JP2010510323A5 - - Google Patents
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- JP2010510323A5 JP2010510323A5 JP2009538506A JP2009538506A JP2010510323A5 JP 2010510323 A5 JP2010510323 A5 JP 2010510323A5 JP 2009538506 A JP2009538506 A JP 2009538506A JP 2009538506 A JP2009538506 A JP 2009538506A JP 2010510323 A5 JP2010510323 A5 JP 2010510323A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- pharmaceutical composition
- composition according
- effective amount
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86078006P | 2006-11-21 | 2006-11-21 | |
| US60/860,780 | 2006-11-21 | ||
| US90274207P | 2007-02-21 | 2007-02-21 | |
| US60/902,742 | 2007-02-21 | ||
| PCT/US2007/085402 WO2008064321A2 (en) | 2006-11-21 | 2007-11-21 | Methods of treating chronic inflammatory diseases using a gm-csf antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010510323A JP2010510323A (ja) | 2010-04-02 |
| JP2010510323A5 true JP2010510323A5 (enExample) | 2011-01-13 |
| JP5410293B2 JP5410293B2 (ja) | 2014-02-05 |
Family
ID=39386167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009538506A Expired - Fee Related JP5410293B2 (ja) | 2006-11-21 | 2007-11-21 | Gm−csfアンタゴニストを用いて慢性炎症性疾患を治療する方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20080206241A1 (enExample) |
| EP (2) | EP2101780B1 (enExample) |
| JP (1) | JP5410293B2 (enExample) |
| KR (1) | KR101517251B1 (enExample) |
| CN (2) | CN105435223A (enExample) |
| AU (1) | AU2007323541B2 (enExample) |
| BR (1) | BRPI0719109A2 (enExample) |
| CA (1) | CA2670288C (enExample) |
| EA (1) | EA200900709A1 (enExample) |
| ES (1) | ES2432173T3 (enExample) |
| IL (1) | IL198829A0 (enExample) |
| MX (1) | MX2009005398A (enExample) |
| NZ (1) | NZ598345A (enExample) |
| SG (1) | SG176503A1 (enExample) |
| WO (1) | WO2008064321A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080206241A1 (en) | 2006-11-21 | 2008-08-28 | Kalobios Pharmaceuticals Inc. | Methods of Treating Chronic Inflammatory Diseases Using a GM-CSF Antagonist |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US20090176654A1 (en) * | 2007-08-10 | 2009-07-09 | Protelix, Inc. | Universal fibronectin type III binding-domain libraries |
| TW200918553A (en) * | 2007-09-18 | 2009-05-01 | Amgen Inc | Human GM-CSF antigen binding proteins |
| US8679502B2 (en) | 2007-11-13 | 2014-03-25 | Evec Inc. | Monoclonal antibodies that bind to HGM-CSF and medical compositions comprising same |
| CA2711763A1 (en) * | 2008-01-15 | 2009-07-23 | Kalobios Pharmaceuticals, Inc. | Methods of treating bone-loss disorders using a gm-csf antagonist |
| WO2009126659A1 (en) * | 2008-04-07 | 2009-10-15 | Kalobios Pharmaceuticals, Inc. | Neutralization of gm-csf for the treatment of heart failure |
| KR101824512B1 (ko) * | 2008-04-28 | 2018-02-02 | 휴머니건, 아이엔씨. | 과립구-대식세포 콜로니 자극 인자에 대한 항체 |
| EP3381471B1 (en) | 2008-12-22 | 2024-03-20 | The University of Melbourne | Pain treatment |
| AU2015224416B2 (en) * | 2008-12-22 | 2017-04-20 | The University Of Melbourne | Osteoarthritis treatment |
| DK2376121T4 (da) * | 2008-12-22 | 2021-08-16 | Univ Melbourne | Slidgigtbehandling |
| WO2010093814A1 (en) * | 2009-02-11 | 2010-08-19 | Kalobios Pharmaceuticals, Inc. | Methods of treating dementia using a gm-csf antagonist |
| CA2759506A1 (en) * | 2009-04-23 | 2010-10-28 | Theraclone Sciences, Inc. | Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies |
| US20120116059A1 (en) * | 2009-05-05 | 2012-05-10 | Morphosys Ag | Treatment For M Treatment For Multiple Sclerosis |
| BR112013033944A2 (pt) * | 2011-07-06 | 2017-12-19 | Morphosys Ag | combinação sinérgica |
| KR20210021153A (ko) * | 2012-09-20 | 2021-02-24 | 모르포시스 아게 | 류마티스 관절염에 대한 치료 |
| CN104995210A (zh) * | 2012-09-20 | 2015-10-21 | 莫弗系统股份公司 | 类风湿关节炎的治疗 |
| AR093297A1 (es) * | 2012-10-31 | 2015-05-27 | Amgen Res Munich Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| RU2714919C2 (ru) * | 2013-08-30 | 2020-02-21 | Такеда Гмбх | Антитела, нейтрализующие gm-csf, для применения в лечении ревматоидного артрита или в качестве анальгетиков |
| JP6360696B2 (ja) * | 2014-03-18 | 2018-07-18 | 日本光電工業株式会社 | 血液検査装置および血液検査方法 |
| AU2015263285A1 (en) * | 2014-05-19 | 2016-11-24 | Medimmune Limited | Treatment for rheumatoid arthritis |
| US20180236098A1 (en) * | 2016-08-12 | 2018-08-23 | L.E.A.F. Holdings Group Llc | Alpha and gamma-d polyglutamated antifolates and uses thereof |
| DK3328887T3 (da) | 2016-09-19 | 2021-09-20 | I Mab Biopharma Hangzhou Co Ltd | Anti-GM-CSF antistoffer og anvendelser deraf |
| US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
| US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
| CN111757744A (zh) * | 2017-10-02 | 2020-10-09 | 人源股份有限公司 | 使用gm-csf拮抗剂治疗免疫疗法相关毒性的方法 |
| US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
| US12624086B2 (en) * | 2018-10-31 | 2026-05-12 | Mayo Foundation For Medical Education And Research | Materials and methods for treating cancer |
| MX2022011111A (es) * | 2020-03-08 | 2023-03-02 | Humanigen Inc | Métodos para tratar infección de coronavirus y lesión pulmonar inducida por inflamación resultante. |
| JP2023551549A (ja) * | 2020-12-04 | 2023-12-08 | シーエスエル イノベーション プロプライアタリー リミティド | 炎症性皮膚状態を治療する方法 |
| US20240317846A1 (en) * | 2021-03-08 | 2024-09-26 | Humanigen, Inc. | Methods for treating coronavirus infection and resulting inflammation-induced lung injury |
| CN116887856A (zh) * | 2022-01-20 | 2023-10-13 | 舒泰神(北京)生物制药股份有限公司 | 一种特异性地识别粒细胞-巨噬细胞集落刺激因子受体的抗体制剂及其应用 |
| CN117547474A (zh) * | 2022-08-03 | 2024-02-13 | 苏州隽德生物科技有限公司 | 含磺化杯芳烃的护肤品组合物、药用组合物、及磺化杯芳烃的用途 |
| CN119769464B (zh) * | 2025-01-14 | 2026-07-31 | 浙江中医药大学 | Mtx诱导的骨髓抑制大鼠模型适宜给药剂量的确立方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| NZ234479A (en) * | 1989-07-14 | 1992-03-26 | Schering Corp | Antagonists of gm-csf derived from the carboxyl terminus, antibodies, hybridomas and pharmaceutical compositions containing anti-idiotypic antibodies |
| WO1994009149A1 (en) | 1990-08-10 | 1994-04-28 | Amrad Corporation Limited | Monoclonal antibody |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| ES2246502T3 (es) | 1990-08-29 | 2006-02-16 | Genpharm International, Inc. | Animales no humanos transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ATE239041T1 (de) | 1996-02-09 | 2003-05-15 | Basf Ag | Humane antikörper welche an humanen tnfalpha binden |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US7108852B2 (en) * | 2000-03-20 | 2006-09-19 | Warner-Lambert Company Llc | Methods of treating inflammation using antibodies to M-CSF |
| US7455836B2 (en) * | 2000-05-08 | 2008-11-25 | The University Of Melbourne | Method of treatment and agents useful for same |
| ATE444308T1 (de) | 2002-02-13 | 2009-10-15 | Ludwig Inst Cancer Res | Fusionsproteine humanisierter g250-spezifischer antikörper sowie verwendungen davon |
| GB0224082D0 (en) * | 2002-10-16 | 2002-11-27 | Celltech R&D Ltd | Biological products |
| CN102225194B (zh) * | 2003-03-12 | 2014-07-16 | 健泰科生物技术公司 | Bv8和/或EG-VEGF促进造血的用途 |
| NZ545447A (en) * | 2003-07-23 | 2010-03-26 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
| US7981843B2 (en) | 2004-01-20 | 2011-07-19 | Kalobios Pharmaceuticals, Inc. | Antibody specificity transfer using minimal essential binding determinants |
| CN101905023B (zh) * | 2004-07-16 | 2012-07-11 | 杏林制药株式会社 | 有效的医药使用方法及与副作用发生的防御相关的方法 |
| PL2343380T3 (pl) | 2004-11-16 | 2020-03-31 | Humanigen, Inc. | Wymiana kasety dla regionu zmiennego immunoglobuliny |
| ES2918209T3 (es) | 2005-05-18 | 2022-07-14 | Morphosys Ag | Anticuerpos anti-GM-CSF y usos a partir de los mismos |
| US20080305079A1 (en) * | 2006-01-06 | 2008-12-11 | Mount Sinai School Of Medicine Of New York University | Myeloid Suppressor Cells, Methods For Preparing Them, and Methods For Using Them For Treating Autoimmunity |
| KR101395515B1 (ko) * | 2006-02-08 | 2014-05-14 | 모르포테크, 인크. | 항원성 gm-csf 펩티드 및 gm-csf에 대한 항체 |
| KR101481844B1 (ko) * | 2006-03-27 | 2015-01-13 | 메디뮨 리미티드 | Gm-csf 수용체에 대한 결합 성분 |
| DE102006033837A1 (de) * | 2006-07-21 | 2008-01-31 | Medac Gesellschaft für klinische Spezialpräparate m.b.H | Konzentrierte Methotrexat-Lösungen |
| US20080206241A1 (en) | 2006-11-21 | 2008-08-28 | Kalobios Pharmaceuticals Inc. | Methods of Treating Chronic Inflammatory Diseases Using a GM-CSF Antagonist |
-
2007
- 2007-11-21 US US11/944,162 patent/US20080206241A1/en not_active Abandoned
- 2007-11-21 ES ES07868831T patent/ES2432173T3/es active Active
- 2007-11-21 CN CN201510674256.5A patent/CN105435223A/zh active Pending
- 2007-11-21 WO PCT/US2007/085402 patent/WO2008064321A2/en not_active Ceased
- 2007-11-21 KR KR1020097012906A patent/KR101517251B1/ko not_active Expired - Fee Related
- 2007-11-21 BR BRPI0719109-0A2A patent/BRPI0719109A2/pt not_active IP Right Cessation
- 2007-11-21 AU AU2007323541A patent/AU2007323541B2/en not_active Ceased
- 2007-11-21 EP EP07868831.4A patent/EP2101780B1/en not_active Revoked
- 2007-11-21 EP EP11182971A patent/EP2402013A1/en not_active Withdrawn
- 2007-11-21 CA CA2670288A patent/CA2670288C/en not_active Expired - Fee Related
- 2007-11-21 CN CNA2007800495322A patent/CN101605547A/zh active Pending
- 2007-11-21 EA EA200900709A patent/EA200900709A1/ru unknown
- 2007-11-21 JP JP2009538506A patent/JP5410293B2/ja not_active Expired - Fee Related
- 2007-11-21 SG SG2011085834A patent/SG176503A1/en unknown
- 2007-11-21 NZ NZ598345A patent/NZ598345A/xx not_active IP Right Cessation
- 2007-11-21 MX MX2009005398A patent/MX2009005398A/es active IP Right Grant
-
2009
- 2009-05-19 IL IL198829A patent/IL198829A0/en unknown
-
2015
- 2015-05-14 US US14/712,627 patent/US20150246121A1/en not_active Abandoned
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