JP2015514062A5 - - Google Patents
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- JP2015514062A5 JP2015514062A5 JP2015500673A JP2015500673A JP2015514062A5 JP 2015514062 A5 JP2015514062 A5 JP 2015514062A5 JP 2015500673 A JP2015500673 A JP 2015500673A JP 2015500673 A JP2015500673 A JP 2015500673A JP 2015514062 A5 JP2015514062 A5 JP 2015514062A5
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- JP
- Japan
- Prior art keywords
- agent
- cadherin
- fragment
- secad
- inhibits
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims description 86
- 102000000905 Cadherin Human genes 0.000 claims description 60
- 108050007957 Cadherin Proteins 0.000 claims description 60
- 239000012634 fragment Substances 0.000 claims description 52
- 239000008194 pharmaceutical composition Substances 0.000 claims description 49
- 239000000427 antigen Substances 0.000 claims description 24
- 102000036639 antigens Human genes 0.000 claims description 24
- 108091007433 antigens Proteins 0.000 claims description 24
- 229920001184 polypeptide Polymers 0.000 claims description 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 17
- 201000011510 cancer Diseases 0.000 claims description 17
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 12
- 102000038030 PI3Ks Human genes 0.000 claims description 12
- 108091007960 PI3Ks Proteins 0.000 claims description 12
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims description 12
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims description 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 12
- 239000013604 expression vector Substances 0.000 claims description 12
- 150000007523 nucleic acids Chemical group 0.000 claims description 12
- 230000019491 signal transduction Effects 0.000 claims description 12
- 102000043136 MAP kinase family Human genes 0.000 claims description 10
- 108091054455 MAP kinase family Proteins 0.000 claims description 10
- 239000012636 effector Substances 0.000 claims description 10
- 102000005962 receptors Human genes 0.000 claims description 10
- 108020003175 receptors Proteins 0.000 claims description 10
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 claims description 8
- 102000001301 EGF receptor Human genes 0.000 claims description 8
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 claims description 8
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 8
- 239000002118 L01XE12 - Vandetanib Substances 0.000 claims description 8
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 8
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims description 8
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims description 8
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims description 8
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims description 8
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 claims description 8
- 108091008605 VEGF receptors Proteins 0.000 claims description 8
- 229960000241 vandetanib Drugs 0.000 claims description 8
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 claims description 8
- LSFLAQVDISHMNB-UHFFFAOYSA-N 5-(3-phenylmethoxyphenyl)-7-[3-(pyrrolidin-1-ylmethyl)cyclobutyl]pyrrolo[2,3-d]pyrimidin-4-amine Chemical compound C1=2C(N)=NC=NC=2N(C2CC(CN3CCCC3)C2)C=C1C(C=1)=CC=CC=1OCC1=CC=CC=C1 LSFLAQVDISHMNB-UHFFFAOYSA-N 0.000 claims description 6
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims description 6
- 229960005395 cetuximab Drugs 0.000 claims description 6
- 229960001972 panitumumab Drugs 0.000 claims description 6
- 229960000575 trastuzumab Drugs 0.000 claims description 6
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims description 6
- 229960002833 aflibercept Drugs 0.000 claims description 5
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 claims description 4
- 108091008815 Eph receptors Proteins 0.000 claims description 4
- 102100031968 Ephrin type-B receptor 2 Human genes 0.000 claims description 4
- 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims description 4
- 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 claims description 4
- 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 claims description 4
- 108091008553 MuSK receptors Proteins 0.000 claims description 4
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims description 4
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 claims description 4
- 108091008551 RET receptors Proteins 0.000 claims description 4
- 101710204410 Scaffold protein Proteins 0.000 claims description 4
- 108010017622 Somatomedin Receptors Proteins 0.000 claims description 4
- 102000004584 Somatomedin Receptors Human genes 0.000 claims description 4
- 102000005450 TIE receptors Human genes 0.000 claims description 4
- 108010006830 TIE receptors Proteins 0.000 claims description 4
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 claims description 4
- 230000031146 intracellular signal transduction Effects 0.000 claims description 4
- 230000003211 malignant effect Effects 0.000 claims description 4
- -1 AG1024 Chemical compound 0.000 claims description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 3
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims description 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims description 2
- 208000006593 Urologic Neoplasms Diseases 0.000 claims description 2
- 108010081667 aflibercept Proteins 0.000 claims description 2
- 125000000539 amino acid group Chemical group 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 210000003169 central nervous system Anatomy 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 230000005012 migration Effects 0.000 claims description 2
- 238000013508 migration Methods 0.000 claims description 2
- 210000004994 reproductive system Anatomy 0.000 claims description 2
- 230000011664 signaling Effects 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims description 2
- 229960002760 ziv-aflibercept Drugs 0.000 claims description 2
- 230000000890 antigenic effect Effects 0.000 claims 24
- 230000037361 pathway Effects 0.000 claims 6
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 4
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 4
- 230000004068 intracellular signaling Effects 0.000 claims 4
- 229940126638 Akt inhibitor Drugs 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 230000007717 exclusion Effects 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- LHNIIDJUOCFXAP-UHFFFAOYSA-N pictrelisib Chemical compound C1CN(S(=O)(=O)C)CCN1CC1=CC2=NC(C=3C=4C=NNC=4C=CC=3)=NC(N3CCOCC3)=C2S1 LHNIIDJUOCFXAP-UHFFFAOYSA-N 0.000 claims 2
- 239000003197 protein kinase B inhibitor Substances 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- QDITZBLZQQZVEE-YBEGLDIGSA-N (5z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)\C1=C\C1=CC=C(N=CC=C2C=3C=CN=CC=3)C2=C1 QDITZBLZQQZVEE-YBEGLDIGSA-N 0.000 claims 1
- KVLFRAWTRWDEDF-IRXDYDNUSA-N AZD-8055 Chemical compound C1=C(CO)C(OC)=CC=C1C1=CC=C(C(=NC(=N2)N3[C@H](COCC3)C)N3[C@H](COCC3)C)C2=N1 KVLFRAWTRWDEDF-IRXDYDNUSA-N 0.000 claims 1
- CWHUFRVAEUJCEF-UHFFFAOYSA-N BKM120 Chemical compound C1=NC(N)=CC(C(F)(F)F)=C1C1=CC(N2CCOCC2)=NC(N2CCOCC2)=N1 CWHUFRVAEUJCEF-UHFFFAOYSA-N 0.000 claims 1
- 239000012824 ERK inhibitor Substances 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 229940124647 MEK inhibitor Drugs 0.000 claims 1
- 239000012828 PI3K inhibitor Substances 0.000 claims 1
- 239000012823 PI3K/mTOR inhibitor Substances 0.000 claims 1
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims 1
- 229950003628 buparlisib Drugs 0.000 claims 1
- 229960002271 cobimetinib Drugs 0.000 claims 1
- BSMCAPRUBJMWDF-KRWDZBQOSA-N cobimetinib Chemical compound C1C(O)([C@H]2NCCCC2)CN1C(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F BSMCAPRUBJMWDF-KRWDZBQOSA-N 0.000 claims 1
- 229950006418 dactolisib Drugs 0.000 claims 1
- JOGKUKXHTYWRGZ-UHFFFAOYSA-N dactolisib Chemical compound O=C1N(C)C2=CN=C3C=CC(C=4C=C5C=CC=CC5=NC=4)=CC3=C2N1C1=CC=C(C(C)(C)C#N)C=C1 JOGKUKXHTYWRGZ-UHFFFAOYSA-N 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 229940124302 mTOR inhibitor Drugs 0.000 claims 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims 1
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- SZFPYBIJACMNJV-UHFFFAOYSA-N perifosine Chemical compound CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1 SZFPYBIJACMNJV-UHFFFAOYSA-N 0.000 claims 1
- 229950010632 perifosine Drugs 0.000 claims 1
- 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- 229960000235 temsirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 claims 1
- 238000000034 method Methods 0.000 description 14
- 239000013543 active substance Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 3
- 239000000092 prognostic biomarker Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 208000007860 Anus Neoplasms Diseases 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
- 208000003445 Mouth Neoplasms Diseases 0.000 description 1
- 102000016979 Other receptors Human genes 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 208000024313 Testicular Neoplasms Diseases 0.000 description 1
- 206010057644 Testis cancer Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 208000025188 carcinoma of pharynx Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 201000002313 intestinal cancer Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000005001 male reproductive tract Anatomy 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 201000003120 testicular cancer Diseases 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611390P | 2012-03-15 | 2012-03-15 | |
| US61/611,390 | 2012-03-15 | ||
| US201261736475P | 2012-12-12 | 2012-12-12 | |
| US61/736,475 | 2012-12-12 | ||
| PCT/US2013/032656 WO2013138790A1 (en) | 2012-03-15 | 2013-03-15 | Combination therapies including inhibitors of the extracellular domain of e-cadherin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015514062A JP2015514062A (ja) | 2015-05-18 |
| JP2015514062A5 true JP2015514062A5 (enExample) | 2016-05-12 |
Family
ID=49161879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500673A Pending JP2015514062A (ja) | 2012-03-15 | 2013-03-15 | Ｅ−カドヘリンの細胞外ドメインの阻害剤を含む併用療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20150037354A1 (enExample) |
| EP (1) | EP2844270A4 (enExample) |
| JP (1) | JP2015514062A (enExample) |
| KR (1) | KR20140138956A (enExample) |
| CN (1) | CN104519899A (enExample) |
| CA (1) | CA2867456A1 (enExample) |
| RU (1) | RU2014141114A (enExample) |
| WO (1) | WO2013138790A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9618514B2 (en) | 2012-09-17 | 2017-04-11 | Agios Pharmaceuticals, Inc | Methods of evaluating patients using E-cadherin and vimentin |
| SG11201504022RA (en) | 2012-11-21 | 2015-06-29 | Agios Pharmaceuticals Inc | Glutamase inhibitors and method of use |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
| AU2015231053B2 (en) | 2014-03-21 | 2019-04-11 | Les Laboratoires Servier | Compounds and their methods of use |
| PT3170005T (pt) * | 2014-07-18 | 2019-07-16 | Sanofi Sa | Método para a previsão do resultado de um tratamento com aflibercept de um paciente suspeito de sofrer de um cancro |
| CN111208283B (zh) * | 2018-11-21 | 2023-09-26 | 中国科学院分子细胞科学卓越创新中心 | 增效的肿瘤抑制组合物及其应用 |
| CN115040695B (zh) * | 2021-03-09 | 2023-10-13 | 南开大学 | 一种基于VE-cad-Fc/N-cad-Fc的融合蛋白活性界面的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT414097B (de) * | 2004-06-25 | 2006-09-15 | Petzelbauer Peter Dr | Pharmazeutische zubereitung zur behandlung von schock |
| AU2010242338B2 (en) * | 2009-05-01 | 2013-12-19 | Perseus Proteomics Inc. | Anti-cadherin antibody |
| MX357167B (es) * | 2010-10-27 | 2018-06-28 | Univ New York State Res Found | Composiciones que se dirigen al dominio extracelular soluble de e-caderina y metodos relacionados para terapia de cancer. |
-
2013
- 2013-03-15 JP JP2015500673A patent/JP2015514062A/ja active Pending
- 2013-03-15 KR KR1020147028934A patent/KR20140138956A/ko not_active Withdrawn
- 2013-03-15 US US14/385,351 patent/US20150037354A1/en not_active Abandoned
- 2013-03-15 EP EP13760736.2A patent/EP2844270A4/en not_active Withdrawn
- 2013-03-15 CA CA2867456A patent/CA2867456A1/en not_active Abandoned
- 2013-03-15 RU RU2014141114A patent/RU2014141114A/ru not_active Application Discontinuation
- 2013-03-15 WO PCT/US2013/032656 patent/WO2013138790A1/en not_active Ceased
- 2013-03-15 CN CN201380024208.0A patent/CN104519899A/zh active Pending
-
2018
- 2018-01-29 US US15/882,513 patent/US20190008957A1/en not_active Abandoned
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