JP2010500353A5 - - Google Patents
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- Publication number
- JP2010500353A5 JP2010500353A5 JP2009523806A JP2009523806A JP2010500353A5 JP 2010500353 A5 JP2010500353 A5 JP 2010500353A5 JP 2009523806 A JP2009523806 A JP 2009523806A JP 2009523806 A JP2009523806 A JP 2009523806A JP 2010500353 A5 JP2010500353 A5 JP 2010500353A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- aliphatic
- hydrogen
- optionally substituted
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83615806P | 2006-08-08 | 2006-08-08 | |
| US60/836,158 | 2006-08-08 | ||
| PCT/US2007/017463 WO2008019124A1 (en) | 2006-08-08 | 2007-08-06 | Heteroaryl compounds useful as inhibitors of e1 activating enzymes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013039252A Division JP2013100368A (ja) | 2006-08-08 | 2013-02-28 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500353A JP2010500353A (ja) | 2010-01-07 |
| JP2010500353A5 true JP2010500353A5 (enExample) | 2010-09-24 |
| JP5274460B2 JP5274460B2 (ja) | 2013-08-28 |
Family
ID=38669274
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523806A Expired - Fee Related JP5274460B2 (ja) | 2006-08-08 | 2007-08-06 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
| JP2013039252A Withdrawn JP2013100368A (ja) | 2006-08-08 | 2013-02-28 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
| JP2014214207A Active JP5906297B2 (ja) | 2006-08-08 | 2014-10-21 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
| JP2016058336A Withdrawn JP2016106157A (ja) | 2006-08-08 | 2016-03-23 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013039252A Withdrawn JP2013100368A (ja) | 2006-08-08 | 2013-02-28 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
| JP2014214207A Active JP5906297B2 (ja) | 2006-08-08 | 2014-10-21 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
| JP2016058336A Withdrawn JP2016106157A (ja) | 2006-08-08 | 2016-03-23 | Ｅ１活性化酵素のインヒビターとして有用なヘテロアリール化合物 |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP2049491B1 (enExample) |
| JP (4) | JP5274460B2 (enExample) |
| KR (3) | KR101555258B1 (enExample) |
| CN (2) | CN103923021B (enExample) |
| AR (1) | AR062270A1 (enExample) |
| AT (1) | ATE485276T1 (enExample) |
| AU (1) | AU2007281993B2 (enExample) |
| BR (1) | BRPI0715176A8 (enExample) |
| CA (1) | CA2659894C (enExample) |
| CO (1) | CO6150159A2 (enExample) |
| CY (1) | CY1111121T1 (enExample) |
| DE (1) | DE602007009998D1 (enExample) |
| DK (1) | DK2049491T3 (enExample) |
| EA (2) | EA024793B1 (enExample) |
| ES (1) | ES2354925T3 (enExample) |
| HR (1) | HRP20110017T1 (enExample) |
| IL (4) | IL196845A (enExample) |
| ME (1) | ME02789B (enExample) |
| MX (1) | MX2009001309A (enExample) |
| MY (1) | MY157177A (enExample) |
| NO (1) | NO20090434L (enExample) |
| NZ (1) | NZ574513A (enExample) |
| PL (1) | PL2049491T3 (enExample) |
| PT (1) | PT2049491E (enExample) |
| RS (1) | RS51549B (enExample) |
| SI (1) | SI2049491T1 (enExample) |
| TW (2) | TWI515181B (enExample) |
| WO (1) | WO2008019124A1 (enExample) |
| ZA (1) | ZA200900670B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2949336C (en) | 2007-08-02 | 2018-11-06 | Lei Zhu | Process for the synthesis of e1 activating enzyme inhibitors |
| AU2013204618B2 (en) * | 2007-08-02 | 2015-11-05 | Takeda Pharmaceutical Company Limited | Process for the synthesis of E1 activating enzyme inhibitors |
| ES2543216T3 (es) | 2009-03-13 | 2015-08-17 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Moduladores de tiazolopirimidina como agentes inmunosupresores |
| RU2562245C2 (ru) * | 2009-05-14 | 2015-09-10 | Милленниум Фармасьютикалз, Инк. | ГИДРОХЛОРИД (1S,2S,4R)-4-{ 4-[(1S)-2,3-ДИГИДРО-1Н-ИНДЕН-1-ИЛАМИНО]-7Н-ПИРРОЛО [2,3-d]ПИРИМИДИН-7-ИЛ} -2-ГИДРОКСИЦИКЛОПЕНТИЛ)МЕТИЛ СУЛЬФАМАТА |
| RU2012141536A (ru) * | 2010-03-17 | 2014-04-27 | Ф. Хоффманн-Ля Рош Аг | Имидазопиридины, композиции и способы применения |
| GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
| US8815881B2 (en) | 2010-08-09 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds |
| GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
| HK1199252A1 (en) * | 2011-08-24 | 2015-06-26 | Millennium Pharmaceuticals, Inc. | Inhibitors of nedd8-activating enzyme |
| JP2015502137A (ja) * | 2011-10-07 | 2015-01-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｅ１酵素変異体およびその用途 |
| JP6251176B2 (ja) | 2011-10-28 | 2017-12-20 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎａｅ阻害物質に対する応答のバイオマーカー |
| EP2773360B1 (en) * | 2011-11-03 | 2018-02-28 | Millennium Pharmaceuticals, Inc. | Administration of nedd8-activating enzyme inhibitor and hypomethylating agent |
| EP2794627B1 (en) | 2011-12-22 | 2018-09-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| UA116534C2 (uk) | 2012-02-17 | 2018-04-10 | Мілленніум Фармасьютікалз, Інк. | Піразолопіримідинілові інгібітори убіквітинактивуючого ферменту |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP2674432A1 (en) | 2012-06-14 | 2013-12-18 | LEK Pharmaceuticals d.d. | New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds |
| JP6486826B2 (ja) | 2012-10-01 | 2019-03-20 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 阻害剤に対する応答を予測するためのバイオマーカーおよび方法、ならびにそれらの使用 |
| CN104918939B (zh) * | 2012-11-16 | 2018-08-28 | 默沙东公司 | 人磷脂酰肌醇3-激酶δ的嘌呤抑制剂 |
| EP2764866A1 (en) * | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
| WO2014186388A2 (en) | 2013-05-14 | 2014-11-20 | Millennium Pharmaceutcals, Inc. | Administration of nedd8-activating enzyme inhibitor and chemotherapeutic agents |
| CN105492429A (zh) * | 2013-07-02 | 2016-04-13 | 米伦纽姆医药公司 | Sumo活化酶的杂芳基抑制剂 |
| US9334273B1 (en) | 2014-03-05 | 2016-05-10 | University Of Georgia Research Foundation, Inc. | Efficient and stereoselective synthesis of 2′-fluoro-6′-methylene-carbocyclic adenosine (FMCA) |
| PL3164130T3 (pl) | 2014-07-01 | 2020-02-28 | Millennium Pharmaceuticals, Inc. | Związki heteroarylowe użyteczne jako inhibitory enzymu aktywującego sumo |
| CN105085279A (zh) * | 2015-08-26 | 2015-11-25 | 吴玲 | 制备r-5-氯-1-氨基茚满 |
| CN105111091A (zh) * | 2015-08-26 | 2015-12-02 | 吴玲 | 制备s-3-甲基-1-氨基茚满的方法 |
| CN105061220A (zh) * | 2015-08-26 | 2015-11-18 | 吴玲 | 一种制备r-3-甲基-1-氨基茚满的方法 |
| CN105130824A (zh) * | 2015-08-31 | 2015-12-09 | 吴玲 | 一种制备s-5-溴-1-氨基茚满的方法 |
| WO2019109016A1 (en) | 2017-12-01 | 2019-06-06 | Millennium Pharmaceuticals, Inc. | Biomarkers and methods for treatment with nae inhibitors |
| TW202039481A (zh) | 2018-12-21 | 2020-11-01 | 美商西建公司 | Ripk2之噻吩并吡啶抑制劑 |
| MX2021011606A (es) | 2019-04-02 | 2021-12-10 | Aligos Therapeutics Inc | Compuestos dirigidos a prmt5. |
| CN110229067A (zh) * | 2019-06-05 | 2019-09-13 | 南京焕然生物科技有限公司 | 一种2-氨基茚制备方法 |
| CN112079836B (zh) | 2019-06-13 | 2022-12-13 | 中国科学院上海药物研究所 | 三唑并嘧啶类化合物及其盐、组合物和应用 |
| US11540867B2 (en) | 2019-08-13 | 2023-01-03 | Pioneer Surgical Technology, Inc. | Driver for a bone screw |
| CN110563655A (zh) * | 2019-09-24 | 2019-12-13 | 上海毕得医药科技有限公司 | 一种5-（2-溴乙基）嘧啶的制备方法 |
| MX2022006865A (es) | 2019-12-06 | 2022-07-11 | Vertex Pharma | Tetrahidrofuranos sustituidos como moduladores de canales de sodio. |
| EP4110459A1 (en) * | 2020-02-28 | 2023-01-04 | Remix Therapeutics Inc. | Heterocyclic amides and their use for modulating splicing |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
| CN115124534B (zh) * | 2021-11-23 | 2023-09-15 | 中山大学 | 非核苷酸类prmt5小分子抑制剂、制备方法及用途 |
| JP2025534374A (ja) * | 2022-09-30 | 2025-10-15 | ウィゲン・バイオメディシン・テクノロジー・（シャンハイ）・カンパニー・リミテッド | Ｓｕｍｏ活性化酵素阻害剤としての化合物 |
| WO2024099438A1 (zh) * | 2022-11-11 | 2024-05-16 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
| CN118812375A (zh) * | 2023-04-17 | 2024-10-22 | 中国科学院大连化学物理研究所 | 二芳基硼酸催化环氧化物立体选择性开环的方法 |
| CN119306612A (zh) * | 2023-07-14 | 2025-01-14 | 中国科学院大连化学物理研究所 | 一种反式氨基茚满的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0714957B2 (ja) * | 1987-03-09 | 1995-02-22 | 理化学研究所 | ２′−デオキシ−５−フルオロウリジン誘導体及び制癌剤 |
| AU6500696A (en) * | 1995-07-28 | 1997-02-26 | Cubist Pharmaceuticals, Inc. | Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents |
| AU2003291024A1 (en) * | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| EP1680431A1 (en) * | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
| JP4643156B2 (ja) * | 2004-03-02 | 2011-03-02 | 独立行政法人科学技術振興機構 | Ｎ−アシルスルホンアミド結合を有する新規ホスミドシン類縁体 |
| JP2008503591A (ja) | 2004-06-22 | 2008-02-07 | ライジェル ファーマシューティカルズ， インコーポレイテッド | ユビキチンリガーゼ阻害剤 |
| WO2006084281A1 (en) * | 2005-02-04 | 2006-08-10 | Millennium Pharmaceuticals, Inc. | Inhibitors of e1 activating enzymes |
| JP5231251B2 (ja) * | 2006-02-02 | 2013-07-10 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
-
2007
- 2007-08-06 AT AT07811106T patent/ATE485276T1/de active
- 2007-08-06 WO PCT/US2007/017463 patent/WO2008019124A1/en not_active Ceased
- 2007-08-06 BR BRPI0715176A patent/BRPI0715176A8/pt not_active Application Discontinuation
- 2007-08-06 PT PT07811106T patent/PT2049491E/pt unknown
- 2007-08-06 KR KR1020147009659A patent/KR101555258B1/ko not_active Expired - Fee Related
- 2007-08-06 ME MEP-2011-568A patent/ME02789B/me unknown
- 2007-08-06 CA CA2659894A patent/CA2659894C/en not_active Expired - Fee Related
- 2007-08-06 HR HR20110017T patent/HRP20110017T1/hr unknown
- 2007-08-06 DE DE602007009998T patent/DE602007009998D1/de active Active
- 2007-08-06 EP EP07811106A patent/EP2049491B1/en active Active
- 2007-08-06 ES ES07811106T patent/ES2354925T3/es active Active
- 2007-08-06 EA EA200900285A patent/EA024793B1/ru not_active IP Right Cessation
- 2007-08-06 SI SI200730481T patent/SI2049491T1/sl unknown
- 2007-08-06 MX MX2009001309A patent/MX2009001309A/es active IP Right Grant
- 2007-08-06 NZ NZ574513A patent/NZ574513A/en not_active IP Right Cessation
- 2007-08-06 EA EA201501088A patent/EA201501088A1/ru unknown
- 2007-08-06 RS RSP-2011/0014A patent/RS51549B/sr unknown
- 2007-08-06 PL PL07811106T patent/PL2049491T3/pl unknown
- 2007-08-06 ZA ZA200900670A patent/ZA200900670B/xx unknown
- 2007-08-06 JP JP2009523806A patent/JP5274460B2/ja not_active Expired - Fee Related
- 2007-08-06 MY MYPI20090416A patent/MY157177A/en unknown
- 2007-08-06 KR KR20157002922A patent/KR20150036358A/ko not_active Ceased
- 2007-08-06 AU AU2007281993A patent/AU2007281993B2/en not_active Ceased
- 2007-08-06 KR KR1020097004812A patent/KR101538103B1/ko not_active Expired - Fee Related
- 2007-08-06 DK DK07811106.9T patent/DK2049491T3/da active
- 2007-08-06 CN CN201410133207.6A patent/CN103923021B/zh not_active Expired - Fee Related
- 2007-08-06 CN CN200780033977.1A patent/CN101516850B/zh not_active Expired - Fee Related
- 2007-08-07 TW TW103123369A patent/TWI515181B/zh not_active IP Right Cessation
- 2007-08-07 TW TW96129122A patent/TWI472516B/zh not_active IP Right Cessation
- 2007-08-07 AR ARP070103483A patent/AR062270A1/es not_active Application Discontinuation
-
2009
- 2009-01-29 NO NO20090434A patent/NO20090434L/no not_active Application Discontinuation
- 2009-02-02 IL IL196845A patent/IL196845A/en active IP Right Grant
- 2009-03-05 CO CO09022669A patent/CO6150159A2/es unknown
-
2011
- 2011-01-20 CY CY20111100063T patent/CY1111121T1/el unknown
-
2013
- 2013-02-28 JP JP2013039252A patent/JP2013100368A/ja not_active Withdrawn
-
2014
- 2014-10-21 JP JP2014214207A patent/JP5906297B2/ja active Active
-
2015
- 2015-10-15 IL IL242112A patent/IL242112A/en not_active IP Right Cessation
- 2015-10-15 IL IL242113A patent/IL242113A0/en unknown
-
2016
- 2016-03-23 JP JP2016058336A patent/JP2016106157A/ja not_active Withdrawn
-
2017
- 2017-09-28 IL IL254784A patent/IL254784A0/en unknown
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