JP5253402B2 - 自発的に形成する楕円体の単層リン脂質小胞 - Google Patents

自発的に形成する楕円体の単層リン脂質小胞 Download PDF

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Publication number
JP5253402B2
JP5253402B2 JP2009533551A JP2009533551A JP5253402B2 JP 5253402 B2 JP5253402 B2 JP 5253402B2 JP 2009533551 A JP2009533551 A JP 2009533551A JP 2009533551 A JP2009533551 A JP 2009533551A JP 5253402 B2 JP5253402 B2 JP 5253402B2
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Japan
Prior art keywords
dops
composition
long chain
dppc
phospholipid
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Expired - Fee Related
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JP2009533551A
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Japanese (ja)
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JP2010507580A5 (enExample
JP2010507580A (ja
Inventor
チ，シャオヤン
カートサラス，ジョン
ニー，ム−ピン
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Cincinnati Childrens Hospital Medical Center
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Cincinnati Childrens Hospital Medical Center
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009533551A 2006-10-20 2007-10-19 自発的に形成する楕円体の単層リン脂質小胞 Expired - Fee Related JP5253402B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86231206P 2006-10-20 2006-10-20
US60/862,312 2006-10-20
PCT/US2007/081880 WO2008051818A2 (en) 2006-10-20 2007-10-19 Spontaneously forming ellipsoidal phospholipid unilamellar vesicles

Publications (3)

Publication Number Publication Date
JP2010507580A JP2010507580A (ja) 2010-03-11
JP2010507580A5 JP2010507580A5 (enExample) 2010-12-02
JP5253402B2 true JP5253402B2 (ja) 2013-07-31

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ID=39325270

Family Applications (1)

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JP2009533551A Expired - Fee Related JP5253402B2 (ja) 2006-10-20 2007-10-19 自発的に形成する楕円体の単層リン脂質小胞

Country Status (7)

Country Link
US (1) US20100311844A1 (enExample)
EP (1) EP2081552A2 (enExample)
JP (1) JP5253402B2 (enExample)
CN (1) CN101541307A (enExample)
BR (1) BRPI0717475A2 (enExample)
CA (1) CA2666953A1 (enExample)
WO (1) WO2008051818A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7834147B2 (en) 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
JP5437790B2 (ja) * 2006-04-28 2014-03-12 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
WO2010053489A1 (en) * 2008-11-07 2010-05-14 Children's Hospital Medical Center Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems
CN102614125B (zh) * 2011-02-01 2018-11-02 常州长吉生物技术开发有限公司 SapC-磷脂纳米囊泡冻干制剂、其制备方法及用途
EP2745834B1 (en) * 2012-12-18 2016-09-28 Jens Frauenfeld Salipro particles
PL3043814T3 (pl) 2013-09-13 2021-05-17 Salipro Biotech AB Antygen i sposób jego wytwarzania
CN114642720A (zh) 2018-03-23 2022-06-21 百祥制药公司 皂化蛋白c药物组合物和治疗癌症的方法
WO2021202826A1 (en) * 2020-04-01 2021-10-07 University Of Cincinnati Materials and methods for immunosuppressive tumor microenvironment-targeted cancer therapy
US11833254B2 (en) * 2020-05-27 2023-12-05 University Of Connecticut Discoidal nano universal platform for efficient delivery of PNAs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US6433040B1 (en) * 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
AU751034B2 (en) * 1998-08-28 2002-08-08 Myelos Corporation Cyclic prosaposin-derived peptides and uses thereof
US6872406B2 (en) * 2000-02-11 2005-03-29 Children's Hospital Research Foundation Fusogenic properties of saposin C and related proteins and polypeptides for application to transmembrane drug delivery systems
US7834147B2 (en) * 2003-04-28 2010-11-16 Childrens Hospital Medical Center Saposin C-DOPS: a novel anti-tumor agent
JP5437790B2 (ja) * 2006-04-28 2014-03-12 チルドレンズ ホスピタル メディカル センター 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
WO2010053489A1 (en) * 2008-11-07 2010-05-14 Children's Hospital Medical Center Fusogenic properties of saposin c and related proteins and peptides for application to transmembrane drug delivery systems

Also Published As

Publication number Publication date
CN101541307A (zh) 2009-09-23
BRPI0717475A2 (pt) 2014-03-11
JP2010507580A (ja) 2010-03-11
CA2666953A1 (en) 2008-05-02
WO2008051818A3 (en) 2008-12-24
US20100311844A1 (en) 2010-12-09
WO2008051818A8 (en) 2009-08-06
WO2008051818A2 (en) 2008-05-02
EP2081552A2 (en) 2009-07-29

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