JP2008535549A5 - - Google Patents
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- JP2008535549A5 JP2008535549A5 JP2008503229A JP2008503229A JP2008535549A5 JP 2008535549 A5 JP2008535549 A5 JP 2008535549A5 JP 2008503229 A JP2008503229 A JP 2008503229A JP 2008503229 A JP2008503229 A JP 2008503229A JP 2008535549 A5 JP2008535549 A5 JP 2008535549A5
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- 239000004480 active ingredient Substances 0.000 claims 20
- 238000004519 manufacturing process Methods 0.000 claims 18
- 229920000642 polymer Polymers 0.000 claims 12
- 239000011248 coating agent Substances 0.000 claims 9
- 238000000576 coating method Methods 0.000 claims 9
- 229960002930 sirolimus Drugs 0.000 claims 8
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims 6
- QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 6
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 claims 6
- -1 methylrapamycin Chemical compound 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 238000005755 formation reaction Methods 0.000 claims 3
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
- HKVAMNSJSFKALM-XJFKSLPYSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)C(C)=C[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-XJFKSLPYSA-N 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229960001592 Paclitaxel Drugs 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 229960001967 Tacrolimus Drugs 0.000 claims 2
- CGTADGCBEXYWNE-JUKNQOCSSA-N Zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 2
- 229950009819 Zotarolimus Drugs 0.000 claims 2
- 229960003668 docetaxel Drugs 0.000 claims 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
- 229960005167 everolimus Drugs 0.000 claims 2
- 229930003347 taxol Natural products 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
Claims (30)
- 有効成分の送達のためのコーティングを備える埋め込み型デバイスであって、前記コーティングが、
埋め込み型デバイスの表面の少なくとも一部分上にポリマーを含み、厚さＸを有するプライマー領域と、
前記プライマー領域の少なくとも選択された一部分上にポリマー及び有効成分を含み、厚さＹを有するリザーバー領域と
を含み、前記有効成分が前記リザーバー領域から前記プライマー領域まで移動する前に、前記プライマー領域の外表面から前記埋め込み型デバイスの表面までの厚さＸが測定され、
（ａ）前記厚さＸが、０．１ミクロンから１０ミクロンであり、前記厚さＹが、０．５ミクロンから１０ミクロンであるか、又は
（ｂ）Ｘ／Ｙが、以下の範囲、０．０１から０．２、０．０５から０．２、０．０１から２０、０．０５から２０、０．０１から１、０．０５から１及び０．０１から０．０５から選択される、
デバイス。 - Ｘ／Ｙが、０．０１以上及び２０以下である、請求項１に記載の埋め込み型デバイス。
- Ｘ／Ｙが、０．０１以上及び０．２以下である、請求項１に記載の埋め込み型デバイス。
- Ｘ／Ｙが、０．０５以上及び２０以下である、請求項１に記載の埋め込み型デバイス。
- Ｘ／Ｙが、０．０５以上及び０．２以下である、請求項１に記載の埋め込み型デバイス。
- 前記プライマー領域又は前記リザーバー領域が、エチレンビニルアルコールコポリマー又はポリ（ブチルメタクリレート）を含む、請求項１に記載の埋め込み型デバイス。
- 前記デバイスが患者の体内に挿入された後、前記有効成分が前記リザーバー領域から放出される速度を低減するために、前記リザーバー領域の少なくとも選択された一部分上へのバリア領域の形成をさらに含む、請求項１に記載の埋め込み型デバイス。
- 埋め込み型デバイス用のコーティングの製造方法であって、
埋め込み型デバイスの表面の少なくとも一部分上にポリマーを含み、厚さＸを有するプライマー領域を形成するステップと、
前記プライマー領域の少なくとも選択された一部分上にポリマー及び有効成分を含み、厚さＹを有するリザーバー領域を形成するステップとを含み、
（ａ）前記厚さＸが、０．１ミクロンから１０ミクロンであり、前記厚さＹが、０．５ミクロンから１０ミクロンであるか、又は
（ｂ）Ｘ／Ｙが、以下の範囲、０．０１から０．２、０．０５から０．２、０．０１から２０、０．０５から２０、０．０１から１、０．０５から１及び０．０１から０．０５から選択される、
製造方法。 - Ｘ／Ｙが、０．０１以上及び２０以下である、請求項８に記載の製造方法。
- Ｘ／Ｙが、０．０１以上及び０．２以下である、請求項８に記載の製造方法。
- Ｘ／Ｙが、０．０５以上及び２０以下である、請求項８に記載の製造方法。
- Ｘ／Ｙが、０．０５以上及び０．２以下である、請求項８に記載の製造方法。
- 前記デバイスが患者の体内に挿入された後、前記有効成分が前記リザーバー領域から放出される速度を低減するために、前記リザーバー領域の少なくとも選択された一部分上にバリア領域を形成するステップをさらに含む、請求項８に記載の製造方法。
- 前記プライマー領域又は前記リザーバー領域が、エチレンビニルアルコールコポリマー又はポリ（ブチルメタクリレート）を含む、請求項８に記載の製造方法。
- 有効成分の送達のためのコーティングを備える埋め込み型デバイスであって、前記コーティングが、
埋め込み型デバイスの表面の少なくとも一部分上にポリマーを含み、質量Ｘを有するプライマー領域と、
前記プライマー領域の少なくとも選択された一部分上にポリマー及び有効成分を含み、質量Ｙを有するリザーバー領域とを含み、
Ｘ／Ｙが、以下の範囲、０．０１から０．２、０．０５から０．２及び０．０１から０．０５から選択されるデバイス。 - 前記プライマー領域又は前記リザーバー領域が、エチレンビニルアルコールコポリマー又はポリ（ブチルメタクリレート）を含む、請求項１５に記載の埋め込み型デバイス。
- 前記デバイスが患者の体内に挿入された後、前記有効成分が前記リザーバー領域から放出される速度を低減するために、前記リザーバー領域の少なくとも選択された一部分上へのバリア領域の形成をさらに含む、請求項１５に記載の埋め込み型デバイス。
- 埋め込み型デバイス用のコーティングの製造方法であって、
埋め込み型デバイスの表面の少なくとも一部分上にポリマーを含み、質量Ｘを有するプライマー領域を形成するステップと、
前記プライマー領域の少なくとも選択された一部分上にポリマー及び有効成分を含み、質量Ｙを有するリザーバー領域を形成するステップとを含み、
Ｘ／Ｙが、以下の範囲、０．０１から０．２、０．０５から０．２及び０．０１から０．０５から選択される製造方法。 - 前記デバイスが患者の体内に挿入された後、前記有効成分が前記リザーバー領域から放出される速度を低減するために、前記リザーバー領域の少なくとも選択された一部分上にバリア領域を形成するステップをさらに含む、請求項１８に記載の製造方法。
- 前記プライマー領域又は前記リザーバー領域が、エチレンビニルアルコールコポリマー又はポリ（ブチルメタクリレート）を含む、請求項１８に記載の製造方法。
- 有効成分の送達のためのコーティングを備える埋め込み型デバイスであって、前記コーティングが、
埋め込み型デバイスの表面の少なくとも一部分上にポリマーを含む、質量Ｘを有するプライマー領域と、
前記プライマー領域の少なくとも選択された一部分上にポリマー及び有効成分を含む、前記有効成分を除いた質量Ｙを有するリザーバー領域とを含み、
Ｘ／Ｙが、以下の範囲、０．０１から０．２、０．０５から０．２及び０．０１から０．０５から選択されるデバイス。 - 前記プライマー領域又は前記リザーバー領域が、エチレンビニルアルコールコポリマー又はポリ（ブチルメタクリレート）を含む、請求項２１に記載の埋め込み型デバイス。
- 前記デバイスが患者の体内に挿入された後、前記有効成分が前記リザーバー領域から放出される速度を低減するために、前記リザーバー領域の少なくとも選択された一部分上へのバリア領域の形成をさらに含む、請求項２１に記載の埋め込み型デバイス。
- 埋め込み型デバイス用のコーティングの製造方法であって、
埋め込み型デバイスの表面の少なくとも一部分上にポリマーを含み、質量Ｘを有するプライマー領域を形成するステップと、
前記プライマー領域の少なくとも選択された一部分上にポリマー及び有効成分を含み、前記有効成分を除いた質量Ｙを有するリザーバー領域を形成するステップとを含み、
（ｉ）Ｘ／Ｙが、以下の範囲、０．０１から０．２、０．０５から０．２及び０．０１から０．０５から選択される製造方法。 - 前記デバイスが患者の体内に挿入された後、前記有効成分が前記リザーバー領域から放出される速度を低減するために、前記リザーバー領域の少なくとも選択された一部分上にバリア領域を形成するステップをさらに含む、請求項２４に記載の製造方法。
- 前記プライマー領域又は前記リザーバー領域が、エチレンビニルアルコールコポリマー又はポリ（ブチルメタクリレート）を含む、請求項２４に記載の製造方法。
- 埋め込み型デバイスがステントである、請求項８、１８、２４のいずれか一項に記載の製造方法。
- ステントである、請求項１、２、４、６、１５、１６、２１、２２のいずれか一項に記載の埋め込み型デバイス。
- 有効成分が、ラパマイシン、メチルラパマイシン、エベロリムス、４２−Ｅｐｉ−（テトラゾイルイル）ラパマイシン（ＡＢＴ−５７８）、タクロリムス、４０−Ｏ−（２−ヒドロキシ）エチル−ラパマイシン、４０−Ｏ−（３−ヒドロキシ）プロピルラパマイシン、４０−Ｏ−［２−（２−ヒドロキシ）エトキシ］エチル−ラパマイシン、テトラゾール含有ラパマイシン、パクリタキセル又はドセタキセルである、請求項１、６、７、１５〜１７、２１〜２３のいずれか一項に記載の埋め込み型デバイス。
- 有効成分が、ラパマイシン、メチルラパマイシン、エベロリムス、４２−Ｅｐｉ−（テトラゾイルイル）ラパマイシン（ＡＢＴ−５７８）、タクロリムス、４０−Ｏ−（２−ヒドロキシ）エチル−ラパマイシン、４０−Ｏ−（３−ヒドロキシ）プロピルラパマイシン、４０−Ｏ−［２−（２−ヒドロキシ）エトキシ］エチル−ラパマイシン、テトラゾール含有ラパマイシン、パクリタキセル又はドセタキセルである、請求項８、１３、１４、１８、１９、２０、２４〜２６のいずれか一項に記載の製造方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/089,763 US20050238686A1 (en) | 1999-12-23 | 2005-03-25 | Coating for implantable devices and a method of forming the same |
| PCT/US2006/010810 WO2006104894A2 (en) | 2005-03-25 | 2006-03-23 | Coating for implantable devices and a method of forming the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535549A JP2008535549A (ja) | 2008-09-04 |
| JP2008535549A5 true JP2008535549A5 (ja) | 2009-05-07 |
Family
ID=36939187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503229A Pending JP2008535549A (ja) | 2005-03-25 | 2006-03-23 | 埋め込み型デバイス用コーティング及びその形成方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20050238686A1 (ja) |
| EP (1) | EP1868667A2 (ja) |
| JP (1) | JP2008535549A (ja) |
| WO (1) | WO2006104894A2 (ja) |
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-
2005
- 2005-03-25 US US11/089,763 patent/US20050238686A1/en not_active Abandoned
-
2006
- 2006-03-23 EP EP06739536A patent/EP1868667A2/en not_active Withdrawn
- 2006-03-23 JP JP2008503229A patent/JP2008535549A/ja active Pending
- 2006-03-23 WO PCT/US2006/010810 patent/WO2006104894A2/en active Application Filing
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