JP2023513698A5 - - Google Patents

Info

Publication number
JP2023513698A5
JP2023513698A5 JP2022548450A JP2022548450A JP2023513698A5 JP 2023513698 A5 JP2023513698 A5 JP 2023513698A5 JP 2022548450 A JP2022548450 A JP 2022548450A JP 2022548450 A JP2022548450 A JP 2022548450A JP 2023513698 A5 JP2023513698 A5 JP 2023513698A5
Authority
JP
Japan
Prior art keywords
alkyl
compound according
hydrocarbyl
alkenyl
lipid particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022548450A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023513698A (ja
JP7843707B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/017676 external-priority patent/WO2021163339A1/en
Publication of JP2023513698A publication Critical patent/JP2023513698A/ja
Publication of JP2023513698A5 publication Critical patent/JP2023513698A5/ja
Application granted granted Critical
Publication of JP7843707B2 publication Critical patent/JP7843707B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022548450A 2020-02-11 2021-02-11 肝星細胞への治療薬の脂質ナノ粒子送達のためのカチオン性脂質 Active JP7843707B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062975116P 2020-02-11 2020-02-11
US62/975,116 2020-02-11
PCT/US2021/017676 WO2021163339A1 (en) 2020-02-11 2021-02-11 Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells

Publications (3)

Publication Number Publication Date
JP2023513698A JP2023513698A (ja) 2023-04-03
JP2023513698A5 true JP2023513698A5 (enExample) 2024-02-21
JP7843707B2 JP7843707B2 (ja) 2026-04-10

Family

ID=77292598

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022548450A Active JP7843707B2 (ja) 2020-02-11 2021-02-11 肝星細胞への治療薬の脂質ナノ粒子送達のためのカチオン性脂質

Country Status (11)

Country Link
US (1) US20230139594A1 (enExample)
EP (1) EP4103172A4 (enExample)
JP (1) JP7843707B2 (enExample)
KR (1) KR20220140531A (enExample)
CN (1) CN115697321A (enExample)
AU (1) AU2021218409A1 (enExample)
BR (1) BR112022015803A2 (enExample)
CA (1) CA3170547A1 (enExample)
IL (1) IL295441A (enExample)
MX (1) MX2022009861A (enExample)
WO (1) WO2021163339A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016341309A1 (en) * 2015-10-22 2018-06-07 Modernatx, Inc. Cancer vaccines
CN117045791B (zh) * 2023-03-22 2025-10-03 中国药科大学 肝星状细胞neu1的靶向过表达剂在制备治疗肝纤维化的药物中的应用
TW202543585A (zh) 2024-03-08 2025-11-16 美商健臻公司 脂質奈米粒子
JP2025168864A (ja) * 2024-04-30 2025-11-12 信越化学工業株式会社 含窒素多官能オルガノキシシラン化合物の製造方法
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
WO2026022677A1 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Permanently charged cationic lipids
WO2026022656A2 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Lipid particle formulations with permanently charged cationic lipids
WO2026030375A2 (en) 2024-07-30 2026-02-05 Genzyme Corporation Lipid nanoparticles and methods of manufacture and use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB709345A (en) * 1950-08-28 1954-05-19 California Research Corp Unsymmetrical alkoxy (tri- and tetra-) siloxanes and processes for making the same
US2713064A (en) * 1953-12-07 1955-07-12 Dow Corning Bis-(trialkoxysilyl) benzenes and their use
US3029269A (en) * 1956-08-21 1962-04-10 California Research Corp Silicon esters
DE1180359B (de) * 1962-05-15 1964-10-29 Ruhrchemie Ag Verfahren zur kontinuierlichen Herstellung von Orthokieselsaeureestern
NL134718C (enExample) * 1966-12-01
US3810843A (en) * 1971-05-28 1974-05-14 Gen Electric Silicone-silica compositions
CH632765A5 (de) * 1977-09-09 1982-10-29 Ciba Geigy Ag Verfahren zur herstellung von siliciummodifizierten phthalsaeurederivaten.
US4329486A (en) * 1981-06-29 1982-05-11 Olin Corporation Process for preparing alkoxysilane cluster compounds by reacting a trialkoxysilanol with an amidated alkoxysilane cluster compound
JPH086040B2 (ja) * 1990-10-26 1996-01-24 信越化学工業株式会社 オルガノポリシロキサン組成物
US5534592A (en) * 1995-09-22 1996-07-09 The Goodyear Tire & Rubber Company High performance blend for tire treads
EP1783781A3 (en) * 2003-11-28 2007-10-03 Merck Patent GmbH Organic semiconducting layer formulations comprising polyacenes and organic binder polymers
EP2099953B1 (en) * 2006-09-29 2019-04-03 Momentive Performance Materials Inc. Storage stable composition of partial and/or complete condensate of hydrolyzable organofunctional silane
JP5316743B2 (ja) * 2007-11-01 2013-10-16 Jsr株式会社 ケイ素含有膜形成用組成物およびケイ素含有絶縁膜の形成方法
JP5133092B2 (ja) * 2008-03-06 2013-01-30 花王株式会社 機能性物質放出剤
CN101724127A (zh) * 2008-10-16 2010-06-09 住友橡胶工业株式会社 聚合物、橡胶组合物及使用该橡胶组合物的轮胎
US9375484B2 (en) * 2011-05-31 2016-06-28 Regents Of The University Of Minnesota Taxane silicate prodrugs and nanoparticles
CN102911401B (zh) * 2012-11-08 2014-04-23 广州市回天精细化工有限公司 一种羟基清除剂、其制备方法及含有它的硫化硅橡胶
JP6614014B2 (ja) * 2016-04-26 2019-12-04 信越化学工業株式会社 含窒素オルガノキシシラン化合物およびその製造方法
DE102017221259A1 (de) * 2017-11-28 2019-05-29 Evonik Degussa Gmbh Silanmischungen und Verfahren zu deren Herstellung
WO2019123263A2 (en) * 2017-12-21 2019-06-27 3M Innovative Properties Company Inorganic dental fillers including a silane treated surface
CN108239103B (zh) * 2018-01-02 2020-09-01 深圳市广业电子科技有限公司 一种含有多肟基硅的硅氮化合物
KR20210044771A (ko) * 2018-07-02 2021-04-23 압타미르 테라퓨틱스, 인코포레이티드 인간 지방세포에 대한 치료제의 표적화 전달
AU2021403156A1 (en) * 2020-12-18 2023-07-13 Genevant Sciences Gmbh Peg lipids and lipid nanoparticles

Similar Documents

Publication Publication Date Title
JP2023513698A5 (enExample)
US10980895B2 (en) Ionizable cationic lipid for RNA delivery
US9365610B2 (en) Asymmetric ionizable cationic lipid for RNA delivery
JP2023518944A5 (enExample)
EP1648519B1 (en) Lipid encapsulated interfering rna
JP6077509B2 (ja) 改良されたアミノ脂質および核酸の送達方法
US20170101370A1 (en) Ionizable cationic lipid for rna delivery
JP7708388B2 (ja) 荷電物質を送達する脂質、その製剤、およびその製造方法
JP3631755B2 (ja) ポリオキシエチレン含有脂質二本鎖誘導体
JP2025505971A5 (enExample)
TW202539707A (zh) 用於治療b型肝炎之治療組成物及方法
JPWO1995025764A1 (ja) ポリオキシエチレン含有脂質二本鎖誘導体
JP2022087209A (ja) B型肝炎を治療するための治療用組成物及び方法
JP2023534206A5 (enExample)
JP2004508012A (ja) エンドソーム膜不安定剤を用いたsplp媒介性トランスフェクションの強化方法
CN118632690A (zh) 含有可生物降解的酯键的可电离脂质和包含其的脂质纳米颗粒
KR102911928B1 (ko) 신규 이온화 가능한 지질 및 이를 포함하는 지질나노입자
CN119032086A (zh) 含硫化物的可电离脂质和包含该可电离脂质的脂质纳米颗粒
WO2025016446A1 (en) Lipids and lipid nanoparticles
CN118164866A (zh) 阳离子脂质化合物及其组合物和应用
NL2019801B1 (en) Delivery vectors
WO2025080572A1 (en) Liver asialoglycoprotein receptor targeted lipid and uses thereof
CN119424366A (zh) 靶向次级淋巴器官的脂质纳米颗粒及其制备方法和用途
JP2023510253A (ja) アルキル化ヌクレオシド、ならびにそれらの組成物および核酸送達のための方法
NZ791587B2 (en) Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells