JP2010507580A5 - - Google Patents
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- Publication number
- JP2010507580A5 JP2010507580A5 JP2009533551A JP2009533551A JP2010507580A5 JP 2010507580 A5 JP2010507580 A5 JP 2010507580A5 JP 2009533551 A JP2009533551 A JP 2009533551A JP 2009533551 A JP2009533551 A JP 2009533551A JP 2010507580 A5 JP2010507580 A5 JP 2010507580A5
- Authority
- JP
- Japan
- Prior art keywords
- dops
- long chain
- dppc
- composition
- prosaposin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 23
- 238000000034 method Methods 0.000 claims 20
- 150000003904 phospholipids Chemical class 0.000 claims 20
- WTBFLCSPLLEDEM-JIDRGYQWSA-N 1,2-dioleoyl-sn-glycero-3-phospho-L-serine Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC WTBFLCSPLLEDEM-JIDRGYQWSA-N 0.000 claims 16
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 12
- 150000002632 lipids Chemical class 0.000 claims 12
- 102100036197 Prosaposin Human genes 0.000 claims 9
- 101710152403 Prosaposin Proteins 0.000 claims 9
- 125000000129 anionic group Chemical group 0.000 claims 8
- 102100031242 Deoxyhypusine synthase Human genes 0.000 claims 6
- 101000844963 Homo sapiens Deoxyhypusine synthase Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000017852 Saposin Human genes 0.000 claims 5
- 108050007079 Saposin Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- DSNRWDQKZIEDDB-GCMPNPAFSA-N [(2r)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(z)-octadec-9-enoyl]oxypropyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC DSNRWDQKZIEDDB-GCMPNPAFSA-N 0.000 claims 4
- 239000002356 single layer Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 239000002691 unilamellar liposome Substances 0.000 claims 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 230000002902 bimodal effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86231206P | 2006-10-20 | 2006-10-20 | |
| US60/862,312 | 2006-10-20 | ||
| PCT/US2007/081880 WO2008051818A2 (en) | 2006-10-20 | 2007-10-19 | Spontaneously forming ellipsoidal phospholipid unilamellar vesicles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010507580A JP2010507580A (ja) | 2010-03-11 |
| JP2010507580A5 true JP2010507580A5 (enExample) | 2010-12-02 |
| JP5253402B2 JP5253402B2 (ja) | 2013-07-31 |
Family
ID=39325270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533551A Expired - Fee Related JP5253402B2 (ja) | 2006-10-20 | 2007-10-19 | 自発的に形成する楕円体の単層リン脂質小胞 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100311844A1 (enExample) |
| EP (1) | EP2081552A2 (enExample) |
| JP (1) | JP5253402B2 (enExample) |
| CN (1) | CN101541307A (enExample) |
| BR (1) | BRPI0717475A2 (enExample) |
| CA (1) | CA2666953A1 (enExample) |
| WO (1) | WO2008051818A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834147B2 (en) | 2003-04-28 | 2010-11-16 | Childrens Hospital Medical Center | Saposin C-DOPS: a novel anti-tumor agent |
| JP5437790B2 (ja) * | 2006-04-28 | 2014-03-12 | チルドレンズ ホスピタル メディカル センター | 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物 |
| WO2010053489A1 (en) * | 2008-11-07 | 2010-05-14 | Children's Hospital Medical Center | Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems |
| CN102614125B (zh) * | 2011-02-01 | 2018-11-02 | 常州长吉生物技术开发有限公司 | SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途 |
| EP2745834B1 (en) * | 2012-12-18 | 2016-09-28 | Jens Frauenfeld | Salipro particles |
| PL3043814T3 (pl) | 2013-09-13 | 2021-05-17 | Salipro Biotech AB | Antygen i sposób jego wytwarzania |
| CN114642720A (zh) | 2018-03-23 | 2022-06-21 | 百祥制药公司 | 皂化蛋白c药物组合物和治疗癌症的方法 |
| WO2021202826A1 (en) * | 2020-04-01 | 2021-10-07 | University Of Cincinnati | Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy |
| US11833254B2 (en) * | 2020-05-27 | 2023-12-05 | University Of Connecticut | Discoidal nano universal platform for efficient delivery of PNAs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4921706A (en) * | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
| US6433040B1 (en) * | 1997-09-29 | 2002-08-13 | Inhale Therapeutic Systems, Inc. | Stabilized bioactive preparations and methods of use |
| AU751034B2 (en) * | 1998-08-28 | 2002-08-08 | Myelos Corporation | Cyclic prosaposin-derived peptides and uses thereof |
| US6872406B2 (en) * | 2000-02-11 | 2005-03-29 | Children's Hospital Research Foundation | Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems |
| US7834147B2 (en) * | 2003-04-28 | 2010-11-16 | Childrens Hospital Medical Center | Saposin C-DOPS: a novel anti-tumor agent |
| JP5437790B2 (ja) * | 2006-04-28 | 2014-03-12 | チルドレンズ ホスピタル メディカル センター | 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物 |
| WO2010053489A1 (en) * | 2008-11-07 | 2010-05-14 | Children's Hospital Medical Center | Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems |
-
2007
- 2007-10-19 BR BRPI0717475-6A patent/BRPI0717475A2/pt not_active IP Right Cessation
- 2007-10-19 CA CA002666953A patent/CA2666953A1/en not_active Abandoned
- 2007-10-19 EP EP07854199A patent/EP2081552A2/en not_active Withdrawn
- 2007-10-19 US US12/445,707 patent/US20100311844A1/en not_active Abandoned
- 2007-10-19 WO PCT/US2007/081880 patent/WO2008051818A2/en not_active Ceased
- 2007-10-19 JP JP2009533551A patent/JP5253402B2/ja not_active Expired - Fee Related
- 2007-10-19 CN CNA2007800438762A patent/CN101541307A/zh active Pending
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