CN101541307A - 自发形成的椭圆体磷脂单层囊泡 - Google Patents

自发形成的椭圆体磷脂单层囊泡 Download PDF

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Publication number
CN101541307A
CN101541307A CNA2007800438762A CN200780043876A CN101541307A CN 101541307 A CN101541307 A CN 101541307A CN A2007800438762 A CNA2007800438762 A CN A2007800438762A CN 200780043876 A CN200780043876 A CN 200780043876A CN 101541307 A CN101541307 A CN 101541307A
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CN
China
Prior art keywords
chain
lipid
dops
liposome
dppc
Prior art date
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Pending
Application number
CNA2007800438762A
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English (en)
Chinese (zh)
Inventor
X·齐
J·凯特萨拉斯
M-P·纽
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Cincinnati Children's Hospital Medical Center
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Cincinnati Children's Hospital Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Children's Hospital Medical Center filed Critical Cincinnati Children's Hospital Medical Center
Publication of CN101541307A publication Critical patent/CN101541307A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800438762A 2006-10-20 2007-10-19 自发形成的椭圆体磷脂单层囊泡 Pending CN101541307A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86231206P 2006-10-20 2006-10-20
US60/862,312 2006-10-20

Publications (1)

Publication Number Publication Date
CN101541307A true CN101541307A (zh) 2009-09-23

Family

ID=39325270

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800438762A Pending CN101541307A (zh) 2006-10-20 2007-10-19 自发形成的椭圆体磷脂单层囊泡

Country Status (7)

Country Link
US (1) US20100311844A1 (enExample)
EP (1) EP2081552A2 (enExample)
JP (1) JP5253402B2 (enExample)
CN (1) CN101541307A (enExample)
BR (1) BRPI0717475A2 (enExample)
CA (1) CA2666953A1 (enExample)
WO (1) WO2008051818A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614125A (zh) * 2011-02-01 2012-08-01 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN105188672B (zh) * 2012-12-18 2017-07-25 塞利普洛生物技术有限责任公司 Salipro颗粒
US10682411B2 (en) 2018-03-23 2020-06-16 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7834147B2 (en) 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
CN101583346B (zh) * 2006-04-28 2015-08-19 儿童医院医疗中心 用于穿膜药物递送系统的皂化蛋白c和相关蛋白及肽的促融合性质
AU2008363813A1 (en) * 2008-11-07 2010-05-14 Children's Hospital Medical Center Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems
LT3043814T (lt) 2013-09-13 2021-02-25 Salipro Biotech AB Antigenas ir jo gamybos būdas
EP4125816A4 (en) * 2020-04-01 2024-01-10 University of Cincinnati MATERIALS AND METHODS FOR CANCER THERAPY TARGETING AN IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT
US11833254B2 (en) * 2020-05-27 2023-12-05 University Of Connecticut Discoidal nano universal platform for efficient delivery of PNAs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
WO2000012553A1 (en) * 1998-08-28 2000-03-09 Myelos Corporation Cyclic prosaposin-derived peptides and uses thereof
US6872406B2 (en) * 2000-02-11 2005-03-29 Children's Hospital Research Foundation Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
CN101583346B (zh) * 2006-04-28 2015-08-19 儿童医院医疗中心 用于穿膜药物递送系统的皂化蛋白c和相关蛋白及肽的促融合性质
AU2008363813A1 (en) * 2008-11-07 2010-05-14 Children's Hospital Medical Center Fusogenic properties of saposin C and related proteins and peptides for application to transmembrane drug delivery systems

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614125A (zh) * 2011-02-01 2012-08-01 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN102614125B (zh) * 2011-02-01 2018-11-02 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN108926535A (zh) * 2011-02-01 2018-12-04 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN108926535B (zh) * 2011-02-01 2020-12-29 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、 其制备方法及用途
CN105188672B (zh) * 2012-12-18 2017-07-25 塞利普洛生物技术有限责任公司 Salipro颗粒
US10682411B2 (en) 2018-03-23 2020-06-16 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer
US11590227B2 (en) 2018-03-23 2023-02-28 Bexion Pharmaceuticals, Inc. Saposin C pharmaceutical compositions and methods of treating cancer
US12194099B2 (en) 2018-03-23 2025-01-14 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer

Also Published As

Publication number Publication date
BRPI0717475A2 (pt) 2014-03-11
EP2081552A2 (en) 2009-07-29
JP5253402B2 (ja) 2013-07-31
JP2010507580A (ja) 2010-03-11
US20100311844A1 (en) 2010-12-09
WO2008051818A3 (en) 2008-12-24
CA2666953A1 (en) 2008-05-02
WO2008051818A2 (en) 2008-05-02
WO2008051818A8 (en) 2009-08-06

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Application publication date: 20090923