|
NL154598B
(nl)
|
1970-11-10 |
1977-09-15 |
Organon Nv |
Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
|
|
US3901654A
(en)
|
1971-06-21 |
1975-08-26 |
Biological Developments |
Receptor assays of biologically active compounds employing biologically specific receptors
|
|
US3817827A
(en)
|
1972-03-30 |
1974-06-18 |
Scott Paper Co |
Soft absorbent fibrous webs containing elastomeric bonding material and formed by creping and embossing
|
|
US3935074A
(en)
|
1973-12-17 |
1976-01-27 |
Syva Company |
Antibody steric hindrance immunoassay with two antibodies
|
|
US3996345A
(en)
|
1974-08-12 |
1976-12-07 |
Syva Company |
Fluorescence quenching with immunological pairs in immunoassays
|
|
US4034074A
(en)
|
1974-09-19 |
1977-07-05 |
The Board Of Trustees Of Leland Stanford Junior University |
Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
|
|
US3993754A
(en)
|
1974-10-09 |
1976-11-23 |
The United States Of America As Represented By The United States Energy Research And Development Administration |
Liposome-encapsulated actinomycin for cancer chemotherapy
|
|
US3984533A
(en)
|
1975-11-13 |
1976-10-05 |
General Electric Company |
Electrophoretic method of detecting antigen-antibody reaction
|
|
US4086257A
(en)
|
1976-10-12 |
1978-04-25 |
Sears Barry D |
Phosphatidyl quaternary ammonium compounds
|
|
US4098876A
(en)
|
1976-10-26 |
1978-07-04 |
Corning Glass Works |
Reverse sandwich immunoassay
|
|
CH624011A5
(enExample)
|
1977-08-05 |
1981-07-15 |
Battelle Memorial Institute |
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4452901A
(en)
|
1980-03-20 |
1984-06-05 |
Ciba-Geigy Corporation |
Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4522803A
(en)
|
1983-02-04 |
1985-06-11 |
The Liposome Company, Inc. |
Stable plurilamellar vesicles, their preparation and use
|
|
US4588578A
(en)
|
1983-08-08 |
1986-05-13 |
The Liposome Company, Inc. |
Lipid vesicles prepared in a monophase
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
US5453566A
(en)
|
1986-03-28 |
1995-09-26 |
Calgene, Inc. |
Antisense regulation of gene expression in plant/cells
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
CA1340323C
(en)
|
1988-09-20 |
1999-01-19 |
Arnold E. Hampel |
Rna catalyst for cleaving specific rna sequences
|
|
GB8822492D0
(en)
|
1988-09-24 |
1988-10-26 |
Considine J |
Apparatus for removing tumours from hollow organs of body
|
|
US5725871A
(en)
|
1989-08-18 |
1998-03-10 |
Danbiosyst Uk Limited |
Drug delivery compositions comprising lysophosphoglycerolipid
|
|
AU637800B2
(en)
|
1989-08-31 |
1993-06-10 |
City Of Hope |
Chimeric dna-rna catalytic sequences
|
|
US5286634A
(en)
|
1989-09-28 |
1994-02-15 |
Stadler Joan K |
Synergistic method for host cell transformation
|
|
US5707644A
(en)
|
1989-11-04 |
1998-01-13 |
Danbiosyst Uk Limited |
Small particle compositions for intranasal drug delivery
|
|
US6753423B1
(en)
|
1990-01-11 |
2004-06-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
|
|
US6365730B1
(en)
|
1990-06-19 |
2002-04-02 |
Gene Shears Pty. Limited |
DNA-Armed ribozymes and minizymes
|
|
US5789573A
(en)
|
1990-08-14 |
1998-08-04 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
|
|
ES2061416T3
(es)
|
1990-10-12 |
1997-03-01 |
Max Planck Gesellschaft |
Ribozimas modificadas.
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US6831166B2
(en)
|
1992-10-23 |
2004-12-14 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5756353A
(en)
|
1991-12-17 |
1998-05-26 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol-and liposome-based delivery
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
EP0642589A4
(en)
|
1992-05-11 |
1997-05-21 |
Ribozyme Pharm Inc |
METHOD AND REAGENT TO INHIBIT VIRAL REPLICATION.
|
|
ES2105262T3
(es)
|
1992-05-18 |
1997-10-16 |
Minnesota Mining & Mfg |
Dispositivo de suministro de farmaco a traves de las mucosas.
|
|
US5792451A
(en)
|
1994-03-02 |
1998-08-11 |
Emisphere Technologies, Inc. |
Oral drug delivery compositions and methods
|
|
EP0786522A2
(en)
|
1992-07-17 |
1997-07-30 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic RNA molecules for treatment of stenotic conditions
|
|
IL108367A0
(en)
|
1993-01-27 |
1994-04-12 |
Hektoen Inst For Medical Resea |
Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
|
|
US5426039A
(en)
|
1993-09-08 |
1995-06-20 |
Bio-Rad Laboratories, Inc. |
Direct molecular cloning of primer extended DNA containing an alkane diol
|
|
US5801154A
(en)
|
1993-10-18 |
1998-09-01 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of multidrug resistance-associated protein
|
|
US5591317A
(en)
|
1994-02-16 |
1997-01-07 |
Pitts, Jr.; M. Michael |
Electrostatic device for water treatment
|
|
US5631359A
(en)
|
1994-10-11 |
1997-05-20 |
Ribozyme Pharmaceuticals, Inc. |
Hairpin ribozymes
|
|
US5639725A
(en)
|
1994-04-26 |
1997-06-17 |
Children's Hospital Medical Center Corp. |
Angiostatin protein
|
|
EP1179340A3
(en)
|
1994-09-30 |
2003-05-07 |
INEX Pharmaceutical Corp. |
Compositions for the introduction of polyanionic materials into cells
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
|
WO1996011266A2
(en)
|
1994-10-05 |
1996-04-18 |
Amgen Inc. |
Method for inhibiting smooth muscle cell proliferation and oligonucleotides for use therein
|
|
US5783683A
(en)
|
1995-01-10 |
1998-07-21 |
Genta Inc. |
Antisense oligonucleotides which reduce expression of the FGFRI gene
|
|
US5580579A
(en)
|
1995-02-15 |
1996-12-03 |
Nano Systems L.L.C. |
Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
|
|
IE80468B1
(en)
|
1995-04-04 |
1998-07-29 |
Elan Corp Plc |
Controlled release biodegradable nanoparticles containing insulin
|
|
US5976567A
(en)
|
1995-06-07 |
1999-11-02 |
Inex Pharmaceuticals Corp. |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5705385A
(en)
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
US5747470A
(en)
|
1995-06-07 |
1998-05-05 |
Gen-Probe Incorporated |
Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
|
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US20040142895A1
(en)
|
1995-10-26 |
2004-07-22 |
Sirna Therapeutics, Inc. |
Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway
|
|
US20030216335A1
(en)
|
2001-11-30 |
2003-11-20 |
Jennifer Lockridge |
Method and reagent for the modulation of female reproductive diseases and conditions
|
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
|
US6713069B1
(en)
|
1996-04-16 |
2004-03-30 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Compositions and methods for detecting, preventing, and treating African Hemorrhagic Fever
|
|
US20050119470A1
(en)
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
|
US6111085A
(en)
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
|
US6174861B1
(en)
|
1996-10-22 |
2001-01-16 |
The Children's Medical Center Corporation |
Methods of inhibiting angiogenesis via increasing in vivo concentrations of endostatin protein
|
|
US5739119A
(en)
|
1996-11-15 |
1998-04-14 |
Galli; Rachel L. |
Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
|
|
US6406705B1
(en)
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
AU733310C
(en)
|
1997-05-14 |
2001-11-29 |
University Of British Columbia, The |
High efficiency encapsulation of charged therapeutic agents in lipid vesicles
|
|
US6110745A
(en)
|
1997-07-24 |
2000-08-29 |
Inex Pharmaceuticals Corp. |
Preparation of lipid-nucleic acid particles using a solvent extraction and direct hydration method
|
|
US6320017B1
(en)
|
1997-12-23 |
2001-11-20 |
Inex Pharmaceuticals Corp. |
Polyamide oligomers
|
|
US6852334B1
(en)
|
1999-04-20 |
2005-02-08 |
The University Of British Columbia |
Cationic peg-lipids and methods of use
|
|
JP5117648B2
(ja)
|
1999-04-20 |
2013-01-16 |
ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア |
カチオン性ｐｅｇ脂質および使用方法。
|
|
EP1212085B1
(en)
|
1999-08-27 |
2007-10-31 |
INEX Pharmaceuticals Corp. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US7189705B2
(en)
|
2000-04-20 |
2007-03-13 |
The University Of British Columbia |
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
|
|
ES2307568T3
(es)
|
2000-12-08 |
2008-12-01 |
Coley Pharmaceutical Gmbh |
Acidos nucleicos de tipo cpg y metodos de uso de los mismos.
|
|
US7053150B2
(en)
|
2000-12-18 |
2006-05-30 |
Nektar Therapeutics Al, Corporation |
Segmented polymers and their conjugates
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
WO2002087541A1
(en)
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
|
US20030130186A1
(en)
|
2001-07-20 |
2003-07-10 |
Chandra Vargeese |
Conjugates and compositions for cellular delivery
|
|
US20050282188A1
(en)
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
DE10163098B4
(de)
|
2001-10-12 |
2005-06-02 |
Alnylam Europe Ag |
Verfahren zur Hemmung der Replikation von Viren
|
|
EP1432724A4
(en)
|
2002-02-20 |
2006-02-01 |
Sirna Therapeutics Inc |
RNA inhibition mediated inhibition of MAP KINASE GENES
|
|
CA2515243A1
(en)
|
2002-02-22 |
2003-08-28 |
Klaus Strebhardt |
Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
|
|
EP1519714B1
(en)
|
2002-06-28 |
2010-10-20 |
Protiva Biotherapeutics Inc. |
Method and apparatus for producing liposomes
|
|
AU2003261231A1
(en)
|
2002-07-26 |
2004-02-16 |
Chiron Corporation |
Modified small interfering rna molecules and methods of use
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US20040167090A1
(en)
|
2003-02-21 |
2004-08-26 |
Monahan Sean D. |
Covalent modification of RNA for in vitro and in vivo delivery
|
|
WO2004090108A2
(en)
|
2003-04-03 |
2004-10-21 |
Alnylam Pharmaceuticals |
Irna conjugates
|
|
ES2702942T3
(es)
|
2003-04-17 |
2019-03-06 |
Alnylam Pharmaceuticals Inc |
Agentes de ARNi modificados
|
|
CA2532228C
(en)
|
2003-07-16 |
2017-02-14 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
US7514574B2
(en)
*
|
2003-08-07 |
2009-04-07 |
Ooi Wong |
Biodegradable penetration enhancers with multiple hydrophilic moieties
|
|
EP1664316B1
(en)
|
2003-09-15 |
2012-08-29 |
Protiva Biotherapeutics Inc. |
Polyethyleneglycol-modified lipid compounds and uses thereof
|
|
CA2569664C
(en)
|
2004-06-07 |
2013-07-16 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
|
JP4764426B2
(ja)
|
2004-06-07 |
2011-09-07 |
プロチバ バイオセラピューティクス インコーポレイティッド |
カチオン性脂質および使用方法
|
|
WO2006031901A2
(en)
|
2004-09-10 |
2006-03-23 |
Somagenics, Inc. |
SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF
|
|
CA2587411A1
(en)
|
2004-11-17 |
2006-05-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of apolipoprotein b
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
CN101267805A
(zh)
|
2005-07-27 |
2008-09-17 |
普洛体维生物治疗公司 |
制造脂质体的系统和方法
|
|
WO2007048046A2
(en)
|
2005-10-20 |
2007-04-26 |
Protiva Biotherapeutics, Inc. |
Sirna silencing of filovirus gene expression
|
|
CN101346393B
(zh)
|
2005-11-02 |
2015-07-22 |
普洛体维生物治疗公司 |
修饰的siRNA分子及其应用
|
|
US20070218122A1
(en)
|
2005-11-18 |
2007-09-20 |
Protiva Biotherapeutics, Inc. |
siRNA silencing of influenza virus gene expression
|
|
US7871967B2
(en)
*
|
2007-02-12 |
2011-01-18 |
Chevron U.S.A. Inc. |
Diester-based lubricants and methods of making same
|
|
CN111808084A
(zh)
*
|
2008-11-10 |
2020-10-23 |
阿布特斯生物制药公司 |
用于递送治疗剂的新型脂质和组合物
|
|
US20130085091A1
(en)
|
2011-09-29 |
2013-04-04 |
Chevron U.S.A. Inc. |
Industrial oil comprising a bio-derived ester
|
|
AU2012347605B2
(en)
*
|
2011-12-07 |
2017-09-21 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
|
EP2817287B1
(en)
*
|
2012-02-24 |
2018-10-03 |
Arbutus Biopharma Corporation |
Trialkyl cationic lipids and methods of use thereof
|
|
WO2013151665A2
(en)
|
2012-04-02 |
2013-10-10 |
modeRNA Therapeutics |
Modified polynucleotides for the production of proteins associated with human disease
|
|
CA2869748C
(en)
|
2012-04-12 |
2017-10-24 |
Yale University |
Vehicles for controlled delivery of different pharmaceutical agents
|
|
US9744103B1
(en)
|
2013-03-08 |
2017-08-29 |
Chad Ricker |
Infant teething apparatus
|
|
JP6620093B2
(ja)
|
2013-07-23 |
2019-12-11 |
アービュートゥス バイオファーマ コーポレイションＡｒｂｕｔｕｓ Ｂｉｏｐｈａｒｍａ Ｃｏｒｐｏｒａｔｉｏｎ |
メッセンジャーｒｎａを送達するための組成物及び方法
|
|
EP3083556B1
(en)
*
|
2013-12-19 |
2019-12-25 |
Novartis AG |
Lipids and lipid compositions for the delivery of active agents
|
|
JP2018509387A
(ja)
|
2015-01-21 |
2018-04-05 |
フェーズアールエックス インコーポレイテッド |
細胞に治療および診断剤を送達するための方法、組成物、ならびにシステム
|
|
WO2016197132A1
(en)
|
2015-06-04 |
2016-12-08 |
Protiva Biotherapeutics Inc. |
Treating hepatitis b virus infection using crispr
|
|
WO2016197133A1
(en)
|
2015-06-04 |
2016-12-08 |
Protiva Biotherapeutics, Inc. |
Delivering crispr therapeutics with lipid nanoparticles
|
|
CN109563511A
(zh)
|
2016-06-30 |
2019-04-02 |
阿布特斯生物制药公司 |
用于递送信使rna的组合物和方法
|
|
WO2018232120A1
(en)
|
2017-06-14 |
2018-12-20 |
Modernatx, Inc. |
Compounds and compositions for intracellular delivery of agents
|
|
EP3764816B1
(en)
*
|
2018-03-16 |
2026-01-28 |
Dow Global Technologies Llc |
Foam control in food
|