JP2010500353A5 - - Google Patents

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Publication number
JP2010500353A5
JP2010500353A5 JP2009523806A JP2009523806A JP2010500353A5 JP 2010500353 A5 JP2010500353 A5 JP 2010500353A5 JP 2009523806 A JP2009523806 A JP 2009523806A JP 2009523806 A JP2009523806 A JP 2009523806A JP 2010500353 A5 JP2010500353 A5 JP 2010500353A5
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JP
Japan
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ring
aliphatic
hydrogen
optionally substituted
compound
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JP2009523806A
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English (en)
Japanese (ja)
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JP2010500353A (ja
JP5274460B2 (ja
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Priority claimed from PCT/US2007/017463 external-priority patent/WO2008019124A1/en
Publication of JP2010500353A publication Critical patent/JP2010500353A/ja
Publication of JP2010500353A5 publication Critical patent/JP2010500353A5/ja
Application granted granted Critical
Publication of JP5274460B2 publication Critical patent/JP5274460B2/ja
Expired - Fee Related legal-status Critical Current
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JP2009523806A 2006-08-08 2007-08-06 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 Expired - Fee Related JP5274460B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83615806P 2006-08-08 2006-08-08
US60/836,158 2006-08-08
PCT/US2007/017463 WO2008019124A1 (en) 2006-08-08 2007-08-06 Heteroaryl compounds useful as inhibitors of e1 activating enzymes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013039252A Division JP2013100368A (ja) 2006-08-08 2013-02-28 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物

Publications (3)

Publication Number Publication Date
JP2010500353A JP2010500353A (ja) 2010-01-07
JP2010500353A5 true JP2010500353A5 (enExample) 2010-09-24
JP5274460B2 JP5274460B2 (ja) 2013-08-28

Family

ID=38669274

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2009523806A Expired - Fee Related JP5274460B2 (ja) 2006-08-08 2007-08-06 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2013039252A Withdrawn JP2013100368A (ja) 2006-08-08 2013-02-28 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2014214207A Active JP5906297B2 (ja) 2006-08-08 2014-10-21 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2016058336A Withdrawn JP2016106157A (ja) 2006-08-08 2016-03-23 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2013039252A Withdrawn JP2013100368A (ja) 2006-08-08 2013-02-28 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2014214207A Active JP5906297B2 (ja) 2006-08-08 2014-10-21 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物
JP2016058336A Withdrawn JP2016106157A (ja) 2006-08-08 2016-03-23 Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物

Country Status (29)

Country Link
EP (1) EP2049491B1 (enExample)
JP (4) JP5274460B2 (enExample)
KR (3) KR101555258B1 (enExample)
CN (2) CN103923021B (enExample)
AR (1) AR062270A1 (enExample)
AT (1) ATE485276T1 (enExample)
AU (1) AU2007281993B2 (enExample)
BR (1) BRPI0715176A8 (enExample)
CA (1) CA2659894C (enExample)
CO (1) CO6150159A2 (enExample)
CY (1) CY1111121T1 (enExample)
DE (1) DE602007009998D1 (enExample)
DK (1) DK2049491T3 (enExample)
EA (2) EA201501088A1 (enExample)
ES (1) ES2354925T3 (enExample)
HR (1) HRP20110017T1 (enExample)
IL (4) IL196845A (enExample)
ME (1) ME02789B (enExample)
MX (1) MX2009001309A (enExample)
MY (1) MY157177A (enExample)
NO (1) NO20090434L (enExample)
NZ (1) NZ574513A (enExample)
PL (1) PL2049491T3 (enExample)
PT (1) PT2049491E (enExample)
RS (1) RS51549B (enExample)
SI (1) SI2049491T1 (enExample)
TW (2) TWI515181B (enExample)
WO (1) WO2008019124A1 (enExample)
ZA (1) ZA200900670B (enExample)

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GB201012889D0 (en) 2010-08-02 2010-09-15 Univ Leuven Kath Antiviral activity of novel bicyclic heterocycles
US8815881B2 (en) 2010-08-09 2014-08-26 Hoffmann-La Roche Inc. 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds
GB201015411D0 (en) 2010-09-15 2010-10-27 Univ Leuven Kath Anti-cancer activity of novel bicyclic heterocycles
SG11201400102WA (en) * 2011-08-24 2014-03-28 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
JP2015502137A (ja) * 2011-10-07 2015-01-22 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｅ１酵素変異体およびその用途
JP6238900B2 (ja) 2011-10-28 2017-11-29 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｎａｅ阻害物質に対する応答のバイオマーカー
KR101987861B1 (ko) * 2011-11-03 2019-06-11 밀레니엄 파머슈티컬스 인코퍼레이티드 Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여
SG10201913554YA (en) 2011-12-22 2020-03-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
CN104136399B (zh) * 2012-02-17 2018-08-07 米伦纽姆医药公司 泛素活化酶的吡唑并嘧啶基抑制剂
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
EP2674432A1 (en) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds
EP2904115B1 (en) 2012-10-01 2018-08-08 Millennium Pharmaceuticals, Inc. Biomarkers and methods to predict response to inhibitors and uses thereof
BR112015011148A8 (pt) 2012-11-16 2019-10-01 Merck Sharp & Dohme composto, composição farmacêutica, e combinação
EP2764866A1 (en) * 2013-02-07 2014-08-13 IP Gesellschaft für Management mbH Inhibitors of nedd8-activating enzyme
CA2923752A1 (en) 2013-05-14 2014-11-20 Millennium Pharmaceuticals, Inc. Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents
CN105492429A (zh) * 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
US9334273B1 (en) 2014-03-05 2016-05-10 University Of Georgia Research Foundation, Inc. Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA)
BR112016030787B1 (pt) * 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso
CN105111091A (zh) * 2015-08-26 2015-12-02 吴玲 制备s-3-甲基-1-氨基茚满的方法
CN105085279A (zh) * 2015-08-26 2015-11-25 吴玲 制备r-5-氯-1-氨基茚满
CN105061220A (zh) * 2015-08-26 2015-11-18 吴玲 一种制备r-3-甲基-1-氨基茚满的方法
CN105130824A (zh) * 2015-08-31 2015-12-09 吴玲 一种制备s-5-溴-1-氨基茚满的方法
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
WO2020132384A1 (en) 2018-12-21 2020-06-25 Celgene Corporation Thienopyridine inhibitors of ripk2
MA55556A (fr) 2019-04-02 2022-02-09 Aligos Therapeutics Inc Composés ciblant prmt5
CN110229067A (zh) * 2019-06-05 2019-09-13 南京焕然生物科技有限公司 一种2-氨基茚制备方法
CN112079836B (zh) 2019-06-13 2022-12-13 中国科学院上海药物研究所 三唑并嘧啶类化合物及其盐、组合物和应用
US11540867B2 (en) 2019-08-13 2023-01-03 Pioneer Surgical Technology, Inc. Driver for a bone screw
CN110563655A (zh) * 2019-09-24 2019-12-13 上海毕得医药科技有限公司 一种5-（2-溴乙基）嘧啶的制备方法
BR112022010924A2 (pt) 2019-12-06 2022-09-06 Vertex Pharma Tetra-hidrofuranos substituídos como moduladores de canais de sódio
JP7736700B2 (ja) * 2020-02-28 2025-09-09 リミックス セラピューティクス インコーポレイテッド 複素環アミド及びスプライシングを調節するためのその使用
SMT202500481T1 (it) 2021-06-04 2026-01-12 Vertex Pharma N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof
CN115124534B (zh) * 2021-11-23 2023-09-15 中山大学 非核苷酸类prmt5小分子抑制剂、制备方法及用途
US20260035382A1 (en) * 2022-09-30 2026-02-05 Wigen Biomedicine Technology (shanghai) Co., Ltd. Compounds as sumo activating enzyme inhibitors
CN120112536A (zh) * 2022-11-11 2025-06-06 微境生物医药科技(上海)有限公司 作为sumo活化酶抑制剂的化合物
CN118812375A (zh) * 2023-04-17 2024-10-22 中国科学院大连化学物理研究所 二芳基硼酸催化环氧化物立体选择性开环的方法
CN119306612B (zh) * 2023-07-14 2026-03-20 中国科学院大连化学物理研究所 一种反式氨基茚满的制备方法

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JP4643156B2 (ja) * 2004-03-02 2011-03-02 独立行政法人科学技術振興機構 Ｎ−アシルスルホンアミド結合を有する新規ホスミドシン類縁体
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