JP2010500889A5 - - Google Patents
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- Publication number
- JP2010500889A5 JP2010500889A5 JP2009516894A JP2009516894A JP2010500889A5 JP 2010500889 A5 JP2010500889 A5 JP 2010500889A5 JP 2009516894 A JP2009516894 A JP 2009516894A JP 2009516894 A JP2009516894 A JP 2009516894A JP 2010500889 A5 JP2010500889 A5 JP 2010500889A5
- Authority
- JP
- Japan
- Prior art keywords
- stent
- rapamycin
- stent according
- polymer
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000642 polymer Polymers 0.000 claims 7
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 7
- 229960002930 sirolimus Drugs 0.000 claims 7
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 7
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 102100022337 Integrin alpha-V Human genes 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- JOAHPSVPXZTVEP-YXJHDRRASA-N Terguride Chemical compound C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)NC(=O)N(CC)CC)=C3C2=CNC3=C1 JOAHPSVPXZTVEP-YXJHDRRASA-N 0.000 claims 1
- 108010048673 Vitronectin Receptors Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000001680 brushing effect Effects 0.000 claims 1
- 229960000590 celecoxib Drugs 0.000 claims 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 238000001523 electrospinning Methods 0.000 claims 1
- NGOGFTYYXHNFQH-UHFFFAOYSA-N fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 claims 1
- 229960002435 fasudil Drugs 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 229960003587 lisuride Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 229940044551 receptor antagonist Drugs 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 239000000344 soap Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229960001967 tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960004558 terguride Drugs 0.000 claims 1
- 229960003433 thalidomide Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006030586 | 2006-07-03 | ||
| PCT/DE2007/001173 WO2008003298A2 (de) | 2006-07-03 | 2007-07-03 | Herstellung, verfahren und verwendung von wirkstofffreisetzenden medizinprodukten zur permanenten offenhaltung von blutgefässen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148906A Division JP5689377B2 (ja) | 2006-07-03 | 2011-07-05 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500889A JP2010500889A (ja) | 2010-01-14 |
| JP2010500889A5 true JP2010500889A5 (enExample) | 2011-03-17 |
Family
ID=38669027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516894A Pending JP2010500889A (ja) | 2006-07-03 | 2007-07-03 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
| JP2011148906A Expired - Fee Related JP5689377B2 (ja) | 2006-07-03 | 2011-07-05 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148906A Expired - Fee Related JP5689377B2 (ja) | 2006-07-03 | 2011-07-05 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20100063585A1 (enExample) |
| EP (2) | EP2386322B1 (enExample) |
| JP (2) | JP2010500889A (enExample) |
| KR (2) | KR101226256B1 (enExample) |
| CN (2) | CN101583384A (enExample) |
| AU (2) | AU2007271554B2 (enExample) |
| BR (2) | BRPI0714193A2 (enExample) |
| CA (2) | CA2775940A1 (enExample) |
| DE (1) | DE112007002054A5 (enExample) |
| ES (1) | ES2663284T3 (enExample) |
| IL (2) | IL196296A (enExample) |
| MX (3) | MX2009000090A (enExample) |
| NZ (2) | NZ592795A (enExample) |
| PL (1) | PL2386322T3 (enExample) |
| RU (2) | RU2432183C9 (enExample) |
| WO (1) | WO2008003298A2 (enExample) |
| ZA (2) | ZA200900788B (enExample) |
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| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
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2007
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- 2007-07-03 KR KR1020097002256A patent/KR20090045916A/ko not_active Ceased
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