JP2010516229A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010516229A5 JP2010516229A5 JP2009544477A JP2009544477A JP2010516229A5 JP 2010516229 A5 JP2010516229 A5 JP 2010516229A5 JP 2009544477 A JP2009544477 A JP 2009544477A JP 2009544477 A JP2009544477 A JP 2009544477A JP 2010516229 A5 JP2010516229 A5 JP 2010516229A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- antigen
- binding fragment
- hcmv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 31
- 102000036639 antigens Human genes 0.000 claims 31
- 108091007433 antigens Proteins 0.000 claims 31
- 239000012634 fragment Substances 0.000 claims 30
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 13
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- 230000002163 immunogen Effects 0.000 claims 3
- 238000006386 neutralization reaction Methods 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 101100315698 Human cytomegalovirus (strain Merlin) UL131A gene Proteins 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 210000002919 epithelial cell Anatomy 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000000066 myeloid cell Anatomy 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0700133.2A GB0700133D0 (en) | 2007-01-04 | 2007-01-04 | Human cytomegalovirus neutralising antibodies and use thereof |
| GB0700133.2 | 2007-01-04 | ||
| PCT/IB2008/001111 WO2008084410A2 (en) | 2007-01-04 | 2008-01-03 | Human cytomegalovirus neutralising antibodies and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043126A Division JP2014141501A (ja) | 2007-01-04 | 2014-03-05 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010516229A JP2010516229A (ja) | 2010-05-20 |
| JP2010516229A5 true JP2010516229A5 (Direct) | 2011-02-24 |
| JP5710123B2 JP5710123B2 (ja) | 2015-04-30 |
Family
ID=37801734
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544477A Expired - Fee Related JP5710123B2 (ja) | 2007-01-04 | 2008-01-03 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2014043126A Pending JP2014141501A (ja) | 2007-01-04 | 2014-03-05 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014043126A Pending JP2014141501A (ja) | 2007-01-04 | 2014-03-05 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US7955599B2 (Direct) |
| EP (3) | EP2118140B1 (Direct) |
| JP (2) | JP5710123B2 (Direct) |
| KR (2) | KR101541927B1 (Direct) |
| CN (1) | CN101657467B (Direct) |
| AU (1) | AU2008204258B2 (Direct) |
| BR (1) | BRPI0806185A2 (Direct) |
| CA (1) | CA2673755C (Direct) |
| CO (1) | CO6220862A2 (Direct) |
| CR (1) | CR10961A (Direct) |
| CY (1) | CY1114271T1 (Direct) |
| DK (1) | DK2118140T3 (Direct) |
| EC (1) | ECSP099547A (Direct) |
| ES (2) | ES2526907T3 (Direct) |
| GB (1) | GB0700133D0 (Direct) |
| GT (1) | GT200900188A (Direct) |
| HR (1) | HRP20130877T1 (Direct) |
| IL (1) | IL199585A (Direct) |
| MA (1) | MA31225B1 (Direct) |
| MX (1) | MX2009007320A (Direct) |
| MY (2) | MY150709A (Direct) |
| NZ (1) | NZ578844A (Direct) |
| PL (1) | PL2118140T3 (Direct) |
| PT (2) | PT2118140E (Direct) |
| RU (1) | RU2469045C2 (Direct) |
| SG (3) | SG177943A1 (Direct) |
| SI (1) | SI2118140T1 (Direct) |
| TN (1) | TN2009000285A1 (Direct) |
| UA (1) | UA100682C2 (Direct) |
| WO (1) | WO2008084410A2 (Direct) |
| ZA (1) | ZA200905408B (Direct) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2654563A1 (en) * | 2006-06-07 | 2007-12-21 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
| US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| GB0700133D0 (en) * | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| WO2009021150A2 (en) | 2007-08-08 | 2009-02-12 | California Pacific Medical Center | Platelet derived growth factor receptor supports cytomegalovirus infectivity |
| AU2012203417B2 (en) * | 2008-07-16 | 2014-07-10 | Institute For Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| CN102143974B (zh) * | 2008-07-16 | 2015-03-25 | 生命医学研究学会 | 人巨细胞病毒中和抗体及其用途 |
| CA2730776C (en) | 2008-07-16 | 2018-12-11 | Institute For Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| EP2313433A2 (en) * | 2008-07-25 | 2011-04-27 | Institute for Research in Biomedicine | Neutralizing anti-influenza a virus antibodies and uses thereof |
| AU2010232202B2 (en) | 2009-04-01 | 2013-08-29 | Evec Incorporated | Monoclonal antibody capable of binding to specific discontinuous epitope occurring in AD1 region of human cytomegalovirus gB glycoprotein, and antigen-binding fragment thereof |
| SG181901A1 (en) | 2009-12-23 | 2012-08-30 | 4Antibody Ag | Binding members for human cytomegalovirus |
| WO2011159938A2 (en) | 2010-06-16 | 2011-12-22 | Trellis Bioscience, Inc. | High affinity human antibodies to human cytomegalovirus (cmv) gb protein |
| LT3418300T (lt) | 2011-07-18 | 2021-01-11 | Institute For Research In Biomedicine | Neutralizuojantys antikūnai prieš gripo virusą a ir jų panaudojimas |
| JP2015518471A (ja) | 2012-03-28 | 2015-07-02 | ジェネンテック， インコーポレイテッド | 抗ｈｃｍｖイディオタイプ抗体およびそれらの使用 |
| WO2014099908A1 (en) * | 2012-12-17 | 2014-06-26 | Genentech, Inc. | Methods for inhibiting viral infection in transplant patients |
| LT3052192T (lt) | 2013-10-02 | 2020-12-10 | Medimmune, Llc | Neutralizuojantys antikūnai prieš gripą a ir jų naudojimas |
| CN119161468A (zh) | 2014-07-15 | 2024-12-20 | 免疫医疗有限责任公司 | 中和抗乙型流感抗体及其用途 |
| US20160069643A1 (en) * | 2014-09-06 | 2016-03-10 | Philip Lyren | Weapon Targeting System |
| HRP20211510T1 (hr) | 2015-06-01 | 2021-12-24 | Medimmune, Llc | Neutralizirajuće vezujuće molekule protiv influence i njihova uporaba |
| MX2018008302A (es) * | 2016-01-08 | 2018-09-21 | Aimm Therapeutics Bv | Anticuerpo antigrupo de diferenciacion 9 (anti-cd9) terapeutico. |
| SG11201805001UA (en) | 2016-01-13 | 2018-07-30 | Medimmune Llc | Method of treating influenza a |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| WO2017184562A1 (en) | 2016-04-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Cmv neutralizing antigen binding proteins |
| EP3749690A1 (en) * | 2018-02-05 | 2020-12-16 | Stichting VU | Inverse agonistic anti-us28 antibodies |
| CN109580944A (zh) * | 2018-12-07 | 2019-04-05 | 潍坊医学院 | 一种人巨细胞病毒检测试纸及其制造方法 |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| CN109738631A (zh) * | 2019-01-21 | 2019-05-10 | 潍坊医学院 | 一种人巨细胞病毒IgM抗体检测试纸的制备方法 |
| CN118465272B (zh) * | 2019-12-04 | 2025-08-19 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
| CN118580343B (zh) * | 2022-10-21 | 2025-08-19 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1061943A (en) | 1964-09-10 | 1967-03-15 | Carter S Ink Co | Marking composition |
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4294817A (en) | 1977-11-25 | 1981-10-13 | International Diagnostic Technology, Inc. | Method of fluoro immunoassay |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4313927A (en) | 1979-10-19 | 1982-02-02 | Ames-Yissum Ltd. | Immunoassay method for detecting viral antibodies in whole blood samples |
| US4334016A (en) | 1980-06-19 | 1982-06-08 | The Wistar Institute Of Anatomy And Biology | Human osteogenic sarcoma cell line and use thereof for immunofluorescent antibody test |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| FR2543570B1 (fr) | 1983-03-31 | 1985-08-09 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus humains, hybridomes secreteurs de ces anticorps et polypeptides porteurs d'un determinant antigenique sequentiel de cytomegalovirus humains |
| US4617379A (en) | 1983-06-14 | 1986-10-14 | Miles Laboratories, Inc. | High titer cytomegalovirus immune serum globulin |
| GB8404368D0 (en) | 1984-02-20 | 1984-03-28 | Cogent Ltd | Monoclonal antibodies to human cytomegalovirus |
| US6100064A (en) | 1984-04-06 | 2000-08-08 | Chiron Corporation | Secreted viral proteins useful for vaccines and diagnostics |
| FR2563630B1 (fr) | 1984-04-27 | 1988-02-19 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus et procedes pour le diagnostic in vitro des infections par les cytomegalovirus humains et d'une proteine-kinase inductible par les cytomegalovirus et susceptible d'etre reconnue par les susdits anticorps monoclonaux |
| US4783399A (en) | 1984-05-04 | 1988-11-08 | Scripps Clinic And Research Foundation | Diagnostic system for the detection of cytomegalovirus |
| US4743562A (en) | 1984-08-21 | 1988-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Purified human cytomegalovirus protein |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4950595A (en) | 1984-09-28 | 1990-08-21 | Teijin Limited | Mouse-human hybridoma which produces antivirus-human antibody, process for preparation thereof, and antivirus-human monoclonal antibody |
| US4808518A (en) | 1985-02-11 | 1989-02-28 | University Of Tennessee Research Corporation | Recovery of cytomegalovirus antigen and use thereof in an assay |
| US4804627A (en) | 1985-05-09 | 1989-02-14 | Sloan-Kettering Institute For Cancer Research | Method for cloning lymphoblastoid cells |
| US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| ATE110084T1 (de) | 1985-12-06 | 1994-09-15 | Teijin Ltd | Anticytomegaloviraler menschlicher monoklonaler antikörper und dessen herstellung. |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| US5153311A (en) | 1986-11-24 | 1992-10-06 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus gCII |
| US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
| LU86752A1 (fr) | 1987-01-30 | 1988-08-23 | Univ Bruxelles | Procede de production d'anticorps monoclonaux humains(igg)anticytomegalovirus et anticorps monoclonaux ainsi obtenus |
| FI884924A7 (fi) | 1987-10-28 | 1989-04-29 | Oncogen | Yhdistelmä-DNA-tekniikalla tuotettuja ihmisimmunoglobuliineja |
| US5180813A (en) | 1989-03-24 | 1993-01-19 | University Of Iowa Research Foundation | Early envelope glycoprotein of human cytomegalovirus (hmcv) and monoclonal antibodies to the glycoproteins |
| US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| WO1991004277A1 (en) | 1989-09-14 | 1991-04-04 | Children's Biomedical Research Institute | Monoclonal antibodies specific to cytomegalovirus glycoprotein |
| WO1991005876A1 (en) | 1989-10-20 | 1991-05-02 | Children's Biomedical Research Institute | Human cytomegalovirus-specific monoclonal antibody cocktail |
| GB9008223D0 (en) | 1990-04-11 | 1990-06-13 | Royal Free Hosp School Med | Improvements relating to the detection of viruses |
| DE4035174A1 (de) | 1990-11-06 | 1992-05-07 | Biotest Ag | Verfahren zur bestimmung von proteinen in koerperfluessigkeiten und mittel zur durchfuehrung des verfahrens |
| US5997878A (en) | 1991-03-07 | 1999-12-07 | Connaught Laboratories | Recombinant poxvirus-cytomegalovirus, compositions and uses |
| JPH053794A (ja) * | 1991-06-26 | 1993-01-14 | Green Cross Corp:The | 抗サイトメガロウイルスヒトモノクローナル抗体およびその産生細胞 |
| DE4128684A1 (de) | 1991-08-29 | 1993-03-04 | Behringwerke Ag | Hcmv-spezifische peptide, mittel dazu und ihre verwendung |
| ATE173543T1 (de) | 1992-04-10 | 1998-12-15 | Thomas Totterman | Verfahren zum nachweis einer cmv-infektion |
| SE9201281L (sv) | 1992-04-23 | 1993-10-24 | Bioinvent Int Ab | Nya humana monoklonala antikroppar och förfarande för framställning därav |
| JPH05260961A (ja) * | 1992-05-21 | 1993-10-12 | Teijin Ltd | サイトメガロウイルスに対するヒト・モノクローナル抗体を産生するハイブリドーマ |
| GB9221654D0 (en) * | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
| CA2154346A1 (en) | 1993-01-21 | 1994-08-04 | John A. Zaia | Prevention and treatment of cytomegalovirus using aminopeptidase |
| US5750106A (en) | 1993-01-28 | 1998-05-12 | Novartis Ag | Human monoclonal antibodies to cytomegalovirus |
| EP0683675A4 (en) | 1993-01-28 | 1997-05-21 | Sandoz Pharmaceuticals Corp | HUMAN MONOCLONAL ANTIBODIES AGAINST CYTOMEGALOVIRUS. |
| WO1994025490A1 (en) | 1993-04-30 | 1994-11-10 | The Scripps Research Institute | Human monoclonal antibodies to human cytomegalovirus, and methods therefor |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| EP0702083A3 (de) | 1994-07-26 | 1997-01-15 | Biotest Ag | Polypeptide und Fusionsproteine bestehend aus dem UL 57 Leserahmen bzw. dem C-terminalen Bereich des Tegumentproteins pp150 aus HCMV, entsprechende Oligonucleotide und Nachweis reagentien |
| US5783383A (en) | 1995-05-23 | 1998-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of detecting cytomegalovirus (CMV) |
| US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| US5800981A (en) | 1996-02-22 | 1998-09-01 | University Of Limburg | Human cytomegalovirus antigen and its use |
| WO1998002746A1 (en) | 1996-07-12 | 1998-01-22 | Akzo Nobel N.V. | Peptide reagent for the detection of human cytomegalovirus (cmv) |
| EP0964686A4 (en) | 1996-08-14 | 2000-10-18 | Wistar Inst | METHODS AND COMPOSITIONS FOR PREVENTING OR INHIBITING THE DEVELOPMENT OF ATHEROSCLEROTIC DAMAGE |
| EP1003841A4 (en) | 1997-01-30 | 2002-04-17 | Cedars Sinai Medical Center | CREATION OF A HSV-8 + LYMPHOMATORY CELL LINE, PRODUCT VIRUS, ANTIBODIES, DIAGNOSTIC METHOD AND KIT FOR DETECTING HSV-8 INFECTION |
| US6183752B1 (en) | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
| US6300104B1 (en) | 1997-06-19 | 2001-10-09 | The Regents Of The University Of California | Secretory immunoglobulin produced by single cells and methods for making and using same |
| BR9815496A (pt) | 1997-07-18 | 2001-12-18 | Connaught Lab | Vacinas de ácido nucléico que codificam proteìna gde vìrus sincicial respiratório |
| CA2309826A1 (en) | 1997-11-14 | 1999-05-27 | Connaught Laboratories Limited | Alphavirus vectors for paramyxovirus vaccines |
| DE19756214C1 (de) | 1997-12-17 | 1999-02-25 | Biotest Ag | Polypeptide mit Aminosäuresequenzen aus dem N-terminalen Bereich von gp116 und deren Verwendung bei der Diagnostik, Prophylaxe und Therapie |
| ATE226444T1 (de) | 1998-03-12 | 2002-11-15 | Genentech Inc | Verwendung von fgf-5 polypetiden zur vorbeugung des absterbens retinaler neuronen und behandlung okularer krankheiten |
| EP1091763B1 (de) | 1998-06-29 | 2003-09-17 | Wolfgang Bergter | Antivirale und antiretrovirale radioimmunpharmaka auf der basis von alpha- und beta-strahlern |
| RU2133472C1 (ru) | 1998-09-16 | 1999-07-20 | Унитарное государственное Московское предприятие по производству бактерийных препаратов | Способ диагностики активной стадии цитомегаловирусной инфекции человека |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| ITMI20012160A1 (it) | 2001-10-18 | 2003-04-18 | Edoardo Marchisio | Sistema immunoenzimatico per la caratterizzazione antigenica dell'infezione attiva da cytomegalovirus e cmv confirmation test |
| US6828113B2 (en) | 2002-03-21 | 2004-12-07 | Cornell Research Foundation, Inc. | IgM antibodies to the 70 kDa heat shock protein as a marker for cytomegalovirus infection |
| EP1578980A4 (en) | 2002-04-01 | 2013-01-02 | Agensys Inc | NUCLEIC ACID SUITABLE FOR THE TREATMENT AND DETECTION OF CANCER AND CORRESPONDING PROTEIN HAVING NAME 213P1F11 |
| RU2239453C2 (ru) * | 2002-12-03 | 2004-11-10 | Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" | Препарат иммуноглобулина человека против цитомегаловируса и способ его получения |
| EP1597280B2 (en) | 2003-02-26 | 2016-08-24 | Institute for Research in Biomedicine | Monoclonal antibody production by ebv transformation of b cells |
| WO2004076645A2 (en) | 2003-02-27 | 2004-09-10 | University Of Massachusetts | Compositions and methods for cytomegalovirus treatment |
| WO2004078926A2 (en) | 2003-02-28 | 2004-09-16 | Board Of Trustees Operating Michigan State University | Immunologigal markers |
| HUE035082T2 (en) | 2004-06-21 | 2018-05-02 | Squibb & Sons Llc | Interferon alpha receptor 1 antibodies and their use |
| BE1016287A6 (nl) | 2004-07-14 | 2006-07-04 | Picanol Nv | Gaapvormingsonderdeel voor een weefmachine en weefmachine. |
| WO2006056027A1 (en) | 2004-11-29 | 2006-06-01 | The Council Of The Queensland Institute Of Medical Research | Human cytomegalovirus immunotherapy |
| AU2005333155B2 (en) | 2005-03-14 | 2011-11-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies against Hendra and Nipah viruses |
| ATE513034T1 (de) | 2005-12-16 | 2011-07-15 | Ribovax Biotechnologies Sa | Verfahren zur gewinnung immortalisierter antikörpersezernierender zellen |
| JPWO2007094423A1 (ja) | 2006-02-15 | 2009-07-09 | 株式会社イーベック | ヒトサイトメガロウイルスに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| CA2652538C (en) | 2006-05-19 | 2016-06-28 | Teva Pharmaceutical Industries, Ltd. | Fusion proteins, uses thereof and processes for producing same |
| CA2654563A1 (en) | 2006-06-07 | 2007-12-21 | The Trustees Of Princeton University | Cytomegalovirus surface protein complex for use in vaccines and as a drug target |
| ATE503769T1 (de) | 2006-12-15 | 2011-04-15 | Ribovax Biotechnologies Sa | Antikörper gegen das humane cytomegalie-virus (hcmv) |
| US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| US8361473B2 (en) | 2007-03-29 | 2013-01-29 | Technion Research & Development Foundation Ltd. | Antibodies and their uses for diagnosis and treatment of cytomegalovirus infection and associated diseases |
| US20080248042A1 (en) | 2007-04-05 | 2008-10-09 | Irccs Centro Di Riferimento Oncologico Di Aviano, | Monoclonal antibody cross-reactive against infective agent causing a B-cell expansion and IgG-Fc |
| US20110171233A1 (en) | 2007-08-22 | 2011-07-14 | Ribovax Biotechnologies S.A. | Antibodies Against Human Cytomegalovirus (HCMV) |
| US7763261B2 (en) | 2007-12-19 | 2010-07-27 | Dcb-Usa Llc | Anti-human cytomegalovirus antibodies |
| CA2730776C (en) | 2008-07-16 | 2018-12-11 | Institute For Research In Biomedicine | Human cytomegalovirus neutralizing antibodies and use thereof |
| CN102143974B (zh) | 2008-07-16 | 2015-03-25 | 生命医学研究学会 | 人巨细胞病毒中和抗体及其用途 |
-
2007
- 2007-01-04 GB GBGB0700133.2A patent/GB0700133D0/en not_active Ceased
-
2008
- 2008-01-03 SG SG2011097805A patent/SG177943A1/en unknown
- 2008-01-03 SG SG2013042544A patent/SG192399A1/en unknown
- 2008-01-03 CA CA2673755A patent/CA2673755C/en active Active
- 2008-01-03 KR KR1020097016334A patent/KR101541927B1/ko not_active Expired - Fee Related
- 2008-01-03 MX MX2009007320A patent/MX2009007320A/es active IP Right Grant
- 2008-01-03 EP EP08737590.3A patent/EP2118140B1/en active Active
- 2008-01-03 PT PT87375903T patent/PT2118140E/pt unknown
- 2008-01-03 HR HRP20130877AT patent/HRP20130877T1/hr unknown
- 2008-01-03 PL PL08737590T patent/PL2118140T3/pl unknown
- 2008-01-03 UA UAA200908229A patent/UA100682C2/ru unknown
- 2008-01-03 AU AU2008204258A patent/AU2008204258B2/en not_active Ceased
- 2008-01-03 CN CN2008800071531A patent/CN101657467B/zh not_active Expired - Fee Related
- 2008-01-03 KR KR1020147021517A patent/KR101659306B1/ko not_active Expired - Fee Related
- 2008-01-03 MY MYPI20092825 patent/MY150709A/en unknown
- 2008-01-03 DK DK08737590.3T patent/DK2118140T3/da active
- 2008-01-03 US US11/969,104 patent/US7955599B2/en not_active Expired - Fee Related
- 2008-01-03 BR BRPI0806185-8A patent/BRPI0806185A2/pt not_active Application Discontinuation
- 2008-01-03 EP EP14188865.1A patent/EP2860189A3/en not_active Withdrawn
- 2008-01-03 PT PT121560486T patent/PT2487187E/pt unknown
- 2008-01-03 MY MYPI2013003538A patent/MY161200A/en unknown
- 2008-01-03 WO PCT/IB2008/001111 patent/WO2008084410A2/en not_active Ceased
- 2008-01-03 SI SI200831025T patent/SI2118140T1/sl unknown
- 2008-01-03 NZ NZ578844A patent/NZ578844A/xx not_active IP Right Cessation
- 2008-01-03 ES ES12156048.6T patent/ES2526907T3/es active Active
- 2008-01-03 SG SG2013042486A patent/SG191635A1/en unknown
- 2008-01-03 EP EP12156048.6A patent/EP2487187B1/en not_active Not-in-force
- 2008-01-03 ES ES08737590T patent/ES2426987T3/es active Active
- 2008-01-03 JP JP2009544477A patent/JP5710123B2/ja not_active Expired - Fee Related
- 2008-01-03 RU RU2009129403/10A patent/RU2469045C2/ru active
-
2009
- 2009-06-25 IL IL199585A patent/IL199585A/en not_active IP Right Cessation
- 2009-07-01 GT GT200900188A patent/GT200900188A/es unknown
- 2009-07-03 TN TNP2009000285A patent/TN2009000285A1/fr unknown
- 2009-07-29 EC EC2009009547A patent/ECSP099547A/es unknown
- 2009-07-31 CR CR10961A patent/CR10961A/es unknown
- 2009-08-03 ZA ZA200905408A patent/ZA200905408B/xx unknown
- 2009-08-04 CO CO09081236A patent/CO6220862A2/es not_active Application Discontinuation
- 2009-08-04 MA MA32141A patent/MA31225B1/fr unknown
-
2011
- 2011-04-22 US US13/092,364 patent/US8309089B2/en not_active Expired - Fee Related
-
2012
- 2012-09-14 US US13/619,305 patent/US8545848B2/en not_active Expired - Fee Related
-
2013
- 2013-08-26 CY CY20131100726T patent/CY1114271T1/el unknown
- 2013-09-30 US US14/041,799 patent/US9149524B2/en not_active Expired - Fee Related
-
2014
- 2014-03-05 JP JP2014043126A patent/JP2014141501A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010516229A5 (Direct) | ||
| RU2009129403A (ru) | Антитела, нейтрализующие цитомегаловирус человека, и их применение | |
| JP2011528902A5 (Direct) | ||
| JP2020079252A5 (Direct) | ||
| RU2011105062A (ru) | Нейтрализующие антитела против вируса гриппа а и их использование | |
| JP2012504955A5 (Direct) | ||
| JP2022031635A5 (Direct) | ||
| JP2018521638A5 (Direct) | ||
| JP2018535650A5 (Direct) | ||
| IL266756A (en) | Human monoclonal antibodies that bind to MASP 2 and suppress MASP-dependent complement activation, methods for their production and uses | |
| JP2020500538A5 (Direct) | ||
| FI3484915T3 (fi) | Uusia zikavirusepitooppeihin spesifisesti sitoutuvia vasta-aineita ja niiden käyttöjä | |
| RU2588467C3 (ru) | Стабильные и растворимые антитела, ингибирующие vegf | |
| JP2014511179A5 (Direct) | ||
| RU2016129274A (ru) | Канинизированные мышиные антитела к человеческому pd-1 | |
| JP2011527899A5 (Direct) | ||
| JP2014519334A5 (Direct) | ||
| JP2018035138A5 (Direct) | ||
| RU2017134495A (ru) | Антитела к альфа-рецептору собачьего интерлейкина-4 | |
| JP2015534982A5 (Direct) | ||
| JP2012513214A5 (Direct) | ||
| JP2015511817A5 (Direct) | ||
| JP2017533694A5 (Direct) | ||
| JP2015503909A5 (Direct) | ||
| JP2015514068A5 (Direct) |