JP2010500889A5 - - Google Patents
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- JP2010500889A5 JP2010500889A5 JP2009516894A JP2009516894A JP2010500889A5 JP 2010500889 A5 JP2010500889 A5 JP 2010500889A5 JP 2009516894 A JP2009516894 A JP 2009516894A JP 2009516894 A JP2009516894 A JP 2009516894A JP 2010500889 A5 JP2010500889 A5 JP 2010500889A5
- Authority
- JP
- Japan
- Prior art keywords
- stent
- rapamycin
- stent according
- polymer
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 7
- 229920000642 polymer Polymers 0.000 claims 7
- 229960002930 sirolimus Drugs 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- RZEKVGVHFLEQIL-UHFFFAOYSA-N Celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- NGOGFTYYXHNFQH-UHFFFAOYSA-N Fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 claims 1
- 102100019438 ITGAV Human genes 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- 210000002381 Plasma Anatomy 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001451 Polypropylene glycol Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- BKRGVLQUQGGVSM-KBXCAEBGSA-N Revanil Chemical compound C1=CC(C=2[C@H](N(C)C[C@H](C=2)NC(=O)N(CC)CC)C2)=C3C2=CNC3=C1 BKRGVLQUQGGVSM-KBXCAEBGSA-N 0.000 claims 1
- 229960001967 Tacrolimus Drugs 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- JOAHPSVPXZTVEP-YXJHDRRASA-N Terguride Chemical compound C1=CC([C@H]2C[C@@H](CN(C)[C@@H]2C2)NC(=O)N(CC)CC)=C3C2=CNC3=C1 JOAHPSVPXZTVEP-YXJHDRRASA-N 0.000 claims 1
- 229960003433 Thalidomide Drugs 0.000 claims 1
- UEJJHQNACJXSKW-UHFFFAOYSA-N Thalidomide Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
- 108010048673 Vitronectin Receptors Proteins 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000001680 brushing Effects 0.000 claims 1
- 229960000590 celecoxib Drugs 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000007598 dipping method Methods 0.000 claims 1
- 238000001523 electrospinning Methods 0.000 claims 1
- 229960002435 fasudil Drugs 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 239000008240 homogeneous mixture Substances 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 229960003587 lisuride Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920000747 poly(lactic acid) polymer Polymers 0.000 claims 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
- 200000000008 restenosis Diseases 0.000 claims 1
- 239000000344 soap Substances 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 229960004558 terguride Drugs 0.000 claims 1
Claims (11)
- 乳酸およびグリコール酸のコポリマー、ポリラクチド、ポリグリコリド、ポリビニルピロリドン、ポリプロピレングリコール、ポリエチレングリコール、またはポリビニルアルコールおよびこれらのポリマーの誘導体もしくは組み合わせの少なくとも１つのポリマー層、ならびにラパマイシンでコーティングされた、ステント。
- ラパマイシンが、再狭窄予防の必要性に時間適合および用量適合する溶出グラフ内の少なくとも２つの増加段階によって特徴付けられる１つのポリマーもしくはポリマー誘導体もしくは均一混合物を通って連続的に溶出される、請求項１に記載のステント。
- ラパマイシンの前記溶出グラフが２つの傾斜を有する、請求項１または２に記載のステント。
- ラパマイシンを含むＰＬＧＡのポリマー層でコーティングされた、請求項１から３のいずれかに記載のステント。
- 前記ステントが、血液適合性ポリマーの最下コーティングを有する、請求項１から４のいずれかに記載のステント。
- 前記血液適合性コーティングが、前記ステントの表面に共有結合されている、請求項５に記載のステント。
- ラパマイシンが、第２の活性薬剤と組み合わされて存在する、請求項１から６のいずれかに記載のステント。
- 前記第２の活性薬剤が、タクロリムス、パクリタキセルおよびその誘導体、ファスジル（登録商標）、ビトロネクチンレセプターアンタゴニスト、サリドマイド、シクロスポリンＡ、テルグリド、リスリド、セレコキシブを含む群から選択される、請求項７に記載のステント。
- ラパマイシンが、０．００１〜１０ｍｇ／ｃｍ ２ ・ステント表面の濃度を有する、請求項１から８のいずれかに記載のステント。
- ステント支柱だけではなくステント支柱間の隙間もまた、ラパマイシンが存在するポリマーでコーティングされる、請求項１から９のいずれかに記載のステント。
- 前記ステントが、スプレー法、ディッピング法、ブラッシング法、ピペッティング法、エレクトロスピニング法、シャボン玉法、プラズマ法、および／またはレーザー技術によって、連続的または逐次的にコーティングされる、請求項１から１０のいずれかに記載のステント。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006030586 | 2006-07-03 | ||
| PCT/DE2007/001173 WO2008003298A2 (de) | 2006-07-03 | 2007-07-03 | Herstellung, verfahren und verwendung von wirkstofffreisetzenden medizinprodukten zur permanenten offenhaltung von blutgefässen |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148906A Division JP5689377B2 (ja) | 2006-07-03 | 2011-07-05 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010500889A JP2010500889A (ja) | 2010-01-14 |
| JP2010500889A5 true JP2010500889A5 (ja) | 2011-03-17 |
Family
ID=38669027
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009516894A Pending JP2010500889A (ja) | 2006-07-03 | 2007-07-03 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
| JP2011148906A Active JP5689377B2 (ja) | 2006-07-03 | 2011-07-05 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148906A Active JP5689377B2 (ja) | 2006-07-03 | 2011-07-05 | 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100063585A1 (ja) |
| EP (2) | EP2046410B1 (ja) |
| JP (2) | JP2010500889A (ja) |
| KR (2) | KR101226256B1 (ja) |
| CN (2) | CN101583384A (ja) |
| AU (2) | AU2007271554B2 (ja) |
| BR (2) | BRPI0714193A2 (ja) |
| CA (2) | CA2775940A1 (ja) |
| DE (1) | DE112007002054A5 (ja) |
| ES (1) | ES2663284T3 (ja) |
| HK (1) | HK1161696A1 (ja) |
| IL (2) | IL196296A (ja) |
| MX (2) | MX2009000090A (ja) |
| NZ (2) | NZ574597A (ja) |
| PL (1) | PL2386322T3 (ja) |
| RU (2) | RU2432183C9 (ja) |
| WO (1) | WO2008003298A2 (ja) |
| ZA (2) | ZA200900788B (ja) |
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| DE102019116791B4 (de) * | 2019-06-21 | 2023-10-26 | InnoRa Gesellschaft mbH | Stent mit sofort ablösbarer Beschichtung |
| CN111001044A (zh) * | 2019-12-30 | 2020-04-14 | 上海申淇医疗科技有限公司 | 一种药物球囊、其涂覆药物的制备及药物球囊的制备方法 |
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- 2007-07-03 AU AU2007271554A patent/AU2007271554B2/en not_active Ceased
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- 2007-07-03 CN CNA2007800324371A patent/CN101583384A/zh active Pending
- 2007-07-03 EP EP07764422.7A patent/EP2046410B1/de active Active
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- 2007-07-03 RU RU2009104348/15A patent/RU2432183C9/ru not_active IP Right Cessation
- 2007-07-03 PL PL11075120T patent/PL2386322T3/pl unknown
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- 2007-07-03 EP EP11075120.3A patent/EP2386322B1/de active Active
- 2007-07-03 WO PCT/DE2007/001173 patent/WO2008003298A2/de active Application Filing
- 2007-07-03 CN CN201110182944.1A patent/CN102258811B/zh active Active
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