JP2010501163A5 - - Google Patents
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- JP2010501163A5 JP2010501163A5 JP2009524812A JP2009524812A JP2010501163A5 JP 2010501163 A5 JP2010501163 A5 JP 2010501163A5 JP 2009524812 A JP2009524812 A JP 2009524812A JP 2009524812 A JP2009524812 A JP 2009524812A JP 2010501163 A5 JP2010501163 A5 JP 2010501163A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- prlr
- amino acid
- extracellular domain
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 101001123448 Homo sapiens Prolactin receptor Proteins 0.000 claims description 63
- 102100029000 Prolactin receptor Human genes 0.000 claims description 63
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 44
- 238000000034 method Methods 0.000 claims description 36
- 206010028980 Neoplasm Diseases 0.000 claims description 21
- 201000011510 cancer Diseases 0.000 claims description 21
- 229940124597 therapeutic agent Drugs 0.000 claims description 19
- 230000026731 phosphorylation Effects 0.000 claims description 15
- 238000006366 phosphorylation reaction Methods 0.000 claims description 15
- 210000004027 cell Anatomy 0.000 claims description 12
- 238000010494 dissociation reaction Methods 0.000 claims description 12
- 230000005593 dissociations Effects 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 239000012830 cancer therapeutic Substances 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 229920001184 polypeptide Polymers 0.000 claims description 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 8
- 101100409237 Homo sapiens PRLR gene Proteins 0.000 claims description 6
- 101100409239 Mus musculus Prlr gene Proteins 0.000 claims description 6
- 230000006698 induction Effects 0.000 claims description 6
- 230000000977 initiatory effect Effects 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 238000012216 screening Methods 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 4
- 101150009057 JAK2 gene Proteins 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 101150024075 Mapk1 gene Proteins 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 101100353203 Rattus norvegicus Prlr gene Proteins 0.000 claims description 4
- 239000012634 fragment Substances 0.000 claims description 4
- 210000004602 germ cell Anatomy 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 230000004048 modification Effects 0.000 claims description 4
- 238000012986 modification Methods 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 230000035755 proliferation Effects 0.000 claims description 3
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims description 2
- 108091035707 Consensus sequence Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 108091054455 MAP kinase family Proteins 0.000 claims description 2
- 102000043136 MAP kinase family Human genes 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 230000033115 angiogenesis Effects 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 230000005907 cancer growth Effects 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 229960000975 daunorubicin Drugs 0.000 claims description 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 238000006471 dimerization reaction Methods 0.000 claims description 2
- 229960004679 doxorubicin Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000013604 expression vector Substances 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 210000005265 lung cell Anatomy 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 125000003729 nucleotide group Chemical group 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 229940071643 prefilled syringe Drugs 0.000 claims description 2
- 210000005267 prostate cell Anatomy 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000008685 targeting Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 230000006711 vascular endothelial growth factor production Effects 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 14
- 238000011275 oncology therapy Methods 0.000 claims 1
- 239000000463 material Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83864806P | 2006-08-18 | 2006-08-18 | |
| US60/838,648 | 2006-08-18 | ||
| US94636007P | 2007-06-26 | 2007-06-26 | |
| US60/946,360 | 2007-06-26 | ||
| PCT/US2007/076160 WO2008022295A2 (en) | 2006-08-18 | 2007-08-17 | Prlr-specific antibody and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012274384A Division JP2013055959A (ja) | 2006-08-18 | 2012-12-17 | Ｐｒｌｒ特異的抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010501163A JP2010501163A (ja) | 2010-01-21 |
| JP2010501163A5 true JP2010501163A5 (https=) | 2011-08-18 |
| JP5517619B2 JP5517619B2 (ja) | 2014-06-11 |
Family
ID=39083161
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009524812A Expired - Fee Related JP5517619B2 (ja) | 2006-08-18 | 2007-08-17 | Ｐｒｌｒ特異的抗体およびその使用 |
| JP2012274384A Withdrawn JP2013055959A (ja) | 2006-08-18 | 2012-12-17 | Ｐｒｌｒ特異的抗体およびその使用 |
| JP2016074116A Withdrawn JP2016130250A (ja) | 2006-08-18 | 2016-04-01 | Ｐｒｌｒ特異的抗体およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012274384A Withdrawn JP2013055959A (ja) | 2006-08-18 | 2012-12-17 | Ｐｒｌｒ特異的抗体およびその使用 |
| JP2016074116A Withdrawn JP2016130250A (ja) | 2006-08-18 | 2016-04-01 | Ｐｒｌｒ特異的抗体およびその使用 |
Country Status (37)
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR062435A1 (es) * | 2006-08-18 | 2008-11-05 | Xoma Technology Ltd | Anticuerpo especifico prlr (receptor de prolactina) y sus usos |
| EP2277044B1 (en) * | 2008-05-13 | 2015-06-17 | Genentech, Inc. | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
| EP2473531A4 (en) * | 2009-09-03 | 2013-05-01 | Merck Sharp & Dohme | Anti-gitr antibodies |
| CN102597775A (zh) * | 2009-09-25 | 2012-07-18 | 佐马技术有限公司 | 筛选方法 |
| EP2332995A1 (en) * | 2009-12-10 | 2011-06-15 | Bayer Schering Pharma Aktiengesellschaft | Neutralizing prolactin receptor antibodies and their therapeutic use |
| PH12013500703A1 (en) | 2010-10-13 | 2013-05-20 | Janssen Biotech Inc | Human oncostatin m antibodies and methods of use |
| EP2630160B1 (en) * | 2010-10-18 | 2016-11-09 | MediaPharma S.r.l. | Erbb3 binding antibody |
| WO2012136519A1 (en) | 2011-04-06 | 2012-10-11 | Bayer Pharma Aktiengesellschaft | Use of neutralizing prolactin receptor antibodies for the treatment and prevention of antiestrogen-resistant breast cancer |
| EP2530089A1 (en) | 2011-06-03 | 2012-12-05 | Bayer Pharma Aktiengesellschaft | Neutralising prolactin receptor antibody Mat3 and its therapeutical use |
| CN102250244A (zh) * | 2011-07-07 | 2011-11-23 | 南京医科大学 | 人源抗人催乳素受体抗体及其应用 |
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| EP2847228B1 (en) | 2012-05-10 | 2018-07-25 | Bayer Pharma Aktiengesellschaft | Antibodies capable of binding to the coagulation factor xi and/or its activated form factor xia and uses thereof |
| AR091649A1 (es) * | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
| CN102746402A (zh) * | 2012-07-09 | 2012-10-24 | 南京医科大学 | 全人源抗人催乳素受体单链抗体及其应用 |
| PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
| US8883979B2 (en) * | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| CN105102480B (zh) * | 2012-12-24 | 2019-04-16 | 艾伯维公司 | 催乳素受体结合蛋白及其用途 |
| EP2968538A1 (en) * | 2013-03-15 | 2016-01-20 | Bayer HealthCare LLC | Anti-prolactin receptor antibody formulations |
| TWI641620B (zh) | 2013-08-21 | 2018-11-21 | 再生元醫藥公司 | 抗－ｐｒｌｒ抗體及其用途 |
| US9545451B2 (en) | 2013-08-21 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Anti-PRLR antibodies and methods for killing PRLR-expressing cells |
| BR112016013347B1 (pt) * | 2013-12-26 | 2023-12-12 | Mitsubishi Tanabe Pharma Corporation | Anticorpo monoclonal humano neutralizante anti-il-33, composição farmacêutica, inibidor da expressão de citocinas, molécula de ácido nucleico, vetor, célula bacteriana transgênica, método de produção e uso dos mesmos |
| SG10201900002QA (en) | 2014-01-24 | 2019-02-27 | Dana Farber Cancer Institue Inc | Antibody molecules to pd-1 and uses thereof |
| EP3099717B1 (en) | 2014-01-31 | 2019-03-27 | Novartis AG | Antibody molecules to tim-3 and uses thereof |
| US20150259420A1 (en) | 2014-03-14 | 2015-09-17 | Novartis Ag | Antibody molecules to lag-3 and uses thereof |
| CN117442748A (zh) | 2014-10-02 | 2024-01-26 | 希望之城公司 | 多价中间表位、中间表位结合抗体及其用途 |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| TWI716362B (zh) | 2014-10-14 | 2021-01-21 | 瑞士商諾華公司 | 針對ｐｄ－ｌ１之抗體分子及其用途 |
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| DK3317301T3 (da) | 2015-07-29 | 2021-06-28 | Immutep Sas | Kombinationsterapier omfattende antistofmolekyler mod lag-3 |
| EP3370768B9 (en) | 2015-11-03 | 2022-03-16 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
| WO2017106656A1 (en) | 2015-12-17 | 2017-06-22 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
| US10654934B2 (en) | 2016-04-01 | 2020-05-19 | Innovative Cellular Therapeutics CO., LTD. | Use of chimeric antigen receptor modified cells to treat cancer |
| CN109219445B (zh) | 2016-04-01 | 2022-08-26 | 上海煦顼技术有限公司 | 嵌合抗原受体修饰细胞治疗癌症的应用 |
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| FI3635009T3 (fi) | 2017-06-07 | 2026-04-07 | Regeneron Pharma | Koostumuksia ja menetelmiä entsyymien internalisoimiseksi |
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| WO2019043634A2 (en) | 2017-08-30 | 2019-03-07 | Beijing Xuanyi Pharmasciences Co., Ltd. | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
| CN111629715A (zh) | 2018-01-18 | 2020-09-04 | 弗莱德哈钦森癌症研究中心 | 通过调节细胞活化状态改变体内免疫细胞的炎症状态 |
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| KR102909650B1 (ko) | 2018-03-13 | 2026-01-08 | 터스크 테라퓨틱스 리미티드 | 종양 특이적 세포 고갈에 대한 항-cd25 |
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| CN109627337B (zh) * | 2018-12-29 | 2023-07-21 | 上海复宏汉霖生物技术股份有限公司 | 一种抗prlr的单克隆抗体及其制备方法和应用 |
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