JP2010518386A5 - - Google Patents
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- Publication number
- JP2010518386A5 JP2010518386A5 JP2009548631A JP2009548631A JP2010518386A5 JP 2010518386 A5 JP2010518386 A5 JP 2010518386A5 JP 2009548631 A JP2009548631 A JP 2009548631A JP 2009548631 A JP2009548631 A JP 2009548631A JP 2010518386 A5 JP2010518386 A5 JP 2010518386A5
- Authority
- JP
- Japan
- Prior art keywords
- hemoglobin
- level
- sample
- free
- pregnant female
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010044495 Fetal Hemoglobin Proteins 0.000 claims 17
- 241000124008 Mammalia Species 0.000 claims 13
- 201000011461 pre-eclampsia Diseases 0.000 claims 12
- 239000000523 sample Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 239000012472 biological sample Substances 0.000 claims 10
- 108010054147 Hemoglobins Proteins 0.000 claims 9
- 102000001554 Hemoglobins Human genes 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 5
- 239000011230 binding agent Substances 0.000 claims 3
- 208000002296 eclampsia Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 102000007513 Hemoglobin A Human genes 0.000 claims 2
- 108010085682 Hemoglobin A Proteins 0.000 claims 2
- 238000003149 assay kit Methods 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 230000001605 fetal effect Effects 0.000 claims 2
- 150000003278 haem Chemical class 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 210000005059 placental tissue Anatomy 0.000 claims 2
- 230000036470 plasma concentration Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000004393 prognosis Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000003966 Alpha-1-microglobulin Human genes 0.000 claims 1
- 101800001761 Alpha-1-microglobulin Proteins 0.000 claims 1
- 102000008857 Ferritin Human genes 0.000 claims 1
- 108050000784 Ferritin Proteins 0.000 claims 1
- 238000008416 Ferritin Methods 0.000 claims 1
- 102000016761 Haem oxygenases Human genes 0.000 claims 1
- 108050006318 Haem oxygenases Proteins 0.000 claims 1
- 108091005886 Hemoglobin subunit gamma Proteins 0.000 claims 1
- 102100038617 Hemoglobin subunit gamma-2 Human genes 0.000 claims 1
- 102000013271 Hemopexin Human genes 0.000 claims 1
- 108010026027 Hemopexin Proteins 0.000 claims 1
- 102000008133 Iron-Binding Proteins Human genes 0.000 claims 1
- 108010035210 Iron-Binding Proteins Proteins 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0700339 | 2007-02-12 | ||
| SE0700339-5 | 2007-02-12 | ||
| PCT/EP2008/001051 WO2008098734A1 (en) | 2007-02-12 | 2008-02-12 | Diagnosis and treatment of preeclampsia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013150603A Division JP5792772B2 (ja) | 2007-02-12 | 2013-07-19 | 子癇前症の診断及び治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518386A JP2010518386A (ja) | 2010-05-27 |
| JP2010518386A5 true JP2010518386A5 (enExample) | 2011-03-31 |
| JP5604111B2 JP5604111B2 (ja) | 2014-10-08 |
Family
ID=39295873
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009548631A Expired - Fee Related JP5604111B2 (ja) | 2007-02-12 | 2008-02-12 | 子癇前症の診断及び治療 |
| JP2013150603A Expired - Fee Related JP5792772B2 (ja) | 2007-02-12 | 2013-07-19 | 子癇前症の診断及び治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013150603A Expired - Fee Related JP5792772B2 (ja) | 2007-02-12 | 2013-07-19 | 子癇前症の診断及び治療 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8568999B2 (enExample) |
| EP (3) | EP2111555B1 (enExample) |
| JP (2) | JP5604111B2 (enExample) |
| KR (2) | KR101608501B1 (enExample) |
| AU (1) | AU2008214837B2 (enExample) |
| BR (1) | BRPI0808340A2 (enExample) |
| CA (1) | CA2674204C (enExample) |
| DK (2) | DK2111555T3 (enExample) |
| EA (2) | EA022609B1 (enExample) |
| ES (2) | ES2599003T3 (enExample) |
| HR (2) | HRP20130809T1 (enExample) |
| HU (1) | HUE031613T2 (enExample) |
| MX (2) | MX2009008408A (enExample) |
| NZ (1) | NZ578077A (enExample) |
| PL (2) | PL2614832T3 (enExample) |
| PT (2) | PT2111555E (enExample) |
| WO (1) | WO2008098734A1 (enExample) |
| ZA (1) | ZA200905101B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008098734A1 (en) * | 2007-02-12 | 2008-08-21 | Stefan Hansson | Diagnosis and treatment of preeclampsia |
| EP2313106B1 (en) | 2008-07-18 | 2016-03-30 | A1M Pharma AB | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin |
| WO2011095981A1 (en) * | 2010-02-03 | 2011-08-11 | St. John's Research Institute | An in-vitro method for characterizing hemoglobin variant |
| AU2011231982B2 (en) | 2010-03-24 | 2014-02-20 | Preelumina Diagnostics Ab | HbF and A1M as early stage markers for preeclampsia |
| CA2794721A1 (en) * | 2010-03-31 | 2011-10-13 | Sekisui Medical Co., Ltd. | Assay utilizing immunochromatography, immunochromatographic test strip, and assay reagent kit for immunochromatography |
| EP2766726A1 (en) | 2011-10-14 | 2014-08-20 | Aarhus Universitet | Diagnostic and prognostic use of prombp-complexes |
| ES2599034T3 (es) * | 2012-09-05 | 2017-01-31 | A1M Pharma Ab | Alfa-1-microglobulina para su uso en el tratamiento de enfermedades relacionadas con mitocondrias |
| US10928402B2 (en) | 2012-12-28 | 2021-02-23 | Nx Prenatal Inc. | Treatment of spontaneous preterm birth |
| US20140186332A1 (en) * | 2012-12-28 | 2014-07-03 | NX Pharmagen | Biomarkers of preterm birth |
| CA2977458A1 (en) | 2015-03-16 | 2016-09-22 | A1M Pharma Ab | Biomarkers for preeclampsia |
| KR101732933B1 (ko) | 2015-07-29 | 2017-05-08 | 영남대학교 산학협력단 | 신생아의 성장 또는 심혈관계 질환 예후 진단 방법 |
| CN109072479A (zh) | 2015-12-04 | 2018-12-21 | Nx产前公司 | 使用循环微粒对自发性早产风险进行分层 |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| DK3768709T3 (da) * | 2018-03-19 | 2024-01-29 | Regeneron Pharma | Mikrochip-kapillærelektroforese-assays og reagenser |
| US11418353B2 (en) * | 2019-08-26 | 2022-08-16 | Micron Technology, Inc. | Security descriptor generation |
| CN111626280B (zh) * | 2020-04-13 | 2021-09-07 | 北京邮电大学 | 一种无定位点答题卡识别方法和装置 |
| JP7543575B2 (ja) * | 2022-09-05 | 2024-09-02 | 栄研化学株式会社 | 遊離ヘモグロビン測定試薬、遊離ヘモグロビン測定方法および抗ヘモグロビン抗体 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1337778A1 (ru) | 1984-06-25 | 1987-09-15 | Новосибирский государственный медицинский институт | Способ диагностики т жести позднего токсикоза беременных |
| US5079171A (en) | 1988-09-15 | 1992-01-07 | Adeza Biomedical Corporation | Determining pregnancy induced hypertension and eclampsia by immunoassay of cellular fibronectin |
| US5238819A (en) | 1988-12-14 | 1993-08-24 | The Regents Of The University Of California | Diagnostic assay for the detection of preeclampsia |
| US5939272A (en) | 1989-01-10 | 1999-08-17 | Biosite Diagnostics Incorporated | Non-competitive threshold ligand-receptor assays |
| US5108898A (en) | 1989-01-18 | 1992-04-28 | Peters John H | Use of fibronectin having a variable included type III repeat sequence as a marker for toxemia in pregnancy |
| US5612034A (en) * | 1990-10-03 | 1997-03-18 | Redcell, Inc. | Super-globuling for in vivo extended lifetimes |
| US5166133A (en) | 1991-04-17 | 1992-11-24 | Cetus Corporation | Method for inhibing adhesion of white blood cells to endothelial cells |
| US6103691A (en) | 1994-03-23 | 2000-08-15 | Tschesche; Harald | Utilisation of angiogenin and/or α1 -microglobulin and/or complement factor D in order to inhibit the secretion of proteins |
| US5849474A (en) * | 1995-12-06 | 1998-12-15 | Olson; Camilla M. | Diagnosis of preeclampsia in mammals |
| US5910482A (en) * | 1996-03-19 | 1999-06-08 | Board Of Regents, The University Of Texas System | Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor |
| US6169816B1 (en) * | 1997-05-14 | 2001-01-02 | Applied Imaging, Inc. | Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images |
| JP2001348342A (ja) | 2001-04-12 | 2001-12-18 | Nippon Zoki Pharmaceut Co Ltd | 免疫調整・抗炎症剤 |
| DE60233301D1 (de) | 2001-05-04 | 2009-09-24 | Biosite Inc | Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs |
| EP1423706B1 (en) | 2001-09-04 | 2007-04-18 | IQ Corporation B.V. | Determination and quantification of red blood cell populations in samples |
| CN1522369A (zh) * | 2002-03-29 | 2004-08-18 | ���µ�����ҵ��ʽ���� | 血液处理方法及其装置、血红蛋白类测定方法及其装置 |
| DE10237423A1 (de) | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| CA2525236C (en) * | 2003-06-20 | 2015-03-24 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| AR045074A1 (es) | 2003-07-23 | 2005-10-12 | Applied Research Systems | Uso de cd164 soluble en desordenes inflamatorios y autoinmunes |
| KR20060110306A (ko) * | 2003-11-26 | 2006-10-24 | 사노피-아벤티스 도이칠란트 게엠베하 | 상승된 심혈관 위험에 대한 징후로서 세뇨관성 단백뇨 |
| WO2005093413A2 (en) * | 2004-03-22 | 2005-10-06 | Yale University | Diagnosis and treatment of preeclampsia |
| US20070292421A1 (en) * | 2005-07-28 | 2007-12-20 | Feinberg Bruce B | Method for treating preeclampsia |
| GB0600916D0 (en) | 2006-01-17 | 2006-02-22 | Perkinelmer Instr Las Inc | detecting and predicting pre-eclampsia |
| AU2007207089A1 (en) * | 2006-01-18 | 2007-07-26 | Wick, Immunologische Diagnostik U. Beratung Kg | Test systems for the analysis of polypeptides and cells adhering to silicones |
| WO2008098734A1 (en) * | 2007-02-12 | 2008-08-21 | Stefan Hansson | Diagnosis and treatment of preeclampsia |
| WO2009108073A1 (en) | 2008-02-28 | 2009-09-03 | Auckland Uniservices Limited | Biomarkers for prediction of preeclampsia and/or cardiovascular disease |
| EP2313106B1 (en) | 2008-07-18 | 2016-03-30 | A1M Pharma AB | Medical use of the radical scavenger and antioxidant alpha-1-microglobulin |
| AU2011231982B2 (en) | 2010-03-24 | 2014-02-20 | Preelumina Diagnostics Ab | HbF and A1M as early stage markers for preeclampsia |
-
2008
- 2008-02-12 WO PCT/EP2008/001051 patent/WO2008098734A1/en not_active Ceased
- 2008-02-12 ES ES13160275.7T patent/ES2599003T3/es active Active
- 2008-02-12 MX MX2009008408A patent/MX2009008408A/es active IP Right Grant
- 2008-02-12 US US12/526,941 patent/US8568999B2/en not_active Expired - Fee Related
- 2008-02-12 HR HRP20130809AT patent/HRP20130809T1/hr unknown
- 2008-02-12 EP EP08707674.1A patent/EP2111555B1/en not_active Not-in-force
- 2008-02-12 EP EP13160275.7A patent/EP2614832B1/en not_active Not-in-force
- 2008-02-12 EA EA200970758A patent/EA022609B1/ru not_active IP Right Cessation
- 2008-02-12 KR KR1020147017284A patent/KR101608501B1/ko not_active Expired - Fee Related
- 2008-02-12 EP EP13160278.1A patent/EP2613150A1/en not_active Withdrawn
- 2008-02-12 ES ES08707674T patent/ES2426069T3/es active Active
- 2008-02-12 NZ NZ578077A patent/NZ578077A/en not_active IP Right Cessation
- 2008-02-12 DK DK08707674.1T patent/DK2111555T3/da active
- 2008-02-12 CA CA2674204A patent/CA2674204C/en not_active Expired - Fee Related
- 2008-02-12 MX MX2013001577A patent/MX347788B/es unknown
- 2008-02-12 EA EA201500335A patent/EA031877B1/ru not_active IP Right Cessation
- 2008-02-12 HU HUE13160275A patent/HUE031613T2/en unknown
- 2008-02-12 PT PT87076741T patent/PT2111555E/pt unknown
- 2008-02-12 PT PT131602757T patent/PT2614832T/pt unknown
- 2008-02-12 PL PL13160275T patent/PL2614832T3/pl unknown
- 2008-02-12 PL PL08707674T patent/PL2111555T3/pl unknown
- 2008-02-12 KR KR1020097019056A patent/KR101454013B1/ko not_active Expired - Fee Related
- 2008-02-12 BR BRPI0808340A patent/BRPI0808340A2/pt not_active Application Discontinuation
- 2008-02-12 DK DK13160275.7T patent/DK2614832T3/da active
- 2008-02-12 JP JP2009548631A patent/JP5604111B2/ja not_active Expired - Fee Related
- 2008-02-12 AU AU2008214837A patent/AU2008214837B2/en not_active Ceased
-
2009
- 2009-07-21 ZA ZA2009/05101A patent/ZA200905101B/en unknown
-
2013
- 2013-07-19 JP JP2013150603A patent/JP5792772B2/ja not_active Expired - Fee Related
- 2013-09-17 US US14/028,971 patent/US20140065170A1/en not_active Abandoned
-
2016
- 2016-10-03 HR HRP20161266TT patent/HRP20161266T1/hr unknown
-
2018
- 2018-01-26 US US15/880,943 patent/US10359406B2/en not_active Expired - Fee Related
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