JP2010506952A5 - - Google Patents
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- Publication number
- JP2010506952A5 JP2010506952A5 JP2009533509A JP2009533509A JP2010506952A5 JP 2010506952 A5 JP2010506952 A5 JP 2010506952A5 JP 2009533509 A JP2009533509 A JP 2009533509A JP 2009533509 A JP2009533509 A JP 2009533509A JP 2010506952 A5 JP2010506952 A5 JP 2010506952A5
- Authority
- JP
- Japan
- Prior art keywords
- gel formulation
- present
- diclofenac
- gel
- dmso
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 19
- 238000009472 formulation Methods 0.000 claims 17
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 15
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 9
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 6
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 6
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 6
- 229960001259 diclofenac Drugs 0.000 claims 5
- 229960001193 diclofenac sodium Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims 5
- 239000002562 thickening agent Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 208000006820 Arthralgia Diseases 0.000 claims 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 229920002125 Sokalan® Polymers 0.000 claims 2
- 229960001631 carbomer Drugs 0.000 claims 2
- 125000001664 diethylamino group Chemical class [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000004907 flux Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82975606P | 2006-10-17 | 2006-10-17 | |
| US60/829,756 | 2006-10-17 | ||
| PCT/US2007/081674 WO2008049020A2 (en) | 2006-10-17 | 2007-10-17 | Diclofenac gel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010506952A JP2010506952A (ja) | 2010-03-04 |
| JP2010506952A5 true JP2010506952A5 (cg-RX-API-DMAC10.html) | 2010-12-02 |
| JP5432716B2 JP5432716B2 (ja) | 2014-03-05 |
Family
ID=39023542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533509A Expired - Fee Related JP5432716B2 (ja) | 2006-10-17 | 2007-10-17 | ジクロフェナクゲル |
Country Status (14)
| Country | Link |
|---|---|
| US (14) | US8252838B2 (cg-RX-API-DMAC10.html) |
| EP (2) | EP2626063B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5432716B2 (cg-RX-API-DMAC10.html) |
| CN (2) | CN101588791A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007311019B2 (cg-RX-API-DMAC10.html) |
| BR (1) | BRPI0717769A2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2666398C (cg-RX-API-DMAC10.html) |
| DK (1) | DK2086504T3 (cg-RX-API-DMAC10.html) |
| IL (1) | IL198161A (cg-RX-API-DMAC10.html) |
| MX (1) | MX2009004038A (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ577020A (cg-RX-API-DMAC10.html) |
| RU (1) | RU2463038C2 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2008049020A2 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA200903135B (cg-RX-API-DMAC10.html) |
Families Citing this family (46)
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| AU2006291134C1 (en) | 2005-09-12 | 2013-08-15 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same |
| WO2007033082A2 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
| CN101588791A (zh) | 2006-10-17 | 2009-11-25 | 纽沃研究公司 | 双氯芬酸凝胶 |
| US20100100060A1 (en) * | 2008-10-17 | 2010-04-22 | Novartis Ag | Applicator for pharmaceutical product and method of using same |
| BRPI0921494A2 (pt) | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
| US8546450B1 (en) | 2009-03-31 | 2013-10-01 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
| US8618164B2 (en) | 2009-03-31 | 2013-12-31 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
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| WO2016116909A2 (en) * | 2015-01-23 | 2016-07-28 | Dr. Reddy's Laboratories Limited | Non-staining topical gel compositions of nimesulide |
| US10716754B2 (en) | 2016-03-28 | 2020-07-21 | Tioga Research, Inc. | Topical formulation |
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| CN113498340A (zh) | 2018-11-20 | 2021-10-12 | 恩福莱克逊治疗有限公司 | 用于治疗皮肤疾病噻吩基苯胺化合物 |
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| WO2020106306A1 (en) | 2018-11-20 | 2020-05-28 | Nflection Therapeutics, Inc. | Cyanoaryl-aniline compounds for treatment of dermal disorders |
| WO2020106304A1 (en) * | 2018-11-20 | 2020-05-28 | Nflection Therapeutics, Inc. | Topical formulations |
| WO2021061913A1 (en) * | 2019-09-27 | 2021-04-01 | Encube Ethicals, Pvt. Ltd. | Diclofenac sodium topical solution |
| JP7515582B2 (ja) | 2019-11-06 | 2024-07-12 | スマーテック トピカル，インコーポレイテッド | シクロオキシゲナーゼ阻害剤の局所配合剤およびその使用 |
| CN110687229A (zh) * | 2019-11-12 | 2020-01-14 | 山东省药学科学院 | 一种双氯芬酸钠原料及其制剂中有关物质的分析方法 |
| WO2022040773A1 (en) | 2020-08-26 | 2022-03-03 | Canadian Nano Pharmaceutical Technology Inc. | Nano-emulsion based compositions, methods for their preparation and their use in delivery of active ingredients |
| US12508221B2 (en) * | 2020-09-11 | 2025-12-30 | PS Therapy Ltd | Topical compositions and methods of use |
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| CN114259461B (zh) * | 2021-11-29 | 2023-09-12 | 海南全星制药有限公司 | 一种双氯芬酸钠凝胶及其制备方法 |
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-
2007
- 2007-10-17 CN CNA2007800464038A patent/CN101588791A/zh active Pending
- 2007-10-17 WO PCT/US2007/081674 patent/WO2008049020A2/en not_active Ceased
- 2007-10-17 RU RU2009118392/15A patent/RU2463038C2/ru not_active IP Right Cessation
- 2007-10-17 JP JP2009533509A patent/JP5432716B2/ja not_active Expired - Fee Related
- 2007-10-17 BR BRPI0717769 patent/BRPI0717769A2/pt not_active Application Discontinuation
- 2007-10-17 EP EP13166999.6A patent/EP2626063B1/en active Active
- 2007-10-17 CA CA2666398A patent/CA2666398C/en active Active
- 2007-10-17 CN CN201410667941.0A patent/CN104606126A/zh active Pending
- 2007-10-17 AU AU2007311019A patent/AU2007311019B2/en not_active Ceased
- 2007-10-17 ZA ZA200903135A patent/ZA200903135B/xx unknown
- 2007-10-17 DK DK07863421T patent/DK2086504T3/da active
- 2007-10-17 NZ NZ577020A patent/NZ577020A/en not_active IP Right Cessation
- 2007-10-17 MX MX2009004038A patent/MX2009004038A/es active IP Right Grant
- 2007-10-17 EP EP20070863421 patent/EP2086504B1/en active Active
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2008
- 2008-06-05 US US12/134,121 patent/US8252838B2/en not_active Expired - Fee Related
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2009
- 2009-04-16 IL IL198161A patent/IL198161A/en active IP Right Grant
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2012
- 2012-08-01 US US13/564,688 patent/US8563613B2/en not_active Expired - Fee Related
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2013
- 2013-09-12 US US14/025,781 patent/US8871809B2/en active Active
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2014
- 2014-09-25 US US14/497,096 patent/US9066913B2/en not_active Expired - Fee Related
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2015
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- 2015-01-14 US US14/596,813 patent/US20150126606A1/en not_active Abandoned
- 2015-05-06 US US14/705,649 patent/US9220784B2/en active Active
- 2015-05-06 US US14/705,606 patent/US9168304B2/en active Active
- 2015-05-06 US US14/705,636 patent/US9168305B2/en active Active
- 2015-05-06 US US14/705,593 patent/US9339551B2/en not_active Expired - Fee Related
- 2015-10-26 US US14/922,903 patent/US9339552B2/en not_active Expired - Fee Related
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2016
- 2016-04-06 US US15/092,139 patent/US9539335B2/en not_active Expired - Fee Related
- 2016-12-05 US US15/368,781 patent/US20170266296A1/en not_active Abandoned
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2019
- 2019-09-18 US US16/575,120 patent/US20200237919A1/en not_active Abandoned