CA2867456A1 - Combination therapies including inhibitors of the extracellular domain of e-cadherin - Google Patents
Combination therapies including inhibitors of the extracellular domain of e-cadherin Download PDFInfo
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- CA2867456A1 CA2867456A1 CA2867456A CA2867456A CA2867456A1 CA 2867456 A1 CA2867456 A1 CA 2867456A1 CA 2867456 A CA2867456 A CA 2867456A CA 2867456 A CA2867456 A CA 2867456A CA 2867456 A1 CA2867456 A1 CA 2867456A1
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Classifications
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261611390P | 2012-03-15 | 2012-03-15 | |
| US61/611,390 | 2012-03-15 | ||
| US201261736475P | 2012-12-12 | 2012-12-12 | |
| US61/736,475 | 2012-12-12 | ||
| PCT/US2013/032656 WO2013138790A1 (en) | 2012-03-15 | 2013-03-15 | Combination therapies including inhibitors of the extracellular domain of e-cadherin |
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| CA2867456A1 true CA2867456A1 (en) | 2013-09-19 |
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| CA2867456A Abandoned CA2867456A1 (en) | 2012-03-15 | 2013-03-15 | Combination therapies including inhibitors of the extracellular domain of e-cadherin |
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| Country | Link |
|---|---|
| US (2) | US20150037354A1 (enExample) |
| EP (1) | EP2844270A4 (enExample) |
| JP (1) | JP2015514062A (enExample) |
| KR (1) | KR20140138956A (enExample) |
| CN (1) | CN104519899A (enExample) |
| CA (1) | CA2867456A1 (enExample) |
| RU (1) | RU2014141114A (enExample) |
| WO (1) | WO2013138790A1 (enExample) |
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| EP2895623B1 (en) | 2012-09-17 | 2018-08-22 | Agios Pharmaceuticals, Inc. | Use of e-cadherin and vimentin for selection of treatment responsive patients |
| EP2922832B1 (en) | 2012-11-21 | 2019-10-09 | Agios Pharmaceuticals, Inc. | Glutaminase inhibitors and methods of use |
| US9029531B2 (en) | 2012-11-22 | 2015-05-12 | Agios Pharmaceuticals, Inc. | Compounds and their methods of use |
| WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
| BR112016021620A2 (pt) | 2014-03-21 | 2018-07-10 | Agios Pharmaceuticals Inc | compostos e seus métodos de uso |
| ES2732925T3 (es) * | 2014-07-18 | 2019-11-26 | Sanofi Sa | Método para predecir el resultado de un tratamiento con aflibercept de un paciente que se sospecha que padece un cáncer |
| CN111208283B (zh) * | 2018-11-21 | 2023-09-26 | 中国科学院分子细胞科学卓越创新中心 | 增效的肿瘤抑制组合物及其应用 |
| CN115040695B (zh) * | 2021-03-09 | 2023-10-13 | 南开大学 | 一种基于VE-cad-Fc/N-cad-Fc的融合蛋白活性界面的应用 |
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|---|---|---|---|---|
| AT414097B (de) * | 2004-06-25 | 2006-09-15 | Petzelbauer Peter Dr | Pharmazeutische zubereitung zur behandlung von schock |
| CN102753579A (zh) * | 2009-05-01 | 2012-10-24 | 国立大学法人东京大学 | 抗钙粘着蛋白抗体 |
| AU2011319777B2 (en) * | 2010-10-27 | 2016-12-08 | The Research Foundation For The State University Of New York | Compositions targeting the soluble extracellular domain of E-cadherin and related methods for cancer therapy |
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2013
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- 2013-03-15 CN CN201380024208.0A patent/CN104519899A/zh active Pending
- 2013-03-15 EP EP13760736.2A patent/EP2844270A4/en not_active Withdrawn
- 2013-03-15 US US14/385,351 patent/US20150037354A1/en not_active Abandoned
- 2013-03-15 CA CA2867456A patent/CA2867456A1/en not_active Abandoned
- 2013-03-15 RU RU2014141114A patent/RU2014141114A/ru not_active Application Discontinuation
- 2013-03-15 KR KR1020147028934A patent/KR20140138956A/ko not_active Withdrawn
- 2013-03-15 JP JP2015500673A patent/JP2015514062A/ja active Pending
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2018
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|---|---|
| JP2015514062A (ja) | 2015-05-18 |
| EP2844270A4 (en) | 2016-01-27 |
| US20190008957A1 (en) | 2019-01-10 |
| CN104519899A (zh) | 2015-04-15 |
| KR20140138956A (ko) | 2014-12-04 |
| EP2844270A1 (en) | 2015-03-11 |
| US20150037354A1 (en) | 2015-02-05 |
| RU2014141114A (ru) | 2016-05-10 |
| WO2013138790A1 (en) | 2013-09-19 |
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