CN101541307A - 自发形成的椭圆体磷脂单层囊泡 - Google Patents

自发形成的椭圆体磷脂单层囊泡 Download PDF

Info

Publication number
CN101541307A
CN101541307A CNA2007800438762A CN200780043876A CN101541307A CN 101541307 A CN101541307 A CN 101541307A CN A2007800438762 A CNA2007800438762 A CN A2007800438762A CN 200780043876 A CN200780043876 A CN 200780043876A CN 101541307 A CN101541307 A CN 101541307A
Authority
CN
China
Prior art keywords
chain
lipid
dops
liposome
dppc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800438762A
Other languages
English (en)
Chinese (zh)
Inventor
X·齐
J·凯特萨拉斯
M-P·纽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cincinnati Childrens Hospital Medical Center
Original Assignee
Cincinnati Childrens Hospital Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cincinnati Childrens Hospital Medical Center filed Critical Cincinnati Childrens Hospital Medical Center
Publication of CN101541307A publication Critical patent/CN101541307A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800438762A 2006-10-20 2007-10-19 自发形成的椭圆体磷脂单层囊泡 Pending CN101541307A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86231206P 2006-10-20 2006-10-20
US60/862,312 2006-10-20

Publications (1)

Publication Number Publication Date
CN101541307A true CN101541307A (zh) 2009-09-23

Family

ID=39325270

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800438762A Pending CN101541307A (zh) 2006-10-20 2007-10-19 自发形成的椭圆体磷脂单层囊泡

Country Status (7)

Country Link
US (1) US20100311844A1 (enExample)
EP (1) EP2081552A2 (enExample)
JP (1) JP5253402B2 (enExample)
CN (1) CN101541307A (enExample)
BR (1) BRPI0717475A2 (enExample)
CA (1) CA2666953A1 (enExample)
WO (1) WO2008051818A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614125A (zh) * 2011-02-01 2012-08-01 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN105188672B (zh) * 2012-12-18 2017-07-25 塞利普洛生物技术有限责任公司 Salipro颗粒
US10682411B2 (en) 2018-03-23 2020-06-16 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7834147B2 (en) 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
JP5437790B2 (ja) * 2006-04-28 2014-03-12 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
WO2010053489A1 (en) * 2008-11-07 2010-05-14 Children's Hospital Medical Center Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems
PL3043814T3 (pl) 2013-09-13 2021-05-17 Salipro Biotech AB Antygen i sposób jego wytwarzania
WO2021202826A1 (en) * 2020-04-01 2021-10-07 University Of Cincinnati Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy
US11833254B2 (en) * 2020-05-27 2023-12-05 University Of Connecticut Discoidal nano universal platform for efficient delivery of PNAs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
AU751034B2 (en) * 1998-08-28 2002-08-08 Myelos Corporation Cyclic prosaposin-derived peptides and uses thereof
US6872406B2 (en) * 2000-02-11 2005-03-29 Children's Hospital Research Foundation Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
JP5437790B2 (ja) * 2006-04-28 2014-03-12 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
WO2010053489A1 (en) * 2008-11-07 2010-05-14 Children's Hospital Medical Center Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102614125A (zh) * 2011-02-01 2012-08-01 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN102614125B (zh) * 2011-02-01 2018-11-02 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN108926535A (zh) * 2011-02-01 2018-12-04 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
CN108926535B (zh) * 2011-02-01 2020-12-29 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、 其制备方法及用途
CN105188672B (zh) * 2012-12-18 2017-07-25 塞利普洛生物技术有限责任公司 Salipro颗粒
US10682411B2 (en) 2018-03-23 2020-06-16 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer
US11590227B2 (en) 2018-03-23 2023-02-28 Bexion Pharmaceuticals, Inc. Saposin C pharmaceutical compositions and methods of treating cancer
US12194099B2 (en) 2018-03-23 2025-01-14 Bexion Pharmaceuticals Inc. Saposin C pharmaceutical compositions and methods of treating cancer

Also Published As

Publication number Publication date
BRPI0717475A2 (pt) 2014-03-11
JP2010507580A (ja) 2010-03-11
CA2666953A1 (en) 2008-05-02
WO2008051818A3 (en) 2008-12-24
US20100311844A1 (en) 2010-12-09
WO2008051818A8 (en) 2009-08-06
WO2008051818A2 (en) 2008-05-02
EP2081552A2 (en) 2009-07-29
JP5253402B2 (ja) 2013-07-31

Similar Documents

Publication Publication Date Title
CN101541307A (zh) 自发形成的椭圆体磷脂单层囊泡
EP1713446B1 (en) Ternary non-lamellar lipid compositions
JP5513713B2 (ja) 非層状分散を生じる組成物
CN1096850C (zh) 活性药剂控制释放的多泡脂质体的制备
Boomer et al. Acid-triggered release from sterically stabilized fusogenic liposomes via a hydrolytic dePEGylation strategy
CN101583346B (zh) 用于穿膜药物递送系统的皂化蛋白c和相关蛋白及肽的促融合性质
JP2002507966A (ja) 薬学的組成物の調製
EP2687204B1 (en) Vector for pulmonary delivery, inducing agent, and uses
JP7621657B2 (ja) リポソームの製造方法
CN109077994A (zh) 小分子水凝胶-纳米粒复合药物载体及其在皮肤/粘膜给药系统中的应用
Shanmugam et al. Nanostructured self assembled lipid materials for drug delivery and tissue engineering
Gopi et al. Liposomal nanostructures: Properties and applications
CN107735170A (zh) 聚合物‑脂质共混物形成的管状和囊泡结构及其形成方法
Bangale et al. Stealth liposomes: a novel approach of targeted drug delivery in cancer therapy
Sawant et al. Liposome: A novel drug delivery system
Wasankar et al. Liposome as a drug delivery system-a review
JP2011508780A (ja) 抗真菌薬の増強された送達
Liu et al. Micelle morphology phase diagram in a phospholipid, PEGylated lipid, and peptide amphiphiles ternary system
Rajendiran et al. Advances in Liposome Technology: An Intensive Review of Formulation, Therapeutic Applications, and Challenges
JP3908776B2 (ja) 細胞への遺伝子導入用組成物
ES2356920T3 (es) Composiciones lipídicas ternarias no laminares.
Tipugade et al. Insights of Nanocochleates in Conventional Drug Delivery System.
CN111787908A (zh) 用于生产脂质载体的方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20090923