JP2008528696A - 低免疫原性のタンパク質製剤のための組成物および方法 - Google Patents

低免疫原性のタンパク質製剤のための組成物および方法 Download PDF

Info

Publication number
JP2008528696A
JP2008528696A JP2007554228A JP2007554228A JP2008528696A JP 2008528696 A JP2008528696 A JP 2008528696A JP 2007554228 A JP2007554228 A JP 2007554228A JP 2007554228 A JP2007554228 A JP 2007554228A JP 2008528696 A JP2008528696 A JP 2008528696A
Authority
JP
Japan
Prior art keywords
protein
lipid
complex
fviii
phospholipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007554228A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008528696A5 (enExample
Inventor
バラスブラマニアン，サティアマンガラム
ストラウビンガー，ロバート，エム．
ラマニ，カールティク
プロヒット，ビベック，エス．
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of the State University of New York
Original Assignee
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York
Publication of JP2008528696A publication Critical patent/JP2008528696A/ja
Publication of JP2008528696A5 publication Critical patent/JP2008528696A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2007554228A 2005-02-02 2006-02-02 低免疫原性のタンパク質製剤のための組成物および方法 Pending JP2008528696A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/049,134 US7351688B2 (en) 2003-02-05 2005-02-02 Compositions and methods for less immunogenic protein formulations
PCT/US2006/003779 WO2006084095A1 (en) 2005-02-02 2006-02-02 Compositions and methods for less immunogenic protein formulations

Publications (2)

Publication Number Publication Date
JP2008528696A true JP2008528696A (ja) 2008-07-31
JP2008528696A5 JP2008528696A5 (enExample) 2009-04-02

Family

ID=36777576

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007554228A Pending JP2008528696A (ja) 2005-02-02 2006-02-02 低免疫原性のタンパク質製剤のための組成物および方法

Country Status (7)

Country Link
US (1) US7351688B2 (enExample)
EP (1) EP1858532A4 (enExample)
JP (1) JP2008528696A (enExample)
AU (1) AU2006210609A1 (enExample)
CA (1) CA2596280A1 (enExample)
NZ (1) NZ560327A (enExample)
WO (1) WO2006084095A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014513135A (ja) * 2011-05-05 2014-05-29 コーディネイティッド プログラム ディベロップメント，エルエルシー コクリエート組成物およびその製造および使用方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117469A2 (en) 2006-03-30 2007-10-18 The Research Foundation Of State University Of New York Compositions of less immunogenic and long-circulating protein-lipid complexes
EP1988101A1 (en) * 2007-05-04 2008-11-05 Novo Nordisk A/S Improvement of factor VIII polypeptide titers in cell cultures
US20120164189A1 (en) * 2009-07-07 2012-06-28 Balu-Iyer Sathy V Lipidic Compositions for Induction of Immune Tolerance
US10617640B2 (en) * 2009-07-07 2020-04-14 The Research Foundation For The State University Of New York Phosphoserine containing compositions for immune tolerance induction
WO2011016043A2 (en) * 2009-08-06 2011-02-10 Technion Research & Development Foundation Ltd. Antibiotic drug delivery and potentiation
US10138290B2 (en) 2010-10-05 2018-11-27 Novo Nordisk Healthcare Ag Process for protein production
US10064922B2 (en) * 2011-10-06 2018-09-04 The Research Foundation For The State University Of New York Compositions and methods for immune tolerance induction
WO2015048145A1 (en) 2013-09-24 2015-04-02 The Research Foundation For The State University Of New York Compositions and methods for reducing antigen-specific immunogenicity
US11083782B2 (en) * 2016-04-05 2021-08-10 The Research Foundation For The State University Of New York Phosphoserine containing compositions for immune tolerance induction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020132982A1 (en) * 2000-11-30 2002-09-19 Balasubramanian Sathyamangalam V. AHF associated dispersion system and method for preparation
WO2004071420A2 (en) * 2003-02-05 2004-08-26 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127502A (en) 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4795806A (en) 1987-07-16 1989-01-03 Miles Laboratories, Inc. Phospholipid affinity purification of Factor VIII:C
US5580856A (en) 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
WO1998048837A1 (en) 1997-04-30 1998-11-05 Enzon, Inc. Polyalkylene oxide-modified single chain polypeptides
SE513221C2 (sv) * 1998-04-17 2000-07-31 Net Insight Ab Förfarande och anordning för allokering av tidluckor till en kanal i ett kretskopplat tidsmultiplexerat nät
MXPA00010241A (es) 1998-04-27 2004-09-06 Opperbas Holding Bv Composicion farmaceutica que comprende el factor viii y liposomas neutrales..
ZA200305980B (en) 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
WO2003013245A1 (en) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020132982A1 (en) * 2000-11-30 2002-09-19 Balasubramanian Sathyamangalam V. AHF associated dispersion system and method for preparation
WO2004071420A2 (en) * 2003-02-05 2004-08-26 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014513135A (ja) * 2011-05-05 2014-05-29 コーディネイティッド プログラム ディベロップメント，エルエルシー コクリエート組成物およびその製造および使用方法

Also Published As

Publication number Publication date
US20050227913A1 (en) 2005-10-13
US7351688B2 (en) 2008-04-01
AU2006210609A1 (en) 2006-08-10
NZ560327A (en) 2011-03-31
EP1858532A1 (en) 2007-11-28
CA2596280A1 (en) 2006-08-10
EP1858532A4 (en) 2011-05-11
WO2006084095A1 (en) 2006-08-10

Similar Documents

Publication Publication Date Title
Środa et al. Repeated injections of PEG-PE liposomes generate anti-PEG antibodies
JP4545928B2 (ja) 第ｖｉｉｉ因子及び中性リポソームを含有する薬学的組成物
JP3270478B2 (ja) 強化されたドラッグ・デリバリーのためのスフィンゴソーム
JP5160534B2 (ja) 低免疫原性および長時間循環性タンパク質−脂質複合体の組成物
WO2011005850A1 (en) Lipidic compositions for induction of immune tolerance
US8110218B2 (en) Compositions and methods for less immunogenic protein-lipid complexes
Ramani et al. Phosphatidylserine containing liposomes reduce immunogenicity of recombinant human factor VIII (rFVIII) in a murine model of hemophilia A
US7351688B2 (en) Compositions and methods for less immunogenic protein formulations
JPH11507628A (ja) 改良されたリポソーム製剤
Kuznetsova et al. Differential binding of plasma proteins by liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the bilayer
US20040229793A1 (en) Compositions and methods for less immunogenic protein formulations
JP2008544990A (ja) 低免疫原性蛋白質−脂質複合体に関する組成物および方法
US7875288B2 (en) Method for treating blood coagulation disorders
US10064922B2 (en) Compositions and methods for immune tolerance induction
Peng et al. Phosphatidylinositol containing lipidic particles reduces immunogenicity and catabolism of factor VIII in hemophilia a mice
US20070167359A1 (en) Pharmaceutical composition comprising proteins and/or polypeptides and colloidal particles
Miclea et al. Effect of phosphatidylethanolamine and polyethylene glycol on the immunogenicity and pharmacokinetic properties of PS containing liposomal B domain deleted rFVIII in a murine model of hemophilia A
Ramani et al. Preclinical Evaluation of PEGylated Liposomal-Recombinant Human FVIII in a Murine Model of Hemophilia A
MX2008000223A (en) Compositions and methods for less immunogenic pr0tein-lip1d complexes
Ramani et al. Liposomal Nano-and Micro-Particulates Containing Phosphatidylserine Reduce the Immunogenicity of Recombinant Human Factor VIII (rFVIII) in a Murine Model of Hemophilia A

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090130

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090130

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111116

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120711