CN105435223A - 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 - Google Patents

使用gm-csf拮抗剂治疗慢性炎症疾病的方法 Download PDF

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Publication number
CN105435223A
CN105435223A CN201510674256.5A CN201510674256A CN105435223A CN 105435223 A CN105435223 A CN 105435223A CN 201510674256 A CN201510674256 A CN 201510674256A CN 105435223 A CN105435223 A CN 105435223A
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antibody
csf
purposes
patient
methotrexate
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Chinese (zh)
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克里斯托弗·R·贝炳东
杰弗里·T·亚兰东
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Humanigen Inc
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Kalobios Pharmaceuticals Inc
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243Colony Stimulating Factors
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    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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CN201510674256.5A 2006-11-21 2007-11-21 使用gm-csf拮抗剂治疗慢性炎症疾病的方法 Pending CN105435223A (zh)

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US86078006P 2006-11-21 2006-11-21
US60/860,780 2006-11-21
US90274207P 2007-02-21 2007-02-21
US60/902,742 2007-02-21
CNA2007800495322A CN101605547A (zh) 2006-11-21 2007-11-21 使用gm-csf拮抗剂治疗慢性炎症疾病的方法

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CNA2007800495322A Pending CN101605547A (zh) 2006-11-21 2007-11-21 使用gm-csf拮抗剂治疗慢性炎症疾病的方法

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US (2) US20080206241A1 (enExample)
EP (2) EP2101780B1 (enExample)
JP (1) JP5410293B2 (enExample)
KR (1) KR101517251B1 (enExample)
CN (2) CN105435223A (enExample)
AU (1) AU2007323541B2 (enExample)
BR (1) BRPI0719109A2 (enExample)
CA (1) CA2670288C (enExample)
EA (1) EA200900709A1 (enExample)
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KR20210021153A (ko) * 2012-09-20 2021-02-24 모르포시스 아게 류마티스 관절염에 대한 치료
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US10899831B2 (en) 2017-10-02 2021-01-26 Humanigen, Inc. Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity
US11673962B2 (en) 2017-10-02 2023-06-13 Humanigen, Inc. Method of increasing the efficacy of CAR-T immunotherapy using lenzilumab
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