JPWO2020069445A5 - - Google Patents
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- Publication number
- JPWO2020069445A5 JPWO2020069445A5 JP2021517802A JP2021517802A JPWO2020069445A5 JP WO2020069445 A5 JPWO2020069445 A5 JP WO2020069445A5 JP 2021517802 A JP2021517802 A JP 2021517802A JP 2021517802 A JP2021517802 A JP 2021517802A JP WO2020069445 A5 JPWO2020069445 A5 JP WO2020069445A5
- Authority
- JP
- Japan
- Prior art keywords
- glycero
- composition
- phosphocholine
- composition according
- phosphoethanolamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738717P | 2018-09-28 | 2018-09-28 | |
| US62/738,717 | 2018-09-28 | ||
| US201962885036P | 2019-08-09 | 2019-08-09 | |
| US62/885,036 | 2019-08-09 | ||
| PCT/US2019/053661 WO2020069445A1 (en) | 2018-09-28 | 2019-09-27 | Lipid nanoparticle formulations comprising lipidated cationic peptide compounds for nucleic acid delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022502451A JP2022502451A (ja) | 2022-01-11 |
| JPWO2020069445A5 true JPWO2020069445A5 (enExample) | 2022-10-05 |
| JP7430713B2 JP7430713B2 (ja) | 2024-02-13 |
Family
ID=69952323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517802A Active JP7430713B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための脂質化カチオン性ペプチド化合物を含む脂質ナノ粒子製剤 |
| JP2021517865A Active JP7418419B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021517865A Active JP7418419B2 (ja) | 2018-09-28 | 2019-09-27 | 核酸送達のための第三級アミノ脂質化カチオン性ペプチド |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US20210324002A1 (enExample) |
| EP (2) | EP3856757A4 (enExample) |
| JP (2) | JP7430713B2 (enExample) |
| KR (2) | KR20210068093A (enExample) |
| CN (2) | CN112805294A (enExample) |
| AU (2) | AU2019347774A1 (enExample) |
| BR (2) | BR112021005815A2 (enExample) |
| CA (2) | CA3110914A1 (enExample) |
| IL (2) | IL281135B2 (enExample) |
| MX (2) | MX2021003421A (enExample) |
| MY (1) | MY204458A (enExample) |
| SG (2) | SG11202102164PA (enExample) |
| WO (2) | WO2020069445A1 (enExample) |
| ZA (2) | ZA202101376B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021003421A (es) * | 2018-09-28 | 2021-06-15 | Nutcracker Therapeutics Inc | Formulaciones de nanoparticulas lipidicas que comprenden compuestos peptidicos cationicos lipidados para el suministro de acidos nucleicos. |
| US20220323594A1 (en) * | 2019-08-09 | 2022-10-13 | Nutcracker Therapeutics, Inc. | Lipidated cationic peptide-peg compositions for nucleic acid delivery |
| AU2021259571A1 (en) * | 2020-04-22 | 2022-10-27 | Nutcracker Therapeutics, Inc. | mRNA treatment nanoparticles |
| WO2022032058A1 (en) | 2020-08-07 | 2022-02-10 | Nutcracker Therapeutics, Inc. | Multicomponent delivery systems for polyanionic cargo compound delivery |
| NL2026825B1 (en) | 2020-08-07 | 2022-04-05 | Nutcracker Therapeutics Inc | Multicomponent delivery system for polyanionic cargo compound delivery |
| JP2023552555A (ja) * | 2020-12-07 | 2023-12-18 | トラスティーズ オブ タフツ カレッジ | リピドイド組成物およびその使用方法 |
| WO2022235923A2 (en) * | 2021-05-05 | 2022-11-10 | Arcturus Therapeutics, Inc. | Peptide-lipid conjugates |
| NL2029057B1 (en) | 2021-08-06 | 2023-02-21 | Nutcracker Therapeutics Inc | Compositions comprising hydroxyethyl-capped cationic peptoids |
| AU2022323376A1 (en) | 2021-08-06 | 2024-02-22 | Nutcracker Therapeutics, Inc. | Compositions comprising hydroxyethyl-capped cationic peptoids |
| CN114778712B (zh) * | 2022-03-21 | 2023-06-02 | 天津键凯科技有限公司 | 一种聚乙二醇脂质及含有该脂质的脂质纳米粒含量的检测方法 |
| JP2025531758A (ja) | 2022-09-09 | 2025-09-25 | ナッツクラッカー セラピューティクス， インコーポレイテッド | 核酸送達のための２－アミノプロパン－１，３－ジオールでキャップされたカチオン性ペプトイド |
| WO2025006851A1 (en) | 2023-06-29 | 2025-01-02 | Nutcracker Therapeutics, Inc. | Ethyl modified rna caps and methods of use |
| WO2025053636A1 (ko) * | 2023-09-05 | 2025-03-13 | 한국생명공학연구원 | 지질 나노 입자를 이용한 핵산 전달 시스템 |
| WO2025137277A1 (en) | 2023-12-19 | 2025-06-26 | Nutcracker Therapeutics, Inc. | Degradable peptoids |
| US20250381150A1 (en) | 2024-03-08 | 2025-12-18 | Genzyme Corporation | Lipid nanoparticles |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026030375A2 (en) | 2024-07-30 | 2026-02-05 | Genzyme Corporation | Lipid nanoparticles and methods of manufacture and use thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
| US7422902B1 (en) | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| WO1998051278A2 (en) | 1997-05-14 | 1998-11-19 | Inex Pharmaceuticals Corporation | High efficiency encapsulation of charged therapeutic agents in lipid vesicles |
| US6191115B1 (en) * | 1998-08-12 | 2001-02-20 | Abbott Laboratories | C-terminus modified heptapeptide LHRH analogs |
| EP1144609B1 (en) | 1999-08-27 | 2008-03-05 | Novartis Vaccines and Diagnostics, Inc. | Chimeric antisense oligonucleotides and cell transfecting formulations thereof |
| WO2002088318A2 (en) * | 2001-04-30 | 2002-11-07 | Targeted Genetics Corporation | Lipid-comprising drug delivery complexes and methods for their production |
| DE60334618D1 (de) | 2002-06-28 | 2010-12-02 | Protiva Biotherapeutics Inc | Verfahren und vorrichtung zur herstellung von liposomen |
| CN101291653B (zh) * | 2003-07-16 | 2012-06-27 | 普洛体维生物治疗公司 | 脂质包封的干扰rna |
| CN1906308B (zh) * | 2003-12-19 | 2011-09-14 | 诺华疫苗和诊断公司 | 小干扰rna的细胞转染制剂、相关组合物以及制备和使用方法 |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
| EP2155351B1 (en) | 2007-06-04 | 2021-02-17 | Pressure Biosciences, Inc. | Pressure-enhanced extraction and partitioning of molecules |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| WO2009132131A1 (en) * | 2008-04-22 | 2009-10-29 | Alnylam Pharmaceuticals, Inc. | Amino lipid based improved lipid formulation |
| DK2355851T3 (en) | 2008-11-10 | 2018-06-25 | Arbutus Biopharma Corp | Newly known lipids and compositions for release of therapeutic agents |
| US20110305769A1 (en) * | 2008-11-17 | 2011-12-15 | Enzon Pharmaceuticals, Inc. | Branched cationic lipids for nucleic acids delivery system |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| US20110053829A1 (en) * | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| EP2496700B1 (en) | 2009-11-04 | 2017-03-01 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| ME03091B (me) | 2009-12-01 | 2019-01-20 | Translate Bio Inc | Isporuka irnk za povećanje ekspresije proteina i enzima u humanim genetskim oboljenjima |
| DK2575767T3 (en) | 2010-06-04 | 2017-03-13 | Sirna Therapeutics Inc | HOWEVER UNKNOWN LOW MOLECULAR CATIONIC LIPIDS TO PROCESS OIGONUCLEOTIDES |
| US9006417B2 (en) | 2010-06-30 | 2015-04-14 | Protiva Biotherapeutics, Inc. | Non-liposomal systems for nucleic acid delivery |
| WO2012053741A2 (ko) | 2010-10-22 | 2012-04-26 | 성균관대학교산학협력단 | Rna 간섭을 유도하는 핵산 분자 및 그 용도 |
| CA2832073A1 (en) * | 2011-04-12 | 2012-10-18 | Terrence R. Burke | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| US9579338B2 (en) | 2011-11-04 | 2017-02-28 | Nitto Denko Corporation | Method of producing lipid nanoparticles for drug delivery |
| US9035039B2 (en) | 2011-12-22 | 2015-05-19 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing SMAD4 |
| US9446132B2 (en) | 2012-03-27 | 2016-09-20 | Sima Therapeutics, Inc. | Diether based biodegradable cationic lipids for siRNA delivery |
| WO2013151326A1 (en) | 2012-04-04 | 2013-10-10 | Samyang Biopharmaceuticals Corporation | Method of preparing composition for delivering an anionic drug |
| BR112014030677A2 (pt) | 2012-06-08 | 2022-07-19 | Shire Human Genetic Therapies | distribuição pulmonar de mrna para células-alvo não-pulmonares |
| US20150182461A1 (en) | 2012-06-19 | 2015-07-02 | Massachussets Institute Of Technology | Mass Production and Size Control of Nanoparticles Through Controlled Microvortices |
| TW201726599A (zh) | 2012-07-06 | 2017-08-01 | 協和醱酵麒麟有限公司 | 陽離子性脂質 |
| AU2013355258A1 (en) | 2012-12-07 | 2015-06-11 | Alnylam Pharmaceuticals, Inc. | Improved nucleic acid lipid particle formulations |
| KR20150127582A (ko) | 2013-03-14 | 2015-11-17 | 샤이어 휴먼 지네틱 테라피즈 인크. | 4''-티오 개질된 뉴클레오티드를 갖는 리보핵산 및 관련 방법 |
| SG11201510747RA (en) | 2013-08-21 | 2016-03-30 | Curevac Ag | Method for increasing expression of rna-encoded proteins |
| RU2021109685A (ru) | 2014-04-23 | 2021-04-13 | МОДЕРНАТиЭкс, ИНК. | Вакцины на основе нуклеиновых кислот |
| CA2951707A1 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| ES2555160B1 (es) | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| ES2747842T3 (es) | 2014-12-15 | 2020-03-11 | Dicerna Pharmaceuticals Inc | Acidos nucleicos de doble hebra modificados por ligando |
| IL288342B2 (en) | 2015-07-22 | 2024-02-01 | Nitto Denko Corp | Compositions and methods for nanoparticle lyophile forms |
| MA47016A (fr) | 2015-10-22 | 2018-08-29 | Modernatx Inc | Vaccins contre les virus respiratoires |
| WO2017100154A1 (en) * | 2015-12-07 | 2017-06-15 | Purdue Research Foundation | Inhibitors for proliferating cell nuclear antigen and uses |
| CN108367022A (zh) | 2015-12-13 | 2018-08-03 | 日东电工株式会社 | 具有高活性和降低脱靶的sirna结构 |
| US20210284998A1 (en) * | 2016-10-03 | 2021-09-16 | Precision Nanosystems Inc. | Compositions for Transfecting Resistant Cell Types |
| CN110114058B (zh) | 2016-11-10 | 2023-05-26 | 川斯勒佰尔公司 | 用于递送mrna的改进的基于ice的脂质纳米颗粒制剂 |
| WO2018107061A1 (en) | 2016-12-09 | 2018-06-14 | Board Of Regents, The University Of Texas System | Hybrid exosomal-polymeric (hexpo) nano-platform for delivery of rnai therapeutics |
| CN110799647A (zh) | 2017-06-23 | 2020-02-14 | 马萨诸塞大学 | 双尾自递送sirna及相关的方法 |
| MX2021003421A (es) * | 2018-09-28 | 2021-06-15 | Nutcracker Therapeutics Inc | Formulaciones de nanoparticulas lipidicas que comprenden compuestos peptidicos cationicos lipidados para el suministro de acidos nucleicos. |
-
2019
- 2019-09-27 MX MX2021003421A patent/MX2021003421A/es unknown
- 2019-09-27 JP JP2021517802A patent/JP7430713B2/ja active Active
- 2019-09-27 KR KR1020217012769A patent/KR20210068093A/ko not_active Ceased
- 2019-09-27 CA CA3110914A patent/CA3110914A1/en active Pending
- 2019-09-27 KR KR1020217012768A patent/KR20210068092A/ko not_active Ceased
- 2019-09-27 EP EP19866196.9A patent/EP3856757A4/en active Pending
- 2019-09-27 AU AU2019347774A patent/AU2019347774A1/en not_active Abandoned
- 2019-09-27 CN CN201980062070.0A patent/CN112805294A/zh active Pending
- 2019-09-27 US US17/279,508 patent/US20210324002A1/en not_active Abandoned
- 2019-09-27 SG SG11202102164PA patent/SG11202102164PA/en unknown
- 2019-09-27 BR BR112021005815-0A patent/BR112021005815A2/pt not_active IP Right Cessation
- 2019-09-27 EP EP19864088.0A patent/EP3856146A4/en not_active Withdrawn
- 2019-09-27 BR BR112021004929-0A patent/BR112021004929A2/pt not_active IP Right Cessation
- 2019-09-27 SG SG11202102163SA patent/SG11202102163SA/en unknown
- 2019-09-27 WO PCT/US2019/053661 patent/WO2020069445A1/en not_active Ceased
- 2019-09-27 US US17/279,460 patent/US20210322575A1/en not_active Abandoned
- 2019-09-27 CN CN201980062278.2A patent/CN112789031B/zh not_active Expired - Fee Related
- 2019-09-27 JP JP2021517865A patent/JP7418419B2/ja active Active
- 2019-09-27 WO PCT/US2019/053655 patent/WO2020069442A1/en not_active Ceased
- 2019-09-27 MY MYPI2021001653A patent/MY204458A/en unknown
- 2019-09-27 AU AU2019351268A patent/AU2019351268A1/en not_active Abandoned
- 2019-09-27 MX MX2021003420A patent/MX2021003420A/es unknown
- 2019-09-27 IL IL281135A patent/IL281135B2/en unknown
- 2019-09-27 CA CA3111476A patent/CA3111476A1/en active Pending
-
2021
- 2021-02-26 ZA ZA2021/01376A patent/ZA202101376B/en unknown
- 2021-03-03 ZA ZA2021/01465A patent/ZA202101465B/en unknown
- 2021-03-19 IL IL281653A patent/IL281653A/en unknown
- 2021-06-14 US US17/347,539 patent/US11446394B2/en active Active
- 2021-06-14 US US17/347,498 patent/US11701434B2/en active Active
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