JP2006502416A5 - - Google Patents
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- Publication number
- JP2006502416A5 JP2006502416A5 JP2004543745A JP2004543745A JP2006502416A5 JP 2006502416 A5 JP2006502416 A5 JP 2006502416A5 JP 2004543745 A JP2004543745 A JP 2004543745A JP 2004543745 A JP2004543745 A JP 2004543745A JP 2006502416 A5 JP2006502416 A5 JP 2006502416A5
- Authority
- JP
- Japan
- Prior art keywords
- mhc
- binding
- monomer
- binding peptide
- putative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims 25
- LZOIGVDSAMDBIO-LXWJMTKESA-N (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](N)CCSC)C1=CC=CC=C1 LZOIGVDSAMDBIO-LXWJMTKESA-N 0.000 claims 18
- 108010066345 MHC binding peptide Proteins 0.000 claims 18
- 230000027455 binding Effects 0.000 claims 15
- 102000043131 MHC class II family Human genes 0.000 claims 6
- 108091054438 MHC class II family Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- 102000043129 MHC class I family Human genes 0.000 claims 4
- 108091054437 MHC class I family Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/269,473 US20040072262A1 (en) | 2002-10-11 | 2002-10-11 | Methods and systems for detecting MHC class I binding peptides |
| PCT/US2003/032370 WO2004034033A2 (en) | 2002-10-11 | 2003-10-10 | Methods and systems for detecting mhc class i and class ii binding peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502416A JP2006502416A (ja) | 2006-01-19 |
| JP2006502416A5 true JP2006502416A5 (enExample) | 2006-11-24 |
| JP4607590B2 JP4607590B2 (ja) | 2011-01-05 |
Family
ID=32068790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543745A Expired - Lifetime JP4607590B2 (ja) | 2002-10-11 | 2003-10-10 | Ｍｈｃクラスｉおよびクラスｉｉ結合ペプチドを検出するための方法およびシステム |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20040072262A1 (enExample) |
| EP (1) | EP1549952B1 (enExample) |
| JP (1) | JP4607590B2 (enExample) |
| CN (1) | CN1703624B (enExample) |
| AU (1) | AU2003284113B2 (enExample) |
| CA (1) | CA2501864C (enExample) |
| WO (1) | WO2004034033A2 (enExample) |
Families Citing this family (39)
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| EP1766393A4 (en) * | 2004-05-07 | 2008-06-18 | Beckman Coulter Inc | MHC-BRIDGE SYSTEM FOR DETECTION OF THE CTL-MEDIATED LYSE OF ANTIGEN-PRESENTING CELLS |
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| US20060084116A1 (en) * | 2004-09-13 | 2006-04-20 | Xencor, Inc. | Analysis of MHC-peptide binding interactions |
| GB2430256B (en) * | 2005-09-19 | 2008-06-25 | Proimmune Ltd | A method of screening MHC molecules |
| WO2007085266A1 (en) * | 2006-01-30 | 2007-08-02 | Dako Denmark A/S | High-speed quantification of antigen specific t-cells in whole blood by flow cytometry |
| US20070192033A1 (en) * | 2006-02-16 | 2007-08-16 | Microsoft Corporation | Molecular interaction predictors |
| US8396671B2 (en) * | 2006-02-16 | 2013-03-12 | Microsoft Corporation | Cluster modeling, and learning cluster specific parameters of an adaptive double threading model |
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| EP2361930A3 (en) | 2007-03-26 | 2011-10-26 | Dako Denmark A/S | Multimers of MHC-peptide complexes and uses thereof in Borrelia infectious diseases |
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| EP2167537A2 (en) | 2007-07-03 | 2010-03-31 | Dako Denmark A/S | Compiled methods for analysing and sorting samples |
| US8628932B2 (en) | 2007-07-03 | 2014-01-14 | One Lambda | Methods of detecting antibodies specific for denatured HLA antigens |
| WO2009039854A2 (en) | 2007-09-27 | 2009-04-02 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| US7842475B2 (en) * | 2008-01-08 | 2010-11-30 | Siemens Healthcare Diagnostics Inc. | Stabilization of solid support assay reagents |
| US10968269B1 (en) | 2008-02-28 | 2021-04-06 | Agilent Technologies, Inc. | MHC multimers in borrelia diagnostics and disease |
| WO2010009735A2 (en) * | 2008-07-23 | 2010-01-28 | Dako Denmark A/S | Combinatorial analysis and repair |
| GB0817244D0 (en) * | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| US8927462B2 (en) | 2010-04-12 | 2015-01-06 | Academia Sinica | Method for identifying HLA complexes associated with adverse drug reactions |
| GB201013767D0 (en) * | 2010-08-17 | 2010-09-29 | Isis Innovation | Identification of ligands and their use |
| SG10201510056SA (en) | 2011-10-28 | 2016-01-28 | Regeneron Pharma | Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules |
| JP6444321B2 (ja) | 2013-02-22 | 2018-12-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヒト化主要組織適合性遺伝子複合体を発現するマウス |
| GB201313352D0 (en) | 2013-07-26 | 2013-09-11 | Isis Innovation | Identification of peptide ligands |
| KR20170083534A (ko) | 2014-09-19 | 2017-07-18 | 리제너론 파마슈티칼스 인코포레이티드 | 키메라 항원 수용체 |
| AU2016246698B2 (en) | 2015-04-06 | 2022-06-02 | Regeneron Pharmaceuticals, Inc. | Humanized T cell mediated immune responses in non-human animals |
| US20170205404A1 (en) * | 2016-01-19 | 2017-07-20 | General Electric Company | Multifunctional beads and methods of use for capturing rare cells |
| RU2653017C1 (ru) * | 2017-06-22 | 2018-05-04 | Общество с ограниченной ответственностью "Лидер Гласс" | Способ переработки специальных видов стекла |
| JPWO2019054409A1 (ja) * | 2017-09-12 | 2020-11-12 | 国立大学法人北海道大学 | Ｈｌａタンパク質に相互作用する物質のスクリーニング方法及びスクリーニング用キット |
| WO2019211864A1 (en) * | 2018-04-29 | 2019-11-07 | Chimera Translational Research Fraternity Private Limited | Molecular fluorescent multiplex assay to identify allo-antibodies against mhc antigens |
| US12258373B2 (en) | 2018-12-17 | 2025-03-25 | Immudex Aps | Panel comprising Borrelia MHC multimers |
| EP4081254A4 (en) * | 2019-12-23 | 2024-04-03 | The Regents Of The University Of California | STABILIZATION OF MHC COMPLEXES |
| IL307238A (en) | 2021-03-31 | 2023-11-01 | Regeneron Pharma | Transgenic mice containing human components of the cellular immune system with an enhanced diversity of the TCRB repertoire |
| WO2024227447A1 (en) * | 2023-05-03 | 2024-11-07 | Immunoracle Inc. | Compositions and methods of analyzing a sample for antigen-specific immune cells |
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| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
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| EP1692504A4 (en) * | 2003-11-03 | 2007-06-27 | Beckman Coulter Inc | METHODS BASED ON DETECTION SOLUTIONS OF PEPTIDES FIXING AT THE MHC |
| EP1766393A4 (en) * | 2004-05-07 | 2008-06-18 | Beckman Coulter Inc | MHC-BRIDGE SYSTEM FOR DETECTION OF THE CTL-MEDIATED LYSE OF ANTIGEN-PRESENTING CELLS |
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-
2002
- 2002-10-11 US US10/269,473 patent/US20040072262A1/en not_active Abandoned
-
2003
- 2003-10-10 JP JP2004543745A patent/JP4607590B2/ja not_active Expired - Lifetime
- 2003-10-10 US US10/684,268 patent/US20040137537A1/en not_active Abandoned
- 2003-10-10 EP EP03776344A patent/EP1549952B1/en not_active Expired - Lifetime
- 2003-10-10 AU AU2003284113A patent/AU2003284113B2/en not_active Expired
- 2003-10-10 WO PCT/US2003/032370 patent/WO2004034033A2/en not_active Ceased
- 2003-10-10 CN CN2003801010208A patent/CN1703624B/zh not_active Expired - Lifetime
- 2003-10-10 CA CA2501864A patent/CA2501864C/en not_active Expired - Lifetime
-
2011
- 2011-02-17 US US13/029,902 patent/US8815528B2/en not_active Expired - Lifetime
-
2014
- 2014-07-21 US US14/336,944 patent/US20150072886A1/en not_active Abandoned
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