JP2010519204A - 窒素含有複素環ケトン類およびそれらのｃ−Ｍｅｔ阻害薬としての使用 - Google Patents

窒素含有複素環ケトン類およびそれらのｃ−Ｍｅｔ阻害薬としての使用 Download PDF

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JP2010519204A
JP2010519204A JP2009549625A JP2009549625A JP2010519204A JP 2010519204 A JP2010519204 A JP 2010519204A JP 2009549625 A JP2009549625 A JP 2009549625A JP 2009549625 A JP2009549625 A JP 2009549625A JP 2010519204 A JP2010519204 A JP 2010519204A
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compound
independently
aryl
heteroaryl
optionally substituted
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JP2010519204A5 (https=
Inventor
アルブレヒト，ブライアン・ケイ
ベロン，ステイーブン
ブツカー，シヨン
チヨン，アラン・シー
ダミコ，デリン
ダンジエロ，ノエル
アルマンジユ，ジヤン−クリストフ
キム，テ−ソン
リウ，ロンピン
ノーマン，マーク・エイチ
ジークムント，アーロン・シー
ステツク，マーキアン
シー，ニン
ヤン，ケビン
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C07D237/16—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009549625A 2007-02-16 2008-02-15 窒素含有複素環ケトン類およびそれらのｃ−Ｍｅｔ阻害薬としての使用 Pending JP2010519204A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90203007P 2007-02-16 2007-02-16
PCT/US2008/002007 WO2008103277A2 (en) 2007-02-16 2008-02-15 Nitrogen-containing heterocyclyl ketones and their use as c-met inhibitors

Publications (2)

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JP2010519204A true JP2010519204A (ja) 2010-06-03
JP2010519204A5 JP2010519204A5 (https=) 2012-04-05

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JP2009549625A Pending JP2010519204A (ja) 2007-02-16 2008-02-15 窒素含有複素環ケトン類およびそれらのｃ−Ｍｅｔ阻害薬としての使用

Country Status (7)

Country Link
US (1) US8314087B2 (https=)
EP (1) EP2114898A2 (https=)
JP (1) JP2010519204A (https=)
AU (1) AU2008219166B2 (https=)
CA (1) CA2676173A1 (https=)
MX (1) MX2009008531A (https=)
WO (1) WO2008103277A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
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JP2019535806A (ja) * 2016-10-27 2019-12-12 フーチェン コサンテール ファーマスーティカル カンパニー リミテッド ｃ−ＭＥＴ阻害剤としてのピリドン系化合物
JP2022009994A (ja) * 2015-06-25 2022-01-14 大鵬薬品工業株式会社 線維症治療剤
JP2023526247A (ja) * 2020-05-13 2023-06-21 エッジワイズ セラピューティクス， インコーポレイテッド 神経筋疾患の処置のためのピリダジノン化合物

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Title
JPN7013001715; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７８５７１-１２-１， ＥＮＴＥＲＥＤ ＳＴＮ ：３０ ＭＡＲ ２００６ *
JPN7013001716; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７８４７４-２８-３， ＥＮＴＥＲＥＤ ＳＴＮ ：２９ ＭＡＲ ２００６ *
JPN7013001717; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７８２４７-８９-３， ＥＮＴＥＲＥＤ ＳＴＮ ：２８ ＭＡＲ ２００６ *
JPN7013001718; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７５１３１-２１-８， ＥＮＴＥＲＥＤ ＳＴＮ ：２４ ＦＥＢ ２００６ *
JPN7013001719; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７４６７９-９８-８， ＥＮＴＥＲＥＤ ＳＴＮ ：２０ ＦＥＢ ２００６ *
JPN7013001720; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７４６７９-９７-７， ＥＮＴＥＲＥＤ ＳＴＮ ：２０ ＦＥＢ ２００６ *
JPN7013001721; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７４６１１-６８-４， ＥＮＴＥＲＥＤ ＳＴＮ ：１９ ＦＥＢ ２００６ *
JPN7013001722; ＤＡＴＡＢＡＳＥ ＲＥＧＩＳＴＲＹ ＯＮ ＳＴＮ， ＲＮ ８７１８０６-８７-０， ＥＮＴＥＲＥＤ ＳＴＮ ：１２ ＪＡＮ ２００６ *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022009994A (ja) * 2015-06-25 2022-01-14 大鵬薬品工業株式会社 線維症治療剤
JP7258985B2 (ja) 2015-06-25 2023-04-17 大鵬薬品工業株式会社 線維症治療剤
US11690838B2 (en) 2015-06-25 2023-07-04 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for fibrosis
JP2019535806A (ja) * 2016-10-27 2019-12-12 フーチェン コサンテール ファーマスーティカル カンパニー リミテッド ｃ−ＭＥＴ阻害剤としてのピリドン系化合物
JP2023526247A (ja) * 2020-05-13 2023-06-21 エッジワイズ セラピューティクス， インコーポレイテッド 神経筋疾患の処置のためのピリダジノン化合物
JP7758687B2 (ja) 2020-05-13 2025-10-22 エッジワイズ セラピューティクス， インコーポレイテッド 神経筋疾患の処置のためのピリダジノン化合物

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US8314087B2 (en) 2012-11-20
AU2008219166A1 (en) 2008-08-28
WO2008103277A2 (en) 2008-08-28
EP2114898A2 (en) 2009-11-11
WO2008103277A3 (en) 2009-04-16
CA2676173A1 (en) 2008-08-28
MX2009008531A (es) 2009-08-26
US20080280917A1 (en) 2008-11-13
AU2008219166B2 (en) 2013-05-16

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