HRP20201761T1 - Prilagođeni liposomi za tretman bakterijskih infekcija - Google Patents
Prilagođeni liposomi za tretman bakterijskih infekcija Download PDFInfo
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- HRP20201761T1 HRP20201761T1 HRP20201761TT HRP20201761T HRP20201761T1 HR P20201761 T1 HRP20201761 T1 HR P20201761T1 HR P20201761T T HRP20201761T T HR P20201761TT HR P20201761 T HRP20201761 T HR P20201761T HR P20201761 T1 HRP20201761 T1 HR P20201761T1
- Authority
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- Croatia
- Prior art keywords
- empty liposomes
- sphingomyelin
- cholesterol
- phosphatidylcholine
- liposomes
- Prior art date
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- 239000002502 liposome Substances 0.000 title claims 58
- 208000035143 Bacterial infection Diseases 0.000 title claims 12
- 208000022362 bacterial infectious disease Diseases 0.000 title claims 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 42
- 239000000203 mixture Substances 0.000 claims 25
- 235000012000 cholesterol Nutrition 0.000 claims 21
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 16
- 230000002265 prevention Effects 0.000 claims 10
- 150000002632 lipids Chemical group 0.000 claims 6
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 239000005526 vasoconstrictor agent Substances 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 239000000232 Lipid Bilayer Substances 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000001147 anti-toxic effect Effects 0.000 claims 1
- 229940124572 antihypotensive agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 150000001982 diacylglycerols Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000013554 lipid monolayer Substances 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- 229940124641 pain reliever Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000008103 phosphatidic acids Chemical class 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 235000003441 saturated fatty acids Nutrition 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 206010040882 skin lesion Diseases 0.000 claims 1
- 231100000444 skin lesion Toxicity 0.000 claims 1
- -1 sphingomyelin Chemical compound 0.000 claims 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Claims (18)
1. Prazni liposomi koji obuhvaćaju 30% (m/m) ili više kolesterola i sfingomijelina, ili mješavine praznih liposoma koje obuhvaćaju 30% (m/m) ili više kolesterola i sfingomijelina, ili fosfatidilkolina i sfingomijelina, s drugim praznim liposomima ili definiranim sastavom lipida za korištenje u tretmanu i prevenciji bakterijskih infekcija.
2. Prazni liposomi koji obuhvaćaju 30% (m/m) ili više kolesterola i sfingomijelina, ili mješavine praznih liposoma koje obuhvaćaju 30% (m/m) ili više kolesterola i sfingomijelina, ili fosfatidilkolina i sfingomijelina, s drugim praznim liposomima koji obuhvaćaju lipide ili fosfolipide odabrani iz skupine koja se sastoji od kolesterola, sfingomijelina, ceramida, fosfatidilkolina, fosfatidiletanolamina, fosfatidilserina, diacilglicerola, i fosfatidnih kiselina koje sadrže jednu ili dvije zasićene ili nezasićene masne kiseline duže od 4 atoma ugljika i sve do 28 atoma ugljika, za korištenje u tretmanu i prevenciji bakterijskih infekcija u skladu sa zahtjevom 1.
3. Mješavina liposoma od praznih liposoma koji obuhvaćaju ili se sastoje od kolesterola i sfingomijelina, s drugim praznim liposomima koji obuhvaćaju ili se sastoje od sfingomijelina, za korištenje u tretmanu i prevenciji bakterijskih infekcija u skladu s bilo kojim od zahtjeva 1 ili 2.
4. Mješavina liposoma od praznih liposoma koji obuhvaćaju ili se sastoje od fosfatidilkolina i sfingomijelina, s drugim praznim liposomima koji obuhvaćaju ili se sastoje od sfingomijelina, za korištenje u tretmanu i prevenciji bakterijskih infekcija u skladu sa zahtjevima 1 ili 2.
5. Mješavina liposoma od praznih liposoma koji obuhvaćaju ili se sastoje od kolesterola i sfingomijelina, s drugim praznim liposomima koji obuhvaćaju ili se sastoje od fosfatidilkolina i sfingomijelina, i s praznim liposomima koji se sastoje od sfingomijelina, za korištenje u tretmanu i prevenciji bakterijskih infekcija u skladu s bilo kojim od zahtjeva 1 do 4.
6. Mješavina liposoma od praznih liposoma koji obuhvaćaju ili se sastoje od kolesterola i sfingomijelina, s drugim praznim liposomima koji obuhvaćaju ili se sastoje od fosfatidilkolina i sfingomijelina, s praznim liposomima koji se sastoje od sfingomijelina, i s praznim liposomima koji obuhvaćaju ili se sastoje od kolesterola i fosfatidilkolina, za korištenje u tretmanu i prevenciji bakterijskih infekcija u skladu s bilo kojim od zahtjeva 1 do 5.
7. Prazni liposomi koji obuhvaćaju kolesterol i sfingomijelin, ili mješavine praznih liposoma koji obuhvaćaju kolesterol i sfingomijelin, ili fosfatidilkolin i sfingomijelin, s drugim praznim liposomima ili definiranim sastavom lipida, naznačeni time su da neki ili svi liposomi modificirani s polietilen glikolom, za korištenje u tretmanu i prevenciji bakterijskih infekcija u skladu s bilo kojim od zahtjeva 1 do 6.
8. Prazni liposomi koji obuhvaćaju kolesterol i sfingomijelin, ili mješavine praznih liposoma koji obuhvaćaju kolesterol i sfingomijelin, ili fosfatidilkolin i sfingomijelin, s drugim praznim liposomima ili definiranim sastavom lipida, za korištenje u tretmanu i prevenciji bakterijemije, lezija na koži inficiranih bakterijama, meningitisa i infekcija dišnog sustava, u skladu s bilo kojim od zahtjeva 1 do 7.
9. Prazni liposomi ili mješavine praznih liposoma za korištenje u skladu s bilo kojim od zahtjeva 1 do 8, naznačeni time da je navedeno korištenje tretman bakterijskih infekcija kod potrebitog pacijenta, i pri čemu je korištena terapeutski učinkovita količina navedenih praznih liposoma ili navedenih mješavina praznih liposoma.
10. Prazni liposomi ili mješavine praznih liposoma za korištenje u skladu sa zahtjevom 9, naznačeni time da je navedena terapeutski učinkovita količina navedenih praznih liposoma ili navedenih mješavina praznih liposoma korištena prije, nakon, zajedno sa ili paralelno sa standardnim antibiotskim lijekovima protiv bakterijske infekcije.
11. Prazni liposomi ili mješavine praznih liposoma za korištenje u skladu s bilo kojim od zahtjeva 1 do 8, naznačeni time da je navedeno korištenje prevencija bakterijske infekcije subjekta izloženog riziku infekcije, pri čemu je korištena preventivna količina navedenih praznih liposoma ili navedenih mješavina praznih liposoma.
12. Dvostruki slojevi lipida ili jednostruki slojevi lipida koji obuhvaćaju 30% (m/m) ili više kolesterola i sfingomijelina, i opcionalno fosfatidilkolina, prekrivajući ne-lipidne površine, za korištenje u tretmanu i prevenciji bakterijskih infekcija.
13. Mješavina praznih liposoma koja obuhvaća 30% (m/m) ili više kolesterola i sfingomijelina, ili fosfatidilkolina i sfingomijelina, s drugim praznim liposomima definiranog sastava lipida.
14. Mješavina u skladu sa zahtjevom 13 od praznih liposoma koja obuhvaća kolesterol i sfingomijelin, ili fosfatidilkolin i sfingomijelin, s praznim liposomima koji se sastoje od sfingomijelina.
15. Mješavina u skladu sa zahtjevom 13 ili 14 od praznih liposoma koja obuhvaća kolesterol i sfingomijelin s drugim praznim liposomima obuhvaćajući fosfatidilkolin i sfingomijelin, i s praznim liposomima koji se sastoje od sfingomijelina.
16. Mješavina u skladu s bilo kojim od zahtjeva 13 do 15 od praznih liposoma koja obuhvaća kolesterol i sfingomijelin s drugim praznim liposomima obuhvaćajući fosfatidilkolin i sfingomijelin, s praznim liposomima koji se sastoje od sfingomijelina, i s praznim liposomima koji obuhvaćaju kolesterol i fosfatidilkolin.
17. Mješavina u skladu s bilo kojim od zahtjeva 13 do 16 od praznih liposoma, naznačena time da su neki ili svi liposomi modificirani s polietilen glikolom.
18. Farmaceutski sastav koji obuhvaća (i) prazne liposome, koji obuhvaćaju 30% (m/m) ili više kolesterola i sfingomijelina, ili mješavinu praznih liposoma, koja obuhvaća 30% (m/m) ili više kolesterola i sfingomijelina ili fosfatidilkolina i sfingomijelina, s drugim praznim liposomima definiranog sastava liposoma; i (ii) daljnji farmaceutski aktivan spoj, pri čemu je poželjno naveden daljnji farmaceutski aktivan spoj odabran od antibiotika, antikancerogenog agensa, protuupalnog lijeka, vazopresora, vazokonstriktora, lijeka protiv bolova i antitoksina.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12171924 | 2012-06-14 | ||
EP13153039 | 2013-01-29 | ||
PCT/EP2013/062207 WO2013186286A1 (en) | 2012-06-14 | 2013-06-13 | Tailored liposomes for the treatment of bacterial infections |
EP13732388.7A EP2861214B1 (en) | 2012-06-14 | 2013-06-13 | Tailored liposomes for the treatment of bacterial infections |
Publications (1)
Publication Number | Publication Date |
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HRP20201761T1 true HRP20201761T1 (hr) | 2020-12-25 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20201761TT HRP20201761T1 (hr) | 2012-06-14 | 2020-10-30 | Prilagođeni liposomi za tretman bakterijskih infekcija |
Country Status (19)
Country | Link |
---|---|
US (4) | US10744089B2 (hr) |
EP (2) | EP2861214B1 (hr) |
JP (2) | JP6382801B2 (hr) |
CN (2) | CN109549925B (hr) |
AU (2) | AU2013276565B2 (hr) |
BR (1) | BR112014031278B1 (hr) |
CA (1) | CA2875470C (hr) |
CY (1) | CY1123337T1 (hr) |
DK (1) | DK2861214T3 (hr) |
ES (1) | ES2821502T3 (hr) |
HK (1) | HK1210018A1 (hr) |
HR (1) | HRP20201761T1 (hr) |
HU (1) | HUE051761T2 (hr) |
LT (1) | LT2861214T (hr) |
PL (1) | PL2861214T3 (hr) |
RS (1) | RS60951B1 (hr) |
RU (1) | RU2672106C2 (hr) |
SI (1) | SI2861214T1 (hr) |
WO (1) | WO2013186286A1 (hr) |
Families Citing this family (13)
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CN109549925B (zh) * | 2012-06-14 | 2022-06-17 | 伯尔尼大学 | 用于治疗细菌感染的定制脂质体 |
WO2015084677A1 (en) | 2013-12-02 | 2015-06-11 | Arytha Biosciences, Llc | Toxoid preparation and uses thereof |
US10739353B2 (en) * | 2014-12-31 | 2020-08-11 | Signpath Pharma, Inc. | Suppression of cytokine release and cytokine storm |
CA3009119A1 (en) * | 2015-12-28 | 2017-07-06 | Mb Biotech Ltd. | Liposomes for treatment of an autoimmune disease |
WO2017177073A1 (en) * | 2016-04-07 | 2017-10-12 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Francisella lipids as broad anti-inflammatory therapeutics and associated methods of use |
PL3471732T3 (pl) | 2016-06-16 | 2020-10-19 | Combioxin Sa | Liposomy do leczenia infekcji wirusowych |
CN110636839B (zh) * | 2017-03-02 | 2023-06-27 | 康柏辛股份有限公司 | 抑制生物膜形成的脂质体 |
US11344497B1 (en) * | 2017-12-08 | 2022-05-31 | Quicksilver Scientific, Inc. | Mitochondrial performance enhancement nanoemulsion |
MX2020010853A (es) * | 2018-04-17 | 2020-11-06 | Combioxin Sa | Tratamiento de la neumonia. |
WO2019202101A1 (en) | 2018-04-20 | 2019-10-24 | Combioxin Sa | Treatment of sepsis and septic shock |
CN111214439B (zh) * | 2018-11-23 | 2023-02-10 | 复旦大学 | 一种具有细菌成孔毒素吸附性能的纳米药物系统及其用途 |
AU2021315452A1 (en) * | 2020-07-31 | 2023-02-02 | Signpath Pharma, Inc. | Suppression of cytokine release and cytokine storm |
CN115054577B (zh) * | 2022-05-17 | 2024-06-21 | 温州医科大学附属第二医院(温州医科大学附属育英儿童医院) | 纳米解毒剂及其在中和mrsa穿孔毒素的应用 |
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