JP2017536092A5 - - Google Patents
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- JP2017536092A5 JP2017536092A5 JP2017517791A JP2017517791A JP2017536092A5 JP 2017536092 A5 JP2017536092 A5 JP 2017536092A5 JP 2017517791 A JP2017517791 A JP 2017517791A JP 2017517791 A JP2017517791 A JP 2017517791A JP 2017536092 A5 JP2017536092 A5 JP 2017536092A5
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- Prior art keywords
- seq
- hepatitis
- nucleic acid
- composition
- lipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002245 particle Substances 0.000 claims description 116
- 239000000203 mixture Substances 0.000 claims description 90
- 241000700721 Hepatitis B virus Species 0.000 claims description 48
- 241000124008 Mammalia Species 0.000 claims description 42
- 239000008194 pharmaceutical composition Substances 0.000 claims description 40
- 108020004459 Small interfering RNA Proteins 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 34
- 208000029570 hepatitis D virus infection Diseases 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 32
- 208000002672 hepatitis B Diseases 0.000 claims description 32
- 230000014509 gene expression Effects 0.000 claims description 26
- 108090000623 proteins and genes Proteins 0.000 claims description 26
- 150000002632 lipids Chemical class 0.000 claims description 21
- 230000030279 gene silencing Effects 0.000 claims description 17
- 208000024891 symptom Diseases 0.000 claims description 17
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 16
- 150000003904 phospholipids Chemical class 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- -1 cationic lipid Chemical class 0.000 claims description 12
- 208000037262 Hepatitis delta Diseases 0.000 claims description 11
- 241000724709 Hepatitis delta virus Species 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical class 0.000 claims description 10
- 102000039446 nucleic acids Human genes 0.000 claims description 10
- 235000012000 cholesterol Nutrition 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 208000019423 liver disease Diseases 0.000 claims description 8
- 230000009885 systemic effect Effects 0.000 claims description 8
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 6
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims description 6
- 238000004220 aggregation Methods 0.000 claims description 6
- 230000002776 aggregation Effects 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000003786 synthesis reaction Methods 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 3
- 208000006454 hepatitis Diseases 0.000 claims description 3
- 231100000283 hepatitis Toxicity 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- 230000010076 replication Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 2
- ARJCMRWHZPDQJG-ASSJVFBPSA-N [(6z,16z)-12-[(z)-dec-4-enyl]docosa-6,16-dien-11-yl] 5-(dimethylamino)pentanoate Chemical compound CCCCC\C=C/CCCC(CCC\C=C/CCCCC)C(CCC\C=C/CCCCC)OC(=O)CCCCN(C)C ARJCMRWHZPDQJG-ASSJVFBPSA-N 0.000 claims description 2
- 229940106189 ceramide Drugs 0.000 claims description 2
- 150000001841 cholesterols Chemical class 0.000 claims description 2
- VHRYAHCCVUHIBM-NSOMFCEZSA-N n,n-dimethyl-1,2-bis[(6z,9z,12z)-octadeca-6,9,12-trienoxy]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCOC(C)C(N(C)C)OCCCCC\C=C/C\C=C/C\C=C/CCCCC VHRYAHCCVUHIBM-NSOMFCEZSA-N 0.000 claims description 2
- XVUQPECVOGMPRU-ZPPAUJSGSA-N n,n-dimethyl-1,2-bis[(9z,12z)-octadeca-9,12-dienoxy]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCOC(C)C(N(C)C)OCCCCCCCC\C=C/C\C=C/CCCCC XVUQPECVOGMPRU-ZPPAUJSGSA-N 0.000 claims description 2
- NFQBIAXADRDUGK-KWXKLSQISA-N n,n-dimethyl-2,3-bis[(9z,12z)-octadeca-9,12-dienoxy]propan-1-amine Chemical compound CCCCC\C=C/C\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/C\C=C/CCCCC NFQBIAXADRDUGK-KWXKLSQISA-N 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 230000029812 viral genome replication Effects 0.000 claims description 2
- 238000013160 medical therapy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462059056P | 2014-10-02 | 2014-10-02 | |
| US62/059,056 | 2014-10-02 | ||
| US201562120149P | 2015-02-24 | 2015-02-24 | |
| US62/120,149 | 2015-02-24 | ||
| PCT/US2015/053569 WO2016054421A1 (en) | 2014-10-02 | 2015-10-01 | Compositions and methods for silencing hepatitis b virus gene expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536092A JP2017536092A (ja) | 2017-12-07 |
| JP2017536092A5 true JP2017536092A5 (enExample) | 2018-03-15 |
Family
ID=54325078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017517791A Pending JP2017536092A (ja) | 2014-10-02 | 2015-10-01 | Ｂ型肝炎ウイルスの遺伝子発現をサイレンシングするための組成物及び方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10415037B2 (enExample) |
| EP (1) | EP3201338B1 (enExample) |
| JP (1) | JP2017536092A (enExample) |
| KR (1) | KR20170075742A (enExample) |
| CN (1) | CN107208095B (enExample) |
| AU (1) | AU2015328012A1 (enExample) |
| BR (1) | BR112017006679A2 (enExample) |
| CA (1) | CA2963271A1 (enExample) |
| CL (1) | CL2017000780A1 (enExample) |
| CO (1) | CO2017004290A2 (enExample) |
| CR (1) | CR20170174A (enExample) |
| IL (1) | IL251450A0 (enExample) |
| PH (1) | PH12017500614A1 (enExample) |
| RU (1) | RU2017114964A (enExample) |
| SG (1) | SG11201702662UA (enExample) |
| TW (2) | TW201623614A (enExample) |
| WO (1) | WO2016054421A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2721333C (en) * | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| ME03091B (me) | 2009-12-01 | 2019-01-20 | Translate Bio Inc | Isporuka irnk za povećanje ekspresije proteina i enzima u humanim genetskim oboljenjima |
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| US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
| PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| BR112014030677A2 (pt) | 2012-06-08 | 2022-07-19 | Shire Human Genetic Therapies | distribuição pulmonar de mrna para células-alvo não-pulmonares |
| CA2904151C (en) | 2013-03-14 | 2023-09-12 | Shire Human Genetic Therapies, Inc. | Cftr mrna compositions and related methods and uses |
| HUE055044T2 (hu) | 2013-03-14 | 2021-10-28 | Translate Bio Inc | MRNS-kódolt ellenanyagok bejuttatására szolgáló eljárások és készítmények |
| KR20150128687A (ko) | 2013-03-14 | 2015-11-18 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna의 정제 방법 |
| ES3032013T3 (en) | 2013-03-15 | 2025-07-14 | Translate Bio Inc | Synergistic enhancement of the delivery of nucleic acids via blended formulations |
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| EA201992208A1 (ru) | 2013-10-22 | 2020-07-31 | Транслейт Био, Инк. | ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
| CN105658800A (zh) | 2013-10-22 | 2016-06-08 | 夏尔人类遗传性治疗公司 | Mrna的cns递送及其用途 |
| BR112016009014B1 (pt) | 2013-10-22 | 2024-02-06 | Translate Bio, Inc | USO DE COMPOSIÇÃO COMPREENDENDO mRNA PARA DEFICIÊNCIA DE ARGININOSSUCINATO SINTETASE |
| KR102739894B1 (ko) | 2014-04-25 | 2024-12-05 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna 의 정제 방법 |
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| AU2015279968B2 (en) | 2014-06-24 | 2019-11-14 | Translate Bio, Inc. | Stereochemically enriched compositions for delivery of nucleic acids |
| CN106456547B (zh) | 2014-07-02 | 2021-11-12 | 川斯勒佰尔公司 | 信使rna的包封 |
| WO2016090262A1 (en) | 2014-12-05 | 2016-06-09 | Shire Human Genetic Therapies, Inc. | Messenger rna therapy for treatment of articular disease |
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-
2015
- 2015-10-01 CR CR20170174A patent/CR20170174A/es unknown
- 2015-10-01 CA CA2963271A patent/CA2963271A1/en not_active Abandoned
- 2015-10-01 EP EP15781007.8A patent/EP3201338B1/en active Active
- 2015-10-01 KR KR1020177011725A patent/KR20170075742A/ko not_active Withdrawn
- 2015-10-01 CN CN201580062374.9A patent/CN107208095B/zh active Active
- 2015-10-01 US US15/515,952 patent/US10415037B2/en active Active
- 2015-10-01 SG SG11201702662UA patent/SG11201702662UA/en unknown
- 2015-10-01 BR BR112017006679A patent/BR112017006679A2/pt not_active Application Discontinuation
- 2015-10-01 RU RU2017114964A patent/RU2017114964A/ru not_active Application Discontinuation
- 2015-10-01 AU AU2015328012A patent/AU2015328012A1/en not_active Abandoned
- 2015-10-01 WO PCT/US2015/053569 patent/WO2016054421A1/en not_active Ceased
- 2015-10-01 JP JP2017517791A patent/JP2017536092A/ja active Pending
- 2015-10-02 TW TW104132625A patent/TW201623614A/zh unknown
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- 2017-03-29 IL IL251450A patent/IL251450A0/en unknown
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