JP2006502416A5 - - Google Patents
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- Publication number
- JP2006502416A5 JP2006502416A5 JP2004543745A JP2004543745A JP2006502416A5 JP 2006502416 A5 JP2006502416 A5 JP 2006502416A5 JP 2004543745 A JP2004543745 A JP 2004543745A JP 2004543745 A JP2004543745 A JP 2004543745A JP 2006502416 A5 JP2006502416 A5 JP 2006502416A5
- Authority
- JP
- Japan
- Prior art keywords
- mhc
- binding
- monomer
- binding peptide
- putative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000178 monomer Substances 0.000 claims 25
- LZOIGVDSAMDBIO-LXWJMTKESA-N (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-4-amino-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoic acid Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](N)CCSC)C1=CC=CC=C1 LZOIGVDSAMDBIO-LXWJMTKESA-N 0.000 claims 18
- 108010066345 MHC binding peptide Proteins 0.000 claims 18
- 230000027455 binding Effects 0.000 claims 15
- 102000043131 MHC class II family Human genes 0.000 claims 6
- 108091054438 MHC class II family Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 5
- 102000043129 MHC class I family Human genes 0.000 claims 4
- 108091054437 MHC class I family Proteins 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/269,473 US20040072262A1 (en) | 2002-10-11 | 2002-10-11 | Methods and systems for detecting MHC class I binding peptides |
| PCT/US2003/032370 WO2004034033A2 (en) | 2002-10-11 | 2003-10-10 | Methods and systems for detecting mhc class i and class ii binding peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006502416A JP2006502416A (ja) | 2006-01-19 |
| JP2006502416A5 true JP2006502416A5 (enExample) | 2006-11-24 |
| JP4607590B2 JP4607590B2 (ja) | 2011-01-05 |
Family
ID=32068790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543745A Expired - Lifetime JP4607590B2 (ja) | 2002-10-11 | 2003-10-10 | Ｍｈｃクラスｉおよびクラスｉｉ結合ペプチドを検出するための方法およびシステム |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20040072262A1 (enExample) |
| EP (1) | EP1549952B1 (enExample) |
| JP (1) | JP4607590B2 (enExample) |
| CN (1) | CN1703624B (enExample) |
| AU (1) | AU2003284113B2 (enExample) |
| CA (1) | CA2501864C (enExample) |
| WO (1) | WO2004034033A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
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| DE102004022435A1 (de) * | 2004-05-06 | 2005-12-08 | Imusyn Gmbh & Co.Kg | Verfahren zur Herstellung löslicher MHC-Proteine |
| JP2007536522A (ja) * | 2004-05-07 | 2007-12-13 | ベックマン コールター インコーポレーティッド | Ｃｔｌの媒介による抗原提示細胞の溶解を検出するためのｍｈｃ架橋系 |
| WO2006009838A2 (en) * | 2004-06-17 | 2006-01-26 | Beckman Coulter, Inc. | Mycobacterium tuberculosis epitopes and methods of use thereof |
| WO2006031883A2 (en) * | 2004-09-13 | 2006-03-23 | Xencor, Inc. | Analysis of mhc-peptide binding interactions |
| GB2430256B (en) * | 2005-09-19 | 2008-06-25 | Proimmune Ltd | A method of screening MHC molecules |
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| US8706421B2 (en) * | 2006-02-16 | 2014-04-22 | Microsoft Corporation | Shift-invariant predictions |
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| EP2069790B1 (en) * | 2006-11-01 | 2015-04-29 | Beckman Coulter, Inc. | Binding surfaces for affinity assays |
| US8121797B2 (en) | 2007-01-12 | 2012-02-21 | Microsoft Corporation | T-cell epitope prediction |
| WO2008116468A2 (en) | 2007-03-26 | 2008-10-02 | Dako Denmark A/S | Mhc peptide complexes and uses thereof in infectious diseases |
| WO2009003493A2 (en) | 2007-07-03 | 2009-01-08 | Dako Denmark A/S | Mhc multimers, methods for their generation, labeling and use |
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| US8628932B2 (en) | 2007-07-03 | 2014-01-14 | One Lambda | Methods of detecting antibodies specific for denatured HLA antigens |
| EP2197908A2 (en) | 2007-09-27 | 2010-06-23 | Dako Denmark A/S | Mhc multimers in tuberculosis diagnostics, vaccine and therapeutics |
| US7842475B2 (en) * | 2008-01-08 | 2010-11-30 | Siemens Healthcare Diagnostics Inc. | Stabilization of solid support assay reagents |
| DK2254592T3 (da) | 2008-02-28 | 2019-09-09 | Dako Denmark As | MHC-multimerer til Borrelia-diagnostik og sygdom |
| US10722562B2 (en) * | 2008-07-23 | 2020-07-28 | Immudex Aps | Combinatorial analysis and repair |
| GB0817244D0 (en) * | 2008-09-20 | 2008-10-29 | Univ Cardiff | Use of a protein kinase inhibitor to detect immune cells, such as T cells |
| US10369204B2 (en) | 2008-10-02 | 2019-08-06 | Dako Denmark A/S | Molecular vaccines for infectious disease |
| US11992518B2 (en) | 2008-10-02 | 2024-05-28 | Agilent Technologies, Inc. | Molecular vaccines for infectious disease |
| EP2558860A4 (en) | 2010-04-12 | 2013-11-13 | Academia Sinica | METHOD OF IDENTIFYING HLA COMPLEXES ASSOCIATED WITH SIDE EFFECTS |
| GB201013767D0 (en) * | 2010-08-17 | 2010-09-29 | Isis Innovation | Identification of ligands and their use |
| RS56330B1 (sr) | 2011-10-28 | 2017-12-29 | Regeneron Pharma | Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc) |
| CN110192541B (zh) | 2013-02-22 | 2022-02-18 | 瑞泽恩制药公司 | 表达人源化主要组织相容性复合物的小鼠 |
| GB201313352D0 (en) | 2013-07-26 | 2013-09-11 | Isis Innovation | Identification of peptide ligands |
| WO2016044745A1 (en) | 2014-09-19 | 2016-03-24 | Regeneron Pharmaceuticals, Inc. | Chimeric antigen receptors |
| KR20240132525A (ko) | 2015-04-06 | 2024-09-03 | 리제너론 파아마슈티컬스, 인크. | 비인간 동물에서의 인간화 t 세포 매개 면역반응 |
| US20170205404A1 (en) * | 2016-01-19 | 2017-07-20 | General Electric Company | Multifunctional beads and methods of use for capturing rare cells |
| RU2653017C1 (ru) * | 2017-06-22 | 2018-05-04 | Общество с ограниченной ответственностью "Лидер Гласс" | Способ переработки специальных видов стекла |
| WO2019054409A1 (ja) * | 2017-09-12 | 2019-03-21 | 国立大学法人北海道大学 | Ｈｌａタンパク質に相互作用する物質のスクリーニング方法及びスクリーニング用キット |
| WO2019211864A1 (en) * | 2018-04-29 | 2019-11-07 | Chimera Translational Research Fraternity Private Limited | Molecular fluorescent multiplex assay to identify allo-antibodies against mhc antigens |
| EP3898666A2 (en) | 2018-12-17 | 2021-10-27 | Immudex ApS | Panel comprising borrelia mhc multimers |
| WO2021133742A1 (en) * | 2019-12-23 | 2021-07-01 | The Regents Of The University Of California | Stabilization of mhc complexes |
| AU2022249328A1 (en) | 2021-03-31 | 2023-09-21 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire |
| WO2024227447A1 (en) * | 2023-05-03 | 2024-11-07 | Immunoracle Inc. | Compositions and methods of analyzing a sample for antigen-specific immune cells |
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| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
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| ATE488767T1 (de) | 2003-07-22 | 2010-12-15 | Beckman Coulter Inc | Verfahren zum nachweis der aktivierung von t- zellen durch mhc-bindende peptide |
| EP1692504A4 (en) * | 2003-11-03 | 2007-06-27 | Beckman Coulter Inc | METHODS BASED ON DETECTION SOLUTIONS OF PEPTIDES FIXING AT THE MHC |
| JP2007536522A (ja) * | 2004-05-07 | 2007-12-13 | ベックマン コールター インコーポレーティッド | Ｃｔｌの媒介による抗原提示細胞の溶解を検出するためのｍｈｃ架橋系 |
| WO2006009838A2 (en) * | 2004-06-17 | 2006-01-26 | Beckman Coulter, Inc. | Mycobacterium tuberculosis epitopes and methods of use thereof |
| JP4505401B2 (ja) | 2005-10-28 | 2010-07-21 | 学校法人同志社 | 受光素子 |
-
2002
- 2002-10-11 US US10/269,473 patent/US20040072262A1/en not_active Abandoned
-
2003
- 2003-10-10 CN CN2003801010208A patent/CN1703624B/zh not_active Expired - Lifetime
- 2003-10-10 WO PCT/US2003/032370 patent/WO2004034033A2/en not_active Ceased
- 2003-10-10 US US10/684,268 patent/US20040137537A1/en not_active Abandoned
- 2003-10-10 CA CA2501864A patent/CA2501864C/en not_active Expired - Lifetime
- 2003-10-10 JP JP2004543745A patent/JP4607590B2/ja not_active Expired - Lifetime
- 2003-10-10 AU AU2003284113A patent/AU2003284113B2/en not_active Expired
- 2003-10-10 EP EP03776344A patent/EP1549952B1/en not_active Expired - Lifetime
-
2011
- 2011-02-17 US US13/029,902 patent/US8815528B2/en not_active Expired - Lifetime
-
2014
- 2014-07-21 US US14/336,944 patent/US20150072886A1/en not_active Abandoned
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