
| JP2004315394A (ja) * | 2003-04-14 | 2004-11-11 | Japan Science & Technology Agency | レストンエボラウイルスに対するモノクローナル抗体及びこれを用いたレストンエボラウイルスの検出方法 |
| US7368249B2 (en) * | 2003-07-24 | 2008-05-06 | The Curators Of The University Of Missouri | Methods and compositions for evaluation and modulation of fertility |
| WO2005052002A2 (en) | 2003-11-20 | 2005-06-09 | Massachusetts Institute Of Technology | Single-domain antibodies and uses thereof |
| FR2874017B1 (fr) * | 2004-08-06 | 2006-11-24 | Bio Rad Pasteur Sa | Peptides vih-1 modifies et leur utilisation en detection d'anticorps anti-vih |
| US20060147997A1 (en) * | 2004-11-30 | 2006-07-06 | Virosys Pharmaceuticals, Inc. | PenetraBodies: receptor-mediated targeted delivery of functionally-active human antibody fragments into cytosol for the treatment of chronic infections and diseases |
| CN103254309B (zh) | 2005-05-18 | 2017-09-26 | 埃博灵克斯股份有限公司 | 针对肿瘤坏死因子α的改进的纳米体TM |
| DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
| WO2008070363A2 (en) | 2006-10-31 | 2008-06-12 | Domantis Limited | Intrabodies |
| US20100166734A1 (en) * | 2006-12-20 | 2010-07-01 | Edward Dolk | Oral delivery of polypeptides |
| KR20090001043A (ko) * | 2007-06-29 | 2009-01-08 | 주식회사 에스엔피 제네틱스 | Ａｌｏｘ１２ 및 ａｌｏｘ１５ 다형성과 아스피린 유도성천식과의 연관성 |
| EP2008666A1 (en) | 2007-06-29 | 2008-12-31 | Institut Pasteur | Use of VHH antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications |
| KR20090001043U (ko) | 2007-07-26 | 2009-02-02 | 김기인 | 공간 보호 책상 |
| WO2009033091A1 (en) | 2007-09-06 | 2009-03-12 | City Of Hope | Treatment of th17-mediated autoimmune disease via inhibition of stat3 |
| AU2008298560A1 (en) * | 2007-09-14 | 2009-03-19 | Ventana Medical Systems, Inc. | Prostate cancer biomarkers |
| WO2009121948A2 (en) * | 2008-04-03 | 2009-10-08 | Vib Vzw | Single domain antibodies capable of modulating bace activity |
| WO2009150539A2 (en) * | 2008-06-10 | 2009-12-17 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against androctonus autralis hector toxins |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| US20100136584A1 (en) * | 2008-09-22 | 2010-06-03 | Icb International, Inc. | Methods for using antibodies and analogs thereof |
| WO2010033913A1 (en) | 2008-09-22 | 2010-03-25 | Icb International, Inc. | Antibodies, analogs and uses thereof |
| US10369204B2 (en) * | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US20110172398A1 (en) * | 2009-10-02 | 2011-07-14 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules for anti-angiogenesis therapy |
| WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
| WO2011163423A2 (en) | 2010-06-22 | 2011-12-29 | University Of Central Florida Research Foundation, Inc. | Methods and compositions for cell permeable stat3 inhibitor |
| NZ780183A (en) * | 2011-06-23 | 2024-12-20 | Ablynx Nv | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
| IL285049B (en) * | 2012-10-18 | 2022-07-01 | California Inst Of Techn | Broad-spectrum neutralizing antibodies against the AIDS virus |
| CA2922698C (en) | 2013-08-29 | 2023-01-03 | City Of Hope | Cell penetrating conjugates comprising non-cell penetrating antibodies covalently attached to one or more phosphorothioate nucleic acids |
| EP2873679A1 (en) | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against amyloid bêta and methods for producing conjugates thereof |
| EP2873680A1 (en) | 2013-11-13 | 2015-05-20 | F.Hoffmann-La Roche Ag | Oligopeptide and methods for producing conjugates thereof |
| EP2899208A1 (en) | 2014-01-28 | 2015-07-29 | F.Hoffmann-La Roche Ag | Camelid single-domain antibody directed against phosphorylated tau proteins and methods for producing conjugates thereof |
| MX379450B (es) | 2014-10-23 | 2025-03-11 | Singh Biotechnology Llc | Anticuerpos de un solo dominio dirigidos contra antígenos intracelulares |
| CN104829710A (zh) * | 2015-03-26 | 2015-08-12 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种抗埃博拉病毒的免疫球蛋白F(ab′)2及其制备方法 |
-
2016
- 2016-10-31 TW TW105135273A patent/TWI746473B/zh not_active IP Right Cessation
- 2016-11-02 RU RU2019126220A patent/RU2742248C2/ru active
- 2016-11-02 US US15/342,044 patent/US10369223B2/en active Active
- 2016-11-02 AU AU2016349876A patent/AU2016349876B2/en not_active Ceased
- 2016-11-02 CA CA3002239A patent/CA3002239A1/en not_active Abandoned
- 2016-11-02 CN CN202110795272.5A patent/CN113512112A/zh not_active Withdrawn
- 2016-11-02 BR BR112018008840-4A patent/BR112018008840B1/pt not_active IP Right Cessation
- 2016-11-02 KR KR1020187015132A patent/KR20180069064A/ko not_active Withdrawn
- 2016-11-02 CN CN201680063523.8A patent/CN108350064B/zh not_active Expired - Fee Related
- 2016-11-02 WO PCT/US2016/060134 patent/WO2017079314A2/en not_active Ceased
- 2016-11-02 JP JP2018543026A patent/JP6918005B2/ja not_active Expired - Fee Related
- 2016-11-02 AR ARP160103341A patent/AR106556A1/es not_active Application Discontinuation
- 2016-11-02 RU RU2018120245A patent/RU2741110C2/ru active
- 2016-11-02 RU RU2019126152A patent/RU2742247C2/ru active
- 2016-11-02 EP EP16862887.3A patent/EP3371215A4/en not_active Withdrawn
- 2016-11-02 MX MX2018005154A patent/MX2018005154A/es unknown
- 2016-11-02 US US15/342,032 patent/US10195277B2/en active Active
-
2018
- 2018-04-16 IL IL258742A patent/IL258742B/en unknown
-
2019
- 2019-06-18 US US16/444,380 patent/US11214626B2/en active Active
-
2021
- 2021-07-20 JP JP2021119218A patent/JP7186266B2/ja active Active
- 2021-11-22 US US17/532,750 patent/US20220089783A1/en not_active Abandoned
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