JP2008528696A5 - - Google Patents

Info

Publication number

JP2008528696A5

JP2008528696A5 JP2007554228A JP2007554228A JP2008528696A5 JP 2008528696 A5 JP2008528696 A5 JP 2008528696A5 JP 2007554228 A JP2007554228 A JP 2007554228A JP 2007554228 A JP2007554228 A JP 2007554228A JP 2008528696 A5 JP2008528696 A5 JP 2008528696A5

Authority

JP

Japan

Prior art keywords

lipid

complex

serine

group

therapeutic agent

Prior art date

2006-02-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 238000000034 method Methods 0.000 claims 13
• 150000003904 phospholipids Chemical class 0.000 claims 8
• TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 6
• ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 6
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 229940124597 therapeutic agent Drugs 0.000 claims 5
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 claims 4
• 229960001153 serine Drugs 0.000 claims 4
• PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims 3
• JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 3
• BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 claims 3
• 239000011230 binding agent Substances 0.000 claims 3
• 229950006137 dexfosfoserine Drugs 0.000 claims 3
• 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 229920002307 Dextran Polymers 0.000 claims 2
• 102000001690 Factor VIII Human genes 0.000 claims 2
• 108010054218 Factor VIII Proteins 0.000 claims 2
• 125000002252 acyl group Chemical group 0.000 claims 2
• 159000000007 calcium salts Chemical class 0.000 claims 2
• 229960000301 factor viii Drugs 0.000 claims 2
• 230000005847 immunogenicity Effects 0.000 claims 2
• 150000002632 lipids Chemical group 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• -1 serine compound Chemical class 0.000 claims 2
• 159000000000 sodium salts Chemical class 0.000 claims 2
• 239000000232 Lipid Bilayer Substances 0.000 claims 1
• 230000002238 attenuated effect Effects 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 239000000693 micelle Substances 0.000 claims 1
• 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims 1
• 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 150000003354 serine derivatives Chemical class 0.000 claims 1